Effects of adenosine monophosphate on the reactivation of latent herpes simplex virus type 1 infections of mice.

abstract：:In vitro interactions of ciprofloxacin with imipenem and amikacin were evaluated by the killing-curve technique against 26 Pseudomonas aeruginosa strains resistant to amikacin and resistant or moderately susceptible to ciprofloxacin and imipenem. Imipenem enhanced killing by ciprofloxacin in tests with 11 strains, whe...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellou H,Petrikkos G

更新日期：1987-06-01 00:00:00

abstract：:In patients with polytrauma or major surgery, severe bacterial infections leading to septic shock and multiorgan failure are still a major cause of death. Prevention of septic shock in patients at risk would be an alternative to treatment of patients with overt septic shock. We therefore conducted a trial with the mon...

journal_title：Antimicrobial agents and chemotherapy

authors： Passlick B,Labeta MO,Izbicki JR,Ostertag P,Löffler T,Siebeck M,Pichlmeier U,Schweiberer L,Ziegler-Heitbrock HW

更新日期：1995-11-01 00:00:00

abstract：:Twenty-three healthy male and female subjects received single 100-mg oral doses of rimantadine hydrochloride on two occasions in an open-label, sequential design with a 6-day washout between doses. The first dose of rimantadine was administered alone, and the second dose was administered concomitantly with cimetidine ...

journal_title：Antimicrobial agents and chemotherapy

authors： Holazo AA,Choma N,Brown SY,Lee LF,Wills RJ

更新日期：1989-06-01 00:00:00

abstract：:Mycobacterium abscessus is a major nontuberculous mycobacterial (NTM) pathogen and is responsible for about 80% of all pulmonary infections caused by rapidly growing mycobacteria. Clofazimine is an effective drug active against M. abscessus, but the mechanism of resistance to clofazimine in M. abscessus is unknown. To...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen Y,Chen J,Zhang S,Shi W,Zhang W,Zhu M,Zhang Y

更新日期：2018-06-26 00:00:00

abstract：:Pradimicin S (PRM-S) is a highly water-soluble, negatively charged derivative of the antibiotic pradimicin A (PRM-A) in which the terminal xylose moiety has been replaced by 3-sulfated glucose. PRM-S does not prevent human immunodeficiency virus (HIV) adsorption on CD4(+) T cells, but it blocks virus entry into its ta...

journal_title：Antimicrobial agents and chemotherapy

authors： Balzarini J,François KO,Van Laethem K,Hoorelbeke B,Renders M,Auwerx J,Liekens S,Oki T,Igarashi Y,Schols D

更新日期：2010-04-01 00:00:00

abstract：:Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquin...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Slifer T,Araujo FG,Polzer RJ,Remington JS

更新日期：1997-05-01 00:00:00

abstract：:Streptomycin binds to the bacterial ribosome and disrupts protein synthesis by promoting misreading of mRNA. Restrictive mutations on the ribosomal subunit protein S12 confer a streptomycin resistance (Strr) phenotype and concomitantly increase the accuracy of the decoding process and decrease the rate of translation....

journal_title：Antimicrobial agents and chemotherapy

authors： Chen C,Blumentritt CA,Curtis MM,Sperandio V,Torres AG,Dudley EG

更新日期：2013-09-01 00:00:00

abstract：:The in vitro activities of a new quinolone, WIN 57273, and the combination of piperacillin and tazobactam, a beta-lactamase inhibitor, were compared with those of cefoxitin, ceftizoxime, chloramphenicol, clindamycin, imipenem, metronidazole, and piperacillin for 123 clinical anaerobic isolates. Ceftizoxime and cefoxit...

journal_title：Antimicrobial agents and chemotherapy

authors： Venezia RA,Yocum DM,Robbiano EM,Echols RM

更新日期：1990-09-01 00:00:00

abstract：:The pharmacokinetics of cefdinir were investigated in six hemodialysis patients. For the present study, two tests were carried out, one with 4 h of hemodialysis and the other without hemodialysis. Cefdinir was given orally to each patient in a dose of 100 mg, and blood was collected serially for 48 h after dosing in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hishida A,Ohishi K,Nagashima S,Kanamaru M,Obara M,Kitada A

更新日期：1998-07-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:Respiratory infection with Burkholderia cenocepacia is associated with accelerated decline in lung function and increased mortality in cystic fibrosis (CF) patients (A. M. Jones, M. E. Dodd, J. R. W. Govan, V. Barcus, C. J. Doherty, J. Morris, and A. K. Webb, Thorax 59:948-951, 2004, http://dx.doi.org/10.1136/thx.2003...

journal_title：Antimicrobial agents and chemotherapy

authors： Balwan A,Nicolau DP,Wungwattana M,Zuckerman JB,Waters V

更新日期：2015-12-31 00:00:00

abstract：:Morbidity and mortality resulting from influenza-like disease are a threat, especially for older adults. To improve case management, next-generation broad-spectrum antiviral therapeutics that are efficacious against major drivers of influenza-like disease, including influenza viruses and respiratory syncytial virus (R...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoon JJ,Toots M,Lee S,Lee ME,Ludeke B,Luczo JM,Ganti K,Cox RM,Sticher ZM,Edpuganti V,Mitchell DG,Lockwood MA,Kolykhalov AA,Greninger AL,Moore ML,Painter GR,Lowen AC,Tompkins SM,Fearns R,Natchus MG,Plemper RK

更新日期：2018-07-27 00:00:00

abstract：:The in vitro susceptibility of Mycobacterium fortuitum and Mycobacterium chelonei to cefmetazole was studied by the agar dilution method. At a concentration of 16 micrograms/ml or lower, 44 isolates (96%) of M. fortuitum and 8 isolates (40%) of M. chelonei were inhibited. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Casal MJ,Rodriguez FC,Benavente MC

更新日期：1985-02-01 00:00:00

abstract：:Herpes simplex ocular infection is a major cause of corneal blindness. Local antiviral treatments exist but are associated with corneal toxicity, and resistance has become an issue. We evaluated the biodistribution and efficacy of a humanized anti-herpes simplex virus (anti-HSV) IgG FAb fragment (AC-8; 53 kDa) followi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berdugo M,Larsen IV,Abadie C,Deloche C,Kowalczuk L,Touchard E,Dubielzig R,Brandt CR,Behar-Cohen F,Combette JM

更新日期：2012-03-01 00:00:00

abstract：:Escherichia coli MRE 600 is a colicinogenic bacterium. Its colicinogenic activity may be ascribed mostly to colicin E1, although it produces a small amount of another, as yet unidentified, colicin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Salaj-Smic E

更新日期：1978-11-01 00:00:00

abstract：:In determining the quality control limits for the Clinical Laboratory Standards Institute-recommended quality control organisms with tigecycline, a number of inconsistencies in the results were encountered that appeared to be related to the age of the Mueller-Hinton broth II. This study was performed to examine the ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Petersen PJ,Bradford PA

更新日期：2005-09-01 00:00:00

abstract：:The metallo-β-lactamase VIM-4, mainly found in Pseudomonas aeruginosa or Acinetobacter baumannii, was produced in Escherichia coli and characterized by biochemical and X-ray techniques. A detailed kinetic study performed in the presence of Zn²+ at concentrations ranging from 0.4 to 100 μM showed that VIM-4 exhibits a ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lassaux P,Traoré DA,Loisel E,Favier A,Docquier JD,Sohier JS,Laurent C,Bebrone C,Frère JM,Ferrer JL,Galleni M

更新日期：2011-03-01 00:00:00

abstract：:The therapeutic activity of ciprofloxacin, enoxacin, and ofloxacin was evaluated in guinea pigs with acute and chronic experimental Pseudomonas aeruginosa pneumonia. Intratracheal instillations of P. aeruginosa resulted in fatal pneumonia in all untreated animals within 36 h. Among treatment groups (80 mg/kg [body wei...

journal_title：Antimicrobial agents and chemotherapy

authors： Kemmerich B,Small GJ,Pennington JE

更新日期：1986-03-01 00:00:00

abstract：:Ten (0.05%) of 18,628 strains of Streptococcus pyogenes isolated from clinical specimens in the 3 years 1968 to 1970 were resistant to lincomycin and erythromycin. All 10 strains were highly resistant to lincomycin, having minimal inhibitory concentration (MIC) values of 200 mug/ml. There were two degrees of resistanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon JM,Lipinski AE

更新日期：1972-04-01 00:00:00

abstract：:Recent Food and Drug Administration (FDA) guidance endorses the use of an early clinical response endpoint as the primary outcome for community-acquired bacterial pneumonia (CABP) trials. While antibiotics will now be approved for CABP, in practice they will primarily be used to treat patients with community-acquired ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zasowski E,Butterfield JM,McNutt LA,Cohen J,Cosler L,Pai MP,Gottwald J,Chen WZ,Lodise TP

更新日期：2014-07-01 00:00:00

abstract：:Pipemidic acid was absorbed well by the oral route. Its peak levels in plasma ranged from 4 to 12 mug/ml at an oral dose of about 50 mg/kg in mice, rats, dogs, monkeys, and men. The protein binding of pipemidic acid was about 20% in dog plasma and about 30% in human serum. Pipemidic acid was distributed to most of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu M,Nakamura S,Takase Y,Kurobe N

更新日期：1975-04-01 00:00:00

abstract：:We report the ex vivo lysogenic transfer of erythromycin and tetracycline resistance genes among group A streptococci (GAS). Of 42 susceptible strains, 69% acquired erythromycin/tetracycline resistance when infected with purified supernatants from strain m46 culture containing the phage Φm46.1. A significant emm-type-...

journal_title：Antimicrobial agents and chemotherapy

authors： Di Luca MC,D'Ercole S,Petrelli D,Prenna M,Ripa S,Vitali LA

更新日期：2010-10-01 00:00:00

abstract：:Nosocomial pneumonia and sepsis, as well as severe diffuse peritonitis, must be treated early in order to prevent complications such as septic shock and organ dysfunctions. With the availability of new broad-spectrum and highly bactericidal antibiotics, the need of combining beta-lactams with aminoglycosides for the t...

journal_title：Antimicrobial agents and chemotherapy

authors： Cometta A,Baumgartner JD,Lew D,Zimmerli W,Pittet D,Chopart P,Schaad U,Herter C,Eggimann P,Huber O

更新日期：1994-06-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:A novel trait for transferable resistance to high concentrations of trimethoprim was found to dominate among enterobacteria collected from different parts of Sri Lanka. Drug resistance was a result of the production of dihydrofolate reductase with a decreased sensitivity to antifolates. By characterization of the part...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundström L,Vinayagamoorthy T,Sköld O

更新日期：1987-01-01 00:00:00

abstract：:In this paper we provide the first biochemical evidence of the existence of a family of structure-related antimicrobial peptides, the siderophore-microcins, in the Enterobacteriaceae family. We isolated and characterized two novel siderophore-microcins, MccM and MccH47, previously characterized through genetic studies...

journal_title：Antimicrobial agents and chemotherapy

authors： Vassiliadis G,Destoumieux-Garzón D,Lombard C,Rebuffat S,Peduzzi J

更新日期：2010-01-01 00:00:00

abstract：:The emergence of human immunodeficiency virus type 1 (HIV-1) strains resistant to highly active antiretroviral therapy necessitates continued drug discovery for the treatment of HIV-1 infection. Most current drug discovery strategies focus upon a single aspect of HIV-1 replication. A virus-cell-based assay, which can ...

journal_title：Antimicrobial agents and chemotherapy

authors： Adelson ME,Pacchia AL,Kaul M,Rando RF,Ron Y,Peltz SW,Dougherty JP

更新日期：2003-02-01 00:00:00

abstract：:Tedizolid and linezolid in vitro activities against 3,032 Gram-positive pathogens collected in Asia-Pacific, Eastern European, and Latin American medical centers during 2014 were assessed. The isolates were tested for susceptibility by the current reference broth microdilution methods. Due to concern over the effect o...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Flamm RK,Jones RN,Farrell DJ,Mendes RE

更新日期：2016-08-22 00:00:00

abstract：:Implant-associated infections (IAIs) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium-aluminum-niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuehl R,Brunetto PS,Woischnig AK,Varisco M,Rajacic Z,Vosbeck J,Terracciano L,Fromm KM,Khanna N

更新日期：2016-03-25 00:00:00

abstract：:We prospectively evaluated serum aminoglycoside (AMG) concentrations in 120 patients who received gentamicin or tobramycin for serious gram-negative bacillary disease. AMG serum concentrations were assayed by microbiological and radioimmunoassay techniques. Correlation between the two assay methods was good. When AMG ...

journal_title：Antimicrobial agents and chemotherapy

authors： Reymann MT,Bradac JA,Cobbs CG,Dismukes WE

更新日期：1979-09-01 00:00:00