In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens.

abstract：:Development of resistance to the antipseudomonal penicillins and cephalosporins mediated by hyperproduction of the chromosomal cephalosporinase AmpC is a major threat to the successful treatment of Pseudomonas aeruginosa infections. Although ampD inactivation has been previously found to lead to a partially derepresse...

journal_title：Antimicrobial agents and chemotherapy

authors： Juan C,Moyá B,Pérez JL,Oliver A

更新日期：2006-05-01 00:00:00

abstract：:We have shown previously that high-dose lipid amphotericin preparations are not more efficacious than lower doses in aspergillosis. We studied toxicity, drug concentrations and localization, and quantitative infection concurrently, using a 4-day model of central nervous system (CNS) aspergillosis to assess early event...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Schwartz JA,Stevens DA

更新日期：2012-08-01 00:00:00

abstract：:Tildipirosin is a 16-membered-ring macrolide developed to treat bacterial pathogens, including Mannheimia haemolytica and Pasteurella multocida, that cause respiratory tract infections in cattle and swine. Here we evaluated the efficacy of tildipirosin at inhibiting protein synthesis on the ribosome (50% inhibitory co...

journal_title：Antimicrobial agents and chemotherapy

authors： Andersen NM,Poehlsgaard J,Warrass R,Douthwaite S

更新日期：2012-11-01 00:00:00

abstract：:A double-site enzyme-linked lactate dehydrogenase enzyme immunodetection assay was tested against field isolates of Plasmodium falciparum for assessing in vitro drug susceptibilities to a wide range of antimalarial drugs. Its sensitivity allowed the use of parasite densities as low as 200 parasites/microl of blood. Be...

journal_title：Antimicrobial agents and chemotherapy

authors： Brockman A,Singlam S,Phiaphun L,Looareesuwan S,White NJ,Nosten F

更新日期：2004-04-01 00:00:00

abstract：:A penicillin beta-lactamase (PCase) was extracted from Pseudomonas aeruginosa Rms139(+) and purified by means of column chromatography. The isoelectric point of Rms139 PCase was 5.7 and its molecular weight was 22,500 +/- 1,000. The optimal pH for the hydrolysis of benzylpenicillin was 7.0 to 7.5 and the optimal tempe...

journal_title：Antimicrobial agents and chemotherapy

authors： Sawada Y,Yaginuma S,Tai M,Iyobe S,Mitsuhashi S

更新日期：1976-01-01 00:00:00

abstract：:Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 microgram/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (vanA, vanB, vanC, vanD, and vanE). We have isolated a...

journal_title：Antimicrobial agents and chemotherapy

authors： McKessar SJ,Berry AM,Bell JM,Turnidge JD,Paton JC

更新日期：2000-11-01 00:00:00

abstract：:The effects of cefodizime and cefuroxime on neutrophil phagocytosis and reactive oxygen production in 54 patients undergoing elective coronary artery bypass grafting were studied. Both drugs were administered twice at a dosage of 40 mg/kg of body weight (pre- and intraoperative). Phagocytic capacity was assessed by me...

journal_title：Antimicrobial agents and chemotherapy

authors： Wenisch C,Bartunek A,Zedtwitz-Liebenstein K,Hiesmayr M,Parschalk B,Pernerstorfer T,Graninger W

更新日期：1997-07-01 00:00:00

abstract：:Sporangiomycin and micrococcin inhibit the binding of aminoacyl-transfer ribonucleic acid into the ribosomal A site in intact bacterial protoplasts. They also prevent the assembly of [ribosome-elongation factor G-guanine nucleotide] complexes in vitro and compete with [(35)S]thiostrepton for ribosomal binding sites. W...

journal_title：Antimicrobial agents and chemotherapy

authors： Cundliffe E,Dixon PD

更新日期：1975-07-01 00:00:00

abstract：:The antibiotic susceptibilities of 43 strains of Escherichia coli O157:H7 identified in the summer of 1996 in Japan were investigated. Growth of 90% of O157 strains was inhibited at a concentration of < or = 0.5 micro/ml by several agents including fosfomycin with glucose-6-phosphate. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuboi I,Ida H,Yoshikawa E,Hiyoshi S,Yamaji E,Nakayama I,Nonomiya T,Shigenobu F,Shimizu M,O'Hara K,Sawai T,Mizuoka K

更新日期：1998-02-01 00:00:00

abstract：:Growth of Mycoplasma pneumoniae was completely prevented by 0.06 mug of actinomycin D/ml, and 0.00375 mug/ml caused 90% inhibition. It thus appears that M. pneumoniae is more susceptible to actinomycin D than previously reported. Low concentrations (0.019 mug/ml) of the antibiotic primarily inhibited ribonucleic acid ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fletcher RD,Jayavasu C,Yoo S,Albertson JN

更新日期：1973-09-01 00:00:00

abstract：:A major clinical challenge for treating infectious diseases is the duration of antimicrobial therapy required to eradicate the pathogen. We hypothesized that modulation of the bacterial replication rate in the context of an antimicrobial exposure is coupled with the rate and extent of bactericidal effects. Herein we d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ambrose PG,VanScoy B,Conde H,McCauley J,Rubino CM,Bhavnani SM

更新日期：2016-12-27 00:00:00

abstract：:A spontaneous Escherichia coli mutant, named Q3, resistant to nalidixic acid was obtained from a previously described clinical isolate of E. coli, Q2, resistant to fluoroquinolones but susceptible to nalidixic acid (E. Cambau, F. Bordon, E. Collatz, and L. Gutmann, Antimicrob. Agents Chemother. 37:1247-1252, 1993). Q3...

journal_title：Antimicrobial agents and chemotherapy

authors： Truong QC,Nguyen Van JC,Shlaes D,Gutmann L,Moreau NJ

更新日期：1997-01-01 00:00:00

abstract：:Salmonella typhimurium isolated in Bombay from fecal samples of 145 patients suffering from gastroenteritis (group 1) and from the cerebrospinal fluid, feces, or blood of 42 patients with systemic salmonellosis (group 2) were examined for the antimicrobial resistance and incompatibility groups of their R plasmids. Mul...

journal_title：Antimicrobial agents and chemotherapy

authors： Rangnekar VM,Banker DD,Jhala HI

更新日期：1983-01-01 00:00:00

abstract：:Maribavir (1263W94, VP-41263) is an oral anticytomegalovirus agent under clinical development. The pharmacokinetics and safety of maribavir and the effects of maribavir on the activities of cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2 (NAT-2), and xanthine oxidase (XO) were eval...

journal_title：Antimicrobial agents and chemotherapy

authors： Ma JD,Nafziger AN,Villano SA,Gaedigk A,Bertino JS Jr

更新日期：2006-04-01 00:00:00

abstract：:The ability of LM cells, thymidine kinase-deficient LM cells (LMTK-), and LMTK- cells transformed to the LMTK+ phenotype by herpes simplex virus type 1 genetic information (LH7 cells) to anabolize the acyclovir congener ganciclovir was examined. About 50-fold more ganciclovir triphosphate was produced by LH7 cells tha...

journal_title：Antimicrobial agents and chemotherapy

authors： St Clair MH,Lambe CU,Furman PA

更新日期：1987-06-01 00:00:00

abstract：:The combination of liposomal amphotericin B (LAMB) and caspofungin (CAS) holds promise to improve the outcome of opportunistic invasive mycoses with poor prognosis. Little is known, however, about the safety and pharmacokinetics of the combination in patients at high risk for these infections. The safety and pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Silling G,Young C,Schwerdtfeger R,Ostermann H,Heinz WJ,Gerss J,Kolve H,Lanvers-Kaminsky C,Vieira Pinheiro JP,Gammelin S,Cornely OA,Wuerthwein G

更新日期：2010-10-01 00:00:00

abstract：:Enterococci are intrinsically resistant to numerous antimicrobial agents. We examined the energy-dependent efflux of radiolabeled drugs from four reference strains of Enterococcus faecalis and a strain of Enterococcus faecium and found that most strains pumped out norfloxacin and chloramphenicol. Efflux of tetracyclin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lynch C,Courvalin P,Nikaido H

更新日期：1997-04-01 00:00:00

abstract：:Parasitic diseases are of enormous public health significance in developing countries-a situation compounded by the toxicity of and resistance to many current chemotherapeutics. We investigated a focused library of 18 structurally diverse bis-acridine compounds for in vitro bioactivity against seven protozoan and one ...

journal_title：Antimicrobial agents and chemotherapy

authors： Caffrey CR,Steverding D,Swenerton RK,Kelly B,Walshe D,Debnath A,Zhou YM,Doyle PS,Fafarman AT,Zorn JA,Land KM,Beauchene J,Schreiber K,Moll H,Ponte-Sucre A,Schirmeister T,Saravanamuthu A,Fairlamb AH,Cohen FE,McKerrow

更新日期：2007-06-01 00:00:00

abstract：:Four out of 143 phenotypically isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis strains that were isolated from patients in Germany in 2011 had mutations in the rifampin resistance-determining region of rpoB. After performing drug susceptibility testing (DST) with two methods, the proportion met...

journal_title：Antimicrobial agents and chemotherapy

authors： Andres S,Hillemann D,Rüsch-Gerdes S,Richter E

更新日期：2014-01-01 00:00:00

abstract：:The genetic basis for fluoroquinolone resistance was examined in 30 high-level fluoroquinolone-resistant Escherichia coli clinical isolates from Beijing, China. Each strain also demonstrated resistance to a variety of other antibiotics. PCR sequence analysis of the quinolone resistance-determining region of the topois...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang H,Dzink-Fox JL,Chen M,Levy SB

更新日期：2001-05-01 00:00:00

abstract：:The antifungal activities of amphotericin B and two triazoles, Sch 39304 and fluconazole, were tested against Histoplasma capsulatum. In this study Sch 39304 compared favorably with amphotericin B in treating histoplasmosis in normal and leukopenic mice, whereas fluconazole was much less active. The differences in the...

journal_title：Antimicrobial agents and chemotherapy

authors： Kobayashi GS,Travis SJ,Rinaldi MG,Medoff G

更新日期：1990-04-01 00:00:00

abstract：:One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains belonged to the genera Enterobacter, Pseudomonas, and Citrobacter. Among these strains, 92% were resistant to cefoperazone, 91%...

journal_title：Antimicrobial agents and chemotherapy

authors： Fung-Tomc J,Dougherty TJ,DeOrio FJ,Simich-Jacobson V,Kessler RE

更新日期：1989-04-01 00:00:00

abstract：:Peroxide antimalarials, including artemisinin, are important for the treatment of multidrug-resistant malaria. These peroxides are known to react with iron or heme to produce reactive intermediates that are thought to be responsible for their antimalarial activities. This study investigated the potential interaction o...

journal_title：Antimicrobial agents and chemotherapy

authors： Creek DJ,Ryan E,Charman WN,Chiu FC,Prankerd RJ,Vennerstrom JL,Charman SA

更新日期：2009-08-01 00:00:00

abstract：:The bioactivity of imipenem at 20 micrograms/ml in various agar and broth media which are commonly used in susceptibility test assays was measured at different storage temperatures over time. Imipenem was found to be more stable at 4 degrees C than at -20 degrees C and least stable in all media at 35 degrees C. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Baron EJ,Hindler JA

更新日期：1984-06-01 00:00:00

abstract：:Colistin is increasingly being utilized against Gram-negative pathogens, including Pseudomonas aeruginosa, resistant to all other antibiotics. Since limited data exist regarding killing by colistin at different initial inocula (CFUo), we evaluated killing of Pseudomonas aeruginosa by colistin at several CFUo and devel...

journal_title：Antimicrobial agents and chemotherapy

authors： Bulitta JB,Yang JC,Yohonn L,Ly NS,Brown SV,D'Hondt RE,Jusko WJ,Forrest A,Tsuji BT

更新日期：2010-05-01 00:00:00

abstract：:More than 10(6) compounds were evaluated in a human immunodeficiency virus type 1 (HIV-1) high-throughput antiviral screen, resulting in the identification of a novel HIV-1 inhibitor (UK-201844). UK-201844 exhibited antiviral activity against HIV-1 NL4-3 in MT-2 and PM1 cells, with 50% effective concentrations of 1.3 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Blair WS,Cao J,Jackson L,Jimenez J,Peng Q,Wu H,Isaacson J,Butler SL,Chu A,Graham J,Malfait AM,Tortorella M,Patick AK

更新日期：2007-10-01 00:00:00

abstract：:Biochemical variations accompanying the acquisition of ethambutol (EMB) resistance in a single-step mutant of Mycobacterium tuberculosis H37Ra were analyzed. Comparative analysis of phospholipids revealed a reduced content in the EMB-resistant strain, particularly in the cell membrane fraction. Significant alterations...

journal_title：Antimicrobial agents and chemotherapy

authors： Sareen M,Khuller GK

更新日期：1990-09-01 00:00:00

abstract：:Lysobactor enzymogenes strain OH11 is an emerging biological control agent of fungal and bacterial diseases. We recently completed its genome sequence and found it contains a large number of gene clusters putatively responsible for the biosynthesis of nonribosomal peptides and polyketides, including the previously ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang W,Li Y,Qian G,Wang Y,Chen H,Li YZ,Liu F,Shen Y,Du L

更新日期：2011-12-01 00:00:00

abstract：:In this study, we synthesized antisense oligodeoxynucleotides (ODNs) with phosphodiester, phosphorothioate (S-ODNs), or methylphosphonate linkages complementary to the splicing acceptor site of immediate-early pre-mRNA 5 of herpes simplex virus type 1 (HSV-1). The antiviral activity of each analog on cytopathic effect...

journal_title：Antimicrobial agents and chemotherapy

authors： Shoji Y,Shimada J,Mizushima Y,Iwasawa A,Nakamura Y,Inouye K,Azuma T,Sakurai M,Nishimura T

更新日期：1996-07-01 00:00:00

abstract：:The role of Ser-235 in the catalytic mechanism of the TEM-1 beta-lactamase has been explored by the study of a mutant enzyme in which Ser-235 has been substituted by alanine (Ala-235 mutant enzyme). A comparative kinetic analysis of both the wild-type and the Ala-235 TEM-1 enzymes revealed little effect of this substi...

journal_title：Antimicrobial agents and chemotherapy

authors： Imtiaz U,Manavathu EK,Lerner SA,Mobashery S

更新日期：1993-11-01 00:00:00