Cefamandole bile levels in patients with hepatobiliary disease.


:Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic dose of 1 g administered by intravenous drip showed therapeutically effective concentrations of cefamandole in 84% (11 of 13) of gall bladder samples with a median of 220 micrograms/ml (range, 1.6 to 1,400), and in 100% (13 of 13) of common bile duct samples with a median of 1,100 micrograms/ml (range, 9.0 to greater than 2,000). Only with complete aseptic cystic duct obstruction was cefamandole undetectable in gall bladder bile.


Uwaydah M,Kantarjian H,Osseiran M,Bal'a F




Has Abstract


1982-12-01 00:00:00












  • Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.

    abstract::Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin great...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jones RN,Fuchs PC,Sommers HM,Gavan TL,Barry AL,Gerlach EH

    更新日期:1980-04-01 00:00:00

  • Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs.

    abstract::The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Dumitru R,Hornby JM,Nickerson KW

    更新日期:2004-07-01 00:00:00

  • INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.

    abstract::INX-08189 is an aryl-phosphoramidate of 6-O-methyl-2'-C-methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10±6 nM against hepatitis C genotype 1b at 72 h. The inhibitory effect on viral replication was rapid, with a 50% effective concentration (EC50) of 35±8 nM at ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Vernachio JH,Bleiman B,Bryant KD,Chamberlain S,Hunley D,Hutchins J,Ames B,Gorovits E,Ganguly B,Hall A,Kolykhalov A,Liu Y,Muhammad J,Raja N,Walters CR,Wang J,Williams K,Patti JM,Henson G,Madela K,Aljarah M,Gilles

    更新日期:2011-05-01 00:00:00

  • Antifungal Susceptibility of the Aspergillus viridinutans Complex: Comparison of Two In Vitro Methods.

    abstract::Cryptic species of Aspergillus fumigatus, including the Aspergillus viridinutans species complex, are increasingly reported to be causes of invasive aspergillosis. Their identification is clinically relevant, as these species frequently have intrinsic resistance to common antifungals. We evaluated the susceptibilities...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lyskova P,Hubka V,Svobodova L,Barrs V,Dhand NK,Yaguchi T,Matsuzawa T,Horie Y,Kolarik M,Dobias R,Hamal P

    更新日期:2018-03-27 00:00:00

  • Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats.

    abstract::Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminogly...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yoshiyama Y,Nishikawa S,Sugiyama T,Kobayashi T,Shimada H,Tomonaga F,Ohdo S,Ogawa N,Nakano S

    更新日期:1993-09-01 00:00:00

  • The Novel Phage-Derived Antimicrobial Agent HY-133 Is Active against Livestock-Associated Methicillin-Resistant Staphylococcus aureus.

    abstract::Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage end...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kaspar U,de Haro Sautto JA,Molinaro S,Peters G,Idelevich EA,Becker K

    更新日期:2018-06-26 00:00:00

  • In vitro activities of ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, and rifampin against fully susceptible and moderately penicillin-resistant Neisseria meningitidis.

    abstract::Moderately penicillin-resistant Neisseria meningitidis was responsible for an outbreak of meningococcal disease in Saskatoon, Saskatchewan, Canada in 1993. We tested fully susceptible and moderately resistant strains of N. meningitidis against ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, penicillin, and ri...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Blondeau JM,Yaschuk Y

    更新日期:1995-11-01 00:00:00

  • D-cycloserine uses an active transport mechanism in the human intestinal cell line Caco 2.

    abstract::In a previous study we have shown that cultured epithelial cell lines can be used to measure the transepithelial passage of antimicrobial agents across the intestine and to obtain information on the mechanisms of transport utilized and predict the bioavailability of the antimicrobial agents after oral administration. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ranaldi G,Islam K,Sambuy Y

    更新日期:1994-06-01 00:00:00

  • ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression.

    abstract::In enterobacteria, the ampG gene encodes a transmembrane protein (permease) that transports 1,6-GlcNAc-anhydro-MurNAc and the 1,6-GlcNAc-anhydro-MurNAc peptide from the periplasm to the cytoplasm, which serve as signal molecules for the induction of ampC β-lactamase. The role of AmpG as a transporter is also essential...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Zhang Y,Bao Q,Gagnon LA,Huletsky A,Oliver A,Jin S,Langaee T

    更新日期:2010-11-01 00:00:00

  • Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection.

    abstract::GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. We have characterized the in vivo pharmacodynamics (PD) of GSK1322322 in immunocompetent animal models of infection with Streptococcus pneumoniae a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hoover J,Lewandowski T,Straub RJ,Novick SJ,DeMarsh P,Aubart K,Rittenhouse S,Zalacain M

    更新日期:2015-10-19 00:00:00

  • Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

    abstract::An Ambler class A β-lactamase gene, bla(CIA-1), was cloned from the reference strain Chryseobacterium indologenes ATCC 29897 and expressed in Escherichia coli BL21. The bla(CIA-1) gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respect...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Matsumoto T,Nagata M,Ishimine N,Kawasaki K,Yamauchi K,Hidaka E,Kasuga E,Horiuchi K,Oana K,Kawakami Y,Honda T

    更新日期:2012-01-01 00:00:00

  • β-lactam combinations that exhibit synergy against Mycobacteroides abscessus clinical isolates.

    abstract::Mycobacteroides abscessus (Mab) is an opportunistic environmental pathogen that can cause chronic pulmonary disease in the setting of structural lung conditions such as bronchiectasis, COPD and cystic fibrosis. These infections are often incurable and associated with rapid lung function decline. Mab is naturally resis...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Story-Roller E,Galanis C,Lamichhane G

    更新日期:2020-12-23 00:00:00

  • Development of rifapentine susceptibility tests for Mycobacterium tuberculosis.

    abstract::Two methods for testing the susceptibility of Mycobacterium tuberculosis to rifapentine have been developed: the agar proportion method and the radiometric BACTEC technique. A critical concentration of 0.5 microg of rifapentine per ml is proposed for both methods since it provides a reliable means of distinguishing be...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Heifets L,Sanchez T,Vanderkolk J,Pham V

    更新日期:1999-01-01 00:00:00

  • ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.

    abstract::Orthopoxvirus infections, such as smallpox, can lead to severe systemic disease and result in considerable morbidity and mortality in immunologically naïve individuals. Treatment with ST-246, a small-molecule inhibitor of virus egress, has been shown to provide protection against severe disease and death induced by se...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Berhanu A,King DS,Mosier S,Jordan R,Jones KF,Hruby DE,Grosenbach DW

    更新日期:2009-12-01 00:00:00

  • Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States.

    abstract::The Infectious Diseases Society of America advocates trimethoprim-sulfamethoxazole (SXT) as initial therapy for females with acute uncomplicated bacterial cystitis in settings where the prevalence of SXT resistance does not exceed 10 to 20%. To determine trends in the activities of SXT, ampicillin, ciprofloxacin, and ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Karlowsky JA,Kelly LJ,Thornsberry C,Jones ME,Sahm DF

    更新日期:2002-08-01 00:00:00

  • Observational Study of Associations between Voriconazole Therapeutic Drug Monitoring, Toxicity, and Outcome in Liver Transplant Patients.

    abstract::The aim of this study was to investigate the variability of the voriconazole plasma level and its relationships with clinical outcomes and adverse events among liver transplant recipients to optimize the efficacy and safety of their treatment. Liver transplant recipients treated with voriconazole were included, and vo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hashemizadeh Z,Badiee P,Malekhoseini SA,Raeisi Shahraki H,Geramizadeh B,Montaseri H

    更新日期:2017-11-22 00:00:00

  • Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans.

    abstract::The 18-amino-acid cationic, tryptophan-rich ApoEdpL-W peptide derived from human ApoE apolipoprotein was shown to have antifungal activity against pathogenic yeasts of the Candida genus (except C. glabrata). ApoEdpL-W was active against planktonic cells and early-stage biofilms but less active against mature biofilms,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rossignol T,Kelly B,Dobson C,d'Enfert C

    更新日期:2011-10-01 00:00:00

  • Effect of Lactobacillus rhamnosus GG Administration on Vancomycin-Resistant Enterococcus Colonization in Adults with Comorbidities.

    abstract::Vancomycin-resistant enterococci (VRE) are endemic in health care settings. These organisms colonize the gastrointestinal tract and can lead to infection which is associated with increased mortality. There is no treatment for VRE colonization. We conducted a randomized, double-blind, placebo-controlled clinical trial ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Doron S,Hibberd PL,Goldin B,Thorpe C,McDermott L,Snydman DR

    更新日期:2015-08-01 00:00:00

  • Evaluation of a flow cytofluorometric method for rapid determination of amphotericin B susceptibility of yeast isolates.

    abstract::A rapid-flow cytofluorometric susceptibility test for in vitro amphotericin B testing of yeasts was evaluated and compared to the National Committee for Clinical Laboratory Standards (NCCLS) M27-T reference broth macrodilution method. The flow cytofluorometric method is based on the detection of decreased green fluore...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Peyron F,Favel A,Guiraud-Dauriac H,El Mzibri M,Chastin C,Dumenil G,Regli P

    更新日期:1997-07-01 00:00:00

  • Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses.

    abstract::Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ekins S,Madrid PB

    更新日期:2020-04-21 00:00:00

  • Comparative in vitro evaluation of BL-P1654 and carbenicillin against Pseudomonas.

    abstract::Prior investigators have reported a broad gram-negative spectrum and a marked anti-Pseudomonas activity in vitro with BL-P1654, 6-[R-alpha-(guanylureido)phenylacetamido]-penicillanic acid. An in vitro comparison of BL-P1654 to carbenicillin was performed against 84 strains of Pseudomonas and 39 strains of Enterobacter...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Overturf GD,Ressler R,Wilkins J

    更新日期:1974-11-01 00:00:00

  • Gallium nitrate is efficacious in murine models of tuberculosis and inhibits key bacterial Fe-dependent enzymes.

    abstract::Acquiring iron (Fe) is critical to the metabolism and growth of Mycobacterium tuberculosis. Disruption of Fe metabolism is a potential approach for novel antituberculous therapy. Gallium (Ga) has many similarities to Fe. Biological systems are often unable to distinguish Ga(3+) from Fe(3+). Unlike Fe(3+), Ga(3+) canno...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Olakanmi O,Kesavalu B,Pasula R,Abdalla MY,Schlesinger LS,Britigan BE

    更新日期:2013-12-01 00:00:00

  • A gene conferring resistance to vancomycin but not teicoplanin in isolates of Enterococcus faecalis and Enterococcus faecium demonstrates homology with vanB, vanA, and vanC genes of enterococci.

    abstract::We report the sequence of a 630-bp fragment of a gene associated with resistance to high levels of vancomycin in a clinical isolate of Enterococcus faecalis which retained susceptibility to teicoplanin. This gene was similar to the recently sequenced vanB and partially homologous with vanA, but it showed less-marked s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gold HS,Unal S,Cercenado E,Thauvin-Eliopoulos C,Eliopoulos GM,Wennersten CB,Moellering RC Jr

    更新日期:1993-08-01 00:00:00

  • Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.

    abstract::Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluc...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chau AS,Chen G,McNicholas PM,Mann PA

    更新日期:2006-11-01 00:00:00

  • Inhibitory effects of quinolones on DNA gyrase of Escherichia coli and topoisomerase II of fetal calf thymus.

    abstract::The in vitro inhibitory effects of quinolones on the bacterial DNA gyrase of Escherichia coli KL-16 and topoisomerase II of fetal calf thymus were compared. All the quinolones tested required higher concentrations to inhibit the topoisomerase II than to inhibit the DNA gyrase, and no correlation existed among their in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hoshino K,Sato K,Une T,Osada Y

    更新日期:1989-10-01 00:00:00

  • In vitro and in vivo evaluation of ceftezole, a new cephalosporin derivative.

    abstract::Ceftezole, a new cephalosporin derivative, was compared with cefazolin, cephaloridine, and cephalothin. Data obtained indicate that it is a broad-spectrum antibiotic, with almost identical antimicrobial activity against pathogenic organisms isolated from patients. The therapeutic effect of ceftezole on experimental in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nishida M,Murakawa T,Kamimura T,Okada N,Sakamoto H,Fukada S,Nakamoto S,Yokota Y,Miki K

    更新日期:1976-07-01 00:00:00

  • Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta-lactamases.

    abstract::Selection of resistance to cefamandole has been observed, and the drug has failed to protect animals lethally infected with certain Enterobacteriaceae that appeared to be highly susceptible in vitro. Using spectrophotometric assays, some of these organisms were found to produce beta-lactamases highly active against ce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sanders CC,Sanders WE Jr

    更新日期:1979-06-01 00:00:00

  • Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.

    abstract::Tildipirosin is a 16-membered-ring macrolide developed to treat bacterial pathogens, including Mannheimia haemolytica and Pasteurella multocida, that cause respiratory tract infections in cattle and swine. Here we evaluated the efficacy of tildipirosin at inhibiting protein synthesis on the ribosome (50% inhibitory co...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Andersen NM,Poehlsgaard J,Warrass R,Douthwaite S

    更新日期:2012-11-01 00:00:00

  • Demonstration of R factors in Bordetella bronchiseptica isolated from pigs.

    abstract::Transferability of drug resistance in strains of Bordetella bronchiseptica isolated from pigs was examined. These strains were resistant to sulfadimethoxine (SA, more than 1,600 mug/ml), streptomycin (SM, more than 800 mug/ml), and aminobenzyl penicillin (APC, 200 mug/ml). All of them could transfer their drug resista...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Terakado N,Azechi H,Ninomiya K,Shimizu T

    更新日期:1973-05-01 00:00:00

  • HIV-positive nigerian adults harbor significantly higher serum lumefantrine levels than HIV-negative individuals seven days after treatment for Plasmodium falciparum infection.

    abstract::Management of coinfection with malaria and HIV is a major challenge to public health in developing countries, and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both infections. Each of the constituent components of artemether-lumef...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chijioke-Nwauche I,van Wyk A,Nwauche C,Beshir KB,Kaur H,Sutherland CJ

    更新日期:2013-09-01 00:00:00