Emergence of cross-resistance to beta-lactam antibiotics in fecal Escherichia coli and Klebsiella strains from neonates treated with ampicillin or cefuroxime.

abstract：:Candida albicans remains the leading causative agent of invasive fungal infection. Although the importance of filamentation in C. albicans pathogenesis has been extensively investigated, in vivo studies to date have been unable to dissect the role of this developmental process in the establishment of infection versus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saville SP,Lazzell AL,Bryant AP,Fretzen A,Monreal A,Solberg EO,Monteagudo C,Lopez-Ribot JL,Milne GT

更新日期：2006-10-01 00:00:00

abstract：:We conducted this double-blind, parallel-group, placebo-controlled, randomized, multiple-ascending-dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of GS-9851 (formerly PSI-7851) in treatment-naïve patients infected with hepatitis C virus (HCV) genotype 1. Thirty-two patients recei...

journal_title：Antimicrobial agents and chemotherapy

authors： Lawitz E,Rodriguez-Torres M,Denning JM,Albanis E,Cornpropst M,Berrey MM,Symonds WT

更新日期：2013-03-01 00:00:00

abstract：:Alpha interferon and ribavirin are required in combination to achieve a sustained virological response in the treatment of hepatitis C virus (HCV) infection. Alpha interferon has direct antiviral activity and also enhances HCV-specific T-cell responses. Ribavirin has little direct activity against HCV but reduces hepa...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes E,Salio M,Cerundolo V,Medlin J,Murphy S,Dusheiko G,Klenerman P

更新日期：2004-09-01 00:00:00

abstract：:We previously demonstrated that the biguanide-based compound NB325 inhibits human immunodeficiency virus type 1 (HIV-1) infection by interacting with the CXCR4 viral coreceptor. This interaction also appeared to be persistent, since HIV-1 infection was inhibited even when the virus was introduced subsequent to the rem...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Keogan S,Zhu W,Kholodovych V,Welsh W,Rando R,Labib M,Wigdahl B,Krebs FC

更新日期：2010-05-01 00:00:00

abstract：:Antibiotic dynamics in the fluid obtained from subcutaneously implanted chambers in rats were similar to those observed in serum following single intramuscular injections of carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gardner WG,Prior RB,Perkins RL

更新日期：1973-08-01 00:00:00

abstract：:Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagenic agent, often a nucleotide analogue. One of its advantages is its broad spectrum nature that renders the strategy potentially effective against emergent...

journal_title：Antimicrobial agents and chemotherapy

authors： Gallego I,Soria ME,Gregori J,de Ávila AI,García-Crespo C,Moreno E,Gadea I,Esteban J,Fernández-Roblas R,Esteban JI,Gómez J,Quer J,Domingo E,Perales C

更新日期：2019-09-30 00:00:00

abstract：:This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined 50% inhibitory concentration (IC50) at least 30 times better than...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzitko K,Paneth A,Plech T,Pawełczyk J,Węglińska L,Paneth P

更新日期：2014-12-01 00:00:00

abstract：:This study compared nine susceptibility testing methods and 12 endpoints for anidulafungin, caspofungin, and micafungin with the same collection of blinded FKS hot spot mutant (n = 29) and wild-type isolates (n = 94). The susceptibility tests included EUCAST Edef 7.1, agar dilution, Etest, and disk diffusion with RPMI...

journal_title：Antimicrobial agents and chemotherapy

authors： Arendrup MC,Garcia-Effron G,Lass-Flörl C,Lopez AG,Rodriguez-Tudela JL,Cuenca-Estrella M,Perlin DS

更新日期：2010-01-01 00:00:00

abstract：:Cryptic species of Aspergillus fumigatus, including the Aspergillus viridinutans species complex, are increasingly reported to be causes of invasive aspergillosis. Their identification is clinically relevant, as these species frequently have intrinsic resistance to common antifungals. We evaluated the susceptibilities...

journal_title：Antimicrobial agents and chemotherapy

authors： Lyskova P,Hubka V,Svobodova L,Barrs V,Dhand NK,Yaguchi T,Matsuzawa T,Horie Y,Kolarik M,Dobias R,Hamal P

更新日期：2018-03-27 00:00:00

abstract：:To compare the effect of ritonavir on plasma amprenavir pharmacokinetics, healthy adults received either fosamprenavir (700 mg twice a day [BID]) or amprenavir (600 mg BID) alone and in combination with ritonavir (100 mg BID). Ritonavir increased plasma amprenavir pharmacokinetic parameters to a similar extent when co...

journal_title：Antimicrobial agents and chemotherapy

authors： Wire MB,Baker KL,Jones LS,Shelton MJ,Lou Y,Thomas GJ,Berrey MM

更新日期：2006-04-01 00:00:00

abstract：:Increasingly frequent reports have described the in vivo loss of daptomycin susceptibility in association with clinical treatment failures. The mechanism(s) of daptomycin resistance is not well understood. We studied an isogenic set of Staphylococcus aureus isolates from the bloodstream of a daptomycin-treated patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones T,Yeaman MR,Sakoulas G,Yang SJ,Proctor RA,Sahl HG,Schrenzel J,Xiong YQ,Bayer AS

更新日期：2008-01-01 00:00:00

abstract：:We assessed cutaneous ethanol (ETOH) and isopropanol (ISOP) absorption after intensive (30 times per h) use of alcohol-based hand-rub solutions by healthcare workers (HCWs). ETOH was detectable in the breath of 6/20 HCWs (0.001 to 0.0025%) at 1 to 2 min postexposure and in the serum of 2/20 HCWs at 5 to 7 min postexpo...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown TL,Gamon S,Tester P,Martin R,Hosking K,Bowkett GC,Gerostamoulos D,Grayson ML

更新日期：2007-03-01 00:00:00

abstract：:The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul AS,Moreira CK,Elsworth B,Allred DR,Duraisingh MT

更新日期：2016-07-22 00:00:00

abstract：:Salmonella enterica serovar Typhi is an important pathogen exclusively for humans and causes typhoid or enteric fever. It has been shown that type IVB pili, encoded by the S. enterica serovar Typhi pil operon located in Salmonella pathogenicity island 7, are important in the pathogenic process. In this study, by using...

journal_title：Antimicrobial agents and chemotherapy

authors： Pan Q,Zhang XL,Wu HY,He PW,Wang F,Zhang MS,Hu JM,Xia B,Wu J

更新日期：2005-10-01 00:00:00

abstract：:In response to the need for rapid, inexpensive, high-throughput assays for antimycobacterial drug screening, a microplate-based assay which uses Alamar blue reagent for determination of growth was evaluated. MICs of 30 antimicrobial agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis H37Ra, and Mycobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins L,Franzblau SG

更新日期：1997-05-01 00:00:00

abstract：:Agar and broth microdilution MICs of RP 74501-RP 74502, a mixture of streptogramin antimicrobial agents that inhibited 90% of 22 Legionella strains tested, were 0.64 and 0.08 microgram/ml, respectively; respective erythromycin values were 1.0 and 0.12 microgram/ml. RP 74501-RP 74502 at 1 microgram/ml was more active t...

journal_title：Antimicrobial agents and chemotherapy

authors： Edelstein PH,Edelstein MA

更新日期：1993-04-01 00:00:00

abstract：:Nemonoxacin (TG-873870) is a novel nonfluorinated quinolone with potent broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens, including vancomycin-nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA), quinolone-resistant MRSA, quinolone-resistant Streptococcus pneumoniae, p...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao GY,Zhang J,Zhang YY,Guo BN,Yu JC,Wu XJ,Chen YC,Wu JF,Shi YG

更新日期：2014-10-01 00:00:00

abstract：:Surveillance studies conducted in the United States over the last decade have revealed increasing resistance among community-acquired respiratory pathogens, especially Streptococcus pneumoniae, that may limit future options for empirical therapy. The objective of this study was to assess the scope and magnitude of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Critchley IA,Brown SD,Traczewski MM,Tillotson GS,Janjic N

更新日期：2007-12-01 00:00:00

abstract：:The antifungal pentapeptide auristatin PHE was recently shown to interfere with microtubule dynamics and nuclear and cellular division in the opportunistic pathogen Cryptococcus neoformans. To gain a broader understanding of the cellular response of C. neoformans to auristatin PHE, mRNA differential display (DD) and r...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Berens ME,Hoelzinger DB,Pettit GR,Winkelmann G,Pettit RK

更新日期：2004-02-01 00:00:00

abstract：:Lamivudine [beta-L-(-)-2',3'-dideoxy-3'-thiacytidine] is a potent inhibitor of hepadnavirus replication and is used both to treat chronic hepatitis B virus (HBV) infections and to prevent reinfection of transplanted livers. Unfortunately, lamivudine-resistant HBV variants do arise during prolonged therapy, indicating ...

journal_title：Antimicrobial agents and chemotherapy

authors： Walters KA,Tipples GA,Allen MI,Condreay LD,Addison WR,Tyrrell L

更新日期：2003-06-01 00:00:00

abstract：:Increasing mobile colistin resistance, mediated by the mcr gene family, in Enterobacteriaceae has become a global concern. Among the 10 reported mcr genes, mcr-8 was first identified in Klebsiella pneumoniae, which could cause severe infections with high mortality. Information about the prevalence and genetic context ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu B,Wang Y,Ling Z,Yu Z,Shen Z,Zhang S,Wang X

更新日期：2020-12-16 00:00:00

abstract：:More than 10(6) compounds were evaluated in a human immunodeficiency virus type 1 (HIV-1) high-throughput antiviral screen, resulting in the identification of a novel HIV-1 inhibitor (UK-201844). UK-201844 exhibited antiviral activity against HIV-1 NL4-3 in MT-2 and PM1 cells, with 50% effective concentrations of 1.3 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Blair WS,Cao J,Jackson L,Jimenez J,Peng Q,Wu H,Isaacson J,Butler SL,Chu A,Graham J,Malfait AM,Tortorella M,Patick AK

更新日期：2007-10-01 00:00:00

abstract：:Determinants encoding resistance to antibiotics, except penicillin, of 5 of 21 Streptococcus anginosus clinical isolates that we examined transferred by conjugation into Enterococcus faecalis and into 1 to 5 streptococcal recipients at frequencies of 10(-6) to 10(-8) transconjugants per donor. No R plasmids were detec...

journal_title：Antimicrobial agents and chemotherapy

authors： Clermont D,Horaud T

更新日期：1990-09-01 00:00:00

abstract：:The hydrophobicity and charge of the cell surface of M protein-positive (M+) and the less virulent M protein-negative (M-) strains of type 12 Streptococcus pyogenes have been studied, respectively, by hydrophobic interaction chromatography and free zone electrophoresis. The M+ strain had a more hydrophobic and a more ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tylewska S,Hjertén S,Wadström T

更新日期：1981-11-01 00:00:00

abstract：:Helicobacter pylori is a major etiological agent in gastroduodenal disorders. The adhesion of H. pylori to human gastric epithelial cells is the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in the prevention of H. pylori infection. Experiments were performed to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayashi S,Sugiyama T,Amano K,Isogai H,Isogai E,Aihara M,Kikuchi M,Asaka M,Yokota K,Oguma K,Fujii N,Hirai Y

更新日期：1998-08-01 00:00:00

abstract：:"Shock and kill" therapeutic strategies toward HIV eradication are based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) and the consequent killing of the reactivated cell by either the cytopathic effect of HIV or an arm of the immune system. We have recently found several benzotri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sorensen ES,Macedo AB,Resop RS,Howard JN,Nell R,Sarabia I,Newman D,Ren Y,Jones RB,Planelles V,Spivak AM,Bosque A

更新日期：2020-07-22 00:00:00

abstract：:Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the infected lesions were cured, as judged by clinical and microbial criteria, compared with 20% of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Evron R,Guizie M,Zehavi U,Polacheck I

更新日期：1990-08-01 00:00:00

abstract：:Twelve healthy volunteers participated in this randomized crossover study to compare the concentrations and recovery levels of fleroxacin and pefloxacin in urine and to assess their bactericidal activities against 12 strains of urinary pathogens with different susceptibilities over a wide range of MICs. The volunteers...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Theuretzbacher U,Kinzig M,Savov O,Sörgel F

更新日期：1998-07-01 00:00:00

abstract：:Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo for 6 weeks. Levels of serum glutamic oxalacetic transami...

journal_title：Antimicrobial agents and chemotherapy

authors： McCormack WM,George H,Donner A,Kodgis LF,Alpert S,Lowe EW,Kass EH

更新日期：1977-11-01 00:00:00

abstract：:In 2002, the first two clinical isolates of vancomycin-resistant Staphylococcus aureus (VRSA) containing vanA were recovered in Michigan and Pennsylvania. Tn1546, a mobile genetic element that encodes high-level vancomycin resistance in enterococci, was present in both isolates. With PCR and DNA sequence analysis, we ...

journal_title：Antimicrobial agents and chemotherapy

authors： Clark NC,Weigel LM,Patel JB,Tenover FC

更新日期：2005-01-01 00:00:00