Analysis of amifloxacin in plasma and urine by high-pressure liquid chromatography and intravenous pharmacokinetics in rhesus monkeys.

abstract：:Early studies of immobilized peptides mainly focused upon the relationship between structural properties and the activity of soluble and surface-tethered sequences. The intention of this study was to analyze the influence of immobilization parameters upon the activity profile of peptides. Resin beads (TentaGel S NH(2)...

journal_title：Antimicrobial agents and chemotherapy

authors： Bagheri M,Beyermann M,Dathe M

更新日期：2009-03-01 00:00:00

abstract：:Initial studies indicate that rifampin may be useful for the treatment of Staphylococcus aureus infections. Because bacterial resistance to rifampin may develop rapidly, its widespread use could result in the emergence of a resistant flora. This study evaluates the effectiveness of rifampin in reducing the nasal carri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sande MA,Mandell GL

更新日期：1975-03-01 00:00:00

abstract：:In the course of surveying for the carbapenem-hydrolyzing metallo-beta-lactamase gene bla(IMP) in pathogenic bacteria by the PCR method, we detected a gene encoding a variant metallo-beta-lactamase, designated IMP-3, which differed from IMP-1 by having low hydrolyzing activity for penicillins and carbapenems. PCR prod...

journal_title：Antimicrobial agents and chemotherapy

authors： Iyobe S,Kusadokoro H,Ozaki J,Matsumura N,Minami S,Haruta S,Sawai T,O'Hara K

更新日期：2000-08-01 00:00:00

abstract：:Pneumonia occurring outside of the hospital setting has traditionally been categorized as community-acquired pneumonia (CAP). However, when pneumonia is associated with health care risk factors (prior hospitalization, dialysis, residing in a nursing home, immunocompromised state), it is now more appropriately classifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Micek ST,Kollef KE,Reichley RM,Roubinian N,Kollef MH

更新日期：2007-10-01 00:00:00

abstract：:Antibiotics are generally not effective against organisms in exopolysaccharide biofilms. A simple method of studying the effect of antibiotics on bacteria in established biofilms is reported. Escherichia coli ATCC 25922 cells grown overnight at 37 degrees C on Mueller-Hinton agar were suspended in buffer and dispensed...

journal_title：Antimicrobial agents and chemotherapy

authors： Prosser BL,Taylor D,Dix BA,Cleeland R

更新日期：1987-10-01 00:00:00

abstract：:Fifty-six strains, representing eight species of salmonellae of diverse geographic origin and possessing a variety of antimicrobial resistance profiles, were tested for susceptibility to niridazole by the agar dilution method. Calculated MICs for 50 and 90% of strains were 4.8 and 16.0 mg/liter, respectively, with a s...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannatyne RM,Jackowski J,Grant RB

更新日期：1986-05-01 00:00:00

abstract：:Weak T-cell reactivity to hepatitis B virus (HBV) is thought to be the dominant cause for chronic HBV infection. Treatment with adefovir dipivoxil (ADV) increases the rate of HBV e antigen (HBeAg) loss; however, the immune mechanisms associated with this treatment response are not understood. Serial analysis of HBV-sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Cooksley H,Chokshi S,Maayan Y,Wedemeyer H,Andreone P,Gilson R,Warnes T,Paganin S,Zoulim F,Frederick D,Neumann AU,Brosgart CL,Naoumov NV

更新日期：2008-01-01 00:00:00

abstract：:Here, we report the first autochthonous cases of infections caused by blaNDM-5 New Delhi metallo-β-lactamase-producing Escherichia coli strains recovered from urine and blood specimens of three patients from Algeria between January 2012 and February 2013. The three isolates belong to sequence type 2659 and they coexpr...

journal_title：Antimicrobial agents and chemotherapy

authors： Sassi A,Loucif L,Gupta SK,Dekhil M,Chettibi H,Rolain JM

更新日期：2014-09-01 00:00:00

abstract：:Antiviral therapeutics are currently unavailable for treatment of coxsackievirus B3, which can cause life-threatening myocarditis. A modified small interfering RNA (siRNA) containing 5'-triphosphate, 3p-siRNA, was shown to induce RNA interference and interferon activation. We aimed to develop a potent antiviral treatm...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahn J,Ko A,Jun EJ,Won M,Kim YK,Ju ES,Jeon ES,Lee H

更新日期：2012-07-01 00:00:00

abstract：:Ampicillin-resistant Enterococcus faecium (ARE) and vancomycin-resistant E. faecium (VRE) are important nosocomial pathogens. We quantified effects of probiotics and antibiotics on intestinal acquisition of ARE colonization in patients hospitalized in two non-intensive care unit (non-ICU) wards with high ARE prevalenc...

journal_title：Antimicrobial agents and chemotherapy

authors： de Regt MJ,Willems RJ,Hené RJ,Siersema PD,Verhaar HJ,Hopmans TE,Bonten MJ

更新日期：2010-07-01 00:00:00

abstract：:An in vitro pharmacodynamic model was used to simulate the in vivo pharmacokinetics of clarithromycin and 14-hydroxyclarithromycin in order to generate time-kill curves for three clinical isolates of Haemophilus influenzae (isolates 2019, 91-183, and 1746). Representative concentrations in serum or lung tissue and the...

journal_title：Antimicrobial agents and chemotherapy

authors： Walker KJ,Larsson AJ,Zabinski RA,Rotschafer JC

更新日期：1994-09-01 00:00:00

abstract：:We assessed the activity and safety of liposomal nystatin, a broad-spectrum antifungal agent, for invasive aspergillosis in patients refractory to or intolerant of amphotericin B. Thirty-three patients were enrolled, received at least one dose of the study drug, and were evaluable for safety. Twenty-six patients had c...

journal_title：Antimicrobial agents and chemotherapy

authors： Offner F,Krcmery V,Boogaerts M,Doyen C,Engelhard D,Ribaud P,Cordonnier C,de Pauw B,Durrant S,Marie JP,Moreau P,Guiot H,Samonis G,Sylvester R,Herbrecht R,EORTC Invasive Fungal Infections Group.

更新日期：2004-12-01 00:00:00

abstract：:Disseminated infections caused by the Mycobacterium avium-M. intracellulare complex (MAC) are the most frequent opportunistic bacterial infections in patients with AIDS. MAC isolates are resistant to many of the standard antituberculous drugs. Failure to obtain significant activities of certain drugs is due to difficu...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehta RT

更新日期：1996-08-01 00:00:00

abstract：:The in vitro activities of penicillin, clindamycin, chloramphenicol, metronidazole, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin-sulbactam, cefoxitin, ceftizoxime, cefotetan, moxalactam, and imipenem against 348 Bacteroides fragilis group isolates collected from six Canadian ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bourgault AM,Lamothe F,Hoban DJ,Dalton MT,Kibsey PC,Harding G,Smith JA,Low DE,Gilbert H

更新日期：1992-02-01 00:00:00

abstract：:Gatifloxacin (GTX), a new fluoroquinolone with extended antibacterial activity, is an interesting candidate for the treatment of chronic bacterial prostatitis (CBP). Besides the antibacterial spectrum, the concentrations in the target tissues and fluids are crucial for the treatment of CBP. Thus, it was of interest to...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber CK,Steghafner M,Kinzig-Schippers M,Sauber C,Sörgel F,Stahlberg HJ,Naber KG

更新日期：2001-01-01 00:00:00

abstract：:The physical and nutritional requirements of the antibiotic-producing slime mold Physarum gyrosum were examined to develop a liquid medium for this myxomycete. Liquid culture is desired to expedite a useful scale of production of antibiotic materials for ease of isolation and structure study. Culture conditions were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor RL,Mallette MF

更新日期：1976-10-01 00:00:00

abstract：:Clostridioides difficile causes severe antibiotic-associated diarrhea and colitis. C. difficile is an anaerobic, Gram-positive sporeformer that is highly resistant to β-lactams, the most commonly prescribed antibiotics. The resistance of C. difficile to β-lactam antibiotics allows the pathogen to replicate and cause d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandhu BK,Edwards AN,Anderson SE,Woods EC,McBride SM

更新日期：2019-12-20 00:00:00

abstract：:(1,3)Beta-D-glucan synthase (EC 2.4.1.34. UDP-glucose: 1,3-beta-D-glucan 3-beta-glucosyltransferase) uses UDP-glucose as substrate and catalyzes the polymerization of glucose ([1,3]-beta-linkages) to form the major carbohydrate component of the fungal cell wall. We have optimized in vitro assay conditions for (1,3)bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Maligie MA,Selitrennikoff CP

更新日期：2005-07-01 00:00:00

abstract：:The activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine against two virulent strains of the Mycobacterium avium complex isolated from patients with AIDS were evaluated in a model of intracellular infection and were compared with that of clarithromycin. Human monocyte-derived macrophages were infect...

journal_title：Antimicrobial agents and chemotherapy

authors： Perronne C,Gikas A,Truffot-Pernot C,Grosset J,Vilde JL,Pocidalo JJ

更新日期：1991-07-01 00:00:00

abstract：:The purpose of this study was to assess the effect of voriconazole on the blood tacrolimus concentration in a liver transplant recipient and to examine the interaction between voriconazole and tacrolimus by using human liver microsomes. Two subjects were enrolled in the clinical study: one received voriconazole, and t...

journal_title：Antimicrobial agents and chemotherapy

authors： Venkataramanan R,Zang S,Gayowski T,Singh N

更新日期：2002-09-01 00:00:00

abstract：:Colistin is increasingly being utilized against Gram-negative pathogens, including Pseudomonas aeruginosa, resistant to all other antibiotics. Since limited data exist regarding killing by colistin at different initial inocula (CFUo), we evaluated killing of Pseudomonas aeruginosa by colistin at several CFUo and devel...

journal_title：Antimicrobial agents and chemotherapy

authors： Bulitta JB,Yang JC,Yohonn L,Ly NS,Brown SV,D'Hondt RE,Jusko WJ,Forrest A,Tsuji BT

更新日期：2010-05-01 00:00:00

abstract：:The increasing incidence and severity of infection by Clostridium difficile have stimulated attempts to develop new antimicrobial therapies. We report here the relative abilities of two antibiotics (metronidazole and vancomycin) in current use for treating C. difficile infection and of a third antimicrobial, surotomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bouillaut L,McBride S,Sorg JA,Schmidt DJ,Suarez JM,Tzipori S,Mascio C,Chesnel L,Sonenshein AL

更新日期：2015-07-01 00:00:00

abstract：:Few studies have estimated the excess inpatient costs due to nosocomial cultures of Gram-negative bacteria (GNB), and those that do are often subject to time-dependent bias. Our objective was to generate estimates of the attributable costs of the underlying infections associated with nosocomial cultures by using a uni...

journal_title：Antimicrobial agents and chemotherapy

authors： Nelson RE,Stevens VW,Jones M,Khader K,Schweizer ML,Perencevich EN,Rubin MA,Samore MH

更新日期：2018-10-24 00:00:00

abstract：:An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium clavulanate and oxacillin, distinguished type I chromosomally mediated enzymes from other beta-lactamases of gram-negative bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr,Moland ES

更新日期：1986-12-01 00:00:00

abstract：:In this study, we characterized two tigecycline-resistant Klebsiella pneumoniae isolates from dog urine samples. The isolates were genetically unrelated, belonging to sequence type 11 (ST11) and ST147, both classically related to human isolates. To the best of our knowledge, this is the first identification of tigecyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Ovejero CM,Escudero JA,Thomas-Lopez D,Hoefer A,Moyano G,Montero N,Martin-Espada C,Gonzalez-Zorn B

更新日期：2017-05-24 00:00:00

abstract：:The biosynthetic gene cluster of the aminocoumarin antibiotic coumermycin A(1) was cloned by screening of a cosmid library of Streptomyces rishiriensis DSM 40489 with heterologous probes from a dTDP-glucose 4,6-dehydratase gene, involved in deoxysugar biosynthesis, and from the aminocoumarin resistance gyrase gene gyr...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang ZX,Li SM,Heide L

更新日期：2000-11-01 00:00:00

abstract：:The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma fermentans, Mycoplasma genitalium, and Ureaplasma species to DC-159a, an investigational fluoroquinolone, in comparison with those to other agents were determined. Macrolides were the most active agen...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB

更新日期：2008-10-01 00:00:00

abstract：:The effect of liposomal encapsulation of ampicillin on the antibacterial activity against intracellular Listeria monocytogenes was studied by comparing survival of L. monocytogenes within peritoneal mouse macrophages in the presence of free ampicillin alone or in combination with liposome-entrapped ampicillin. In the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakker-Woudenberg IA,Lokerse AF,Vink-van den Berg JC,Roerdink FH,Michel MF

更新日期：1986-08-01 00:00:00

abstract：:Our aim was to assess the effect of miconazole oral gel on the pharmacokinetics of oral oxycodone. In an open crossover study with two phases, 12 healthy volunteers took a single oral dose of 10 mg of immediate-release oxycodone with or without thrice-daily 85-mg miconazole oral gel treatment. The plasma concentration...

journal_title：Antimicrobial agents and chemotherapy

authors： Grönlund J,Saari TI,Hagelberg N,Neuvonen PJ,Olkkola KT,Laine K

更新日期：2011-03-01 00:00:00

abstract：:Ninety-two strains of Yersinia pestis recovered over a 21-year period were evaluated for susceptibility to traditional and newer antimicrobial agents. In vitro resistance was noted only against rifampin and imipenem (approximately 20% of strains). The most active compounds (MIC at which 90% of the isolates tested are ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wong JD,Barash JR,Sandfort RF,Janda JM

更新日期：2000-07-01 00:00:00