Production of high-titered interferon in cultures of human diploid cells.

abstract：:Pseudomonas asiatica is a recently proposed species of the genus Pseudomonas This study describes eight isolates of carbapenem-resistant P. asiatica harboring blaNDM-1 and blaVIM-2, genes encoding metallo-β-lactamase (MBL). These isolates were obtained from urine samples of patients hospitalized in Myanmar. These isol...

journal_title：Antimicrobial agents and chemotherapy

authors： Tohya M,Tada T,Watanabe S,Kuwahara-Arai K,Zin KN,Zaw NN,Aung MY,Mya S,Zan KN,Kirikae T,Tin HH

更新日期：2019-07-25 00:00:00

abstract：:The effect of antacid on the bioavailability of cefprozil was investigated in a two-way crossover study. Eight healthy male subjects received a single 500-mg oral dose of cefprozil with and without coadministration of 30 ml of an antacid suspension containing magnesium hydroxide and aluminum hydroxide (Maalox). Cefpro...

journal_title：Antimicrobial agents and chemotherapy

authors： Shyu WC,Wilber RB,Pittman KA,Barbhaiya RH

更新日期：1992-05-01 00:00:00

abstract：:The pharmacokinetics and tolerability of a new parenteral carbapenem antibiotic, biapenem (L-627), were studied in healthy elderly volunteers aged 65 to 74 years (71.6 +/- 2.7 years [mean +/- standard deviation], n = 5; group B) and > or = 75 years (77.8 +/- 1.9 years, n = 5; group C), following single intravenous dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Kozawa O,Uematsu T,Matsuno H,Niwa M,Takiguchi Y,Matsumoto S,Minamoto M,Niida Y,Yokokawa M,Nagashima S,Kanamaru M

更新日期：1998-06-01 00:00:00

abstract：:The diversity of tet(S) genetic contexts of 13 enterococci from human, animal, and environmental samples from different geographical areas is reported. The tet(S) gene was linked to either CTn6000 variants of chromosomal location or composite platforms flanked by IS1216 located on plasmids (∼40 to 115 kb). The compara...

journal_title：Antimicrobial agents and chemotherapy

authors： Novais C,Freitas AR,Silveira E,Baquero F,Peixe L,Roberts AP,Coque TM

更新日期：2012-11-01 00:00:00

abstract：:Sulfide production has been proposed to be a universal defense mechanism against antibiotics in bacteria (K. Shatalin, E. Shatalina, A. Mironov, and E. Nudler, Science 334:986-990, 2011, doi:10.1126/science.1209855). To gain insight into the mechanism underlying sulfide protection, we systematically and comparatively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Weikum J,Ritzmann N,Jelden N,Klöckner A,Herkersdorf S,Josten M,Sahl HG,Grein F

更新日期：2018-09-24 00:00:00

abstract：:Actinobacillus actinomycetemcomitans and Capnocytophaga spp. are gram-negative bacteria implicated in the etiology of periodontal disease (particularly in individuals with neutrophil defects) and life-threatening systemic infections. They are resistant to many antibiotics of microbial origin but are sensitive to the n...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyasaki KT,Bodeau AL,Pohl J,Shafer WM

更新日期：1993-12-01 00:00:00

abstract：:The influence of reduced susceptibilities to glycopeptides on the activities of vancomycin and teicoplanin against an isogenic pair of clinical Staphylococcus aureus strains in experimental endocarditis was investigated. While vancomycin was similarly active against both strains, teicoplanin was approximately 100-fold...

journal_title：Antimicrobial agents and chemotherapy

authors： Pavie J,Lefort A,Ploy MC,Massias L,Chau F,Garry L,Denis F,Fantin B

更新日期：2003-06-01 00:00:00

abstract：:It remains controversial whether combination therapy, given empirically or as definitive treatment, for Pseudomonas aeruginosa bacteremia is associated with a better outcome than monotherapy. The aim of the present study was to compare the rates of survival among patients who received either combination therapy or mon...

journal_title：Antimicrobial agents and chemotherapy

authors： Chamot E,Boffi El Amari E,Rohner P,Van Delden C

更新日期：2003-09-01 00:00:00

abstract：:The objective of this study was to determine the population pharmacokinetic parameters of levofloxacin, gatifloxacin, and moxifloxacin following multiple oral doses. Twenty-nine patients with tuberculosis at the University Hospital in Vitória, Brazil, participated. Subjects received multiple doses of one drug (levoflo...

journal_title：Antimicrobial agents and chemotherapy

authors： Peloquin CA,Hadad DJ,Molino LP,Palaci M,Boom WH,Dietze R,Johnson JL

更新日期：2008-03-01 00:00:00

abstract：:Titanium (Ti) is a promising candidate biomaterial for an artificial corneal skirt. Antimicrobial peptide (AMP) immobilization may improve the bactericidal effect of the Ti substrate. In this study, we tested the bactericidal efficacy of a functionalized Ti surface in a rabbit keratitis model. A corneal stromal pocket...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan XW,Goh TW,Saraswathi P,Nyein CL,Setiawan M,Riau A,Lakshminarayanan R,Liu S,Tan D,Beuerman RW,Mehta JS

更新日期：2014-09-01 00:00:00

abstract：:Induction of the cloned ampC Citrobacter freundii beta-lactamase in Escherichia coli by 6-aminopenicillanic acid was prevented by periplasmic TEM beta-lactamase in the same cell. In contrast, cytoplasmic TEM beta-lactamase did not prevent induction. This result implies that entry of the beta-lactam into the cytoplasm ...

journal_title：Antimicrobial agents and chemotherapy

authors： Everett MJ,Chopra I,Bennett PM

更新日期：1990-12-01 00:00:00

abstract：:The in vitro and in vivo activities of modithromycin, a novel bicyclolide, against Legionella pneumophila were compared with those of telithromycin, clarithromycin, azithromycin, and levofloxacin. All the test agents decreased the intracellular growth of viable L. pneumophila bacteria over 96 h of incubation in both t...

journal_title：Antimicrobial agents and chemotherapy

authors： Sato T,Tateda K,Kimura S,Ishii Y,Yamaguchi K

更新日期：2011-04-01 00:00:00

abstract：:The pharmacokinetics of piperacillin were examined after single intravenous doses to three groups of male patients with creatinine clearances of greater than or equal to 60 (group I), greater than or equal to 20 but less than 60 (group II), and less than 20 (group III) ml/min per 1.73 m2. Each of 32 patients received ...

journal_title：Antimicrobial agents and chemotherapy

authors： Welling PG,Craig WA,Bundtzen RW,Kwok FW,Gerber AU,Madsen PO

更新日期：1983-06-01 00:00:00

abstract：:We investigated a possible synergistic effect of a macrolide and beta-lactams against Streptococcus pneumoniae strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin E,Stanek RJ,Mufson MA

更新日期：2003-03-01 00:00:00

abstract：:We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies nee...

journal_title：Antimicrobial agents and chemotherapy

authors： Cairns BJ,Payne RJ

更新日期：2008-12-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:A beta-lactamase was purified from Serratia marcescens GN16694; it hydrolyzed T-5575 and oxime-type cephalosporins, i.e., cefuroxime and ceftazidime. Its isoelectric point and molecular weight were 8.6 and 42,000, respectively. This enzyme was not inhibited by EDTA and clavulanic acid. This enzyme is an unusual beta-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura N,Mitsuhashi S

更新日期：1995-09-01 00:00:00

abstract：:2'-beta-Fluoro-2',3'-dideoxyadenosine (F-ddA) is an acid-stable purine dideoxynucleoside analog active against a wide spectrum of human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains in vitro. F-ddA is presently undergoing a phase I clinical trial at the National Cancer Institute. We induced HIV-1 variants re...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanaka M,Srinivas RV,Ueno T,Kavlick MF,Hui FK,Fridland A,Driscoll JS,Mitsuya H

更新日期：1997-06-01 00:00:00

abstract：:Selective decontamination of the digestive tract (SDD) has been evaluated as a method to prevent colonization and infection in ventilated patients in 40 trials. On the basis of an assumption that cross-infection would be reduced as a consequence of SDD and that this would distort the results of SDD studies that used c...

journal_title：Antimicrobial agents and chemotherapy

authors： Hurley JC

更新日期：1995-04-01 00:00:00

abstract：:Aspergillus fumigatus infections are associated with high mortality rates and high treatment costs. Limited available antifungals and increasing antifungal resistance highlight an urgent need for new antifungals. Thioredoxin reductase (TrxR) is essential for maintaining redox homeostasis and presents as a promising ta...

journal_title：Antimicrobial agents and chemotherapy

authors： Marshall AC,Kidd SE,Lamont-Friedrich SJ,Arentz G,Hoffmann P,Coad BR,Bruning JB

更新日期：2019-02-26 00:00:00

abstract：:A-80556 is a novel fluoroquinolone with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms. A-80556 was more active than ciprofloxacin, ofloxacin, lomefloxacin, and sparfloxacin against gram-positive bacteria. A-80556 was particularly active against Staphylococcus aureus (MIC f...

journal_title：Antimicrobial agents and chemotherapy

authors： Clement JJ,Tanaka SK,Alder J,Vojtko C,Beyer J,Hensey D,Ramer N,McDaniel D,Chu DT

更新日期：1994-05-01 00:00:00

abstract：:Here, we report twoEnterobacter cloacaesequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. TheblaNDM-1-harboring plasmids carry IncA/C2and IncR replicons, showing a mosaic plasmid structure, and theblaNDM-1is harbored on a novel class I integron-li...

journal_title：Antimicrobial agents and chemotherapy

authors： Du H,Chen L,Chavda KD,Pandey R,Zhang H,Xie X,Tang YW,Kreiswirth BN

更新日期：2016-03-25 00:00:00

abstract：:The MICs for 90% of the organisms tested (MIC90S) of 11 antibiotics against 24 clinical isolates of Actinobacillus actinomycetemcomitans were determined by the MIC 2000 system. The lowest MIC90S (16 micrograms/ml) were observed with ceftriaxone and rifampin. The next lowest MIC90S were found with cephapirin, tetracycl...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Shulman D,Shulman ST,Glogowski WG

更新日期：1986-01-01 00:00:00

abstract：:Free-living amoebae of the genus Acanthamoeba are causing serious chronic conditions such as destructive keratitis in contact lens wearers or granulomatous amoebic encephalitis in individuals with compromised immune systems. Both are characterized by the lack of availability of sufficiently effective and uncomplicated...

journal_title：Antimicrobial agents and chemotherapy

authors： Walochnik J,Duchêne M,Seifert K,Obwaller A,Hottkowitz T,Wiedermann G,Eibl H,Aspöck H

更新日期：2002-03-01 00:00:00

abstract：:Leishmania mexicana is a protozoan parasite that causes a disease in humans with frequent relapses after treatment. It is also highly resistant to the currently available drugs. For this reason, there is an urgent need for more effective antileishmanial drugs. Hydroxyurea, an anticancer drug, is toxic to replicating e...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez-Rojano H,Mancilla-Ramirez J,Quiñonez-Diaz L,Galindo-Sevilla N

更新日期：2008-10-01 00:00:00

abstract：:Isavuconazole, the active moiety of the prodrug isavuconazonium sulfate, has potent activity against a wide spectrum of fungal pathogens and is approved for the treatment of invasive aspergillosis, yet little is known about the tissue penetration of isavuconazole at the target sites of infection. Here, we explored the...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee A,Prideaux B,Lee MH,Zimmerman M,Dolgov E,Perlin DS,Zhao Y

更新日期：2019-05-24 00:00:00

abstract：:Hyperbaric oxygen exposures were evaluated for treatment of progressive liver abscesses produced by intraperitoneal injection of combined cultures of Fusobacterium necrophorum plus either Bacteroides fragilis subsp. fragilis or Fusobacterium nucleatum in a mouse model. Infected control and hyperbaric oxygen-exposed mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hill GB

更新日期：1976-02-01 00:00:00

abstract：:Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pentamidine was modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cushion MT,Walzer PD,Ashbaugh A,Rebholz S,Brubaker R,Vanden Eynde JJ,Mayence A,Huang TL

更新日期：2006-07-01 00:00:00

abstract：:Meropenem-vaborbactam is a new agent with the potential to treat carbapenem-resistant Enterobacteriaceae (CRE) infections. We describe the in vitro activity of meropenem-vaborbactam against representative CRE genotypes and laboratory-engineered Escherichia coli isolates harboring mutant blaKPC genes associated with ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson WR,Kline EG,Jones CE,Morder KT,Mettus RT,Doi Y,Nguyen MH,Clancy CJ,Shields RK

更新日期：2019-02-26 00:00:00