Efficacy of trovafloxacin, a new quinolone antibiotic, in experimental staphylococcal endocarditis due to oxacillin-resistant strains.


:Therapeutic options for severe infections caused by strains of oxacillin-resistant Staphylococcus aureus (ORSA) and coagulase-negative staphylococci (ORSE) are very limited. With the increasing resistance of such strains to aminoglycosides, rifampin, and currently available quinolone agents, as well as the recent documentation of increasing resistance of ORSA to vancomycin (VANCO), new treatment alternatives are imperative. The in vivo efficacy of trovafloxacin (TROVA), a new quinolone agent with excellent antistaphylococcal activity in vitro, against experimental endocarditis (IE) due to beta-lactamase-producing ORSA and ORSE strains (ORSA and ORSE IE) was evaluated. TROVA (25 mg/kg of body weight intravenously [i.v.] twice daily [b.i.d]) was compared to VANCO (20 mg/kg i.v. b.i.d.) and two regimens of ampicillin-sulbactam (AMP-SUL; 200 mg/kg intramuscularly [i.m.] three times a day [t.i.d.] and 20 mg/kg i.m. b.i.d.), with all agents given for 3 or 6 days. AMP-SUL was included as a comparative treatment regimen because of its proven efficacy against experimental ORSA and ORSE IE. For both ORSA and ORSE IE, TROVA, AMP-SUL, and VANCO each reduced staphylococcal densities in vegetations compared to untreated controls (P < 0.01). For ORSA IE, TROVA was the most rapidly bactericidal agent--although not to a statistically significant degree--correlating with its superior bactericidal effect in vitro compared to those of VANCO and AMP-SUL.


Bayer AS,Li C,Ing M




Has Abstract


1998-07-01 00:00:00












  • Characterization of a respiratory syncytial virus L protein inhibitor.

    abstract::The respiratory syncytial virus (RSV) L protein is a viral RNA-dependent RNA polymerase that contains multiple enzyme activities required for RSV replication. The RSV L inhibitors described in literature are limited by their cytotoxicity or the lack of RSV B subtype coverage. Here, we characterize a new RSV L inhibito...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tiong-Yip CL,Aschenbrenner L,Johnson KD,McLaughlin RE,Fan J,Challa S,Xiong H,Yu Q

    更新日期:2014-07-01 00:00:00

  • Antifungal therapy in a murine model of disseminated infection by Cryptococcus gattii.

    abstract::We have evaluated the efficacy of posaconazole (PSC), voriconazole (VRC), and amphotericin B (AMB) in a murine model of systemic infection by Cryptococcus gattii using immunocompromised animals and three clinical strains of the fungus. AMB was the most effective drug in prolonging the survival of mice and also in redu...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Calvo E,Pastor FJ,Rodríguez MM,Pujol I,Guarro J

    更新日期:2010-10-01 00:00:00

  • Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV.

    abstract::Quinazoline-2,4-diones, such as PD 0305970, are new DNA gyrase and topoisomerase IV (topo IV) inhibitors with potent activity against gram-positive pathogens, including quinolone-resistant isolates. The mechanistic basis of dione activity vis-à-vis quinolones is not understood. We present evidence for Streptococcus pn...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pan XS,Gould KA,Fisher LM

    更新日期:2009-09-01 00:00:00

  • Preliminary method for direct quantification of colistin methanesulfonate by attenuated total reflectance Fourier transform infrared spectroscopy.

    abstract::Colistin use has increased in response to the advent of infections caused by multidrug-resistant organisms. It is administered parenterally as an inactive prodrug, colistin methanesulfonate (CMS). Various formulations of CMS and labeling conventions can lead to confusion about colistin dosing, and questions remain abo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Niece KL,Akers KS

    更新日期:2015-09-01 00:00:00

  • Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry.

    abstract::One of the major neglected tropical diseases, schistosomiasis, is currently treated and controlled with a single drug, praziquantel. The quest for an alternative drug is fueled by the lack of activity of praziquantel against juvenile Schistosoma worms and the fear of emerging resistance. The synthetic ozonide OZ418 ha...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Leonidova A,Vargas M,Huwyler J,Keiser J

    更新日期:2016-11-21 00:00:00

  • Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae.

    abstract::Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires. In contrast, five of six animals given ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shalit I,Barnea A,Shahar A

    更新日期:1989-05-01 00:00:00

  • Human salivary mucin MUC7 12-mer-L and 12-mer-D peptides: antifungal activity in saliva, enhancement of activity with protease inhibitor cocktail or EDTA, and cytotoxicity to human cells.

    abstract::MUC7 12-mer-L exhibits potent in vitro antifungal activity in low-ionic-strength buffers. In this study, we investigated the anticandidal activity and stability of MUC7 12-mer-L and its all-D-amino-acid isomer, along with Hsn5 12-mer (P113) and magainin-II, in human clarified and unclarified saliva in the absence or p...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wei GX,Bobek LA

    更新日期:2005-06-01 00:00:00

  • High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams.

    abstract::Multidrug-resistant Enterobacteriaceae (MRE) colonize the intestine asymptomatically from where they can breach into the bloodstream and cause life-threatening infections, especially in heavily colonized patients. Despite the clinical relevance of MRE colonization levels, we know little about how they vary in hospital...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Djukovic A,González-Barberá EM,Sanz J,Artacho A,Peñaranda I,Herrera B,Garzón MJ,Salavert M,López-Hontangas JL,Xavier KB,Kuster B,Debrauwer L,Rolain JM,Sanz MA,Xavier JB,Ubeda C

    更新日期:2020-01-27 00:00:00

  • Effect of subinhibitory concentrations of antibiotics on the adhesion of Streptococcus pyogenes to pharyngeal epithelial cells.

    abstract::The hydrophobicity and charge of the cell surface of M protein-positive (M+) and the less virulent M protein-negative (M-) strains of type 12 Streptococcus pyogenes have been studied, respectively, by hydrophobic interaction chromatography and free zone electrophoresis. The M+ strain had a more hydrophobic and a more ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tylewska S,Hjertén S,Wadström T

    更新日期:1981-11-01 00:00:00

  • Randomized comparison of safety and pharmacokinetics of caspofungin, liposomal amphotericin B, and the combination of both in allogeneic hematopoietic stem cell recipients.

    abstract::The combination of liposomal amphotericin B (LAMB) and caspofungin (CAS) holds promise to improve the outcome of opportunistic invasive mycoses with poor prognosis. Little is known, however, about the safety and pharmacokinetics of the combination in patients at high risk for these infections. The safety and pharmacok...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Groll AH,Silling G,Young C,Schwerdtfeger R,Ostermann H,Heinz WJ,Gerss J,Kolve H,Lanvers-Kaminsky C,Vieira Pinheiro JP,Gammelin S,Cornely OA,Wuerthwein G

    更新日期:2010-10-01 00:00:00

  • Treatment of experimental visceral leishmaniasis with amphotericin B in stable albumin microspheres.

    abstract::Hydrophilic albumin microspheres are proposed as a new delivery system for amphotericin B (AMB; AMB microspheres). The acute toxicity of AMB microspheres was lower than that of the AMB-deoxycholate (AMB-Doc) reference formulation in hamsters. Lethal doses in healthy and infected animals were improved at least eight ti...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sánchez-Brunete JA,Dea MA,Rama S,Bolás F,Alunda JM,Raposo R,Méndez MT,Torrado-Santiago S,Torrado JJ

    更新日期:2004-09-01 00:00:00

  • Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis.

    abstract::The optimal approach for empirical antibiotic therapy in patients with severe sepsis and septic shock remains controversial. A retrospective cohort study was conducted in the intensive care units of a university hospital. The data from 760 patients with severe sepsis or septic shock associated with Gram-negative bacte...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Micek ST,Welch EC,Khan J,Pervez M,Doherty JA,Reichley RM,Kollef MH

    更新日期:2010-05-01 00:00:00

  • Ciprofloxacin resistance in clinical isolates of Salmonella typhimurium obtained from two patients.

    abstract::Two patients (patients A and B) infected with Salmonella typhimurium failed ciprofloxacin therapy, and the posttherapy isolates had reduced susceptibilities to quinolones; 6 of 11 isolates from patient B were also cross-resistant to chemically unrelated agents. No transferable resistance, chloramphenicol-acetylating e...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Piddock LJ,Griggs DJ,Hall MC,Jin YF

    更新日期:1993-04-01 00:00:00

  • Anti-Mastigina activities of eight contact lens solutions.

    abstract::The effects of eight contact lens solutions on a Mastigina sp., which was associated with the infected eye of a patient, were studied. The solutions which killed the organism promptly were those which are used for gas-permeable and hard contact lenses. Some solutions for soft contact lenses were more effective than ot...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Niszl IA,Markus MB,van Deventer JM

    更新日期:1995-10-01 00:00:00

  • Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta-lactamases.

    abstract::Selection of resistance to cefamandole has been observed, and the drug has failed to protect animals lethally infected with certain Enterobacteriaceae that appeared to be highly susceptible in vitro. Using spectrophotometric assays, some of these organisms were found to produce beta-lactamases highly active against ce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sanders CC,Sanders WE Jr

    更新日期:1979-06-01 00:00:00

  • Comparison of pharmacokinetics and safety of voriconazole intravenous-to-oral switch in immunocompromised adolescents and healthy adults.

    abstract::The current voriconazole dosing recommendation in adolescents is based on limited efficacy and pharmacokinetic data. To confirm the appropriateness of dosing adolescents like adults, a pharmacokinetic study was conducted in 26 immunocompromised adolescents aged 12 to <17 years following intravenous (IV) voriconazole t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Driscoll TA,Frangoul H,Nemecek ER,Murphey DK,Yu LC,Blumer J,Krance RA,Baruch A,Liu P

    更新日期:2011-12-01 00:00:00

  • Phase I, Dose-Escalating Study of the Safety and Pharmacokinetics of Inhaled Dry-Powder Vancomycin (AeroVanc) in Volunteers and Patients with Cystic Fibrosis: a New Approach to Therapy for Methicillin-Resistant Staphylococcus aureus.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has become a significant acute and chronic respiratory pathogen. While vancomycin is effective against MRSA, its relatively poor penetration into lung secretions and dose-limiting renal toxicity make it less effective in the respiratory setting. As inhaled administrat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Waterer G,Lord J,Hofmann T,Jouhikainen T

    更新日期:2020-02-21 00:00:00

  • Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks.

    abstract::Emtricitabine [(-)FTC] [(-)-beta-2', 3'-dideoxy-5-fluoro-3'-thiacytidine] has been shown to be an effective inhibitor of hepatitis B virus (HBV) in cell culture, with a potency and selectivity that are essentially identical to those of lamivudine. The antiviral activity of oral administration of (-)FTC against WHV rep...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Korba BE,Schinazi RF,Cote P,Tennant BC,Gerin JL

    更新日期:2000-06-01 00:00:00

  • Novel biocatalytic polymer-based antimicrobial coatings as potential ureteral biomaterial: preparation and in vitro performance evaluation.

    abstract::Catheters and other indwelling devices placed inside human body are prone to bacterial infection, causing serious risk to patients. Infections associated with implants are difficult to resolve, and hence the prevention of bacterial colonization of such surfaces is quite appropriate. In this context, the development of...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Dave RN,Joshi HM,Venugopalan VP

    更新日期:2011-02-01 00:00:00

  • Influence of Reactive Oxygen Species on De Novo Acquisition of Resistance to Bactericidal Antibiotics.

    abstract::The radical-based theory proposes that three major classes of bactericidal antibiotics, i.e., β-lactams, quinolones, and aminoglycosides, have in common the downstream formation of lethal levels of reactive oxygen species (ROS) as part of the killing mechanism. If bactericidal antibiotics exhibit a common mechanism, t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hoeksema M,Brul S,Ter Kuile BH

    更新日期:2018-05-25 00:00:00

  • Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains.

    abstract::The polyene antifungal amphotericin B (AmB) is widely used to treat life-threatening fungal infections. Even though AmB resistance is exceptionally rare in fungi, most Aspergillus terreus isolates exhibit an intrinsic resistance against the drug in vivo and in vitro. Heat shock proteins perform a fundamental protectiv...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Blatzer M,Blum G,Jukic E,Posch W,Gruber P,Nagl M,Binder U,Maurer E,Sarg B,Lindner H,Lass-Flörl C,Wilflingseder D

    更新日期:2015-07-01 00:00:00

  • Evaluation of retinal toxicity and efficacy of the anticytomegalovirus compound 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine.

    abstract::Compound 2242, also known as 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine, is the first known antivirally active nucleoside analog with the side chain substituted at the N-7 position of the purine ring system. Our purpose was to evaluate its retinal toxicity and assess the efficacy of its highest nontoxic concent...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Besen G,Chavez-de la Paz E,Tatebayashi M,Flores-Aguilar M,Gangan PA,Munguia D,Wiley CA,Jähne G,Winkler I,Helsberg M

    更新日期:1995-07-01 00:00:00

  • Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits.

    abstract::Cilofungin has potent in vitro activity against Candida albicans, but previous in vivo models using twice daily intermittent dosing regimens have not consistently demonstrated in vivo efficacy. Because of the pharmacokinetics of cilofungin in rabbits, it has been suggested that administration by continuous intravenous...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rouse MS,Tallan BM,Steckelberg JM,Henry NK,Wilson WR

    更新日期:1992-01-01 00:00:00

  • Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance.

    abstract::The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantl...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Diacon AH,Donald PR,Pym A,Grobusch M,Patientia RF,Mahanyele R,Bantubani N,Narasimooloo R,De Marez T,van Heeswijk R,Lounis N,Meyvisch P,Andries K,McNeeley DF

    更新日期:2012-06-01 00:00:00

  • Rapid drug tolerance and dramatic sterilizing effect of moxifloxacin monotherapy in a novel hollow-fiber model of intracellular Mycobacterium kansasii disease.

    abstract::Mycobacterium kansasii is the second most common mycobacterial cause of lung disease. Standard treatment consists of rifampin, isoniazid, and ethambutol for at least 12 months after negative sputum. Thus, shorter-duration therapies are needed. Moxifloxacin has good MICs for M. kansasii. However, good preclinical model...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Srivastava S,Pasipanodya J,Sherman CM,Meek C,Leff R,Gumbo T

    更新日期:2015-04-01 00:00:00

  • Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo.

    abstract::Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro;...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lopes SC,Blanco YC,Justo GZ,Nogueira PA,Rodrigues FL,Goelnitz U,Wunderlich G,Facchini G,Brocchi M,Duran N,Costa FT

    更新日期:2009-05-01 00:00:00

  • Characterization of Tn6238 with a new allele of aac(6')-Ib-cr.

    abstract::Here, we report that the genetic structure of Tn1331 remained conserved in Argentina from 1989 to 2013 (72 of 73 isolates), with the exception being the plasmid-borne Tn1331-like transposon Tn6238 containing a new aac(6')-Ib-cr allele recovered from a colistin-resistant Klebsiella pneumoniae clinical isolate. A bioinf...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Quiroga MP,Orman B,Errecalde L,Kaufman S,Centrón D

    更新日期:2015-05-01 00:00:00

  • International interlaboratory quality control program for measurement of antiretroviral drugs in plasma.

    abstract::An international interlaboratory quality control program for measurement of antiretroviral drugs was initiated. The first round was confined to protease inhibitors and showed large variability in the performance of participating laboratories. The results demonstrate the need for and utility of an ongoing quality contr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Aarnoutse RE,Verweij-van Wissen CP,van Ewijk-Beneken Kolmer EW,Wuis EW,Koopmans PP,Hekster YA,Burger DM

    更新日期:2002-03-01 00:00:00

  • Monte Carlo simulations based on phase 1 studies predict target attainment of ceftobiprole in nosocomial pneumonia patients: a validation study.

    abstract::Monte Carlo simulation (MCS) of antimicrobial dosage regimens during drug development to derive predicted target attainment values is frequently used to choose the optimal dose for the treatment of patients in phase 2 and 3 studies. A criticism is that pharmacokinetic (PK) parameter estimates and variability in health...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Muller AE,Schmitt-Hoffmann AH,Punt N,Mouton JW

    更新日期:2013-05-01 00:00:00

  • Competition of various beta-lactam antibiotics for the major penicillin-binding proteins of Helicobacter pylori: antibacterial activity and effects on bacterial morphology.

    abstract::The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: DeLoney CR,Schiller NL

    更新日期:1999-11-01 00:00:00