Efficacies of vancomycin, arbekacin, and gentamicin alone or in combination against methicillin-resistant Staphylococcus aureus in an in vitro infective endocarditis model.

abstract：:Serious Enterococcus faecalis infections usually require combination therapy to achieve a bactericidal effect. In orthopedic infections, the prognosis of enterococcal etiology is considered poor, and the use of aminoglycosides is questioned. The ampicillin-ceftriaxone combination has recently been accepted as alternat...

journal_title：Antimicrobial agents and chemotherapy

authors： Euba G,Lora-Tamayo J,Murillo O,Pedrero S,Cabo J,Verdaguer R,Ariza J

更新日期：2009-10-01 00:00:00

abstract：:The in vitro antifungal activities of two N-aminoacyl derivatives of amphotericin B methyl ester (AME) were compared by tube dilution with those of amphotericin B and AME, using 60 isolates representing 10 yeast species. A total of 70% of the strains were inhibited by concentrations of the N-aminoacyl AME derivatives ...

journal_title：Antimicrobial agents and chemotherapy

authors： Oblack DL,Hewitt WL,Martin WJ

更新日期：1981-01-01 00:00:00

abstract：:Lamivudine [beta-L-(-)-2',3'-dideoxy-3'-thiacytidine] is a potent inhibitor of hepadnavirus replication and is used both to treat chronic hepatitis B virus (HBV) infections and to prevent reinfection of transplanted livers. Unfortunately, lamivudine-resistant HBV variants do arise during prolonged therapy, indicating ...

journal_title：Antimicrobial agents and chemotherapy

authors： Walters KA,Tipples GA,Allen MI,Condreay LD,Addison WR,Tyrrell L

更新日期：2003-06-01 00:00:00

abstract：:TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations...

journal_title：Antimicrobial agents and chemotherapy

authors： Limburg E,Gahlmann R,Kroll HP,Beyer D

更新日期：2004-02-01 00:00:00

abstract：:The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakken JS,Cavalieri SJ,Gangeness D

更新日期：1990-06-01 00:00:00

abstract：:This study sought to characterize the impact of 3 types of variation on the Standardized Antimicrobial Administration Ratio (SAAR) utilizing local National Healthcare Safety Network (NHSN) data. SAAR and antimicrobial days per 1,000 days present (AD/1000DP) were compiled monthly for Northwestern Memorial Hospital from...

journal_title：Antimicrobial agents and chemotherapy

authors： Avedissian SN,Rhodes NJ,Liu J,Aljefri D,Postelnick MJ,Sutton SH,Zembower TR,Martin D,Pais G,Cruce CE,Scheetz MH

更新日期：2019-02-26 00:00:00

abstract：:Ovotransferrin immobilized by covalent linkage to Sepharose 4B showed a bacteriostatic effect towards Escherichia coli similar to that of free ovotransferrin. The growth of the bacteria, after exposure to the gel-bound ovotransferrin and its removal, depended on the length of exposure. The results suggest that the ant...

journal_title：Antimicrobial agents and chemotherapy

authors： Valenti P,Antonini G,Fanelli MR,Orsi N,Antonini E

更新日期：1982-05-01 00:00:00

abstract：:We studied the influences of antimicrobial agents on the colonization of the respiratory tract and infection with Enterococcus faecalis in intensive care unit (ICU) patients receiving mechanical respiration for at least 3 days. In a matched-cohort analysis, patients receiving topical antimicrobial prophylaxis (TAP) of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonten MJ,Gaillard CA,van Tiel FH,van der Geest S,Stobberingh EE

更新日期：1995-12-01 00:00:00

abstract：:Flaviviruses comprise several medically important viruses, including Japanese encephalitis virus, West Nile virus, dengue virus (DENV), yellow fever virus, and Zika virus (ZIKV). A large outbreak of DENV and ZIKV occurred recently, leading to many cases of illness and death. However, despite decades of effort, we have...

journal_title：Antimicrobial agents and chemotherapy

authors： Chuang FK,Huang SM,Liao CL,Lee AR,Lien SP,Chiu YL,Chang TH,Tsai PL,Lin RJ,Shih CC,Tsai YJ,Lin GJ,Yen LC

更新日期：2019-12-20 00:00:00

abstract：:4,4'-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides of Bacillus subtilis by inhibiting the enzyme d-g...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimi IR,Shoukry S,Zaki Z

更新日期：1976-04-01 00:00:00

abstract：:Sporadic isolates of carbapenem-resistant KPC-2-producing Klebsiella pneumoniae were isolated in Tel Aviv Medical Center during 2005 and 2006, parallel to the emergence of the KPC-3-producing K. pneumoniae sequence type 258 (ST 258). We aimed to study the molecular epidemiology of these isolates and to characterize th...

journal_title：Antimicrobial agents and chemotherapy

authors： Leavitt A,Carmeli Y,Chmelnitsky I,Goren MG,Ofek I,Navon-Venezia S

更新日期：2010-07-01 00:00:00

abstract：:At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephradine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadrox...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeffer M,Jackson A,Ximenes J,de Menezes JP

更新日期：1977-02-01 00:00:00

abstract：:The elimination kinetics of cefotetan (YM09330), a new parenteral semisynthetic cephamycin derivative, were studied in eight healthy volunteers and 41 patients with renal insufficiency after the administration of a single 500-mg dose intravenously. Concentrations of cefotetan in serum and urine were determined by both...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohkawa M,Hirano S,Tokunaga S,Motoi I,Shoda R,Ikeda A,Sugata T,Sawaki M,Shimamura M,Okasho A,Kuroda K

更新日期：1983-01-01 00:00:00

abstract：:A clinical isolate of Bacteroides vulgatus was resistant to tetracycline, clindamycin, ampicillin, cephaloridine, cefoxitin, and other beta-lactam antibiotics except imipenem. beta-Lactam resistance was mediated by a membrane-associated, clavulanate-sensitive cephalosporinase capable of degrading cephalosporins and pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Parker AC,Smith CJ

更新日期：1993-05-01 00:00:00

abstract：:Bacterial protein synthesis is the target for numerous natural and synthetic antibacterial agents. We have developed a poly(U) mRNA-directed aminoacylation/translation protein synthesis system composed of phenyl-tRNA synthetases, ribosomes, and ribosomal factors from Escherichia coli. This system, utilizing purified c...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribble W,Hill WE,Ochsner UA,Jarvis TC,Guiles JW,Janjic N,Bullard JM

更新日期：2010-11-01 00:00:00

abstract：:The emergence of pneumococci resistant to penicillin and other agents prompted us to evaluate intravenous vancomycin for the therapy of pneumococcal meningitis, which has an overall mortality of 30%. Eleven consecutive adult patients with cerebrospinal fluid (CSF)-culture-proven pneumococcal meningitis and positive in...

journal_title：Antimicrobial agents and chemotherapy

authors： Viladrich PF,Gudiol F,Liñares J,Pallarés R,Sabaté I,Rufí G,Ariza J

更新日期：1991-12-01 00:00:00

abstract：:Antibiotic treatment of lung infections may lead to the emergence of resistance in the gut flora. Appropriate dosing regimens could mitigate this adverse effect. In gnotobiotic rats harboring intestinal Escherichia coli and Enterococcus faecium populations, a lung infection by Klebsiella pneumoniae was instigated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Kesteman AS,Perrin-Guyomard A,Laurentie M,Sanders P,Toutain PL,Bousquet-Mélou A

更新日期：2010-07-01 00:00:00

abstract：:A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis (1), and osteomyelitis (1). The most common bacterial pathogen was Pseudomonas aeruginosa, accounting for eight infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Simon GL,Snydman DR,Tally FP,Gorbach SL

更新日期：1980-07-01 00:00:00

abstract：:Oseltamivir is the most widely used anti-influenza drug. In the 2009 H1N1 pandemic, in which the influenza viruses were oseltamivir sensitive, obesity was identified as a risk factor for severe disease and unfavorable outcomes. The aim of this study was to investigate the pharmacokinetic properties of oseltamivir and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jittamala P,Pukrittayakamee S,Tarning J,Lindegardh N,Hanpithakpong W,Taylor WR,Lawpoolsri S,Charunwattana P,Panapipat S,White NJ,Day NP

更新日期：2014-01-01 00:00:00

abstract：:Posaconazole in oral suspension must be taken multiple times a day with food (preferably a high-fat meal) to ensure adequate exposure among patients. We evaluated the effect of food on the bioavailability of a new delayed-release tablet formulation of posaconazole at the proposed clinical dose of 300 mg once daily in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kersemaekers WM,Dogterom P,Xu J,Marcantonio EE,de Greef R,Waskin H,van Iersel ML

更新日期：2015-01-01 00:00:00

abstract：:The class C beta-lactamase of Citrobacter freundii GN346 is a typical cephalosporinase comprising 361 amino acids, and substitution of the glutamic acid at position 219 in the enzyme by lysine was previously shown to broaden its substrate spectrum to oxyimino beta-lactams (K. Tsukamoto, R. Ohno, and T. Sawai, J. Bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Nukaga M,Tsukamoto K,Yamaguchi H,Sawai T

更新日期：1994-06-01 00:00:00

abstract：:Comparative time-kill experiments with Staphylococcus aureus bacteriophage (phage) Sb-1 alone and phage-antibiotic combinations (PACs) against two methicillin-resistant S. aureus (MRSA) strains have shown synergy with both daptomycin-phage and vancomycin-phage combinations. PACs prevented development of phage resistan...

journal_title：Antimicrobial agents and chemotherapy

authors： Kebriaei R,Lev K,Morrisette T,Stamper KC,Abdul-Mutakabbir JC,Lehman SM,Morales S,Rybak MJ

更新日期：2020-06-23 00:00:00

abstract：:Chloramphenicol-resistant strains of Bacteroides fragilis (minimum inhibitory concentration, 12.5 mug/ml) were isolated from a stool specimen which contained multiply resistant Escherichia coli. The enzyme responsible for resistance, chloramphenicol acetyltransferase, was produced constitutively by these strains; the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Britz ML,Wilkinson RG

更新日期：1978-07-01 00:00:00

abstract：:In 2009, the first high-level ceftriaxone-resistant Neisseria gonorrhoeae strain (H041) was isolated in Kyoto, Japan. The present study describes an intensified surveillance (antimicrobial resistance and molecular typing) of Neisseria gonorrhoeae isolates in Kyoto and its neighboring prefecture Osaka, Japan, in 2010 t...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimuta K,Unemo M,Nakayama S,Morita-Ishihara T,Dorin M,Kawahata T,Ohnishi M,Antibiotic-Resistant Gonorrhea Study Group.

更新日期：2013-11-01 00:00:00

abstract：:Yersinia enterocolitica has emerged as an enteropathogen associated with several types of human infections that often require antimicrobial therapy, but little is known about the antimicrobial susceptibilities of pathogenic strains isolated from humans in Canada. To determine the present patterns of antimicrobial susc...

journal_title：Antimicrobial agents and chemotherapy

authors： Preston MA,Brown S,Borczyk AA,Riley G,Krishnan C

更新日期：1994-09-01 00:00:00

abstract：:Omadacycline is a first-in-class aminomethylcycline antibiotic with microbiological activity against Gram-positive and Gram-negative aerobes and anaerobes and atypical bacteria that is being developed for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneu...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun H,Ting L,Machineni S,Praestgaard J,Kuemmell A,Stein DS,Sunkara G,Kovacs SJ,Villano S,Tanaka SK

更新日期：2016-11-21 00:00:00

abstract：:Small unilamellar amphotericin B liposomes can reduce the toxicity of amphotericin B. In this study, we compared the physical, antifungal, pharmocokinetic, and toxic properties of two liposomal amphotericin B products, AmBisome and Anfogen, that have the same chemical composition but are manufactured differently. In v...

journal_title：Antimicrobial agents and chemotherapy

authors： Olson JA,Adler-Moore JP,Jensen GM,Schwartz J,Dignani MC,Proffitt RT

更新日期：2008-01-01 00:00:00

abstract：:Leptospirosis and scrub typhus are important causes of acute fever in Southeast Asia. Options for empirical therapy include doxycycline and azithromycin, but it is unclear whether their efficacies are equivalent. We conducted a multicenter, open, randomized controlled trial with adult patients presenting with acute fe...

journal_title：Antimicrobial agents and chemotherapy

authors： Phimda K,Hoontrakul S,Suttinont C,Chareonwat S,Losuwanaluk K,Chueasuwanchai S,Chierakul W,Suwancharoen D,Silpasakorn S,Saisongkorh W,Peacock SJ,Day NP,Suputtamongkol Y

更新日期：2007-09-01 00:00:00

abstract：:In the eubacterial cell, the peptidoglycan is perpetually hydrolyzed throughout the cell cycle by different enzymes such as lytic transglycosylases, endopeptidases, and amidases. In Escherichia coli, four N-acetylmuramoyl-l-alanine amidases, AmiA, -B, -C, and -D, are present in the periplasm. AmiA, -B, and -C are solu...

journal_title：Antimicrobial agents and chemotherapy

authors： Pennartz A,Généreux C,Parquet C,Mengin-Lecreulx D,Joris B

更新日期：2009-07-01 00:00:00

abstract：:Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with d...

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Shang W,Bush K,Flamm RK

更新日期：2008-04-01 00:00:00