Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community.

abstract：:The gene coding for aminoglycoside 2'-N-acetyltransferase Ia [AAC(2')-Ia] from Providencia stuartii was amplified by PCR and cloned. The resulting construct, pACKF2, was transferred into Escherichia coli for overexpression of AAC(2')-Ia as a fusion protein with an N-terminal hexa-His tag. The fusion protein was isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Franklin K,Clarke AJ

更新日期：2001-08-01 00:00:00

abstract：:We present a 31-year-old female who had undergone an allogeneic bone marrow transplantation and who was started on intravenous posaconazole for pulmonary mycosis while undergoing continuous venovenous hemofiltration (CVVH). We performed steady-state pharmacokinetic evaluations for both posaconazole and sulfobutylether...

journal_title：Antimicrobial agents and chemotherapy

authors： Morris AA,Mueller SW,Rower JE,Washburn T,Kiser TH

更新日期：2015-10-01 00:00:00

abstract：:Two 3-alkyl-substituted 2-hydroxy-1,4-naphthoquinones, NSC 113452 (NSC52) and NSC 113455 (NSC55), were evaluated for activity against Toxoplasma gondii in vitro and in murine models of acute toxoplasmosis. In vitro, both NSC52 and NSC55 significantly inhibited intracellular replication of T. gondii. In vivo, each comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Nasr M,Araujo FG

更新日期：1998-09-01 00:00:00

abstract：:Ten patients with acquired immunodeficiency syndrome with newly diagnosed cytomegalovirus (CMV) retinitis were treated with an induction regimen of intravenous foscarnet, 60 mg/kg of body weight, administered as a 2-h infusion and repeated every 8 h for 14 days. At the end of induction, 9 of 10 patients had stabilized...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobson MA,O'Donnell JJ,Mills J

更新日期：1989-05-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of antimicrobial drug use, gastric acid-suppressive agent use, and infection control practices on the incidence of Clostridium difficile-associated diarrhea (CDAD) in a 426-bed general teaching hospital in Northern Ireland. The study was retrospective and ecologi...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldeyab MA,Harbarth S,Vernaz N,Kearney MP,Scott MG,Funston C,Savage K,Kelly D,Aldiab MA,McElnay JC

更新日期：2009-05-01 00:00:00

abstract：:Viral regulatory complexes perform critical functions during virus replication and are important targets for therapeutic intervention. In HIV, the Tat and Rev proteins form complexes with multiple viral and cellular factors to direct transcription and export of the viral RNA. These complexes are composed of many prote...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura RL,Burlingame MA,Yang S,Crosby DC,Talbot DJ,Chui K,Frankel AD,Renslo AR

更新日期：2017-06-27 00:00:00

abstract：:Growth of Mycoplasma pneumoniae was completely prevented by 0.06 mug of actinomycin D/ml, and 0.00375 mug/ml caused 90% inhibition. It thus appears that M. pneumoniae is more susceptible to actinomycin D than previously reported. Low concentrations (0.019 mug/ml) of the antibiotic primarily inhibited ribonucleic acid ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fletcher RD,Jayavasu C,Yoo S,Albertson JN

更新日期：1973-09-01 00:00:00

abstract：:The in vitro activity of WY-49605 (SUN5555) (WY) was compared with those of cefaclor, cefixime, and amoxicillin-clavulanic acid against 2,958 consecutive clinical isolates from five medical centers and 402 respiratory pathogens from 18 other facilities. Most members of the family Enterobacteriaceae were inhibited by W...

journal_title：Antimicrobial agents and chemotherapy

authors： Sewell D,Barry A,Allen S,Fuchs P,McLaughlin J,Pfaller M

更新日期：1995-07-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:A series of [(aryl)arylsufanylmethyl]pyridines (AASMP) have been synthesized. These compounds inhibited hemozoin formation, formed complexes (K(D) = 12 to 20 muM) with free heme (ferriprotoporphyrin IX) at a pH close to the pH of the parasite food vacuole, and exhibited antimalarial activity in vitro. The inhibition o...

journal_title：Antimicrobial agents and chemotherapy

authors： Kumar S,Das SK,Dey S,Maity P,Guha M,Choubey V,Panda G,Bandyopadhyay U

更新日期：2008-02-01 00:00:00

abstract：:The MICs and MBCs of the new difluorinated quinolone drug sparfloxacin against type strains belonging to 21 species of mycobacteria were screened. The MICs and MBCs were within the range of 0.1 to 2.0 and 0.1 to 4.0 micrograms/ml, respectively (with an MBC/MIC ratio of 1 to 2), and against 18 of the 21 species tested,...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Labrousse V,Goh KS,De Sousa JP

更新日期：1991-12-01 00:00:00

abstract：:Multidrug-resistant tuberculosis (MDR-TB) threatens global TB control. The lengthy treatment includes one of the injectable drugs kanamycin, amikacin, and capreomycin, usually for the first 6 months. These drugs have potentially serious toxicities, and when given as intramuscular injections, dosing can be painful. Adv...

journal_title：Antimicrobial agents and chemotherapy

authors： Dharmadhikari AS,Kabadi M,Gerety B,Hickey AJ,Fourie PB,Nardell E

更新日期：2013-06-01 00:00:00

abstract：:Genome editing using zinc finger nucleases (ZFNs) has been successfully applied to disrupt CCR5 or CXCR4 host factors and inhibit viral entry and infection. Gene therapy using ZFNs to modify the PSIP1 gene, which encodes the lens epithelium-derived growth factor (LEDGF) protein, might restrain an early step of the vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Badia R,Pauls E,Riveira-Munoz E,Clotet B,Esté JA,Ballana E

更新日期：2014-08-01 00:00:00

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00

abstract：:The pharmacokinetics, distribution, and plasma and renal clearance of a new aminoglycoside antibiotic, tobramycin, was studied in the treatment of 18 elderly male patients (average age, 69 years) with urinary tract infections. Ten of these patients had normal renal function and eight had impaired renal function of var...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Westenfelder SR,Madsen PO

更新日期：1973-04-01 00:00:00

abstract：:In our study we examined the anti-human immunodeficiency virus type 1 (anti-HIV-1) activity of a novel HIV-1 protease inhibitor, PNU-140690 (tipranavir), against patient-derived isolates resistant to multiple other protease inhibitors (PIs). The aim of our experiments was to investigate the genotypes and the in vitro ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rusconi S,La Seta Catamancio S,Citterio P,Kurtagic S,Violin M,Balotta C,Moroni M,Galli M,d'Arminio-Monforte A

更新日期：2000-05-01 00:00:00

abstract：:The therapeutic effectiveness of adenine arabinoside 5'-monophosphate (ara-AMP), adenine arabinoside (ara-A), and phosphonoacetic acid (PAA) was compared in three experimental Herpesvirus hominis type 2 infections of mice. In animals inoculated with H. hominis by the intracerebral or intraperitoneal route, both ara-AM...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Richards JT,Overall JC Jr,Glasgow LA

更新日期：1978-01-01 00:00:00

abstract：:One of the major neglected tropical diseases, schistosomiasis, is currently treated and controlled with a single drug, praziquantel. The quest for an alternative drug is fueled by the lack of activity of praziquantel against juvenile Schistosoma worms and the fear of emerging resistance. The synthetic ozonide OZ418 ha...

journal_title：Antimicrobial agents and chemotherapy

authors： Leonidova A,Vargas M,Huwyler J,Keiser J

更新日期：2016-11-21 00:00:00

abstract：:Piperaquine (PQ) is an antimalarial drug whose high lipid solubility suggests that its absorption can be increased by a high-fat meal. We examined the pharmacokinetics of PQ phosphate (500 mg given orally) in the fasting state and after a high-fat meal in eight healthy Caucasian volunteers (randomized crossover). Plas...

journal_title：Antimicrobial agents and chemotherapy

authors： Sim IK,Davis TM,Ilett KF

更新日期：2005-06-01 00:00:00

abstract：:Pseudomonas aeruginosa AH, isolated in Ankara, Turkey, was highly resistant to ceftazidime (MIC, 128 microg/ml) and produced a beta-lactamase that gave a doublet of bands at pIs 8.7 and 8.9. beta-Lactamase production was transferable to P. aeruginosa PU21 by conjugation and was determined by a ca. 450-kb plasmid, pMLH...

journal_title：Antimicrobial agents and chemotherapy

authors： Danel F,Hall LM,Gur D,Livermore DM

更新日期：1997-04-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites lack the enzymes to salvage preformed pyrimidines. For this reason, a combination of a thymidylate synthase inhibitor and the nucleoside thymidine should provide selective antimalarial activity even in the absence of any known active site differences between malarial and mamm...

journal_title：Antimicrobial agents and chemotherapy

authors： Rathod PK,Reshmi S

更新日期：1994-03-01 00:00:00

abstract：:Similar to Neisseria gonorrhoeae, tetracycline-resistant isolates of N. meningitidis, Kingella denitrificans, and Eikenella corrodens contained 25.2-megadalton plasmids carrying the TetM determinant. In contrast, tetracycline-resistant N. subflava biovar perflava-N. sicca and N. mucosa isolates carried the TetM determ...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Johnson SR,Zenilman JM,Roberts MC,Morse SA

更新日期：1988-05-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates have been increasingly reported worldwide, and therapeutic options to treat infections caused by these organisms are limited. We evaluated the activity of ceftazidime-avibactam and comparators against 456 Enterobacteriaceae isolates carryi...

journal_title：Antimicrobial agents and chemotherapy

authors： Castanheira M,Mendes RE,Sader HS

更新日期：2017-02-23 00:00:00

abstract：:More than 250 Providencia strains isolated from the urine of institutionalized elderly patients were tested against cefaclor, cefuroxime, cefetamet, cefpodoxime, ciprofloxacin, and amoxicillin-clavulanic acid. Our results confirm the strong activities of expanded-spectrum oral cephalosporins against Providencia isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Cornaglia G,Frugoni S,Mazzariol A,Piacentini E,Berlusconi A,Fontana R

更新日期：1995-12-01 00:00:00

abstract：:We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (correlation coefficient 0.7838), and OH-ITZ levels were generally higher than that of ITZ (median OH-ITZ:ITZ ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Schwartz IS,Patterson TF,Thompson GR 3rd

更新日期：2021-01-19 00:00:00

abstract：:Within wounds, microorganisms predominantly exist as biofilms. Biofilms are associated with chronic infections and represent a tremendous clinical challenge. As antibiotics are often ineffective against biofilms, use of dispersal agents as adjunctive, topical therapies for the treatment of wound infections involving b...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanchez CJ Jr,Akers KS,Romano DR,Woodbury RL,Hardy SK,Murray CK,Wenke JC

更新日期：2014-08-01 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:Against 307 pneumococci of various resistotypes, dalbavancin MICs were 0.008 to 0.125 microg/ml. All strains were susceptible to vancomycin, teicoplanin, linezolid, and quinupristin-dalfopristin. Dalbavancin at 2x MIC was bactericidal against all 10 pneumococci tested after 24 h. Vancomycin and teicoplanin killed 10 a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin G,Smith K,Ednie LM,Appelbaum PC

更新日期：2005-12-01 00:00:00

abstract：:The activity of a new prototype carbapenem, L-695,256, against clinical isolates of gram-positive and gram-negative aerobes was studied in vitro by agar dilution. L-695,256 was highly active against methicillin-resistant and -susceptible isolates of staphylococci (MICs, 0.016 to 2 micrograms/ml) and against penicillin...

journal_title：Antimicrobial agents and chemotherapy

authors： Rylander M,Rollof J,Jacobsson K,Norrby SR

更新日期：1995-05-01 00:00:00

abstract：:Viral entry inhibitors represent an emerging mode of therapy for human immunodeficiency virus type 1 (HIV-1) infection. PRO 542 (CD4-immunoglobulin G2) is a tetravalent CD4-immunoglobulin fusion protein that broadly neutralizes primary HIV-1 isolates. PRO 542 binds to the viral surface glycoprotein gp120 and blocks at...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobson JM,Israel RJ,Lowy I,Ostrow NA,Vassilatos LS,Barish M,Tran DN,Sullivan BM,Ketas TJ,O'Neill TJ,Nagashima KA,Huang W,Petropoulos CJ,Moore JP,Maddon PJ,Olson WC

更新日期：2004-02-01 00:00:00