Cefamandole bile levels in patients with hepatobiliary disease.

Abstract:

:Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic dose of 1 g administered by intravenous drip showed therapeutically effective concentrations of cefamandole in 84% (11 of 13) of gall bladder samples with a median of 220 micrograms/ml (range, 1.6 to 1,400), and in 100% (13 of 13) of common bile duct samples with a median of 1,100 micrograms/ml (range, 9.0 to greater than 2,000). Only with complete aseptic cystic duct obstruction was cefamandole undetectable in gall bladder bile.

authors

Uwaydah M,Kantarjian H,Osseiran M,Bal'a F

doi

10.1128/aac.22.6.1087

subject

Has Abstract

pub_date

1982-12-01 00:00:00

pages

1087-9

issue

6

eissn

0066-4804

issn

1098-6596

journal_volume

22

pub_type

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