Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information.

abstract：:The pharmacokinetics of cefdinir were investigated in six hemodialysis patients. For the present study, two tests were carried out, one with 4 h of hemodialysis and the other without hemodialysis. Cefdinir was given orally to each patient in a dose of 100 mg, and blood was collected serially for 48 h after dosing in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hishida A,Ohishi K,Nagashima S,Kanamaru M,Obara M,Kitada A

更新日期：1998-07-01 00:00:00

abstract：:Many hospital antimicrobial stewardship programs restrict the availability of selected drugs by requiring prior approval. Carbapenems may be among the restricted drugs, but it is unclear if hospitals that restrict availability actually use fewer carbapenems than hospitals that do not restrict use. Nor is it clear if r...

journal_title：Antimicrobial agents and chemotherapy

authors： Pakyz AL,Oinonen M,Polk RE

更新日期：2009-05-01 00:00:00

abstract：:The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase (RT) is rapidly selected in tissue culture following serial passage of wild-type virus in the presence of increasing concentrations of lamivudine (3TC). M184V is also associated with several alterations of RT enzymatic function in vitr...

journal_title：Antimicrobial agents and chemotherapy

authors： Petrella M,Oliveira M,Moisi D,Detorio M,Brenner BG,Wainberg MA

更新日期：2004-11-01 00:00:00

abstract：:Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an essential protein for blood-stage Plasmodium parasites, but details about its function during malaria's elusive liver stage are unclear...

journal_title：Antimicrobial agents and chemotherapy

authors： Posfai D,Eubanks AL,Keim AI,Lu KY,Wang GZ,Hughes PF,Kato N,Haystead TA,Derbyshire ER

更新日期：2018-03-27 00:00:00

abstract：:Mycobacterium smegmatis DSM43756 inactivates rifampin, and the inactivated antibiotic product recovered from culture medium was ribosylated on the 23-OH group. To study this process, the gene responsible for the inactivation was expressed at high levels by the lac promoter in Escherichia coli conferring resistance to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Quan S,Imai T,Mikami Y,Yazawa K,Dabbs ER,Morisaki N,Iwasaki S,Hashimoto Y,Furihata K

更新日期：1999-01-01 00:00:00

abstract：:The intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime were studied in 68 volunteers who received single, oral doses of azithromycin (0.5 g), clarithormycin (0.5 g), ciprofloxacin (0.5 g), or cefuroxime (0.5 g). In subgroups of four subjects each, the subjects underwent bron...

journal_title：Antimicrobial agents and chemotherapy

authors： Conte JE Jr,Golden J,Duncan S,McKenna E,Lin E,Zurlinden E

更新日期：1996-07-01 00:00:00

abstract：:The minimal inhibitory concentration of temocillin (BRL 17421) against 476 clinical isolates was determined by an agar dilution method. Temocillin was active against most of the Enterobacteriaceae, Haemophilus, and Neisseria strains tested. The compound showed low activity or was inactive against Bacteroides, Campylob...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Landuyt HW,Pyckavet M,Lambert A,Boelaert J

更新日期：1982-10-01 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:Drug repurposing affords the implementation of new treatments at a moderate cost and under a faster time-scale. Most of the clinical drugs against Leishmania share this origin. The antidepressant sertraline has been successfully assayed in a murine model of visceral leishmaniasis. Nevertheless, sertraline targets in L...

journal_title：Antimicrobial agents and chemotherapy

authors： Lima ML,Abengózar MA,Nácher-Vázquez M,Martínez-Alcázar MP,Barbas C,Tempone AG,López-Gonzálvez Á,Rivas L

更新日期：2018-11-26 00:00:00

abstract：:Amphotericin B, the principal drug used for treating systemic mycoses, possesses undesirable toxic properties. The ability of this antibiotic to potentiate antifungal activity of other compounds suggests that lower doses of amphotericin B could be used in combination with a second drug without loss of therapeutic effi...

journal_title：Antimicrobial agents and chemotherapy

authors： Huppert M,Pappagianis D,Sun SH,Gleason-Jordan I,Collins MS,Vukovich KR

更新日期：1976-03-01 00:00:00

abstract：:The pace of resistance against antibiotics almost exceeds that of the development of new drugs. As many bacteria have become resistant to conventional antibiotics, new drugs or drug resources are badly needed to combat antibiotic-resistant pathogens, like methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobi...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao Z,Ma Y,Dai C,Zhao R,Li S,Wu Y,Cao Z,Li W

更新日期：2009-08-01 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with pl...

journal_title：Antimicrobial agents and chemotherapy

authors： Klein K,Grønnemose RB,Alm M,Brinch KS,Kolmos HJ,Andersen TE

更新日期：2017-06-27 00:00:00

abstract：:Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free translation directed by either Escherichia coli or Bacillus subtilis extracts. A second class of analogs tested, including c...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen B,Noller HF,Daubresse G,Oliva B,Misulovin Z,Rothstein DM,Ellestad GA,Gluzman Y,Tally FP,Chopra I

更新日期：1991-11-01 00:00:00

abstract：:The elimination kinetics of cefotetan (YM09330), a new parenteral semisynthetic cephamycin derivative, were studied in eight healthy volunteers and 41 patients with renal insufficiency after the administration of a single 500-mg dose intravenously. Concentrations of cefotetan in serum and urine were determined by both...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohkawa M,Hirano S,Tokunaga S,Motoi I,Shoda R,Ikeda A,Sugata T,Sawaki M,Shimamura M,Okasho A,Kuroda K

更新日期：1983-01-01 00:00:00

abstract：:The biosynthetic gene cluster of the aminocoumarin antibiotic coumermycin A(1) was cloned by screening of a cosmid library of Streptomyces rishiriensis DSM 40489 with heterologous probes from a dTDP-glucose 4,6-dehydratase gene, involved in deoxysugar biosynthesis, and from the aminocoumarin resistance gyrase gene gyr...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang ZX,Li SM,Heide L

更新日期：2000-11-01 00:00:00

abstract：:The novel ATP synthase inhibitor bedaquiline recently received accelerated approval for treatment of multidrug-resistant tuberculosis and is currently being studied as a component of novel treatment-shortening regimens for drug-susceptible and multidrug-resistant tuberculosis. In a limited number of bedaquiline-treate...

journal_title：Antimicrobial agents and chemotherapy

authors： Almeida D,Ioerger T,Tyagi S,Li SY,Mdluli K,Andries K,Grosset J,Sacchettini J,Nuermberger E

更新日期：2016-07-22 00:00:00

abstract：:The antibacterial drug nalidixic acid (Nal) can suppress the growth of Candida albicans at levels of the drug normally found in urine. Growth suppression increases as drug levels are increased, and Nal also causes a similar proportional inhibition of the synthesis of all cellular macromolecules. However, growth temper...

journal_title：Antimicrobial agents and chemotherapy

authors： Sobieski RJ,Brewer AR

更新日期：1976-03-01 00:00:00

abstract：:The evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes in antiviral susceptibility and in receptor-binding specificity. In countries where the highly pathogenic H5N1 virus is endemic or causes regular epidemics, the surveillance of these changes is important fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Naughtin M,Dyason JC,Mardy S,Sorn S,von Itzstein M,Buchy P

更新日期：2011-05-01 00:00:00

abstract：:In both primary rabbit kidney cells and human skin fibroblasts, 5-propyl-2'-deoxyuridine proved inhibitory to herpes simplex virus at a concentration as low as 1 micrograms/ml, whereas concentrations higher than 200 micrograms/ml were required to inhibit vaccinia virus replication or normal cell metabolism. ...

journal_title：Antimicrobial agents and chemotherapy

authors： De Clercq E,Descamps J,Shugar D

更新日期：1978-03-01 00:00:00

abstract：:Suboptimal doses of amphotericin B in combination with either rifampin or 5-fluorocytosine were better than single-drug therapy in the treatment of disseminated Aspergillus fumigatus infection in mice. Despite the increased effectiveness of combination therapy, none of the therapeutic regimens we used completely eradi...

journal_title：Antimicrobial agents and chemotherapy

authors： Arroyo J,Medoff G,Kobayashi GS

更新日期：1977-01-01 00:00:00

abstract：:The inhibitory and bactericidal activities of fortimicin A (FTM-A) alone against Pseudomonas aeruginosa were compared with those of FTM-A in combination with beta-lactam antibiotics. As tested by the checkerboard method, most beta-lactam antibiotics tested had synergistic effects on the inhibitory activity of FTM-A ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamashita K,Kawabe H,Mitsuhashi S

更新日期：1981-07-01 00:00:00

abstract：:We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC(90)) was 4.0 mg/liter. For the Etest method, the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Spanjaard L,Vandenbroucke-Grauls CM

更新日期：2008-05-01 00:00:00

abstract：:There are several major differences between the penicillin-binding proteins (PBPs) of highly penicillin-resistant and -susceptible strains of pneumococci. The highest-molecular-size PBP 1a (98 kilodaltons [kDa]) of susceptible pneumococci is not detectable in resistant bacteria. Instead, resistant strains contain a PB...

journal_title：Antimicrobial agents and chemotherapy

authors： Hakenbeck R,Ellerbrok H,Briese T,Handwerger S,Tomasz A

更新日期：1986-10-01 00:00:00

abstract：:Anidulafungin concentrations were quantified with high-pressure liquid chromatography (HPLC) and UV detection of the ascites fluid and pleural effusion of 10 adult critically ill patients. Samples were collected from ascites fluid and from pleural drains or during paracentesis and thoracentesis, respectively. Anidulaf...

journal_title：Antimicrobial agents and chemotherapy

authors： Welte R,Eller P,Lorenz I,Joannidis M,Bellmann R

更新日期：2018-03-27 00:00:00

abstract：:beta-Lactamases produced by urine isolates from patients in long-term care facilities (LTCFs), outpatient, clinics, and one hospital in a U.S. community were characterized. A total of 1.3% of all Escherichia coli and Klebsiella pneumoniae isolates collected from patients in 30 LTCFs and various outpatient clinics prod...

journal_title：Antimicrobial agents and chemotherapy

authors： Hanson ND,Moland ES,Hong SG,Propst K,Novak DJ,Cavalieri SJ

更新日期：2008-10-01 00:00:00

abstract：:Staphylococci are the leading cause of hospital-acquired infections worldwide. Increasingly, they resist antibiotic treatment owing to the development of multiple antibiotic resistance mechanisms in most strains. Therefore, the activity and efficacy of recombinant lysostaphin as a drug against this pathogen have been ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hertlein T,Sturm V,Lorenz U,Sumathy K,Jakob P,Ohlsen K

更新日期：2014-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has become a significant acute and chronic respiratory pathogen. While vancomycin is effective against MRSA, its relatively poor penetration into lung secretions and dose-limiting renal toxicity make it less effective in the respiratory setting. As inhaled administrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Waterer G,Lord J,Hofmann T,Jouhikainen T

更新日期：2020-02-21 00:00:00

abstract：:Bacillus subtilis strain 168 produces the extremely stable and broad-spectrum lantibiotic sublancin 168. Known sublancin 168-susceptible organisms include important pathogens, such as Staphylococcus aureus. Nevertheless, since its discovery, the mode of action of sublancin 168 has remained elusive. The present studies...

journal_title：Antimicrobial agents and chemotherapy

authors： Kouwen TR,Trip EN,Denham EL,Sibbald MJ,Dubois JY,van Dijl JM

更新日期：2009-11-01 00:00:00

abstract：:The pharmacokinetics and tolerability of a new parenteral carbapenem antibiotic, biapenem (L-627), were studied in healthy elderly volunteers aged 65 to 74 years (71.6 +/- 2.7 years [mean +/- standard deviation], n = 5; group B) and > or = 75 years (77.8 +/- 1.9 years, n = 5; group C), following single intravenous dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Kozawa O,Uematsu T,Matsuno H,Niwa M,Takiguchi Y,Matsumoto S,Minamoto M,Niida Y,Yokokawa M,Nagashima S,Kanamaru M

更新日期：1998-06-01 00:00:00

abstract：:We tested the combined activity of vancomycin and seven beta-lactam antibiotics against Staphylococcus aureus clinical strain Mu3, which displays heterogeneous resistance to vancomycin. When combined with vancomycin, four of the seven tested beta-lactams exhibited an additive effect at or near their MICs, while all sh...

journal_title：Antimicrobial agents and chemotherapy

authors： Aritaka N,Hanaki H,Cui L,Hiramatsu K

更新日期：2001-04-01 00:00:00