Molecular Basis of the Leishmanicidal Activity of the Antidepressant Sertraline as a Drug Repurposing Candidate.

abstract：:Tedizolid and linezolid in vitro activities against 3,032 Gram-positive pathogens collected in Asia-Pacific, Eastern European, and Latin American medical centers during 2014 were assessed. The isolates were tested for susceptibility by the current reference broth microdilution methods. Due to concern over the effect o...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Flamm RK,Jones RN,Farrell DJ,Mendes RE

更新日期：2016-08-22 00:00:00

abstract：:ST-246, a novel compound that inhibits egress of orthopoxvirus from infected cells, is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, placebo-controlled, escalating multiple-dose study was conducted to determine the safety, tolerability, and ph...

journal_title：Antimicrobial agents and chemotherapy

authors： Jordan R,Chinsangaram J,Bolken TC,Tyavanagimatt SR,Tien D,Jones KF,Frimm A,Corrado ML,Pickens M,Landis P,Clarke J,Marbury TC,Hruby DE

更新日期：2010-06-01 00:00:00

abstract：:Temafloxacin, a new fluoroquinolone, alone or in combination with tobramycin, was compared with penicillin, tobramycin, and their combination in the therapy of rabbits with endocarditis caused by Streptococcus adjacens GaDT, a new species of nutritionally variant streptococci. Animals were injected intramuscularly for...

journal_title：Antimicrobial agents and chemotherapy

authors： Cremieux AC,Saleh-Mghir A,Vallois JM,Maziere B,Muffat-Joly M,Devine C,Bouvet A,Pocidalo JJ,Carbon C

更新日期：1992-10-01 00:00:00

abstract：:BO-1341, a new antipseudomonal semisynthetic cephalosporin, was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime, cefotaxime, and cefoperazone. The in vitro activity of BO-1341 was generally superior or comparable to the activities of the reference antibiotics against clinical...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Sanada M,Matsuda K,Hashizume T,Asahi Y,Ushijima R,Ohtake N,Tanaka N

更新日期：1989-09-01 00:00:00

abstract：:The in vitro effects of 19 dicationic diamidine derivatives against the proliferative tachyzoite stages of the apicomplexan parasites Neospora caninum and Toxoplasma gondii were investigated. Four compounds (DB811, DB786, DB750, and DB766) with similar structural properties exhibited profound inhibition of tachyzoite ...

journal_title：Antimicrobial agents and chemotherapy

authors： Leepin A,Stüdli A,Brun R,Stephens CE,Boykin DW,Hemphill A

更新日期：2008-06-01 00:00:00

abstract：:Increasingly frequent reports have described the in vivo loss of daptomycin susceptibility in association with clinical treatment failures. The mechanism(s) of daptomycin resistance is not well understood. We studied an isogenic set of Staphylococcus aureus isolates from the bloodstream of a daptomycin-treated patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones T,Yeaman MR,Sakoulas G,Yang SJ,Proctor RA,Sahl HG,Schrenzel J,Xiong YQ,Bayer AS

更新日期：2008-01-01 00:00:00

abstract：:The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality, and economic hardship. Drug resistance and toxic side effects of old drugs call for novel and unorthodox strategies for new and safe treatment options. We designed methyltriazenyl pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodenko B,Wanner MJ,Alkhaldi AA,Ebiloma GU,Barnes RL,Kaiser M,Brun R,McCulloch R,Koomen GJ,de Koning HP

更新日期：2015-11-01 00:00:00

abstract：:Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of Mycobacterium tuberculosis In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and in vivo efficacy using an optimized oral formulation. Mo...

journal_title：Antimicrobial agents and chemotherapy

authors： Lun S,Tasneen R,Chaira T,Stec J,Onajole OK,Yang TJ,Cooper CB,Mdluli K,Converse PJ,Nuermberger EL,Raj VS,Kozikowski A,Bishai WR

更新日期：2019-06-24 00:00:00

abstract：:Invasive and allergic infections by Aspergillus flavus are more common in tropical and subtropical countries. The emergence of voriconazole (VRC) resistance in A. flavus impacts the management of aspergillosis, as azoles are used as the first-line and empirical therapy. We screened 120 molecularly confirmed A. flavus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sharma C,Kumar R,Kumar N,Masih A,Gupta D,Chowdhary A

更新日期：2018-02-23 00:00:00

abstract：:Endogenous nitric oxide (NO) has antimycobacterial properties. We tested the hypothesis that exogenous (inhaled) NO can be safely delivered and can accelerate airway disinfection for pulmonary tuberculosis patients treated with standard therapy. Exogenous NO administered at 80 ppm for 72 h can be safely delivered but ...

journal_title：Antimicrobial agents and chemotherapy

authors： Long R,Jones R,Talbot J,Mayers I,Barrie J,Hoskinson M,Light B

更新日期：2005-03-01 00:00:00

abstract：:Pulmonary infiltrates in neutropenic hosts with invasive aspergillosis are due to vascular invasion and hemorrhagic infarction. In order to measure the effect of antifungal compounds on this organism-mediated tissue injury, we monitored the course of pulmonary infiltrates by serial ultrafast computerized tomography (U...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh TJ,Garrett K,Feurerstein E,Girton M,Allende M,Bacher J,Francesconi A,Schaufele R,Pizzo PA

更新日期：1995-05-01 00:00:00

abstract：:The activity of gemifloxacin against Haemophilus influenzae and Moraxella catarrhalis was compared to those of 11 other agents. All quinolones were very active (MICs,

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Kelly LM,Hoellman DB,Ednie LM,Clark CL,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：2000-03-01 00:00:00

abstract：:Pyrazinamide (PZA) has important sterilizing activity in tuberculosis (TB) chemotherapy. We describe trends, risk factors, and molecular epidemiology associated with PZA-resistant (PZA(r)) Mycobacterium tuberculosis in New York City (NYC). From 2001 to 2008, all incident culture-positive TB cases reported by the NYC D...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdugo D,Fallows D,Ahuja S,Schluger N,Kreiswirth B,Mathema B

更新日期：2015-10-01 00:00:00

abstract：:A carbapenem-resistant Serratia marcescens strain, 10mdr148, was identified in a Japanese hospital in 2010. The carbapenem resistance of this strain was attributed to the production of a novel metallo-β-lactamase (MBL), named SMB-1 (Serratia metallo-β-lactamase). SMB-1 possessed a zinc binding motif, H(Q)XHXDH (residu...

journal_title：Antimicrobial agents and chemotherapy

authors： Wachino J,Yoshida H,Yamane K,Suzuki S,Matsui M,Yamagishi T,Tsutsui A,Konda T,Shibayama K,Arakawa Y

更新日期：2011-11-01 00:00:00

abstract：:We prospectively evaluated serum aminoglycoside (AMG) concentrations in 120 patients who received gentamicin or tobramycin for serious gram-negative bacillary disease. AMG serum concentrations were assayed by microbiological and radioimmunoassay techniques. Correlation between the two assay methods was good. When AMG ...

journal_title：Antimicrobial agents and chemotherapy

authors： Reymann MT,Bradac JA,Cobbs CG,Dismukes WE

更新日期：1979-09-01 00:00:00

abstract：:Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquin...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Slifer T,Araujo FG,Polzer RJ,Remington JS

更新日期：1997-05-01 00:00:00

abstract：:Chronic wound infections are associated with biofilm formation, which in turn has been correlated with drug resistance. However, the mechanism by which bacteria form biofilms in clinical environments is not clearly understood. This study was designed to investigate the biofilm formation potency of Acinetobacter bauman...

journal_title：Antimicrobial agents and chemotherapy

authors： He X,Lu F,Yuan F,Jiang D,Zhao P,Zhu J,Cheng H,Cao J,Lu G

更新日期：2015-08-01 00:00:00

abstract：:beta-Lactamase identification by colony hybridization with 32P-labeled DNA probes for TEM-1, SHV-1, OXA-1, OXA-2, PSE-1, PSE-2, and PSE-4 was compared with isoelectric focusing in 122 clinical isolates making a variety of enzyme types. All strains producing a probe-type enzyme gave a positive hybridization reaction. C...

journal_title：Antimicrobial agents and chemotherapy

authors： Huovinen S,Huovinén P,Jacoby GA

更新日期：1988-02-01 00:00:00

abstract：:The biological signal molecule nitric oxide (NO) was found to induce biofilm dispersal across a range of bacterial species, which led to its consideration for therapeutic strategies to treat biofilms and biofilm-related infections. However, biofilms are often not completely dispersed after exposure to NO. To better un...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhu X,Oh HS,Ng YCB,Tang PYP,Barraud N,Rice SA

更新日期：2018-02-23 00:00:00

abstract：:With the aim of investigating home therapy for enterococcal endocarditis, we compared the efficacy of teicoplanin combined with gentamicin given once a day or in three daily doses (t.i.d.) with the standard treatment, ampicillin plus gentamicin administered t.i.d., for treating experimental enterococcal endocarditis. ...

journal_title：Antimicrobial agents and chemotherapy

authors： López P,Gavaldà J,Martin MT,Almirante B,Gomis X,Azuaje C,Borrell N,Pou L,Falcó V,Pigrau C,Pahissa A

更新日期：2001-05-01 00:00:00

abstract：:Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stylianou M,Kulesskiy E,Lopes JP,Granlund M,Wennerberg K,Urban CF

更新日期：2014-01-01 00:00:00

abstract：:In a 1964 study of the pharmacokinetic determinants of penicillin cure of gonococcal urethritis, 45 male prisoner volunteers were experimentally infected with strains of Neisseria gonorrhoeae having known in vitro penicillin susceptibility. After developing urethritis, subjects received intramuscular penicillin G and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaffe HW,Schroeter AL,Reynolds GH,Zaidi AA,Martin JE Jr,Thayer JD

更新日期：1979-04-01 00:00:00

abstract：:The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral do...

journal_title：Antimicrobial agents and chemotherapy

authors： Ramon J,Dautrey S,Farinoti R,Carbon C,Rubinstein E

更新日期：1996-01-01 00:00:00

abstract：:We undertook a prospective, randomized open comparison of the broad-spectrum cephalosporins cefepime and ceftazidime in treatment of hospitalized subjects with skin or wound infections and complicated nosocomial urinary tract infections. Cefepime treatment (dosage, 2.0 g intravenously twice daily for 4 to 28 days) was...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry LO,Rodriguez-Gomez G

更新日期：1991-11-01 00:00:00

abstract：:The effects of 6-amino-2-n-pentylthiobenzothiazole (APB), a new antifungal agent, on ergosterol biosynthesis in Candida albicans and Saccharomyces cerevisiae were studied, using [14C]acetate incorporation. In C. albicans, the inhibition of growth was accompanied by a marked inhibition of acetate incorporation in 4-des...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuchta T,Léka C,Farkas P,Bujdáková H,Belajová E,Russell NJ

更新日期：1995-07-01 00:00:00

abstract：:Escherichia coli sequence type 131 (ST131) is a pandemic clonal lineage that is responsible for the global increase in fluoroquinolone resistance and extended-spectrum-β-lactamase (ESBL) producers. The members of ST131 clade C, especially subclades C2 and C1-M27, are associated with ESBLs. We developed a multiplex con...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura Y,Pitout JDD,Peirano G,DeVinney R,Noguchi T,Yamamoto M,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

更新日期：2017-07-25 00:00:00

abstract：:A patient with AIDS and chronic diarrhea caused by Enterocytozoon bieneusi was successfully treated with nitazoxanide, producing a complete clinical and parasitological response, while off of antiviral therapy. This suggests that nitazoxanide may be effective in treating microsporidiosis caused by E. bieneusi, a disea...

journal_title：Antimicrobial agents and chemotherapy

authors： Bicart-Sée A,Massip P,Linas MD,Datry A

更新日期：2000-01-01 00:00:00

abstract：:Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously...

journal_title：Antimicrobial agents and chemotherapy

authors： Joseph P,Abdo MR,Boigegrain RA,Montero JL,Winum JY,Köhler S

更新日期：2007-10-01 00:00:00

abstract：:A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kashyap V,Sharma S,Singh V,Sharma SK,Saquib M,Srivastava R,Shaw AK

更新日期：2014-06-01 00:00:00

abstract：:Treatment of HIV-infected patients coinfected with Mycobacterium tuberculosis is challenging due to drug-drug interactions (DDIs) between antiretrovirals (ARVs) and antituberculosis (anti-TB) drugs. The aim of this study was to quantify the effect of cobicistat (COBI) or ritonavir (RTV) in modulating DDIs between daru...

journal_title：Antimicrobial agents and chemotherapy

authors： Roberts O,Khoo S,Owen A,Siccardi M

更新日期：2017-04-24 00:00:00