Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients.

abstract：:Seventy-two (54.5%) out of 132 fecal samples from a group of yellow-legged gulls in Barcelona, Spain, were positive for Escherichia coli producing either extended-spectrum β-lactamases (ESBL) (51.5%), carbapenemase (1.5%), or cephamycinase (1.5%). The isolation of two carbapenemase-producing E. coli strains is a matte...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Pitart C,Montalvo T,Roca I,Sabaté S,Hurtado JC,Planell R,Marco F,Ramírez B,Peracho V,de Simón M,Vila J

更新日期：2017-01-24 00:00:00

abstract：:The continued evolution of bacterial resistance to the β-lactam class of antibiotics has necessitated countermeasures to ensure continued effectiveness in the treatment of infections caused by bacterial pathogens. One relatively successful approach has been the development of new β-lactam analogs with advantages over ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cotroneo N,Rubio A,Critchley IA,Pillar C,Pucci MJ

更新日期：2020-07-22 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is an essential chaperone involved in the fungal stress response that can be harnessed as a novel antifungal target for the treatment of invasive aspergillosis. We previously showed that genetic repression of Hsp90 reduced Aspergillus fumigatus virulence and potentiated the effect of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Asfaw YG,Steinbach WJ

更新日期：2014-01-01 00:00:00

abstract：:A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rafiq Y,Jabeen K,Hasan R,Jafri S,Laiq R,Malik F,Mangi R,Channa A,Hasan Z

更新日期：2011-02-01 00:00:00

abstract：:The opportunistic Gram-negative pathogen Pseudomonas aeruginosa, known for its intrinsic and acquired antibiotic resistance, has a notorious ability to form biofilms, which often facilitate chronic infections. The evolutionary paths to antibiotic resistance have mainly been investigated in planktonic cultures and are ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahmed MN,Porse A,Sommer MOA,Høiby N,Ciofu O

更新日期：2018-07-27 00:00:00

abstract：:Although the clinical correlates of the reference antifungal susceptibility test results in hematogenous and deep-seated Candida infection are still controversial, we evaluated the clinical correlates of this test in deep-seated Candida infections in non-AIDS patients. Thirty-two non-AIDS patients with hematogenous or...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee SC,Fung CP,Huang JS,Tsai CJ,Chen KS,Chen HY,Lee N,See LC,Shieh WB

更新日期：2000-10-01 00:00:00

abstract：:We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microd...

journal_title：Antimicrobial agents and chemotherapy

authors： Akaniro JC,Vidaurre CE,Stutman HR,Marks MI

更新日期：1990-10-01 00:00:00

abstract：:7-[alpha-(1-Methyl-4-pyridiniothio)-acetamido] cephalosporanic acid, referred to herein as BL-S 217, is a new broad-spectrum semisynthetic cephalosporin that offers several advantages over cephalothin. A comparison of the activity in vitro of these antibiotics indicates that BL-S 217 is about eightfold more effective ...

journal_title：Antimicrobial agents and chemotherapy

authors： Buck RE,Leitner F,Price KE

更新日期：1972-01-01 00:00:00

abstract：:Few oral antibiotics exist for the empirical treatment of extended-spectrum β-lactamase (ESBL) urinary tract infections (UTI). In this study, we sought to determine the activity of fosfomycin against ESBL-producing uropathogens from patients at 3 Veterans Affairs (VA) facilities between 2010 and 2013. Among the ESBL u...

journal_title：Antimicrobial agents and chemotherapy

authors： Linsenmeyer K,Strymish J,Weir S,Berg G,Brecher S,Gupta K

更新日期：2015-11-23 00:00:00

abstract：:A strain of Staphylococcus aureus was planted on filter membranes placed on Trypticase soy agar (BBL). After incubation, the membranes with growing staphylococci were transferred to Trypticase soy agar containing a subinhibitory concentration of penicillin (one-third minimal inhibitory concentration) and again incubat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lorian V

更新日期：1975-06-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites lack the enzymes to salvage preformed pyrimidines. For this reason, a combination of a thymidylate synthase inhibitor and the nucleoside thymidine should provide selective antimalarial activity even in the absence of any known active site differences between malarial and mamm...

journal_title：Antimicrobial agents and chemotherapy

authors： Rathod PK,Reshmi S

更新日期：1994-03-01 00:00:00

abstract：:The binding of the outer membrane-disorganizing peptide polymyxin B nonapeptide (PMBN) to gram-negative bacteria was studied by using tritium-labeled PMBN. Smooth Salmonella typhimurium had a binding capacity of ca. 6 nmol of PMBN per mg (dry weight) of bacteria, which corresponds to ca. 1 X 10(6) to 2 X 10(6) molecul...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Viljanen P

更新日期：1985-04-01 00:00:00

abstract：:We evaluated the in vitro activity of piperacillin alone or in combination with the beta-lactamase inhibitor tazobactam against clinical isolates of Legionella species. At an inoculum of approximately 10(4) CFU, tazobactam, piperacillin, and the 8:1 combination had equivalent activities against Legionella spp. At an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins LA,Wennersten CB,Ferraro MJ,Moellering RC Jr,Eliopoulos GM

更新日期：1994-01-01 00:00:00

abstract：:The emergence of resistance to last-resort antibiotics is a public health concern of global scale. Besides direct person-to-person propagation, environmental pathways might contribute to the dissemination of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). Here, we describe the incidence of blaNDM...

journal_title：Antimicrobial agents and chemotherapy

authors： Mantilla-Calderon D,Jumat MR,Wang T,Ganesan P,Al-Jassim N,Hong PY

更新日期：2016-08-22 00:00:00

abstract：:Spider venoms are vast natural pharmacopoeias selected by evolution. The venom of the ant spider Lachesana tarabaevi contains a wide variety of antimicrobial peptides. We tested six of them (latarcins 1, 2a, 3a, 4b, 5, and cytoinsectotoxin 1a) for their ability to suppress Chlamydia trachomatis infection. HEK293 cells...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazarev VN,Polina NF,Shkarupeta MM,Kostrjukova ES,Vassilevski AA,Kozlov SA,Grishin EV,Govorun VM

更新日期：2011-11-01 00:00:00

abstract：:A new commercial low-density microarray which identifies common extended-spectrum β-lactamase plasmid-mediated cephalosporinase genes, as well as carbapenemase (bla(KPC) and bla(NDM)) genes, was evaluated. We tested 207 clinical and reference/collection isolates of the Enterobacteriaceae possessing different bla genes...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Hujer AM,Naas T,de Castro RR,Endimiani A,Nordmann P,Glupczynski Y,Bonomo RA

更新日期：2011-09-01 00:00:00

abstract：:We studied the resistance mechanism and antimicrobial effects of β-lactams on imipenem-resistant Pseudomonas aeruginosa isolates that were susceptible to ceftazidime as detected by time-kill curve methods. Among 215 P. aeruginosa isolates from hospitalized patients in eight hospitals in the Republic of Korea, 18 isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Wi YM,Choi JY,Lee JY,Kang CI,Chung DR,Peck KR,Song JH,Ko KS

更新日期：2017-05-24 00:00:00

abstract：:The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Morales G,Rodríguez-Avial I,Culebras E,Gómez M,López-Fabal F,Picazo JJ

更新日期：2010-05-01 00:00:00

abstract：:The in vitro activities of HMR 3647 (telithromycin) and HMR 3004, two novel semisynthetic ketolides, were investigated and compared with that of the reference macrolide drug, clarithromycin, against 34 strains of slowly growing mycobacteria at pHs 6.8 and 7.4, as determined radiometrically. The MICs at pH 7.4 were abo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Goh KS,Berchel M,Bryskier A

更新日期：2000-10-01 00:00:00

abstract：:The usefulness of β-lactam antimicrobial agents is threatened as never before by β-lactamase-producing bacteria. For this reason, there has been renewed interest in the development of broad-spectrum β-lactamase inhibitors. Herein we describe the results of dose fractionation and dose-ranging studies carried out using ...

journal_title：Antimicrobial agents and chemotherapy

authors： VanScoy BD,Trang M,McCauley J,Conde H,Bhavnani SM,Friedrich LV,Alexander DC,Ambrose PG

更新日期：2016-06-20 00:00:00

abstract：:Treatment of Mycobacterium abscessus infections is extremely challenging due to its intrinsic resistance to most antibiotics, and research of pathogenesis is limited due to a lack of a practical in vivo model of infection. The objective of this study was to establish a simple in vivo model for M. abscessus infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meir M,Grosfeld T,Barkan D

更新日期：2018-03-27 00:00:00

abstract：:Genotypes of samples from protease inhibitor-naïve patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes. The proportion of non-B subtypes increased with increasing scores, except in weighted algorithms. Virtual and i...

journal_title：Antimicrobial agents and chemotherapy

authors： Stürmer M,Stephan C,Gute P,Knecht G,Bickel M,Brodt HR,Doerr HW,Gürtler L,Lecocq P,van Houtte M

更新日期：2011-11-01 00:00:00

abstract：:Alalevonadifloxacin (WCK 2349) is a novel l-alanine ester prodrug of levonadifloxacin that is being developed as an oral fluoroquinolone antibiotic. The primary objective of this study was to determine and compare plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of levonadifloxacin fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodvold KA,Gotfried MH,Chugh R,Gupta M,Yeole R,Patel A,Bhatia A

更新日期：2018-02-23 00:00:00

abstract：:We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC(90)) was 4.0 mg/liter. For the Etest method, the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Spanjaard L,Vandenbroucke-Grauls CM

更新日期：2008-05-01 00:00:00

abstract：:The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma fermentans, Mycoplasma genitalium, and Ureaplasma species to DC-159a, an investigational fluoroquinolone, in comparison with those to other agents were determined. Macrolides were the most active agen...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB

更新日期：2008-10-01 00:00:00

abstract：:Mezlocillin is a new broad-spectrum semisynthetic penicillin that has shown encouraging in vitro activity against the infecting organisms most likely to cause mortality and morbidity in cancer patients receiving chemotherapy. The serum clearances and urine recoveries of mezlocillin, ampicillin, and carbenicillin were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Issell BF,Bodey GP,Weaver S

更新日期：1978-02-01 00:00:00

abstract：:The activities of cefotaxime, moxalactam, MK 0787 (N-formimidoyl thienamycin), ampicillin, oxacillin, vancomycin, and clindamycin were compared against gram-positive cocci. MK 0787 was the most active and moxalactam was the least active of these drugs, except against methicillin-resistant Staphylococcus aureus, where ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cherubin CE,Corrado ML,Sierra MF,Gombert ME,Shulman M

更新日期：1981-10-01 00:00:00

abstract：:wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). One of these derivat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lentz CS,Sattler JM,Fendler M,Gottwalt S,Halls VS,Strassel S,Arriens S,Hannam JS,Specht S,Famulok M,Mueller AK,Hoerauf A,Pfarr KM

更新日期：2015-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) samples isolated from a parent and two antibiotic-hypersusceptible mutant strains of Escherichia coli were analyzed for polycation affinity and level of binding. Purified salts of the LPSs from the parent strain, UB1005, and from one of the mutant strains, DC1, bound similar amounts of sodium ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rocque WJ,Fesik SW,Haug A,McGroarty EJ

更新日期：1988-03-01 00:00:00

abstract：:Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intra...

journal_title：Antimicrobial agents and chemotherapy

authors： van Wijk F,Waterval J,van Aerde K,Henriet SSV,Meijer FJA,Borra LC,Aarnoutse RE,van Ingen J

更新日期：2019-12-20 00:00:00