Topical enviroxime against rhinovirus infection.

abstract：:The effects of eight contact lens solutions on a Mastigina sp., which was associated with the infected eye of a patient, were studied. The solutions which killed the organism promptly were those which are used for gas-permeable and hard contact lenses. Some solutions for soft contact lenses were more effective than ot...

journal_title：Antimicrobial agents and chemotherapy

authors： Niszl IA,Markus MB,van Deventer JM

更新日期：1995-10-01 00:00:00

abstract：:Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the fre...

journal_title：Antimicrobial agents and chemotherapy

authors： Leib DA,Ruffner KL,Hildebrand C,Schaffer PA,Wright GE,Coen DM

更新日期：1990-06-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans and Capnocytophaga spp. are gram-negative bacteria implicated in the etiology of periodontal disease (particularly in individuals with neutrophil defects) and life-threatening systemic infections. They are resistant to many antibiotics of microbial origin but are sensitive to the n...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyasaki KT,Bodeau AL,Pohl J,Shafer WM

更新日期：1993-12-01 00:00:00

abstract：:Chagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic. Benznidazole is the most commonly used drug for the etiological treatment of Chagas disease. Patients treated with benznidazole suffer frequent adverse drug re...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldasoro E,Pinazo MJ,Oliveira I,Munoz J,Posada E,Requena-Méndez A,Serret N,Gascon J

更新日期：2015-01-01 00:00:00

abstract：:Attenuated activity of echinocandin antifungals at high concentrations, known as the "paradoxical effect," is a well-established phenomenon in Candida albicans and Aspergillus fumigatus. In the yeast C. albicans, upregulation of chitin biosynthesis via the protein kinase C (PKC), high-osmolarity glycerol response (HOG...

journal_title：Antimicrobial agents and chemotherapy

authors： Fortwendel JR,Juvvadi PR,Perfect BZ,Rogg LE,Perfect JR,Steinbach WJ

更新日期：2010-04-01 00:00:00

abstract：:We determined the antibiotic susceptibilities of 1,785 enterococcal bloodstream isolates collected over 25 years. Antibiotic resistance emerged at a greater rate in Enterococcus faecium than in other enterococcal species, and E. faecium isolates became proportionally more common over time. Our findings confirm the pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Murdoch DR,Mirrett S,Harrell LJ,Monahan JS,Reller LB

更新日期：2002-11-01 00:00:00

abstract：:Stenotrophomonas maltophilia is an opportunistic pathogen with increasing prevalence, which is able to cause infections in immunocompromised patients or in those with a previous pathology. The treatment of the infections caused by this bacterium is often complicated due to the several intrinsic antibiotic resistance m...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanco P,Corona F,Sánchez MB,Martínez JL

更新日期：2017-04-24 00:00:00

abstract：:A sensitive and specific high-pressure liquid chromatographic method is described for the determination of the antibacterial drug flumequine and a major metabolite, 7-hydroxyflumequine, in human plasma and urine. The assay was linear over a concentration range of 1 to 120 micrograms/ml for both compounds. This method ...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison LI,Schuppan D,Rohlfing SR,Hansen AR,Hansen CS,Funk ML,Collins SH,Ober RE

更新日期：1984-03-01 00:00:00

abstract：:A double-blind study was performed to compare the clinical response and the incidence of side effects in 2,581 patients administered ampicillin or cyclacillin for infections of the genitourinary or respiratory tract, infections of the skin and soft tissues, or for otitis media. There was no significant difference in c...

journal_title：Antimicrobial agents and chemotherapy

authors： Gold JA,Hegarty CP,Deitch MW,Walker BR

更新日期：1979-01-01 00:00:00

abstract：:Ex vivo assay systems provide a powerful approach to studying human malaria parasite biology and to testing antimalarials. For rodent malaria parasites, short-term in vitro culture and ex vivo antimalarial susceptibility assays are relatively cumbersome, relying on in vivo passage for synchronization, since ring-stage...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang ZW,Malleret B,Russell B,Rénia L,Claser C

更新日期：2016-10-21 00:00:00

abstract：:We investigated the evolution of resistance to the antifungal drug itraconazole in replicate populations of Aspergillus fumigatus that were founded from a strain with a genotype of sensitivity to a single drug and then propagated under uniform conditions. For each population, conidia were serially transferred 10 times...

journal_title：Antimicrobial agents and chemotherapy

authors： da Silva Ferreira ME,Capellaro JL,dos Reis Marques E,Malavazi I,Perlin D,Park S,Anderson JB,Colombo AL,Arthington-Skaggs BA,Goldman MH,Goldman GH

更新日期：2004-11-01 00:00:00

abstract：:The stability of antipseudomonal beta-lactams in concentrated solutions was examined in view of their potential administration by continuous infusion with external pumps (for intensive care patients) or with portable pumps carried under clothing (for cystic fibrosis patients). Aztreonam (100 g/liter), piperacillin (12...

journal_title：Antimicrobial agents and chemotherapy

authors： Viaene E,Chanteux H,Servais H,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-08-01 00:00:00

abstract：:Sterol delta22-desaturase has been purified from a strain of Candida glabrata with a disruption in the gene encoding sterol 14alpha-demethylase (cytochrome P-45051; CYP51). The purified cytochrome P-450 exhibited sterol delta22-desaturase activity in a reconstituted system with NADPH-cytochrome P-450 reductase in dila...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamb DC,Maspahy S,Kelly DE,Manning NJ,Geber A,Bennett JE,Kelly SL

更新日期：1999-07-01 00:00:00

abstract：:Currently, CTX-M β-lactamases are among the most prevalent and most heterogeneous extended-spectrum β-lactamases (ESBLs). In general, CTX-M enzymes are susceptible to inhibition by β-lactamase inhibitors. However, it is unknown if the pathway to inhibition by β-lactamase inhibitors for CTX-M ESBLs is similar to TEM an...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethel CR,Taracila M,Shyr T,Thomson JM,Distler AM,Hujer KM,Hujer AM,Endimiani A,Papp-Wallace K,Bonnet R,Bonomo RA

更新日期：2011-07-01 00:00:00

abstract：:The clinical vancomycin-intermediate Staphylococcus aureus (VISA) strain Mu50 carries two mutations in the vraSR and graRS two-component regulatory systems (TCRSs), namely, vraS(I5N) and graR(N197S) (hereinafter designated graR). The clinical heterogeneously vancomycin-intermediate S. aureus (hVISA) strain Mu3 shares ...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo M,Hishinuma T,Katayama Y,Cui L,Kapi M,Hiramatsu K

更新日期：2011-09-01 00:00:00

abstract：:The present study demonstrates the in vitro effectiveness of the macrolide rokitamycin and the phenothiazine compound chlorpromazine against Acanthamoeba castellanii. Growth curve evaluations revealed that both drugs inhibit trophozoite growth in dose- and time-dependent ways. The effects of both drugs when they were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mattana A,Biancu G,Alberti L,Accardo A,Delogu G,Fiori PL,Cappuccinelli P

更新日期：2004-12-01 00:00:00

abstract：:Gentamicin and tobramycin inhibited the accumulation of extracellular proteases secreted by Pseudomonas aeruginosa. The secretion of protease was inhibited at concentrations of these drugs that were below the level required to inhibit general protein synthesis. Neither magnesium ions nor high ionic strength antagonize...

journal_title：Antimicrobial agents and chemotherapy

authors： Warren RL,Baker NR,Johnson J,Stapleton MJ

更新日期：1985-04-01 00:00:00

abstract：:The intrinsic mechanisms of resistance to beta-lactam antibiotics in Serratia marcescens IFO 12648 were investigated, comparing the action of benzylpenicillin, apalcillin, cefazolin, and ceftizoxime. The minimal inhibitory concentrations for this strain were 1,600, 3.13, 6,400, and 0.05 microgram/ml, respectively. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Takata N,Suginaka H,Kotani S,Ogawa M,Kosaki G

更新日期：1981-03-01 00:00:00

abstract：:Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy. Itraconazole acts through inhibition of a P-450 enzyme undertaking sterol 14alpha demethylation. In vitro resistance in Aspergillus fumig...

journal_title：Antimicrobial agents and chemotherapy

authors： Denning DW,Venkateswarlu K,Oakley KL,Anderson MJ,Manning NJ,Stevens DA,Warnock DW,Kelly SL

更新日期：1997-06-01 00:00:00

abstract：:Despite the marketing of a series of new antibiotics for antibiotic-resistant gram-positive bacteria, no new agents for multiple-antibiotic-resistant gram-negative infections will be available for quite some time. Clinicians will need to find more effective ways to utilize available agents. Colistin is an older but no...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson BW,Ibrahim KH,Hovde LB,Fromm TL,Reed MD,Rotschafer JC

更新日期：2003-03-01 00:00:00

abstract：:Although human immunodeficiency virus (HIV) coinfection is the most important risk factor for a poor antituberculosis (anti-TB) treatment response, its effect on the pharmacokinetics of the first-line drugs in children is understudied. This study examined the pharmacokinetics of the four first-line anti-TB drugs in ch...

journal_title：Antimicrobial agents and chemotherapy

authors： Antwi S,Yang H,Enimil A,Sarfo AM,Gillani FS,Ansong D,Dompreh A,Orstin A,Opoku T,Bosomtwe D,Wiesner L,Norman J,Peloquin CA,Kwara A

更新日期：2017-01-24 00:00:00

abstract：:Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significan...

journal_title：Antimicrobial agents and chemotherapy

authors： Vieira JLF,Rivera JGB,de Sena LWP,Ferreira MVD

更新日期：2020-02-21 00:00:00

abstract：:Treatment of exacerbations of chronic Pseudomonas aeruginosa infections in patients with cystic fibrosis (CF) is highly challenging due to hypermutability, biofilm formation, and an increased risk of resistance emergence. We evaluated the impact of ciprofloxacin and meropenem as monotherapy and in combination in the d...

journal_title：Antimicrobial agents and chemotherapy

authors： Bilal H,Bergen PJ,Tait JR,Wallis SC,Peleg AY,Roberts JA,Oliver A,Nation RL,Landersdorfer CB

更新日期：2020-06-23 00:00:00

abstract：:A series of 1-cyclopropyl-8-methoxy-quinazoline-2,4-diones was synthesized and evaluated for lowering the ratio of the antimicrobial MIC in gyrase resistance mutants to that in the gyr(+) (wild type) using isogenic strains of Escherichia coli. Dione features that lowered this ratio were a 3-amino group and C-7 ring st...

journal_title：Antimicrobial agents and chemotherapy

authors： German N,Malik M,Rosen JD,Drlica K,Kerns RJ

更新日期：2008-11-01 00:00:00

abstract：:The density of the biofilm layer produced on a plastic surface by 23 clinical isolates and 1 reference strain of slime-positive, coagulase-negative staphylococci was measured following growth in subinhibitory concentrations (sub-MICs) of cefamandole or vancomycin ranging from 2 to 0.008 micrograms/ml. All strains were...

journal_title：Antimicrobial agents and chemotherapy

authors： Dunne WM Jr

更新日期：1990-03-01 00:00:00

abstract：:We have developed and validated a high-performance liquid chromatography method coupled with a mass detector to quantify itraconazole, voriconazole, and posaconazole using quinoxaline as the internal standard. The method involves protein precipitation with acetonitrile. Mean accuracy (percent deviation from the true v...

journal_title：Antimicrobial agents and chemotherapy

authors： Baietto L,D'Avolio A,Ventimiglia G,De Rosa FG,Siccardi M,Simiele M,Sciandra M,Di Perri G

更新日期：2010-08-01 00:00:00

abstract：:The kinetics of the entry of three aminoglycosides into inner-ear tissues of the guinea pig after acute and chronic administration were compared: gentamicin toxic to the cochlea and the vestibule, amikacin preferentially cochleotoxic, and netilmicin of low ototoxic liability. During constant intravenous infusion, leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Dulon D,Aran JM,Zajic G,Schacht J

更新日期：1986-07-01 00:00:00

abstract：:Acute pulmonary exacerbations (APE) involving Pseudomonas aeruginosa are associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Drug resistance is a significant challenge to treatment. Ceftazidime-avibactam (CZA) demonstrates excellent in vitro activity against isolates recovered from CF p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Wang J,Jayne J,Fukushima L,Rao AP,D'Argenio DZ,Beringer PM

更新日期：2017-09-22 00:00:00

abstract：:High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled in a French multicenter prospective cohort ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grégoire M,Dailly E,Le Turnier P,Garot D,Guimard T,Bernard L,Tattevin P,Vandamme YM,Hoff J,Lemaitre F,Verdier MC,Deslandes G,Bellouard R,Sébille V,Chiffoleau A,Boutoille D,Navas D,Asseray N

更新日期：2019-08-23 00:00:00

abstract：:Antibiotic dynamics in the fluid obtained from subcutaneously implanted chambers in rats were similar to those observed in serum following single intramuscular injections of carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gardner WG,Prior RB,Perkins RL

更新日期：1973-08-01 00:00:00