Antibiotic susceptibility of enterohemorrhagic Escherichia coli O157:H7 isolated from an outbreak in Japan in 1996.

abstract：:Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite-killing activity with the histone methyltransferase inhibitor BIX-01294 and its analogue TM2-115. Here, we further characterize these diaminoqu...

journal_title：Antimicrobial agents and chemotherapy

authors： Malmquist NA,Sundriyal S,Caron J,Chen P,Witkowski B,Menard D,Suwanarusk R,Renia L,Nosten F,Jiménez-Díaz MB,Angulo-Barturen I,Santos Martínez M,Ferrer S,Sanz LM,Gamo FJ,Wittlin S,Duffy S,Avery VM,Ruecker A,Delves MJ

更新日期：2015-02-01 00:00:00

abstract：:Piperacillin and vancomycin were used as initial empirical therapy for 211 febrile episodes in cancer patients. The response rate in 95 episodes of documented infection was 72%. The response of bacteremias, soft tissue infections, and pneumonias was 78, 71, and 38%, respectively. The response in infections caused by g...

journal_title：Antimicrobial agents and chemotherapy

authors： Jadeja L,Bolivar R,Fainstein V,Keating M,McCredie K,Hay M,Bodey GP

更新日期：1984-09-01 00:00:00

abstract：:An experiment was conducted in animal facilities to compare the impacts of four avian colibacillosis treatments-oxytetracycline (OTC), trimethoprim-sulfadimethoxine (SXT), amoxicillin (AMX), or enrofloxacin (ENR)-on the susceptibility of Escherichia coli in broiler intestinal tracts. Birds were first orally inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Dheilly A,Le Devendec L,Mourand G,Bouder A,Jouy E,Kempf I

更新日期：2012-01-01 00:00:00

abstract：:Trimethoprim resistance dihydrofolate reductase genes from plasmids known to be exchanging between human and animal populations were mapped. The dihydrofolate reductase gene has been highly conserved in all plasmids, but differences in the flanking regions provide evidence that the most recent exchange of plasmids bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Campbell IG,Mee BJ

更新日期：1987-09-01 00:00:00

abstract：:Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG str...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohnishi M,Ono E,Shimuta K,Watanabe H,Okamura N

更新日期：2010-07-01 00:00:00

abstract：:Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH2) for its union to the mitochondrial bc1 complex, preventing the ubiquinone-8,9 (UQ) redox recycling, which is a necessary step in pyrimidine biosynthesis. This study focused on UQ biosynthesis in Plasmodium falciparum and adopted proof-of-c...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdaguer IB,Crispim M,Zafra CA,Sussmann RAC,Buriticá NL,Melo HR,Azevedo MF,Almeida FG,Kimura EA,Katzin AM

更新日期：2021-01-25 00:00:00

abstract：:Actinobacillus actinomycetemcomitans, a pathogen associated with aggressive periodontitis, resists phagocytic killing by polymorphonuclear leukocytes (PMNs). It is susceptible to ciprofloxacin, which PMNs actively accumulate. This study tested the hypothesis that ciprofloxacin-loaded PMNs are more effective at killing...

journal_title：Antimicrobial agents and chemotherapy

authors： Cacchillo DA,Walters JD

更新日期：2002-06-01 00:00:00

abstract：:The current recommendations for intravenous (i.v.) acyclovir dosing in obese patients suggest using ideal body weight (IBW) rather than total body weight (TBW). To our knowledge, no pharmacokinetic analysis has validated this recommendation. This single-dose pharmacokinetic study was conducted in an inpatient oncology...

journal_title：Antimicrobial agents and chemotherapy

authors： Turner RB,Cumpston A,Sweet M,Briggs F,Slain D,Wen S,Craig M,Hamadani M,Petros W

更新日期：2016-01-11 00:00:00

abstract：:Many hospital antimicrobial stewardship programs restrict the availability of selected drugs by requiring prior approval. Carbapenems may be among the restricted drugs, but it is unclear if hospitals that restrict availability actually use fewer carbapenems than hospitals that do not restrict use. Nor is it clear if r...

journal_title：Antimicrobial agents and chemotherapy

authors： Pakyz AL,Oinonen M,Polk RE

更新日期：2009-05-01 00:00:00

abstract：:A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luque S,Hope W,Campillo N,Muñoz-Bermúdez R,Sorli L,Barceló-Vidal J,González-Colominas E,Alvarez-Lerma F,Masclans JR,Montero M,Horcajada JP,Grau S

更新日期：2019-06-24 00:00:00

abstract：:Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment with doxycycline suggested that the disease phase during which treatment is initiated influences o...

journal_title：Antimicrobial agents and chemotherapy

authors： McClure JC,Crothers ML,Schaefer JJ,Stanley PD,Needham GR,Ewing SA,Stich RW

更新日期：2010-12-01 00:00:00

abstract：:A significant cause of mortality in the intensive care unit (ICU) is multidrug-resistant (MDR) Gram-negative bacteria, such as MDR Acinetobacter baumannii (MDR-AB) and Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp). The aim of the present study was to compare the clinical features, therapy, and o...

journal_title：Antimicrobial agents and chemotherapy

authors： Russo A,Giuliano S,Ceccarelli G,Alessandri F,Giordano A,Brunetti G,Venditti M

更新日期：2018-05-25 00:00:00

abstract：:Sordarin derivatives constitute a new group of synthetic antifungal agents that selectively inhibit fungal protein synthesis. They have demonstrated in vitro activity against the most important fungal pathogens, both yeast and filamentous. This new family of compounds has also shown in vivo activity against murine Can...

journal_title：Antimicrobial agents and chemotherapy

authors： Aviles P,Pateman A,San Roman R,Guillén MJ,Gómez De Las Heras F,Gargallo-Viola D

更新日期：2001-10-01 00:00:00

abstract：:The comparative in vitro activity of SMT19969, a novel, narrow-spectrum, nonabsorbable agent, was studied against 50 ribotype-defined Clostridium difficile strains, 174 Gram-positive and 136 Gram-negative intestinal anaerobes, and 40 Gram-positive aerobes. SMT19969 was one dilution more active against C. difficile iso...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Tyrrell KL,Merriam CV

更新日期：2013-10-01 00:00:00

abstract：:β-Lactam antibiotics that inhibit penicillin-binding proteins (PBPs) have been widely used in the treatment of bacterial infections. However, the molecular basis underlying the different inhibitory potencies of β-lactams against specific PBPs is not fully understood. Here, we present the crystal structures of penicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JH,Cha HJ,Kim YG

更新日期：2018-08-27 00:00:00

abstract：:Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new assay system in agar plates, the radial diffusion assay, to evaluate the effects of human defensins against gram-positive...

journal_title：Antimicrobial agents and chemotherapy

authors： Takemura H,Kaku M,Kohno S,Hirakata Y,Tanaka H,Yoshida R,Tomono K,Koga H,Wada A,Hirayama T,Kamihira S

更新日期：1996-10-01 00:00:00

abstract：:Fluconazole, an inhibitor of certain human cytochrome P-450 isozymes, is used for the prevention and treatment of a broad range of fungal infections that predominantly affect immunocompromised individuals. This study evaluated the influence of fluconazole on the steady-state pharmacokinetics of delavirdine, a nonnucle...

journal_title：Antimicrobial agents and chemotherapy

authors： Borin MT,Cox SR,Herman BD,Carel BJ,Anderson RD,Freimuth WW

更新日期：1997-09-01 00:00:00

abstract：:In a retrospective review of 24 patients with histoplasmosis, blastomycosis, or coccidioidomycosis treated with voriconazole (most for salvage therapy), the outcome was favorable (improved or stable) for 22 (95.8%) within 2 months of starting voriconazole and for 20 (83.3%) at the last follow-up. Prospective studies a...

journal_title：Antimicrobial agents and chemotherapy

authors： Freifeld A,Proia L,Andes D,Baddour LM,Blair J,Spellberg B,Arnold S,Lentnek A,Wheat LJ

更新日期：2009-04-01 00:00:00

abstract：:Two coumarins, inhibitors of the B subunit of DNA gyrase, and six quinolones, inhibitors of the A subunit, were tested against Escherichia coli topoisomerase I-catalyzed DNA relaxation. Coumarins had no effect, whereas quinolones were inhibitors of the enzyme. This inhibition was compared with that of DNA gyrase and c...

journal_title：Antimicrobial agents and chemotherapy

authors： Tabary X,Moreau N,Dureuil C,Le Goffic F

更新日期：1987-12-01 00:00:00

abstract：:Ceftizoxime, a new cephalosporin, was active against Pseudomonas cepacia, Flavobacterium meningosepticum, Alcaligenes faecalis, and Acinetobacter calcoaceticus and was more potent against Pseudomonas aeruginosa and Pseudomonas putida than was carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yabuuchi E,Ito T,Tanimura E,Yamamoto N,Ohyama A

更新日期：1981-07-01 00:00:00

abstract：:A comparison was made of the in vitro activity of ciprofloxacin (Bay o 9867) with nine other antibiotics against isolates of Campylobacter jejuni, Salmonella spp., Shigella spp., Yersinia enterocolitica, Clostridium difficile, Vibrio spp., and Escherichia coli. Minimum inhibitory concentrations of ciprofloxacin were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodman LJ,Fliegelman RM,Trenholme GM,Kaplan RL

更新日期：1984-04-01 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:Assessment of drug susceptibility has become an integral part of influenza virus surveillance. In this study, we describe the drug resistance profile of influenza A(H3N2) virus, A/Mississippi/05/2011, collected from a patient treated with oseltamivir and detected via surveillance. An MDCK cell-grown isolate of this vi...

journal_title：Antimicrobial agents and chemotherapy

authors： Tamura D,Nguyen HT,Sleeman K,Levine M,Mishin VP,Yang H,Guo Z,Okomo-Adhiambo M,Xu X,Stevens J,Gubareva LV

更新日期：2013-12-01 00:00:00

abstract：:Heteroresistance refers to the presence, within a large population of antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibilities. Ceftaroline is a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to detect the prevalen...

journal_title：Antimicrobial agents and chemotherapy

authors： Saravolatz SN,Martin H,Pawlak J,Johnson LB,Saravolatz LD

更新日期：2014-06-01 00:00:00

abstract：:WR99210, a dihydrofolate reductase inhibitor, has promising in vitro activity against Mycobacterium avium complex (MAC). The in vitro activities of WR99210 alone and in combination with a fixed concentration of dapsone (0.5 microgram/ml) were evaluated against 35 clinical MAC isolates by a broth dilution method. The M...

journal_title：Antimicrobial agents and chemotherapy

authors： Shah LM,DeStefano MS,Cynamon MH

更新日期：1996-11-01 00:00:00

abstract：:The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dumitru R,Hornby JM,Nickerson KW

更新日期：2004-07-01 00:00:00

abstract：:Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoyle BD,Alcantara J,Costerton JW

更新日期：1992-09-01 00:00:00

abstract：:Alalevonadifloxacin (WCK 2349) is a novel l-alanine ester prodrug of levonadifloxacin that is being developed as an oral fluoroquinolone antibiotic. The primary objective of this study was to determine and compare plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of levonadifloxacin fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodvold KA,Gotfried MH,Chugh R,Gupta M,Yeole R,Patel A,Bhatia A

更新日期：2018-02-23 00:00:00

abstract：:By the time-kill curve method, the combination of N-formimidoyl thienamycin and gentamicin showed synergism against 47 of 48 strains of enterococci, whereas the combination of N-formimidoyl thienamycin and tobramycin was synergistic against 46 strains. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanakunakorn C,Tisone JC

更新日期：1982-12-01 00:00:00

abstract：:Drug repositioning is the only feasible option to immediately address the COVID-19 global challenge. We screened a panel of 48 FDA-approved drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which were preselected by an assay of SARS-CoV. We identified 24 potential antiviral drug candidates aga...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeon S,Ko M,Lee J,Choi I,Byun SY,Park S,Shum D,Kim S

更新日期：2020-06-23 00:00:00