Survey of Bacteroides fragilis group susceptibility patterns in Canada.

abstract：:We previously reported that the multidrug-resistant (MDR) Acinetobacter baumannii strain MDR-ZJ06, belonging to European clone II, was widely spread in China. In this study, we report the whole-genome sequence of this clinically important strain. A 38.6-kb AbaR-type genomic resistance island (AbaR22) was identified in...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou H,Zhang T,Yu D,Pi B,Yang Q,Zhou J,Hu S,Yu Y

更新日期：2011-10-01 00:00:00

abstract：:A number of compounds, as exemplified by verapamil and desipramine, have been shown to enhance the susceptibility of resistant malaria parasites to chloroquine. The mechanism by which these agents reverse resistance is still controversial but is though to involve alterations in drug transport causing an increase in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Ndifor AM,Howells RE,Bray PG,Ngu JL,Ward SA

更新日期：1993-06-01 00:00:00

abstract：:We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no di...

journal_title：Antimicrobial agents and chemotherapy

authors： Lionakis MS,Chamilos G,Lewis RE,Wiederhold NP,Raad II,Samonis G,Kontoyiannis DP

更新日期：2006-01-01 00:00:00

abstract：:Curcumin, a principal component of turmeric, acts as an immunomodulator regulating the host defenses in response to a diseased condition. The role of curcumin in controlling certain infectious diseases is highly controversial. It is known to alleviate symptoms of Helicobacter pylori infection and exacerbate that of Le...

journal_title：Antimicrobial agents and chemotherapy

authors： Marathe SA,Sen M,Dasgupta I,Chakravortty D

更新日期：2012-11-01 00:00:00

abstract：:The effects of binding and the bactericidal action of vancomycin on the arrangement and mobilities of cell wall polymers in Bacillus licheniformis were investigated by (15)N nuclear magnetic resonance spectroscopy. The bactericidal action of vancomycin led to reduced mobilities of cell wall teichoic acid and teichuron...

journal_title：Antimicrobial agents and chemotherapy

authors： Irving CS,Lapidot A

更新日期：1978-11-01 00:00:00

abstract：:Chagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic. Benznidazole is the most commonly used drug for the etiological treatment of Chagas disease. Patients treated with benznidazole suffer frequent adverse drug re...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldasoro E,Pinazo MJ,Oliveira I,Munoz J,Posada E,Requena-Méndez A,Serret N,Gascon J

更新日期：2015-01-01 00:00:00

abstract：:Fluoroquinolone antibiotics are prescribed for the treatment of Salmonella enterica infections, but resistance to this family of antibiotics is growing. Here we report that loss of the global regulatory protein cyclic AMP (cAMP) receptor protein (CRP) or its allosteric effector, cAMP, reduces susceptibility to fluoroq...

journal_title：Antimicrobial agents and chemotherapy

authors： Kary SC,Yoneda JRK,Olshefsky SC,Stewart LA,West SB,Cameron ADS

更新日期：2017-10-24 00:00:00

abstract：:Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Suzuki S,Yamazaki T,Narita M,Okazaki N,Suzuki I,Andoh T,Matsuoka M,Kenri T,Arakawa Y,Sasaki T

更新日期：2006-02-01 00:00:00

abstract：:Amphotericin B lipid complex for injection (ABLC) is a suspension of amphotericin B complexed with the lipids L-alpha-dimyristoylphosphatidylcholine (DMPC) and L-alpha-dimyristoylphosphatidylglycerol. ABLC is less toxic than amphotericin B deoxycholate (AmB-d), while it maintains the antifungal activity of AmB-d. Acti...

journal_title：Antimicrobial agents and chemotherapy

authors： Swenson CE,Perkins WR,Roberts P,Ahmad I,Stevens R,Stevens DA,Janoff AS

更新日期：1998-04-01 00:00:00

abstract：:Minocycline and valproic acid are potential adjuvant therapies for the treatment of human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine whether minocycline alone or in combination with valproic acid affected atazanavir plasma concentrations. Twelve adult HIV-i...

journal_title：Antimicrobial agents and chemotherapy

authors： DiCenzo R,Peterson DR,Cruttenden K,Mariuz P,Rezk NL,Hochreiter J,Gelbard H,Schifitto G

更新日期：2008-09-01 00:00:00

abstract：:We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at positi...

journal_title：Antimicrobial agents and chemotherapy

authors： Welsh KJ,Barlow M,Tenover FC,Biddle JW,Rasheed JK,Clark LA,McGowan JE Jr

更新日期：2005-03-01 00:00:00

abstract：:Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes ...

journal_title：Antimicrobial agents and chemotherapy

authors： Reno JM,Lee LF,Boezi JA

更新日期：1978-02-01 00:00:00

abstract：:Therapeutic options for severe infections caused by strains of oxacillin-resistant Staphylococcus aureus (ORSA) and coagulase-negative staphylococci (ORSE) are very limited. With the increasing resistance of such strains to aminoglycosides, rifampin, and currently available quinolone agents, as well as the recent docu...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Li C,Ing M

更新日期：1998-07-01 00:00:00

abstract：:In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28°C and 35°C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demonstrated susceptibil...

journal_title：Antimicrobial agents and chemotherapy

authors： Heine HS,Hershfield J,Marchand C,Miller L,Halasohoris S,Purcell BK,Worsham PL

更新日期：2015-04-01 00:00:00

abstract：:A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Schoenknecht FD,Shadomy S,Sherris JC,Thornsberry C,Washington JA,Kammer RB

更新日期：1979-01-01 00:00:00

abstract：:The motility of viable Trichomonas vaginalis organisms is readily demonstrable in a clinical wet mount or cultured specimens. We attempted to determine whether migration is a dynamic process such that the organisms move to avoid exposure to toxic antimicrobial agents. With the use of axenic cultures of T. vaginalis th...

journal_title：Antimicrobial agents and chemotherapy

authors： Sugarman B,Mummaw N

更新日期：1988-09-01 00:00:00

abstract：:The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted significant scientific interest as models for targeting and management o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parisot J,Carey S,Breukink E,Chan WC,Narbad A,Bonev B

更新日期：2008-02-01 00:00:00

abstract：:3-Deazauridine, a synthetic analogue of uridine and a potential antitumor agent, was found to possess antiviral activity against a number of ribonucleic acid-containing animal viruses in mammalian cell culture. Inhibition of virus-induced cytopathogenic effects by 3-deazauridine was observed in cells infected with rhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Shannon WM,Arnett G,Schabel FM Jr

更新日期：1972-09-01 00:00:00

abstract：:Invasive fungal diseases are generally difficult to treat and often fatal. The therapeutic agents available to treat fungi are limited, and there is a critical need for new agents to combat these deadly infections. Antifungal compound development has been hindered by the challenge of creating agents that are highly ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Rank LA,Walsh NM,Liu R,Lim FY,Bok JW,Huang M,Keller NP,Gellman SH,Hull CM

更新日期：2017-09-22 00:00:00

abstract：:The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida,...

journal_title：Antimicrobial agents and chemotherapy

authors： Takenouchi T,Tabata F,Iwata Y,Hanzawa H,Sugawara M,Ohya S

更新日期：1996-08-01 00:00:00

abstract：:An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium clavulanate and oxacillin, distinguished type I chromosomally mediated enzymes from other beta-lactamases of gram-negative bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr,Moland ES

更新日期：1986-12-01 00:00:00

abstract：:A new SHV-derived extended-spectrum beta-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 3...

journal_title：Antimicrobial agents and chemotherapy

authors： Kurokawa H,Yagi T,Shibata N,Shibayama K,Kamachi K,Arakawa Y

更新日期：2000-06-01 00:00:00

abstract：:We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lennerstrand J,Stammers DK,Larder BA

更新日期：2001-07-01 00:00:00

abstract：:The in vitro susceptibilities of 112 clinical isolates of Haemophilus ducreyi to six antimicrobial agents were determined. These isolates were obtained in Kigali, Rwanda, during three studies on genital ulcer disease performed in 1986 (18 isolates), 1988 (23 isolates), and 1991 (71 isolates). All H. ducreyi isolates w...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Dyck E,Bogaerts J,Smet H,Tello WM,Mukantabana V,Piot P

更新日期：1994-07-01 00:00:00

abstract：:Staphylococcin 462 is a proteinaceous inhibitor produced by Staphylococcus aureus strain 462. In broth cultures, susceptible S. aureus strain 140 and 19 respond to treatment with the bacteriocin by stopping growth and cell division. Examination of macromolecular synthesis by measuring the incorporation of radioactive ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hale EM,Hinsdill RD

更新日期：1975-01-01 00:00:00

abstract：:We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme i...

journal_title：Antimicrobial agents and chemotherapy

authors： Moriyama B,Elinoff J,Danner RL,Gea-Banacloche J,Pennick G,Rinaldi MG,Walsh TJ

更新日期：2009-04-01 00:00:00

abstract：:beta-Lactamase production was investigated in cultures of 25 Klebsiella pneumoniae isolates isolated at a hospital in Durban, South Africa, in 1994 and 1996. Twenty of these isolates gave ceftazidime MIC/ceftazidime plus clavulanate MIC ratios of >/=8, implying production of extended-spectrum beta-lactamases (ESBLs), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Essack SY,Hall LM,Pillay DG,McFadyen ML,Livermore DM

更新日期：2001-01-01 00:00:00

abstract：:Mycobacterium abscessus is a major nontuberculous mycobacterial (NTM) pathogen and is responsible for about 80% of all pulmonary infections caused by rapidly growing mycobacteria. Clofazimine is an effective drug active against M. abscessus, but the mechanism of resistance to clofazimine in M. abscessus is unknown. To...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen Y,Chen J,Zhang S,Shi W,Zhang W,Zhu M,Zhang Y

更新日期：2018-06-26 00:00:00

abstract：:Due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (AMPs) are considered promising candidates for future therapeutic use. Amphibian skin is one of the richest sources of such AMPs. In the pr...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangoni ML,Maisetta G,Di Luca M,Gaddi LM,Esin S,Florio W,Brancatisano FL,Barra D,Campa M,Batoni G

更新日期：2008-01-01 00:00:00

abstract：:We conducted time-kill studies to evaluate the inhibitory activities of either cefotaxime or minocycline alone and the two drugs in combination against a clinical strain of Vibrio vulnificus. The MICs of cefotaxime and minocycline were 0.03 and 0.06 microg/ml, respectively. When approximately 5 x 10(5) CFU of V. vulni...

journal_title：Antimicrobial agents and chemotherapy

authors： Chuang YC,Liu JW,Ko WC,Lin KY,Wu JJ,Huang KY

更新日期：1997-10-01 00:00:00