Ex Vivo Maturation Assay for Testing Antimalarial Sensitivity of Rodent Malaria Parasites.

abstract：:Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin great...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Fuchs PC,Sommers HM,Gavan TL,Barry AL,Gerlach EH

更新日期：1980-04-01 00:00:00

abstract：:Passive antibody administration is a potentially useful approach for the therapy of human Cryptococcus neoformans infections. To evaluate the efficacy of the human immunoglobulin G1 (IgG1) constant region against C. neoformans and to construct murine antibody derivatives with reduced immunogenicities and longer half-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Zebedee SL,Koduri RK,Mukherjee J,Mukherjee S,Lee S,Sauer DF,Scharff MD,Casadevall A

更新日期：1994-07-01 00:00:00

abstract：:Nonreplicating bacteria are known to be (or at least commonly thought to be) refractory to antibiotics to which they are genetically susceptible. Here, we explore the sensitivity to killing by bactericidal antibiotics of three classes of nonreplicating populations of planktonic bacteria: (i) stationary phase, when the...

journal_title：Antimicrobial agents and chemotherapy

authors： McCall IC,Shah N,Govindan A,Baquero F,Levin BR

更新日期：2019-06-24 00:00:00

abstract：:Monte Carlo simulation (MCS) of antimicrobial dosage regimens during drug development to derive predicted target attainment values is frequently used to choose the optimal dose for the treatment of patients in phase 2 and 3 studies. A criticism is that pharmacokinetic (PK) parameter estimates and variability in health...

journal_title：Antimicrobial agents and chemotherapy

authors： Muller AE,Schmitt-Hoffmann AH,Punt N,Mouton JW

更新日期：2013-05-01 00:00:00

abstract：:Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use of the streptomycin (STR)-dependent M. tuberculosis 18b strain as a tool for assessing drug potency against nonreplicating bacteria both in vitro and in vivo. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Vocat A,Hartkoorn RC,Lechartier B,Zhang M,Dhar N,Cole ST,Sala C

更新日期：2015-07-01 00:00:00

abstract：:PCR was used to amplify a 238-bp region from Helicobacter pylori which corresponded to the quinolone resistance-determining region in Escherichia coli. The gyrA gene of H. pylori was cloned and sequenced. An open reading frame of 2,478 nucleotides coded for a polypeptide of 826 amino acids with a calculated molecular ...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore RA,Beckthold B,Wong S,Kureishi A,Bryan LE

更新日期：1995-01-01 00:00:00

abstract：:Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminogly...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoshiyama Y,Nishikawa S,Sugiyama T,Kobayashi T,Shimada H,Tomonaga F,Ohdo S,Ogawa N,Nakano S

更新日期：1993-09-01 00:00:00

abstract：:Teicoplanin was evaluated in 47 patients with severe infections, including 14 patients with bone infections, 11 patients with soft-tissue infections, 7 patients with endocarditis, 5 patients with pneumonia, 3 patients with septic thrombophlebitis, 3 patients with septicemia of unknown origin, and 4 patients with misce...

journal_title：Antimicrobial agents and chemotherapy

authors： Glupczynski Y,Lagast H,Van der Auwera P,Thys JP,Crokaert F,Yourassowsky E,Meunier-Carpentier F,Klastersky J,Kains JP,Serruys-Schoutens E

更新日期：1986-01-01 00:00:00

abstract：:The outer membrane of gram-negative cells excludes hydrophobic molecules and is responsible for the resistance of these cells to a number of dyes, detergents, and antibiotics. We describe a test for hydrophobic permeability in which a series of tetracyclines with various hydrophobicities are used. Normal Escherichia c...

journal_title：Antimicrobial agents and chemotherapy

authors： Leive L,Telesetsky S,Coleman WG Jr,Carr D

更新日期：1984-05-01 00:00:00

abstract：:The postantibiotic subminimum inhibitory concentration effect (PA SME) may simulate in vivo drug exposure more accurately than the postantibiotic effect (PAE) since subinhibitory concentrations of drug persist between antibiotic dosings. In this study, we compared the PAEs and PA SMEs of levofloxacin and ciprofloxacin...

journal_title：Antimicrobial agents and chemotherapy

authors： Licata L,Smith CE,Goldschmidt RM,Barrett JF,Frosco M

更新日期：1997-05-01 00:00:00

abstract：:Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality. The existence of seven BoNT serotypes (A-G), which differ between 35% to 68% in amino acid sequence, necessitates the development of serot...

journal_title：Antimicrobial agents and chemotherapy

authors： Snow DM,Riling K,Kimbler A,Espinoza Y,Wong D,Pham K,Martinez Z,Kraus CN,Conrad F,Garcia-Rodriguez C,Cobb RR,Marks JD,Tomic MT

更新日期：2019-10-07 00:00:00

abstract：:We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014 to 2016 from humans (n = 3) and chicken meat (n = 6). Whole-genome and plasmid sequencing identified the mcr-1 gene integrated in IncX4 (of which, one strain carried the mcr-1.2 variant)...

journal_title：Antimicrobial agents and chemotherapy

authors： Donà V,Bernasconi OJ,Pires J,Collaud A,Overesch G,Ramette A,Perreten V,Endimiani A

更新日期：2017-10-24 00:00:00

abstract：:Thirty-two strains of Trichophyton rubrum and 16 strains of Trichophyton mentagrophytes isolated from patients with tinea unguium in various parts of Germany were subjected to a microdilution test with six systemic or topical antimycotic agents. Apart from griseofulvin, there were no species-specific differences betwe...

journal_title：Antimicrobial agents and chemotherapy

authors： Korting HC,Ollert M,Abeck D

更新日期：1995-05-01 00:00:00

abstract：:Three procedures were presented for appraising the ability of antibacterial chemicals and formulations to suppress the growth of microorganisms on human skin. In each of these, the microflora was quantified after the skin had been occlusively covered for a day or more, a circumstance which, in the absence of a deterre...

journal_title：Antimicrobial agents and chemotherapy

authors： Marples RR,Kligman AM

更新日期：1974-03-01 00:00:00

abstract：:We examined the in vitro susceptibilities of three reference strains and 41 recent clinical isolates of herpes simplex virus types 1 and 2 to 5-ethyl-2'-deoxyuridine. This thymidine analog exerts a type 2-preferential but not a type 2-specific antiviral effect. Utilizing a microtiter assay with BHK-21 cells, we found ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teh CZ,Sacks SL

更新日期：1983-05-01 00:00:00

abstract：:Minimum inhibitory and bactericidal concentrations of four antibiotics and their combinations were determined for 38 strains of enterococci by a microtitration tube dilution technique. The drugs were ampicillin, vancomycin, gentamicin, and streptomycin; the combinations were ampicillin-gentamicin, ampicillin-streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Harwick HJ,Kalmanson GM,Guze LB

更新日期：1973-10-01 00:00:00

abstract：:The current treatment of chronic hepatitis C is based on pegylated alpha interferon (PEG-IFN-α) and ribavirin. The aim of this study was to identify biological and clinical variables related to IFN therapy that could predict patient outcome. The study enrolled 47 patients treated with PEG-IFN and ribavirin combined th...

journal_title：Antimicrobial agents and chemotherapy

authors： François C,Coulouarn C,Descamps V,Castelain S,Brochot E,Baron A,Duchaussoy I,Capron D,Nguyen-Khac E,Duverlie G

更新日期：2012-02-01 00:00:00

abstract：:Human cryptococcosis can occur as a primary or opportunistic infection and develops as an acute, subacute, or chronic systemic infection involving different organs of the host. Given the limited therapeutic options and the occasional resistance to fluconazole, there is a need to develop novel drugs for the treatment o...

journal_title：Antimicrobial agents and chemotherapy

authors： Sá NP,Lima CM,Lino CI,Barbeira PJS,Baltazar LM,Santos DA,Oliveira RB,Mylonakis E,Fuchs BB,Johann S

更新日期：2017-07-25 00:00:00

abstract：:Both ampicillin and cefuroxime therapy of neonates selected drug- and species-dependent beta-lactam resistance patterns in fecal strains of Escherichia coli and Klebsiella spp. This was in contrast to our previous findings that ampicillin, but not cefuroxime, contributed to the emergence of beta-lactam resistance also...

journal_title：Antimicrobial agents and chemotherapy

authors： Tullus K,Berglund B,Burman LG

更新日期：1990-02-01 00:00:00

abstract：:Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam hydrolysis and class B metalloenzymes which require divalent zinc ions for substrate hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Jacoby GA

更新日期：2010-03-01 00:00:00

abstract：:Miltefosine (MT) is a membrane-active alkylphospholipid licensed for the topical treatment of breast cancer skin metastases and the oral treatment of leishmaniasis, although its mechanism of action remains unclear. Electron paramagnetic resonance (EPR) spectroscopy of a spin-labeled lipid and a thiol-specific spin lab...

journal_title：Antimicrobial agents and chemotherapy

authors： Moreira RA,Mendanha SA,Fernandes KS,Matos GG,Alonso L,Dorta ML,Alonso A

更新日期：2014-06-01 00:00:00

abstract：:The VanR-VanS two-component system is responsible for inducing resistance to glycopeptide antibiotics in various bacteria. We have performed a comparative study of the VanR-VanS systems from two streptomyces strains, Streptomyces coelicolor and Streptomyces toyocaensis, to characterize how the two proteins cooperate t...

journal_title：Antimicrobial agents and chemotherapy

authors： Novotna GB,Kwun MJ,Hong HJ

更新日期：2015-12-28 00:00:00

abstract：:The pharmacokinetic disposition of 2 g of cefoxitin administered intravenously over 30 min was determined in six patients undergoing continuous ambulatory peritoneal dialysis for chronic renal failure. During the 6-h dialysate dwell time after the drug infusion, the mean apparent volume of distribution for cefoxitin w...

journal_title：Antimicrobial agents and chemotherapy

authors： Greaves WL,Kreeft JH,Ogilvie RI,Richards GK

更新日期：1981-02-01 00:00:00

abstract：:Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribu...

journal_title：Antimicrobial agents and chemotherapy

authors： Blandizzi C,Malizia T,Batoni G,Ghelardi E,Baschiera F,Bruschini P,Senesi S,Campa M,Del Tacca M

更新日期：2002-05-01 00:00:00

abstract：:To date, the majority of pharmacokinetic/pharmacodynamic (PK/PD) discussions have focused on PK/PD relationships evaluated at steady-state drug concentrations. However, a concern with reliance upon steady-state drug concentrations is that it ignores events occurring while the pathogen is exposed to intermittent subopt...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez MN,Papich MG,Drusano GL

更新日期：2012-06-01 00:00:00

abstract：:Three hundred ninety-four patients, aged 6 months to 12 years, entered a multicenter, randomized, controlled, investigator-blind study comparing cefdinir, 7 mg/kg of body weight twice a day, with cephalexin, 10 mg/kg four times a day, each given for 10 days. The most common infections treated were impetigo and seconda...

journal_title：Antimicrobial agents and chemotherapy

authors： Tack KJ,Keyserling CH,McCarty J,Hedrick JA

更新日期：1997-04-01 00:00:00

abstract：:Serratia marcescens S-95, which displayed an unusually high degree of resistance to aminoglycosides, including kanamycins and gentamicins, was isolated in 2002 from a patient in Japan. The resistance was mediated by a large plasmid which was nonconjugative but transferable to an Escherichia coli recipient by transform...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Yokoyama K,Yamane K,Wachino J,Shibata N,Yagi T,Shibayama K,Kato H,Arakawa Y

更新日期：2004-02-01 00:00:00

abstract：:The small-colony-variant (SCV) phenotype of Staphylococcus aureus has been associated with difficult-to-treat infections, reduced antimicrobial susceptibility, and intracellular persistence. This study represents a detailed intra- and extracellular investigation of a clinical wild-type (WT) S. aureus strain and its co...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandberg A,Lemaire S,Van Bambeke F,Tulkens PM,Hughes D,von Eiff C,Frimodt-Møller N

更新日期：2011-04-01 00:00:00

abstract：:The objective of this study was to determine risk factors for the development of resistance to β-lactams/β-lactamase inhibitors (βL/βLIs) and ertapenem among Bacteroides species bacteremia. We conducted a retrospective case-control study of 101 adult patients with Bacteroides species bacteremia at a 1,051-bed tertiary...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith JM,Avdic E,Tamma PD,Zhang L,Carroll KC,Cosgrove SE

更新日期：2015-08-01 00:00:00

abstract：:The morphology of cells of the H37Ra strain of Mycobacterium tuberculosis exposed to 0.5 mug of isonicotinic acid hydrazide (isoniazid) per ml was examined by scanning electron microscopy (SEM). Cells that were exposed to isoniazid for 3 h showed no detectable change, whereas cells exposed to the drug for 24 h exhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Takayama K,Wang L,Merkal RS

更新日期：1973-07-01 00:00:00