Efficacy of trovafloxacin, a new quinolone antibiotic, in experimental staphylococcal endocarditis due to oxacillin-resistant strains.


:Therapeutic options for severe infections caused by strains of oxacillin-resistant Staphylococcus aureus (ORSA) and coagulase-negative staphylococci (ORSE) are very limited. With the increasing resistance of such strains to aminoglycosides, rifampin, and currently available quinolone agents, as well as the recent documentation of increasing resistance of ORSA to vancomycin (VANCO), new treatment alternatives are imperative. The in vivo efficacy of trovafloxacin (TROVA), a new quinolone agent with excellent antistaphylococcal activity in vitro, against experimental endocarditis (IE) due to beta-lactamase-producing ORSA and ORSE strains (ORSA and ORSE IE) was evaluated. TROVA (25 mg/kg of body weight intravenously [i.v.] twice daily [b.i.d]) was compared to VANCO (20 mg/kg i.v. b.i.d.) and two regimens of ampicillin-sulbactam (AMP-SUL; 200 mg/kg intramuscularly [i.m.] three times a day [t.i.d.] and 20 mg/kg i.m. b.i.d.), with all agents given for 3 or 6 days. AMP-SUL was included as a comparative treatment regimen because of its proven efficacy against experimental ORSA and ORSE IE. For both ORSA and ORSE IE, TROVA, AMP-SUL, and VANCO each reduced staphylococcal densities in vegetations compared to untreated controls (P < 0.01). For ORSA IE, TROVA was the most rapidly bactericidal agent--although not to a statistically significant degree--correlating with its superior bactericidal effect in vitro compared to those of VANCO and AMP-SUL.


Bayer AS,Li C,Ing M




Has Abstract


1998-07-01 00:00:00












  • In117, an unusual In0-like class 1 integron containing CR1 and bla(CTX-M-2) and associated with a Tn21-like element.

    abstract::An unusual In0-like class 1 integron containing a common region that includes the putative recombinase gene named orf513 (CR1) and bla(CTX-M-2) was characterized from Escherichia coli. The integron contained an unusual gene cassette array, estX-aadA1, embedded between the 5'-conserved segment (5'-CS) and 3'-CS1 region...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Valverde A,Cantón R,Galán JC,Nordmann P,Baquero F,Coque TM

    更新日期:2006-02-01 00:00:00

  • Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy chinese subjects.

    abstract::Morinidazole, a 5-nitroimidazole antimicrobial drug, has been approved for the treatment of amoebiasis, trichomoniasis, and anaerobic bacterial infections in China. It was reported that drug-drug interaction happened after the coadministration of ornidazole, an analog of morinidazole, and rifampin or ketoconazole. The...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pang X,Zhang Y,Gao R,Zhong K,Zhong D,Chen X

    更新日期:2014-10-01 00:00:00

  • Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

    abstract::A new 3-N-aminoglycoside acetyltransferase is described, which possesses a wider substrate range than any such enzyme so far discovered in clinical isolates of antibiotic-resistant bacteria. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Biddlecome S,Haas M,Davies J,Miller GH,Rane DF,Daniels PJ

    更新日期:1976-06-01 00:00:00

  • Role of plasma proteins in pharmacokinetics of micafungin, an antifungal antibiotic, in analbuminemic rats.

    abstract::There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Abe F,Ueyama J,Kawasumi N,Nadai M,Hayashi T,Kato M,Ohnishi M,Saito H,Takeyama N,Hasegawa T

    更新日期:2008-09-01 00:00:00

  • Incorporating Stage-Specific Drug Action into Pharmacological Modeling of Antimalarial Drug Treatment.

    abstract::Pharmacological modeling of antiparasitic treatment based on a drug's pharmacokinetic and pharmacodynamic properties plays an increasingly important role in identifying optimal drug dosing regimens and predicting their potential impact on control and elimination programs. Conventional modeling of treatment relies on m...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hodel EM,Kay K,Hastings IM

    更新日期:2016-04-22 00:00:00

  • T-8581, a new orally and parenterally active triazole antifungal agent: in vitro and in vivo evaluations.

    abstract::T-8581 is a new water-soluble triazole antifungal agent. The geometric mean IC80s (GM-IC80S; where the IC80 is the lowest drug concentration which reduced the optical density at 630 nm by 80% compared with the optical density at 630 nm of the drug-free control) for Candida albicans were as follows: T-8581, 0.218 micro...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yotsuji A,Shimizu K,Araki H,Fujimaki K,Nishida N,Hori R,Annen N,Yamamoto S,Hayakawa H,Imaizumi H,Watanbe Y,Narita H

    更新日期:1997-01-01 00:00:00

  • Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients.

    abstract::Vancomycin is a renally excreted drug, and its body clearance correlates with creatinine clearance. However, the renal function estimation equation that best predicts vancomycin clearance has not been established yet. The objective of this study was to compare the abilities of different renal function estimation equat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Glatard A,Bourguignon L,Jelliffe RW,Maire P,Neely MN,Goutelle S

    更新日期:2015-01-01 00:00:00

  • Candida in the Respiratory Tract Potentially Triggers Galactomannan Positivity in Nonhematological Patients.

    abstract::BAL fluid samples from critically ill patients shared a rate of 29% false-positive galactomannan results. We aimed to determine whether Candida species abundance in BAL fluid causes galactomannan (GM) positivity. A total of 89 Candida culture-positive BAL fluid samples from patients without suspicion of invasive asper...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Aigner M,Wanner M,Kreidl P,Lass-Flörl C,Lackner M

    更新日期:2019-05-24 00:00:00

  • Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings.

    abstract::The potent antiretroviral pyrimidinediones IQP-0528 (PYD1) and IQP-0532 (PYD2) were formulated in polyurethane intravaginal rings (IVRs) as prophylactic drug delivery systems to prevent the sexual transmission of HIV-1. To aid in the selection of a pyrimidinedione candidate and the optimal loading of the drug in the I...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Johnson TJ,Srinivasan P,Albright TH,Watson-Buckheit K,Rabe L,Martin A,Pau CP,Hendry RM,Otten R,McNicholl J,Buckheit R Jr,Smith J,Kiser PF

    更新日期:2012-03-01 00:00:00

  • Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.

    abstract::Morbidity and mortality resulting from influenza-like disease are a threat, especially for older adults. To improve case management, next-generation broad-spectrum antiviral therapeutics that are efficacious against major drivers of influenza-like disease, including influenza viruses and respiratory syncytial virus (R...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yoon JJ,Toots M,Lee S,Lee ME,Ludeke B,Luczo JM,Ganti K,Cox RM,Sticher ZM,Edpuganti V,Mitchell DG,Lockwood MA,Kolykhalov AA,Greninger AL,Moore ML,Painter GR,Lowen AC,Tompkins SM,Fearns R,Natchus MG,Plemper RK

    更新日期:2018-07-27 00:00:00

  • Distribution of [14C]aztreonam in rat tissue.

    abstract::[14C]aztreonam was administered intramuscularly (50 mg/kg) to male and female rats. Groups of 10 rats (five male and five female) were sacrificed at 0.25, 2, 6, and 24 h after dosing. Blood and various tissues were removed from six rats (three male and three female) in each group for determination of total radioactivi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Singhvi SM,Ita CE,Shaw JM,Migdalof BH

    更新日期:1984-08-01 00:00:00

  • Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations.

    abstract::In this study, two identical copies of a 23S-5S gene cluster, which are separately situated within the Helicobacter pylori UA802 chromosome, were cloned and sequenced. Comparison of the DNA sequence of the H. pylori 23S rRNA gene with known sequences of other bacterial 23S rRNA genes indicated that the H. pylori UA802...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Taylor DE,Ge Z,Purych D,Lo T,Hiratsuka K

    更新日期:1997-12-01 00:00:00

  • Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania.

    abstract::A vancomycin-resistant Staphylococcus aureus (VRSA) isolate was obtained from a patient in Pennsylvania in September 2002. Species identification was confirmed by standard biochemical tests and analysis of 16S ribosomal DNA, gyrA, and gyrB sequences; all of the results were consistent with the S. aureus identification...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tenover FC,Weigel LM,Appelbaum PC,McDougal LK,Chaitram J,McAllister S,Clark N,Killgore G,O'Hara CM,Jevitt L,Patel JB,Bozdogan B

    更新日期:2004-01-01 00:00:00

  • Experimental therapy of cladosporiosis and sporotrichosis with 5-fluorocytosine.

    abstract::Cladosporium trichoides and Sporothrix schenckii are fungi known to be pathogenic for man. No effective chemotherapy is available for cladosporiosis, and systemic sporotrichosis can be very resistant to antifungal chemotherapy. Experimental infections of mice with these fungi resembled their respective infections in m...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Block ER,Jennings AE,Bennett JE

    更新日期:1973-01-01 00:00:00

  • Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand.

    abstract::Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gaillard T,Sriprawat K,Briolant S,Wangsing C,Wurtz N,Baragatti M,Lavina M,Pascual A,Nosten F,Pradines B

    更新日期:2015-08-01 00:00:00

  • Targeting antibacterial agents by using drug-carrying filamentous bacteriophages.

    abstract::Bacteriophages have been used for more than a century for (unconventional) therapy of bacterial infections, for half a century as tools in genetic research, for 2 decades as tools for discovery of specific target-binding proteins, and for nearly a decade as tools for vaccination or as gene delivery vehicles. Here we p...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yacoby I,Shamis M,Bar H,Shabat D,Benhar I

    更新日期:2006-06-01 00:00:00

  • Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium.

    abstract::In response to the need for rapid, inexpensive, high-throughput assays for antimycobacterial drug screening, a microplate-based assay which uses Alamar blue reagent for determination of growth was evaluated. MICs of 30 antimicrobial agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis H37Ra, and Mycobacter...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Collins L,Franzblau SG

    更新日期:1997-05-01 00:00:00

  • Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.

    abstract::The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effects of single nucleotide polymorphisms (SNPs) in cytochrome P450 isoenzyme genes (CYP, n...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Staehli Hodel EM,Csajka C,Ariey F,Guidi M,Kabanywanyi AM,Duong S,Decosterd LA,Olliaro P,Beck HP,Genton B

    更新日期:2013-02-01 00:00:00

  • Molecular Analysis of a blaIMP-1-Harboring Class 3 Integron in Multidrug-Resistant Pseudomonas fulva.

    abstract::A multidrug-resistant (MDR) Pseudomonas fulva strain was isolated in 2006 from a urine sample. The isolate harbored the blaIMP-1 gene, which was located in a chromosomal Tn402-like class 3 integron as a gene cassette array of aacA31-fosE-blaIMP-1 Two mutations in gyrA and one mutation in parC were detected in quinolon...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yamamoto M,Matsumura Y,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

    更新日期:2018-07-27 00:00:00

  • Azasordarins: susceptibility of fluconazole-susceptible and fluconazole-resistant clinical isolates of Candida spp. to GW 471558.

    abstract::The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreas...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cuenca-Estrella M,Mellado E,Díaz-Guerra TM,Monzón A,Rodríguez-Tudela JL

    更新日期:2001-06-01 00:00:00

  • Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats.

    abstract::We investigated the contribution of multidrug resistance-associated protein 2 (MRP2) to the secretory transport of grepafloxacin and compared its functional role with that of P-glycoprotein (P-gp) by using Sprague-Dawley rats (SDRs) and Eisai hyperbilirubinemic rats (EHBRs), in which MRP2 is hereditarily defective. In...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Naruhashi K,Tamai I,Inoue N,Muraoka H,Sai Y,Suzuki N,Tsuji A

    更新日期:2002-02-01 00:00:00

  • Inhibition of lipid synthesis in Escherichia coli cells by the antibiotic cerulenin.

    abstract::The antibiotic cerulenin markedly inhibits the growth of Escherichia coli. The effects of the antibiotic on cellular syntheses were studied by measuring the incorporation of labeled precursors into lipids and macromolecules. During the first 40 min after the addition of cerulenin to a culture of growing cells, lipid s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Goldberg I,Walker JR,Bloch K

    更新日期:1973-05-01 00:00:00

  • Evaluation of retinal toxicity and efficacy of the anticytomegalovirus compound 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine.

    abstract::Compound 2242, also known as 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine, is the first known antivirally active nucleoside analog with the side chain substituted at the N-7 position of the purine ring system. Our purpose was to evaluate its retinal toxicity and assess the efficacy of its highest nontoxic concent...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Besen G,Chavez-de la Paz E,Tatebayashi M,Flores-Aguilar M,Gangan PA,Munguia D,Wiley CA,Jähne G,Winkler I,Helsberg M

    更新日期:1995-07-01 00:00:00

  • Molecular characterization of blaNDM-1 in a sequence type 235 Pseudomonas aeruginosa isolate from France.

    abstract::An NDM-1 carbapenemase-producing Pseudomonas aeruginosa isolate was recovered from a patient hospitalized in France after a previous hospitalization in Serbia. Genetic studies revealed that the blaNDM-1 gene was surrounded by insertion sequence ISAba125 and a truncated bleomycin resistance gene. This blaNDM-1 region w...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Janvier F,Jeannot K,Tessé S,Robert-Nicoud M,Delacour H,Rapp C,Mérens A

    更新日期:2013-07-01 00:00:00

  • Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia.

    abstract::We tested 32 Candida isolates recovered in the early 1990s from the bloodstreams of patients with candidemia for in vitro susceptibility to fluconazole and determined if MIC and/or the daily dose of fluconazole/MIC ratio correlated with the response to therapy. This is a unique data set since 87.5% (28/32) of patients...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Clancy CJ,Yu VL,Morris AJ,Snydman DR,Nguyen MH

    更新日期:2005-08-01 00:00:00

  • Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program.

    abstract::Linezolid was tested against 32 species of uncommonly isolated gram-positive organisms (3,251 strains) by reference MIC methods and found to be highly active (MIC50 range, 0.25 to 2 microg/ml; MIC90 range, 0.25 to 2 microg/ml). Only one isolate (viridans group streptococcus; 0.03% of tested strains) was resistant to l...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jones RN,Stilwell MG,Hogan PA,Sheehan DJ

    更新日期:2007-04-01 00:00:00

  • Effect of porins and plasmid-mediated AmpC beta-lactamases on the efficacy of beta-lactams in rat pneumonia caused by Klebsiella pneumoniae.

    abstract::The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC beta-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No differences between these ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Padilla E,Alonso D,Doménech-Sánchez A,Gomez C,Pérez JL,Albertí S,Borrell N

    更新日期:2006-06-01 00:00:00

  • Genetic context and structural diversity of class 1 integrons from human commensal bacteria in a hospital intensive care unit.

    abstract::Most surveys for class 1 integrons are at least partly predicated on PCR screening that targets integron conserved regions. However, class 1 integrons are structurally diverse, so dependence on conserved regions may lead to missing clinically relevant examples of class 1 integrons. Here, we surveyed a commensal popula...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Betteridge T,Partridge SR,Iredell JR,Stokes HW

    更新日期:2011-08-01 00:00:00

  • Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.

    abstract::The antiviral activity of a new series of thymidine analogs was determined against vaccinia virus (VV), cowpox virus (CV), herpes simplex virus, and varicella-zoster virus. Several compounds were identified that had good activity against each of the viruses, including a set of novel 5-substituted deoxyuridine analogs....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Prichard MN,Keith KA,Johnson MP,Harden EA,McBrayer A,Luo M,Qiu S,Chattopadhyay D,Fan X,Torrence PF,Kern ER

    更新日期:2007-05-01 00:00:00

  • Aminoglycoside phosphotransferase-II-mediated amikacin resistance in Escherichia coli.

    abstract::An Escherichia coli strain with a plasmidic amikacin resistance has been selected for which the evidence strongly indicates that resistance is mediated by aminoglycoside phosphotransferase [APH(3')-II]: (i) this resistance was coupled with resistance against kanamycin and neomycin; (ii) partially purified APH(3')-II[A...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bongaerts GP,Kaptijn GM

    更新日期:1981-09-01 00:00:00