Efficacy of monoclonal antibodies against defined antigens for passive immunotherapy of chronic gastrointestinal cryptosporidiosis.

abstract：:Titanium (Ti) is a promising candidate biomaterial for an artificial corneal skirt. Antimicrobial peptide (AMP) immobilization may improve the bactericidal effect of the Ti substrate. In this study, we tested the bactericidal efficacy of a functionalized Ti surface in a rabbit keratitis model. A corneal stromal pocket...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan XW,Goh TW,Saraswathi P,Nyein CL,Setiawan M,Riau A,Lakshminarayanan R,Liu S,Tan D,Beuerman RW,Mehta JS

更新日期：2014-09-01 00:00:00

abstract：:Prolonged antimicrobial therapy is recommended for methicillin-susceptible Staphylococcus aureus (MSSA) bone and joint infections (BJI), but its safety profile and risk factors for severe adverse events (SAE) in clinical practice are unknown. We addressed these issues in a retrospective cohort study (2001 to 2011) ana...

journal_title：Antimicrobial agents and chemotherapy

authors： Valour F,Karsenty J,Bouaziz A,Ader F,Tod M,Lustig S,Laurent F,Ecochard R,Chidiac C,Ferry T,Lyon BJI Study Group.

更新日期：2014-01-01 00:00:00

abstract：:A fluorometric assay, based on the natural fluorescence of the quinolone nucleus, was used to determine the uptake of ofloxacin by human polymorphonuclear leukocytes. The ratio of cellular concentration to extracellular concentration (C/E) at 20 min and 37 degrees C was 7.2, using an extracellular concentration of 5 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Pascual A,Garcia I,Perea EJ

更新日期：1989-05-01 00:00:00

abstract：:The aim of this study was to characterize a novel extended-spectrum beta-lactamase that belongs to the TEM family, the TEM-149 enzyme, and that was isolated from the urine of two hospitalized patients from different hospitals in southern Italy. The peculiarity of this enzyme was the finding of a valine residue at posi...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Celenza G,De Santis F,Pellegrini C,Forcella C,Rossolini GM,Stefani S,Amicosante G

更新日期：2008-03-01 00:00:00

abstract：:We have studied the pharmacokinetics of amphotericin B (AmB) in lung lymph circulation and bronchial-wash fluid after intravenous infusion and inhalation, respectively. For two experiments with awake sheep, we used lung lymph fistulas and tracheotomy. In experiment 1, AmB concentrations in plasma and lung lymph after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Koizumi T,Kubo K,Kaneki T,Hanaoka M,Hayano T,Miyahara T,Okada K,Fujimoto K,Yamamoto H,Kobayashi T,Sekiguchi M

更新日期：1998-07-01 00:00:00

abstract：:A sensitive and specific high-pressure liquid chromatographic method is described for the determination of the antibacterial drug flumequine and a major metabolite, 7-hydroxyflumequine, in human plasma and urine. The assay was linear over a concentration range of 1 to 120 micrograms/ml for both compounds. This method ...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison LI,Schuppan D,Rohlfing SR,Hansen AR,Hansen CS,Funk ML,Collins SH,Ober RE

更新日期：1984-03-01 00:00:00

abstract：:Combination antiretroviral therapy has achieved dramatic reductions in the mortality and morbidity in people with HIV-1 infection. Darunavir (DRV) represents a most efficacious and well-tolerated protease inhibitor (PI) with a high genetic barrier to the emergence of drug-resistant HIV-1. However, highly DRV-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Takamatsu Y,Aoki M,Bulut H,Das D,Amano M,Sheri VR,Kovari LC,Hayashi H,Delino NS,Ghosh AK,Mitsuya H

更新日期：2019-07-25 00:00:00

abstract：:AG1343, a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki = 2 nM), was designed by protein structure-based drug design techniques. AG1343 has potent antiviral activity (95% effective dose = 0.04 microgram/ml) against a number of HIV-1 strains in acute and chronic models of infection. As pa...

journal_title：Antimicrobial agents and chemotherapy

authors： Shetty BV,Kosa MB,Khalil DA,Webber S

更新日期：1996-01-01 00:00:00

abstract：:We compared the in vitro activity of gemifloxacin, a new quinolone antibiotic, to the activities of levofloxacin, moxifloxacin, trovafloxacin, erythromycin, and doxycycline against 20 isolates of Chlamydia pneumoniae. Gemifloxacin was the most active quinolone tested, with a MIC at which 90% of the isolates are inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Reznik T,Kutlin A,Hammerschlag MR

更新日期：1999-11-01 00:00:00

abstract：:Fifty clinical isolates of Streptococcus pneumoniae received by the Streptococcus Laboratory of the Center for Disease Control from August 1976 through March 1977 and 50 pneumococcal strains retrieved from 13- to 16-year storage (originally isolated October 1961 through December 1964) were tested for susceptibility to...

journal_title：Antimicrobial agents and chemotherapy

authors： Cooksey RC,Facklam RR,Thornsberry C

更新日期：1978-04-01 00:00:00

abstract：:The novel 6-substituted acyclouridine derivatives 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT), 1-[(2-hydroxyethoxy)methyl]-6-(3-methylphenylthio)thymine (HEPT-M), 6-cyclohexylthio-1-[(2-hydroxyethoxy) methyl]thymine (HEPT-H), and 1-[(2-hydroxyethoxy)methyl]-6-phenylthio-2- thiothymine (HEPT-S) have proved t...

journal_title：Antimicrobial agents and chemotherapy

authors： Baba M,De Clercq E,Iida S,Tanaka H,Nitta I,Ubasawa M,Takashima H,Sekiya K,Umezu K,Nakashima H

更新日期：1990-12-01 00:00:00

abstract：:Tedizolid and linezolid in vitro activities against 3,032 Gram-positive pathogens collected in Asia-Pacific, Eastern European, and Latin American medical centers during 2014 were assessed. The isolates were tested for susceptibility by the current reference broth microdilution methods. Due to concern over the effect o...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Flamm RK,Jones RN,Farrell DJ,Mendes RE

更新日期：2016-08-22 00:00:00

abstract：:Fosfomycin tromethamine (previously fosfomycin trometamol) is an orally administered fosfomycin which may be used for single-dose therapy of uncomplicated urinary tract infections. Fosfomycin tromethamine, norfloxacin, and trimethoprim-sulfamethoxazole inhibited greater than 90% of 352 bacterial isolates representing ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Fuchs PC

更新日期：1991-06-01 00:00:00

abstract：:Time-kill studies examined the activities of telithromycin (HMR 3647), erythromycin A, azithromycin, clarithromycin, roxithromycin, clindamycin, pristinamycin, amoxicillin-clavulanate, and metronidazole against 11 gram-positive and gram-negative anaerobic bacteria. Time-kill studies were carried out with the addition ...

journal_title：Antimicrobial agents and chemotherapy

authors： Credito KL,Ednie LM,Jacobs MR,Appelbaum PC

更新日期：1999-08-01 00:00:00

abstract：:Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungus Candida albicans, which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN s...

journal_title：Antimicrobial agents and chemotherapy

authors： Willems HME,Stultz JS,Coltrane ME,Fortwendel JP,Peters BM

更新日期：2019-10-22 00:00:00

abstract：:Cryptococcus gattii isolates from the Pacific Northwest have exhibited higher fluconazole MICs than isolates from other sites. The mechanism of fluconazole resistance in C. gattii is unknown. We sought to determine the role of the efflux pumps Mdr1 and Pdr11 in fluconazole susceptibility. Using biolistic transformatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang ML,Uhrig J,Vu K,Singapuri A,Dennis M,Gelli A,Thompson GR 3rd

更新日期：2015-12-07 00:00:00

abstract：:Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use of the streptomycin (STR)-dependent M. tuberculosis 18b strain as a tool for assessing drug potency against nonreplicating bacteria both in vitro and in vivo. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Vocat A,Hartkoorn RC,Lechartier B,Zhang M,Dhar N,Cole ST,Sala C

更新日期：2015-07-01 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:The mechanisms of herpes simplex virus (HSV) inactivation by sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), two anionic surfactants with protein denaturant potency, have been evaluated in cultured cells. Results showed that pretreatment of HSV type 1 (HSV-1) strain F and HSV-2 strain 333 with either surfacta...

journal_title：Antimicrobial agents and chemotherapy

authors： Piret J,Roy S,Gagnon M,Landry S,Désormeaux A,Omar RF,Bergeron MG

更新日期：2002-09-01 00:00:00

abstract：:In vitro activities of erythromycin A, telithromycin, and two investigational ketolides, JNJ-17155437 and JNJ-17155528, were evaluated against clinical bacterial strains, including selected common respiratory tract pathogens. Against 46 macrolide-susceptible and -resistant Streptococcus pneumoniae strains, the MIC(90)...

journal_title：Antimicrobial agents and chemotherapy

authors： Abbanat D,Webb G,Foleno B,Li Y,Macielag M,Montenegro D,Wira E,Bush K

更新日期：2005-01-01 00:00:00

abstract：:Sch 22591 (5-episisomicin), gentamicin, sisomicin, and tobramycin were compared for their ability to protect mice from lethal intraperitoneal challenge with 12 Pseudomonas strains, all susceptible to each of the aminoglycosides (minimal inhibitory concentrations and minimal bactericidal concentrations were

journal_title：Antimicrobial agents and chemotherapy

authors： Goering RV,Sanders CC,Sanders WE Jr

更新日期：1978-12-01 00:00:00

abstract：:Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitchel B,Sundin DR,Patel JB

更新日期：2009-10-01 00:00:00

abstract：:The efficacy of single-dose therapy with 3 g of cephalexin was evaluated in 129 women with symptoms of acute uncomplicated lower urinary tract infections. Of 91 patients with significant bacteriuria, 61 (67%) were cured of their original infection; this was similar to the 54 to 79% cure rates reported in unselected po...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardenas J,Quinn EL,Rooker G,Bavinger J,Pohlod D

更新日期：1986-03-01 00:00:00

abstract：:The present study demonstrates the in vitro effectiveness of the macrolide rokitamycin and the phenothiazine compound chlorpromazine against Acanthamoeba castellanii. Growth curve evaluations revealed that both drugs inhibit trophozoite growth in dose- and time-dependent ways. The effects of both drugs when they were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mattana A,Biancu G,Alberti L,Accardo A,Delogu G,Fiori PL,Cappuccinelli P

更新日期：2004-12-01 00:00:00

abstract：:The in vitro activities of ACH-702 and other antimicrobials against 30 Nocardia brasiliensis isolates were tested. The MIC(50) (MIC for 50% of the strains tested) and MIC(90) values of ACH-702 were 0.125 and 0.5 microg/ml. The same values for econazole were 2 and 4 microg/ml. The MIC(50) and MIC(90) values of imipenem...

journal_title：Antimicrobial agents and chemotherapy

authors： Vera-Cabrera L,Campos-Rivera MP,Escalante-Fuentes WG,Pucci MJ,Ocampo-Candiani J,Welsh O

更新日期：2010-05-01 00:00:00

abstract：:We compared the activity of delavirdine (DLV) plus zidovudine (AZT) (n = 300) with that of AZT (n = 297) against human immunodeficiency virus type 1 in a randomized, double-blind, placebo-controlled trial. DLV exerted a transient antiviral effect, and mutations for resistance to DLV were found in more than 90% of subj...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly V,Moroni M,Concia E,Lazzarin A,Hirschel B,Jost J,Chiodo F,Bentwich Z,Love WC,Hawkins DA,Wilkins EG,Gatell AJ,Vetter N,Greenwald C,Freimuth WW,de Cian W

更新日期：2000-11-01 00:00:00

abstract：:Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±...

journal_title：Antimicrobial agents and chemotherapy

authors： Mandelbrot L,Duro D,Belissa E,Peytavin G

更新日期：2014-09-01 00:00:00

abstract：:Antimalarial 9-anilinoacridines are potent inhibitors of parasite DNA topoisomerase II both in vitro and in situ. 3,6-diamino substitution on the acridine ring greatly improves parasiticidal activity against Plasmodium falciparum by targeting DNA topoisomerase II. A series of 9-anilinoacridines were investigated for t...

journal_title：Antimicrobial agents and chemotherapy

authors： Auparakkitanon S,Noonpakdee W,Ralph RK,Denny WA,Wilairat P

更新日期：2003-12-01 00:00:00

abstract：:A pyridodiazepine amine inhibitor of Helicobacter pylori glutamate racemase (MurI) was characterized. The compound was selectively active against H. pylori, and growth suppression was shown to be mediated through the inhibition of MurI by several methods. In killing kinetics experiments, the compound showed concentrat...

journal_title：Antimicrobial agents and chemotherapy

authors： de Jonge BL,Kutschke A,Newman JV,Rooney MT,Yang W,Cederberg C

更新日期：2015-04-01 00:00:00

abstract：:The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

journal_title：Antimicrobial agents and chemotherapy

authors： Spector SA,Ripley D,Hsia K

更新日期：1989-06-01 00:00:00