Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.

abstract：:Adenosine monophosphate pretreatment of mice with latent herpes simplex virus type 1 infections significantly reduced the rate of reactivation of latent virus. Adenosine monophosphate pretreatment did not, however, eradicate latent virus. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Blue WT,Winland RD,Stobbs DG,Kirksey DF,Savage RE

更新日期：1981-10-01 00:00:00

abstract：:Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane permeability. However, the genetic and molecular mechanisms of transformation of a penicillin-susceptible strain of N. gonorrhoeae to high-leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Ropp PA,Hu M,Olesky M,Nicholas RA

更新日期：2002-03-01 00:00:00

abstract：:The apicomplexan parasites Cryptosporidium and Toxoplasma are serious threats to human health. Cryptosporidiosis is a severe diarrheal disease in malnourished children and immunocompromised individuals, with the only FDA-approved drug treatment currently being nitazoxanide. The existing therapies for toxoplasmosis, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Palencia A,Liu RJ,Lukarska M,Gut J,Bougdour A,Touquet B,Wang ED,Li X,Alley MR,Freund YR,Rosenthal PJ,Hakimi MA,Cusack S

更新日期：2016-09-23 00:00:00

abstract：:Single-dose nevirapine (sd-NVP) and extended NVP prophylaxis are widely used in resource-constrained settings to prevent vertical HIV-1 transmission. We assessed the pharmacokinetics of sd-NVP in 62 HIV-1-positive pregnant Ugandan woman and their newborns who were receiving sd-NVP prophylaxis to prevent mother-to-chil...

journal_title：Antimicrobial agents and chemotherapy

authors： Frank M,von Kleist M,Kunz A,Harms G,Schütte C,Kloft C

更新日期：2011-12-01 00:00:00

abstract：:BackgroundChagas disease reactivation in HIV positive people is an opportunistic infection with 79-100% mortality. It commonly involves the central nervous system (CNS). Early treatment with trypanocidal drugs such as benznidazole (BNZ) is crucial for this severe manifestation of Trypanosoma cruzi infection. However, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernández ML,Marson ME,Mastrantonio GE,Corti MA,Fleitas U,Lloveras SC,Lista N,Priarone MM,Domínguez C,Garcia-Bournissen F

更新日期：2020-12-23 00:00:00

abstract：:The in vitro activities of eight antifungal drugs against clinical isolates of Fonsecaea pedrosoi (n = 21), Fonsecaea monophora (n = 25), and Fonsecaea nubica (n = 9) were tested. The resulting MIC(90)s for all strains (n = 55) were as follows, in increasing order: posaconazole, 0.063 microg/ml; itraconazole, 0.125 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Najafzadeh MJ,Badali H,Illnait-Zaragozi MT,De Hoog GS,Meis JF

更新日期：2010-04-01 00:00:00

abstract：:Cryptosporidium parvum is an important cause of diarrhea in humans and calves and can persistently infect immunocompromised hosts. Presently, there are no consistently effective parasite-specific drugs for cryptosporidiosis. We hypothesized that neutralizing monoclonal antibodies (MAbs) targeting the apical complex an...

journal_title：Antimicrobial agents and chemotherapy

authors： Riggs MW,Schaefer DA,Kapil SJ,Barley-Maloney L,Perryman LE

更新日期：2002-02-01 00:00:00

abstract：:The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effects of single nucleotide polymorphisms (SNPs) in cytochrome P450 isoenzyme genes (CYP, n...

journal_title：Antimicrobial agents and chemotherapy

authors： Staehli Hodel EM,Csajka C,Ariey F,Guidi M,Kabanywanyi AM,Duong S,Decosterd LA,Olliaro P,Beck HP,Genton B

更新日期：2013-02-01 00:00:00

abstract：:Gentamicin and tobramycin inhibited the accumulation of extracellular proteases secreted by Pseudomonas aeruginosa. The secretion of protease was inhibited at concentrations of these drugs that were below the level required to inhibit general protein synthesis. Neither magnesium ions nor high ionic strength antagonize...

journal_title：Antimicrobial agents and chemotherapy

authors： Warren RL,Baker NR,Johnson J,Stapleton MJ

更新日期：1985-04-01 00:00:00

abstract：:The emergence of resistant strains among common and rare Candida species necessitates continuous monitoring of the in vitro susceptibilities of those isolates. We therefore assessed the in vitro activities of micafungin against 1,099 molecularly identified isolates belonging to 5 common and 20 rare Candida species by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meletiadis J,Geertsen E,Curfs-Breuker I,Meis JF,Mouton JW

更新日期：2016-09-23 00:00:00

abstract：:In both scid and BALB/c mouse-Leishmania donovani models, hexadecyphosphocholine (miltefosine) and AmBisome had similar levels of activity. In contrast, sodium stibogluconate (Pentostam) was significantly less active against L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmanial activity of miltef...

journal_title：Antimicrobial agents and chemotherapy

authors： Escobar P,Yardley V,Croft SL

更新日期：2001-06-01 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLoney CR,Schiller NL

更新日期：1999-11-01 00:00:00

abstract：:The effect of incubation with interferon prior to the stimulation of interferon production (priming) and of sequential treatment with cycloheximide and actinomycin D (superinduction) on the interferon yield from polyinosinic-polycytidylic acid (poly I.poly C)-induced diploid human foreskin cell cultures (FS-3 strain) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Havell EA,Vilcek J

更新日期：1972-12-01 00:00:00

abstract：:Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang TS,Liu YC,Sy CL,Chen YS,Tu HZ,Chen BC

更新日期：2008-06-01 00:00:00

abstract：:The in vitro susceptibilities of 266 isolates of Streptococcus agalactiae determined by the agar dilution method showed that 6% of isolates were nonsusceptible to penicillin and 46% was resistant to erythromycin. Of the erythromycin-resistant isolates, 86.3% had the macrolide-lincosamide-streptogramin (MLS) resistance...

journal_title：Antimicrobial agents and chemotherapy

authors： Hsueh PR,Teng LJ,Lee LN,Ho SW,Yang PC,Luh KT

更新日期：2001-11-01 00:00:00

abstract：:Two nitrosoureas, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), with strong carbamoylating and weak alkylating activities, interfered with the induction of potassium leakage and lethal action of amphotericin B (AmB) on Candida albicans. 2-Cyclohexyl isocyanate, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Brajtburg J,Elberg S,Kobayashi GS,Medoff G

更新日期：1988-03-01 00:00:00

abstract：:The susceptibilities of 216 strains of Neisseria gonorrhoeae to a new fluoroquinolone, CP-99,219 were determined. For strains for which the MICs of ciprofloxacin were < or = 0.06 microgram/ml, the MICs at which 90% of the isolates are inhibited (MIC90s) of CP-99,219, ciprofloxacin, and ofloxacin were 0.008, 0.015, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Neal SW,Parekh MC,Rice RJ

更新日期：1995-04-01 00:00:00

abstract：:(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized dioxolanylpurine nucleoside derivatives being developed as potential prodrugs for the antiviral nucleoside analog (-)-beta-D-dioxolane guanine (DXG). In vitro, APD and ACPD are converted to DXG by x...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen H,Boudinot FD,Chu CK,Mcclure HM,Schinazi RF

更新日期：1996-10-01 00:00:00

abstract：:The therapeutic effects produced by formulations of amoxicillin plus clavulanic acid (BRL 25 000A and BRL 25 000G) were compared with those of amoxicillin and clavulanic acid separately against a variety of infections produced by amoxicillin-susceptible and beta-lactamase-producing (amoxicillin-resistant) bacteria. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Boon RJ,Beale AS,Comber KR,Pierce CV,Sutherland R

更新日期：1982-09-01 00:00:00

abstract：:Linezolid is the first member of the oxazolidinones and is active against drug-resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA). Additionally, linezolid shows an immunomodulatory effect, such as inhibition of inflammatory cytokine production. In this study, we examined the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaku N,Yanagihara K,Morinaga Y,Yamada K,Harada Y,Migiyama Y,Nagaoka K,Nakamura S,Izumikawa K,Kohno S

更新日期：2014-07-01 00:00:00

abstract：:Minimal inhibitory concentrations of carbenicillin, chloramphenicol, tetracycline, gentamicin, tobramycin, and trimethoprim-sulfamethoxazole were determined for rough, smooth, and mucoid Pseudomonas sp. isolates from sputa collected from 40 cystic fibrosis patients. Ninety-four percent of the minimal inhibitory concen...

journal_title：Antimicrobial agents and chemotherapy

authors： Maybury BA,Blessing-Moore J,deWit SA,Lewiston NJ,Yeager AS

更新日期：1979-03-01 00:00:00

abstract：:Thirty-two strains of Trichophyton rubrum and 16 strains of Trichophyton mentagrophytes isolated from patients with tinea unguium in various parts of Germany were subjected to a microdilution test with six systemic or topical antimycotic agents. Apart from griseofulvin, there were no species-specific differences betwe...

journal_title：Antimicrobial agents and chemotherapy

authors： Korting HC,Ollert M,Abeck D

更新日期：1995-05-01 00:00:00

abstract：:Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population...

journal_title：Antimicrobial agents and chemotherapy

authors： Francis J,Barnes KI,Workman L,Kredo T,Vestergaard LS,Hoglund RM,Byakika-Kibwika P,Lamorde M,Walimbwa SI,Chijioke-Nwauche I,Sutherland CJ,Merry C,Scarsi KK,Nyagonde N,Lemnge MM,Khoo SH,Bygbjerg IC,Parikh S,Aweeka FT,

更新日期：2020-04-21 00:00:00

abstract：:Induction of the cloned ampC Citrobacter freundii beta-lactamase in Escherichia coli by 6-aminopenicillanic acid was prevented by periplasmic TEM beta-lactamase in the same cell. In contrast, cytoplasmic TEM beta-lactamase did not prevent induction. This result implies that entry of the beta-lactam into the cytoplasm ...

journal_title：Antimicrobial agents and chemotherapy

authors： Everett MJ,Chopra I,Bennett PM

更新日期：1990-12-01 00:00:00

abstract：:The JAK-STAT pathway is activated in both macrophages and lymphocytes upon human immunodeficiency virus type 1 (HIV-1) infection and thus represents an attractive cellular target to achieve HIV suppression and reduced inflammation, which may impact virus sanctuaries. Ruxolitinib and tofacitinib are JAK1/2 inhibitors t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavegnano C,Detorio M,Montero C,Bosque A,Planelles V,Schinazi RF

更新日期：2014-01-01 00:00:00

abstract：:In an open, dose-finding study, a 100% cure rate was observed in patients suffering from uncomplicated gonococcal urethritis who were treated with a single oral dose of either 1.2 g (n = 10), 0.8 g (n = 11), or 0.4 g (n = 10) of cefetamet pivoxil. The MICs of cefetamet for all gonococcal strains ranged from 0.001 to 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Tio TT,Sindhunata IR,Wagenvoort JH,Michel MF,Stolz E

更新日期：1990-04-01 00:00:00

abstract：:The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics, was more permeabl...

journal_title：Antimicrobial agents and chemotherapy

authors： Billman-Jacobe H,Haites RE,Coppel RL

更新日期：1999-12-01 00:00:00

abstract：:Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously...

journal_title：Antimicrobial agents and chemotherapy

authors： Joseph P,Abdo MR,Boigegrain RA,Montero JL,Winum JY,Köhler S

更新日期：2007-10-01 00:00:00

abstract：:Prosthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as a surgical antibiotic prophylaxis at the time of arthroplasty. This retrospective cohort study conducted across 10 hospitals over a 3-year period (January 2006 to December 2008...

journal_title：Antimicrobial agents and chemotherapy

authors： Peel TN,Cheng AC,Buising KL,Choong PF

更新日期：2012-05-01 00:00:00

abstract：:Mycobacterium ulcerans causes Buruli ulcer, a potentially disabling ulcerative skin disease. Only recently was antimicrobial therapy proven effective. Treatment for 2 months with rifampin plus streptomycin was first proposed after experiments in the mouse footpad model demonstrated bactericidal activity. This treatmen...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang T,Li SY,Converse PJ,Almeida DV,Grosset JH,Nuermberger EL

更新日期：2011-01-01 00:00:00