Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture.

abstract：:The pharmacokinetic (PK) properties of intravenous (i.v.) benzylpenicillin in term neonates undergoing moderate hypothermia after perinatal asphyxia were evaluated, as they have been unknown until now. A system-specific modeling approach was applied, in which our recently developed covariate model describing developme...

journal_title：Antimicrobial agents and chemotherapy

authors： Bijleveld YA,de Haan TR,van der Lee JH,Groenendaal F,Dijk PH,van Heijst A,de Jonge RCJ,Dijkman KP,van Straaten HLM,Rijken M,Zonnenberg IA,Cools F,Zecic A,Nuytemans DHGM,van Kaam AH,Mathôt RAA,PharmaCool Study Group.

更新日期：2018-03-27 00:00:00

abstract：:The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136 CYP51 gene in compa...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai K,Tsuchimori N,Okonogi K,Perfect JR,Gotoh O,Yoshida Y

更新日期：1999-05-01 00:00:00

abstract：:In a previous work, we described the possible relationship between a defect of purine-cytosine permease and the acquisition of a cross-resistance to the antifungal combination flucytosine (5FC) and fluconazole (FLC) in Candida lusitaniae (T. Noël, F. François, P. Paumard, C. Chastin, D. Brethes, and J. Villard, Antimi...

journal_title：Antimicrobial agents and chemotherapy

authors： Chapeland-Leclerc F,Bouchoux J,Goumar A,Chastin C,Villard J,Noël T

更新日期：2005-08-01 00:00:00

abstract：:BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more act...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Hashizume T,Matsuda K,Sanada M,Okamoto O,Fukatsu H,Tanaka N

更新日期：1993-12-01 00:00:00

abstract：:A beta-lactamase was purified from Serratia marcescens GN16694; it hydrolyzed T-5575 and oxime-type cephalosporins, i.e., cefuroxime and ceftazidime. Its isoelectric point and molecular weight were 8.6 and 42,000, respectively. This enzyme was not inhibited by EDTA and clavulanic acid. This enzyme is an unusual beta-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura N,Mitsuhashi S

更新日期：1995-09-01 00:00:00

abstract：:The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantl...

journal_title：Antimicrobial agents and chemotherapy

authors： Diacon AH,Donald PR,Pym A,Grobusch M,Patientia RF,Mahanyele R,Bantubani N,Narasimooloo R,De Marez T,van Heeswijk R,Lounis N,Meyvisch P,Andries K,McNeeley DF

更新日期：2012-06-01 00:00:00

abstract：:Gentamicin and tobramycin inhibited the accumulation of extracellular proteases secreted by Pseudomonas aeruginosa. The secretion of protease was inhibited at concentrations of these drugs that were below the level required to inhibit general protein synthesis. Neither magnesium ions nor high ionic strength antagonize...

journal_title：Antimicrobial agents and chemotherapy

authors： Warren RL,Baker NR,Johnson J,Stapleton MJ

更新日期：1985-04-01 00:00:00

abstract：:Fifty-seven cultures of Haemophilus influenzae were tested for production of beta-lactamase by use of a modified, 1-min test. Only the 24 cultures that were ampicillin resistant, whether type b or not, yielded positive results for the enzyme; all ampicillin-susceptible isolates were uniformly negative. The beta-lactam...

journal_title：Antimicrobial agents and chemotherapy

authors： Escamilla J

更新日期：1976-01-01 00:00:00

abstract：:We adopted an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VAN), arbekacin (ABK), and gentamicin (GEN) alone or in combination. Using two strains of clinically isolated methicillin-resistant Staphylococcus aureus, one GEN susceptible (GS171) and one GEN resistant (GR153), fibrin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee DG,Chun HS,Yim DS,Choi SM,Choi JH,Yoo JH,Shin WS,Kang MW

更新日期：2003-12-01 00:00:00

abstract：:Sporangiomycin and micrococcin inhibit the binding of aminoacyl-transfer ribonucleic acid into the ribosomal A site in intact bacterial protoplasts. They also prevent the assembly of [ribosome-elongation factor G-guanine nucleotide] complexes in vitro and compete with [(35)S]thiostrepton for ribosomal binding sites. W...

journal_title：Antimicrobial agents and chemotherapy

authors： Cundliffe E,Dixon PD

更新日期：1975-07-01 00:00:00

abstract：:The efficacy of a new liposomal formulation of amphotericin B was compared to that of amphotericin B deoxycholate (Fungizone) in a murine model of visceral leishmaniasis induced by Leishmania infantum. Median effective doses (ED50) were determined with two different strains: strain 1 was obtained from an untreated pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul M,Durand R,Fessi H,Rivollet D,Houin R,Astier A,Deniau M

更新日期：1997-08-01 00:00:00

abstract：:To test the hypothesis that establishing gastrointestinal colonization with multiresistant Enterococcus faecium (VRE) C68 results from expansion of the enterococcal population in the upper small bowel, we compared VRE quantities recovered from the proximal, middle, and distal segments of the small bowel from mice trea...

journal_title：Antimicrobial agents and chemotherapy

authors： Lakticová V,Hutton-Thomas R,Meyer M,Gurkan E,Rice LB

更新日期：2006-09-01 00:00:00

abstract：:We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

更新日期：2015-08-01 00:00:00

abstract：:Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for...

journal_title：Antimicrobial agents and chemotherapy

authors： Veiga MI,Osório NS,Ferreira PE,Franzén O,Dahlstrom S,Lum JK,Nosten F,Gil JP

更新日期：2014-12-01 00:00:00

abstract：:This study explored metronidazole and hydroxymetronidazole distribution in the cerebrospinal fluid (CSF) of brain-injured patients. Four brain-injured patients with external ventricular drain received 500 mg of metronidazole over 0.5 h every 8 h. CSF and blood samples were collected at steady state over 8 h, and the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Frasca D,Dahyot-Fizelier C,Adier C,Mimoz O,Debaene B,Couet W,Marchand S

更新日期：2014-01-01 00:00:00

abstract：:Eighteen patients developed abnormally low serum glutamic oxaloacetic transaminase values during metronidazole therapy. Metronidazole absorbs at 340 nm, simulating reduced nicotinamide adenine dinucleotide, which is the final colorimetric product of the serum glutamic oxaloacetic transaminase assay. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rissing JP,Newman C,Moore WL Jr

更新日期：1978-10-01 00:00:00

abstract：:Acinetobacter baumannii is a Gram-negative bacterium that causes nosocomial infections worldwide. This microbe's propensity to form biofilms allows it to persist and to survive on clinical abiotic surfaces for long periods. In fact, A. baumannii biofilm formation and its multidrug-resistant nature severely compromise ...

journal_title：Antimicrobial agents and chemotherapy

authors： Krishnamoorthy S,Shah BP,Lee HH,Martinez LR

更新日期：2015-10-12 00:00:00

abstract：:We studied the activity of voriconazole against 400 clinical strains of Aspergillus from the pre-voriconazole (1999 to 2002) and post-voriconazole (2003 to 2007) periods. Although the mean MICs of strains from the post-voriconazole period were slightly higher (0.39 versus 0.57 microg/ml; P < 0.001), all strains were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Guinea J,Recio S,Peláez T,Torres-Narbona M,Bouza E

更新日期：2008-09-01 00:00:00

abstract：:Streptonigrin, a quinone antitumor antibiotic, has been reported to be effective in human trials. A sensitive and precise microbiological assay for the determination of distribution and concentrations of streptonigrin in the body fluids and tissues of treated mice has been developed in an attempt to supplement success...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1974-01-01 00:00:00

abstract：:Analysis of the transport functions of individual Candida albicans plasma membrane drug efflux pumps is hampered by the multitude of endogenous transporters. We have stably expressed C. albicans Cdr1p, the major pump implicated in multiple-drug-resistance phenotypes, from the genomic PDR5 locus in a Saccharomyces cere...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura K,Niimi M,Niimi K,Holmes AR,Yates JE,Decottignies A,Monk BC,Goffeau A,Cannon RD

更新日期：2001-12-01 00:00:00

abstract：:Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of w...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Y,Creek D,Chollet J,Matile H,Charman SA,Wittlin S,Wood JK,Vennerstrom JL

更新日期：2007-08-01 00:00:00

abstract：:Pyronaridine, a Mannich base antimalarial, has demonstrated high in vivo and in vitro efficacy against chloroquine-resistant Plasmodium falciparum. Although this drug has the potential to become a prominent artemisinin combination therapy, little is known about its efficacy against drug-resistant Plasmodium vivax. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Price RN,Marfurt J,Chalfein F,Kenangalem E,Piera KA,Tjitra E,Anstey NM,Russell B

更新日期：2010-12-01 00:00:00

abstract：:Exposure of Staphylococcus aureus to cloxacillin at neutral pH rendered the bacteria more susceptible to subsequent lysis by lysostaphin. This sensitization effect also occurred at lower pH levels which were nonpermissive for the bactericidal action of cloxacillin, but the effect disappeared at pH 5.0. These findings ...

journal_title：Antimicrobial agents and chemotherapy

authors： Craven N,Anderson JC

更新日期：1982-04-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:The linkage between the macrolide efflux gene mef(I) and the chloramphenicol inactivation gene catQ was first described in Streptococcus pneumoniae (strain Spn529), where the two genes are located in a module designated IQ element. Subsequently, two different defective IQ elements were detected in Streptococcus pyogen...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Morroni G,Giovanetti E,Del Grosso M,Pantosti A,Varaldo PE

更新日期：2014-10-01 00:00:00

abstract：:Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wegner DL,Neblett TR

更新日期：1976-12-01 00:00:00

abstract：:The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects. MOR exposure was similar, with an area under the curve from 0 h to infinity (AUC0-∞) treatment ratio for MOR+TDF/MOR of 1.01 (90% confidence interval, 0.97...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu G,Tang W,Lv D,Wu L,Zhou H,Yang X,Zheng Y,Zhai Y,Shentu J

更新日期：2020-04-21 00:00:00

abstract：:The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

更新日期：2019-09-23 00:00:00

abstract：:Daptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bland CM,Bookstaver PB,Lu ZK,Dunn BL,Rumley KF,Southeastern Research Group Endeavor (SERGE-45).

更新日期：2014-10-01 00:00:00

abstract：:A spontaneous Escherichia coli mutant, named Q3, resistant to nalidixic acid was obtained from a previously described clinical isolate of E. coli, Q2, resistant to fluoroquinolones but susceptible to nalidixic acid (E. Cambau, F. Bordon, E. Collatz, and L. Gutmann, Antimicrob. Agents Chemother. 37:1247-1252, 1993). Q3...

journal_title：Antimicrobial agents and chemotherapy

authors： Truong QC,Nguyen Van JC,Shlaes D,Gutmann L,Moreau NJ

更新日期：1997-01-01 00:00:00