Dose-dependent pharmacokinetics of mezlocillin in relation to renal impairment.

abstract：:The hyl(Efm) gene (encoding a putative hyaluronidase) has been found almost exclusively in Enterococcus faecium clinical isolates, and recently, it was shown to be on a plasmid which increased the ability of E. faecium strains to colonize the gastrointestinal tract. In this work, the results of mating experiments betw...

journal_title：Antimicrobial agents and chemotherapy

authors： Arias CA,Panesso D,Singh KV,Rice LB,Murray BE

更新日期：2009-10-01 00:00:00

abstract：:We have shown previously that high-dose lipid amphotericin preparations are not more efficacious than lower doses in aspergillosis. We studied toxicity, drug concentrations and localization, and quantitative infection concurrently, using a 4-day model of central nervous system (CNS) aspergillosis to assess early event...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Schwartz JA,Stevens DA

更新日期：2012-08-01 00:00:00

abstract：:Class D beta-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in b...

journal_title：Antimicrobial agents and chemotherapy

authors： Keith KE,Oyston PC,Crossett B,Fairweather NF,Titball RW,Walsh TR,Brown KA

更新日期：2005-04-01 00:00:00

abstract：:We have recently reported an influenza virus neuraminidase inhibitor, RWJ-270201 (BCX-1812), a novel cyclopentane derivative discovered through structure-based drug design. In this paper, we compare the potency of three compounds, RWJ-270201, oseltamivir, and zanamivir, against neuraminidase enzymes from various subty...

journal_title：Antimicrobial agents and chemotherapy

authors： Bantia S,Parker CD,Ananth SL,Horn LL,Andries K,Chand P,Kotian PL,Dehghani A,El-Kattan Y,Lin T,Hutchison TL,Montgomery JA,Kellog DL,Babu YS

更新日期：2001-04-01 00:00:00

abstract：:DNA gyrase is a bacterial enzyme which catalyzes the ATP-dependent negative supercoiling of DNA. It is the accepted target of quinolones. The enzyme from Citrobacter freundii IID976 was purified by affinity chromatography on novobiocin-Sepharose and heparin-Sepharose. It had two subunits, designated A and B, which clo...

journal_title：Antimicrobial agents and chemotherapy

authors： Aoyama H,Sato K,Fujii T,Fujimaki K,Inoue M,Mitsuhashi S

更新日期：1988-01-01 00:00:00

abstract：:Candida albicans biofilms are generally considered to be resistant to azole antifungal agents but susceptible to echinocandins. We demonstrate that in a sequential therapy regimen, treatment with fluconazole first followed by caspofungin leads to a significant decrease of the efficacy of this echinocandin. Cellular st...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarkar S,Uppuluri P,Pierce CG,Lopez-Ribot JL

更新日期：2014-01-01 00:00:00

abstract：:A PCR-based technique using new fluorescent probes, called molecular beacons, was developed to detect the antifolate resistance-associated S108N point mutation in Plasmodium falciparum. One hundred African clinical isolates were tested by the new method in comparison with the PCR-restriction fragment length polymorphi...

journal_title：Antimicrobial agents and chemotherapy

authors： Durand R,Eslahpazire J,Jafari S,Delabre JF,Marmorat-Khuong A,di Piazza JP,Le Bras J

更新日期：2000-12-01 00:00:00

abstract：:TEM- and SHV-type extended-spectrum beta-lactamases (ESBLs) are the most common ESBLs found in the United States and are prevalent throughout the world. Amino acid substitutions at a number of positions in TEM-1 lead to the ESBL phenotype, although substitutions at residues 104 (E to K), 164 (R to S or H), 238 (G to S...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones CH,Ruzin A,Tuckman M,Visalli MA,Petersen PJ,Bradford PA

更新日期：2009-03-01 00:00:00

abstract：:The potent antiretroviral pyrimidinediones IQP-0528 (PYD1) and IQP-0532 (PYD2) were formulated in polyurethane intravaginal rings (IVRs) as prophylactic drug delivery systems to prevent the sexual transmission of HIV-1. To aid in the selection of a pyrimidinedione candidate and the optimal loading of the drug in the I...

journal_title：Antimicrobial agents and chemotherapy

authors： Johnson TJ,Srinivasan P,Albright TH,Watson-Buckheit K,Rabe L,Martin A,Pau CP,Hendry RM,Otten R,McNicholl J,Buckheit R Jr,Smith J,Kiser PF

更新日期：2012-03-01 00:00:00

abstract：:The outer membrane of gram-negative cells excludes hydrophobic molecules and is responsible for the resistance of these cells to a number of dyes, detergents, and antibiotics. We describe a test for hydrophobic permeability in which a series of tetracyclines with various hydrophobicities are used. Normal Escherichia c...

journal_title：Antimicrobial agents and chemotherapy

authors： Leive L,Telesetsky S,Coleman WG Jr,Carr D

更新日期：1984-05-01 00:00:00

abstract：:The emergence of resistant strains among common and rare Candida species necessitates continuous monitoring of the in vitro susceptibilities of those isolates. We therefore assessed the in vitro activities of micafungin against 1,099 molecularly identified isolates belonging to 5 common and 20 rare Candida species by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meletiadis J,Geertsen E,Curfs-Breuker I,Meis JF,Mouton JW

更新日期：2016-09-23 00:00:00

abstract：:The present study examined the efficacy of using multiple mechanisms as part of a topical microbicide to inactivate herpes simplex virus (HSV) by combining theaflavin-3,3'-digallate (TF-3) and lactic acid (LA) over the pH range of 4.0 to 5.7 to mimic conditions in the female reproductive tract. Six clinical isolates o...

journal_title：Antimicrobial agents and chemotherapy

authors： Isaacs CE,Xu W

更新日期：2013-08-01 00:00:00

abstract：:Active nuclear importation of the human immunodeficiency virus (HIV) type 1 (HIV-1) preintegration complex (PIC) is required for the productive infection of nondividing cells, but it is believed to be dispensable for the infection of proliferating cells, such as activated T lymphocytes. To investigate this question, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Haffar OK,Smithgall MD,Popov S,Ulrich P,Bruce AG,Nadler SG,Cerami A,Bukrinsky MI

更新日期：1998-05-01 00:00:00

abstract：:Approximately 150,000 small-molecule compounds were tested by a robotic screening assay for their ability to inhibit nucleoside triphosphate hydrolase (NTPase), a novel enzyme of the tachyzoite form of Toxoplasma gondii. Five unrelated species of compounds were found to inhibit the activities of both NTPase isoforms (...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai T,Takeuchi T,Diffenderfer J,Sibley LD

更新日期：2002-08-01 00:00:00

abstract：:Shiga toxin (Stx)-producing Escherichia coli (STEC) causes hemorrhagic colitis and hemolytic-uremic syndrome (HUS). The rates of STEC infection and complications, including death, are highest among young children and elderly individuals. There are no causal therapies. Because Stx is the primary pathological agent lead...

journal_title：Antimicrobial agents and chemotherapy

authors： Bitzan M,Poole R,Mehran M,Sicard E,Brockus C,Thuning-Roberson C,Rivière M

更新日期：2009-07-01 00:00:00

abstract：:The continued evolution of bacterial resistance to the β-lactam class of antibiotics has necessitated countermeasures to ensure continued effectiveness in the treatment of infections caused by bacterial pathogens. One relatively successful approach has been the development of new β-lactam analogs with advantages over ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cotroneo N,Rubio A,Critchley IA,Pillar C,Pucci MJ

更新日期：2020-07-22 00:00:00

abstract：:Our aim was to assess the effect of miconazole oral gel on the pharmacokinetics of oral oxycodone. In an open crossover study with two phases, 12 healthy volunteers took a single oral dose of 10 mg of immediate-release oxycodone with or without thrice-daily 85-mg miconazole oral gel treatment. The plasma concentration...

journal_title：Antimicrobial agents and chemotherapy

authors： Grönlund J,Saari TI,Hagelberg N,Neuvonen PJ,Olkkola KT,Laine K

更新日期：2011-03-01 00:00:00

abstract：:A simple technique with antibiotic-impregnated disks has been developed to demonstrate the antibiotic synergism of penicillins and aminoglycosides against enterococci. The two antibiotic disks are placed on inoculated plates so that the distance between their centers is less than the sum of the two radii of their prev...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee WS,Komarmy L

更新日期：1975-01-01 00:00:00

abstract：:This analysis of nearly 10,000 hospital-associated urinary tract infection (UTI) episodes due to Escherichia coli showed that fluoroquinolone and third-generation-cephalosporin resistance rates were 34.5% and 8.6%, respectively; the rate of concurrent resistance to both agents was 7.3%. Fluoroquinolone resistance rate...

journal_title：Antimicrobial agents and chemotherapy

authors： Bidell MR,Palchak M,Mohr J,Lodise TP

更新日期：2016-04-22 00:00:00

abstract：:We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spre...

journal_title：Antimicrobial agents and chemotherapy

authors： Escudero JA,San Millan A,Catalan A,de la Campa AG,Rivero E,Lopez G,Dominguez L,Moreno MA,Gonzalez-Zorn B

更新日期：2007-02-01 00:00:00

abstract：:Toxoplasma gondii and Cryptosporidium parvum, members of the phylum Apicomplexa, are significant pathogens of both humans and animals worldwide for which new and effective therapeutics are needed. Here we describe the activity of the antibiotic boromycin against Toxoplasma and Cryptosporidium Boromycin potently inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Abenoja J,Cotto-Rosario A,O'Connor R

更新日期：2021-01-19 00:00:00

abstract：:After inducing mutagenesis with nitrosoguanidine, we used vancomycin enrichment in isolating auxotrophic mutants of Mycobacterium smegmatis. Compared with cycloserine and penicillin G, which are also cell wall inhibitors, vancomycin, with 24 h of exposure, produced less cell lysis and a greater reduction in viable cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Woodley CL,Baldwin JN,Greenberg J

更新日期：1981-04-01 00:00:00

abstract：:Pseudomonas aeruginosa AH, isolated in Ankara, Turkey, was highly resistant to ceftazidime (MIC, 128 microg/ml) and produced a beta-lactamase that gave a doublet of bands at pIs 8.7 and 8.9. beta-Lactamase production was transferable to P. aeruginosa PU21 by conjugation and was determined by a ca. 450-kb plasmid, pMLH...

journal_title：Antimicrobial agents and chemotherapy

authors： Danel F,Hall LM,Gur D,Livermore DM

更新日期：1997-04-01 00:00:00

abstract：:Since the discovery and use of penicillin, the increase of antibiotic resistance among bacterial pathogens has become a major health concern. The most prevalent resistance mechanism in Gram-negative bacteria is due to β-lactamase expression. Class D β-lactamases are of particular importance due to their presence in mu...

journal_title：Antimicrobial agents and chemotherapy

authors： June CM,Vallier BC,Bonomo RA,Leonard DA,Powers RA

更新日期：2014-01-01 00:00:00

abstract：:A unique group of viridans streptococci has been found in South Africa. These organisms were isolated in close temporal and physical proximity to the isolation of penicillin-resistant pneumococci. The strains were resistant to penicillin, oxacillin, the cephalosporins (all generations), piperacillin, azlocillin, and m...

journal_title：Antimicrobial agents and chemotherapy

authors： Farber BF,Eliopoulos GM,Ward JI,Ruoff KL,Syriopoulou V,Moellering RC Jr

更新日期：1983-11-01 00:00:00

abstract：:R1033 is a plasmid of compatibility group P (= P1) transferred from a wild strain of Pseudomonas aeruginosa. It confers resistance to gentamicin by gentamicin acetyl-transferase 1 and to kanamycin and neomycin by neomycin phosphotransferase 1. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith DI,Lus RG,Rubio Calvo MC,Datta N,Jacob AE,Hedges RW

更新日期：1975-09-01 00:00:00

abstract：:Staphylococcal biofilms are a major cause of therapeutic failure, especially when caused by multiresistant strains. Oral fusidic acid is currently being redeveloped in the United States for skin, skin structure, and orthopedic infections, in which biofilms play a major role. The aim of this study was to examine the ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Siala W,Rodriguez-Villalobos H,Fernandes P,Tulkens PM,Van Bambeke F

更新日期：2018-06-26 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Gag and Gag-Pol proce...

journal_title：Antimicrobial agents and chemotherapy

authors： Speck RR,Flexner C,Tian CJ,Yu XF

更新日期：2000-05-01 00:00:00

abstract：:β-Lactam resistance levels vary among methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, mediated by chromosomal mutations and exogenous resistance gene mecA However, MRSA resistance mechanisms are incompletely understood. A P440L mutation in the RNA polymerase β' subunit (RpoC) in slow-vancomycin-i...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo M,Yamamoto N,Hishinuma T,Hiramatsu K

更新日期：2019-01-29 00:00:00

abstract：:Enviroxime, an inhibitor of rhinovirus replication, was studied in a double-blind, placebo-controlled trial with 99 volunteers. The efficacy of a nasal-spray formulation of enviroxime was tested as pretreatment or as postchallenge treatment for rhinovirus type 4 infection. In the regimens used, drug administration nei...

journal_title：Antimicrobial agents and chemotherapy

authors： Levandowski RA,Pachucki CT,Rubenis M,Jackson GG

更新日期：1982-12-01 00:00:00