Effect of subinhibitory concentrations of antibiotics on the adhesion of Streptococcus pyogenes to pharyngeal epithelial cells.

abstract：:Acyclovir [9-(2-hydroxyethoxymethyl)guanine] (ACV), a potent antiviral compound, was phosphorylated to the same extent by extracts from untreated and iododeoxyuridine-treated Epstein-Barr virus-containing latent D98/HR-1 somatic hybrid cells. ATP was the preferred phosphate donor over other nucleoside triphosphates. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Datta AK,Pagano JS

更新日期：1983-07-01 00:00:00

abstract：:The isolation of trimethoprim-resistant, sulfonamide-susceptible Enterobacteriaceae causing urinary tract infections is reported. The appearance of these strains followed the introduction of trimethoprim alone for use as treatment. Trimethoprim resistance was attributable to plasmids or transposons less frequently in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Towner KJ,Smith MA,Cowlishaw WA

更新日期：1983-04-01 00:00:00

abstract：:Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pentamidine was modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cushion MT,Walzer PD,Ashbaugh A,Rebholz S,Brubaker R,Vanden Eynde JJ,Mayence A,Huang TL

更新日期：2006-07-01 00:00:00

abstract：:Sch 21420 is a new aminoglycoside synthesized from gentamicin B. Susceptibility tests with Sch 21420, amikacin, gentamicin, netilmicin, sisomicin, and tobramycin were performed on a variety of bacterial species including 44 with known mechanisms of resistance to aminoglycosides. Sch 21420 and amikacin had similar effe...

journal_title：Antimicrobial agents and chemotherapy

authors： Thornsberry C,Barry AL,Jones RN,Baker CN,Badal RE,Packer RR

更新日期：1980-08-01 00:00:00

abstract：:The telithromycin susceptibility of 210 erythromycin-resistant pneumococci was tested with the agar diffusion method. Twenty-six erm(B)-positive isolates showed heterogeneous resistance to telithromycin, which was manifested by the presence of colonies inside the inhibition zone. When these cells were cultured and tes...

journal_title：Antimicrobial agents and chemotherapy

authors： Rantala M,Haanperä-Heikkinen M,Lindgren M,Seppälä H,Huovinen P,Jalava J

更新日期：2006-05-01 00:00:00

abstract：:The pharmacokinetics of the antifungal pradimicin derivative BMS 181184 in plasma of normal, catheterized rabbits were characterized after single and multiple daily intravenous administrations of dosages of 10, 25, 50, or 150 mg/kg of body weight, and drug levels in tissues were assessed after multiple dosing. Concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Sein T,Petraitis V,Petraitiene R,Callender D,Gonzalez CE,Giri N,Bacher J,Piscitelli S,Walsh TJ

更新日期：1998-10-01 00:00:00

abstract：:Monte Carlo simulation (MCS) of antimicrobial dosage regimens during drug development to derive predicted target attainment values is frequently used to choose the optimal dose for the treatment of patients in phase 2 and 3 studies. A criticism is that pharmacokinetic (PK) parameter estimates and variability in health...

journal_title：Antimicrobial agents and chemotherapy

authors： Muller AE,Schmitt-Hoffmann AH,Punt N,Mouton JW

更新日期：2013-05-01 00:00:00

abstract：:Beta-lactam resistance in Pseudomonas aeruginosa detected only during ceftazidime therapy of cystic fibrosis patients was studied. Evaluation of resistant and susceptible isolates from one patient and resistant laboratory derivatives indicated that elevated beta-lactamase levels were the primary determinant of resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Schryvers AB,Ogunariwo J,Chamberland S,Godfrey AJ,Rabin HR,Bryan LE

更新日期：1987-09-01 00:00:00

abstract：:Antibiotic penetration to the infection site is critical for obtaining a good clinical outcome in patients with ventilator-associated pneumonia (VAP). Surprisingly few studies have quantified the penetration of β-lactam agents into the lung, as measured by the ratio of area under the concentration-time curve (AUC) in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lodise TP,Sorgel F,Melnick D,Mason B,Kinzig M,Drusano GL

更新日期：2011-04-01 00:00:00

abstract：:The physiological factors that contribute to Mycobacterium abscessus lung infections remain unclear. We determined whether antibiotic treatment targeting a major cystic fibrosis pathogen (i.e., Pseudomonas aeruginosa) could provide the ideal conditions for the establishment of M. abscessus infection. Our data showed t...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Sevilla G,Crabbé A,García-Coca M,Aguilera-Correa JJ,Esteban J,Pérez-Jorge C

更新日期：2019-10-22 00:00:00

abstract：:Neisseria meningitidis has been relatively slow to acquire resistance to penicillin. We previously reported an increase in the incidence of invasive meningococcal disease (IMD) strains with decreased susceptibility to penicillin (DSP) in Ontario. Our objectives were to evaluate trends in IMD with DSP, to identify case...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown EM,Fisman DN,Drews SJ,Dolman S,Rawte P,Brown S,Jamieson F

更新日期：2010-03-01 00:00:00

abstract：:Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably les...

journal_title：Antimicrobial agents and chemotherapy

authors： Coates JA,Cammack N,Jenkinson HJ,Mutton IM,Pearson BA,Storer R,Cameron JM,Penn CR

更新日期：1992-01-01 00:00:00

abstract：:Assessment of drug susceptibility has become an integral part of influenza virus surveillance. In this study, we describe the drug resistance profile of influenza A(H3N2) virus, A/Mississippi/05/2011, collected from a patient treated with oseltamivir and detected via surveillance. An MDCK cell-grown isolate of this vi...

journal_title：Antimicrobial agents and chemotherapy

authors： Tamura D,Nguyen HT,Sleeman K,Levine M,Mishin VP,Yang H,Guo Z,Okomo-Adhiambo M,Xu X,Stevens J,Gubareva LV

更新日期：2013-12-01 00:00:00

abstract：:The global dissemination and increasing incidence of carbapenem-resistant, Gram-negative organisms have resulted in acute public health concerns. Here, we present a retrospective multicenter study on molecular characterization of metallo-β-lactamase (MBL)-producing clinical Escherichia coli isolates recovered from ext...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranjan A,Shaik S,Mondal A,Nandanwar N,Hussain A,Semmler T,Kumar N,Tiwari SK,Jadhav S,Wieler LH,Ahmed N

更新日期：2016-10-21 00:00:00

abstract：:Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosin...

journal_title：Antimicrobial agents and chemotherapy

authors： Eriksson B,Helgstrand E,Johansson NG,Larsson A,Misiorny A,Norén JO,Philipson L,Stenberg K,Stening G,Stridh S,Oberg B

更新日期：1977-06-01 00:00:00

abstract：:A total of 113 patients were randomly allocated to receive either ticarcillin plus clavulanic acid (total dose, 20.8 g) or clindamycin (total dose, 2.4 g) plus amikacin (total dose, 1 g) as perioperative antimicrobial prophylaxis for major head and neck surgery. The two groups were similar in age, prior antineoplastic...

journal_title：Antimicrobial agents and chemotherapy

authors： Gerard M,Meunier F,Dor P,Andry G,Chantrain G,Van der Auwera P,Daneau D,Klastersky J

更新日期：1988-10-01 00:00:00

abstract：:Extended-infusion ceftolozane-tazobactam treatment at 1.5 g every 8 h was used to treat multidrug-resistant Pseudomonas aeruginosa in a critically ill patient on continuous venovenous hemofiltration. Serum drug concentrations were measured at 1, 4, 5, 6, and 8 h after the start of infusion. Prefilter levels of ceftolo...

journal_title：Antimicrobial agents and chemotherapy

authors： Oliver WD,Heil EL,Gonzales JP,Mehrotra S,Robinett K,Saleeb P,Nicolau DP

更新日期：2015-12-28 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has become a significant acute and chronic respiratory pathogen. While vancomycin is effective against MRSA, its relatively poor penetration into lung secretions and dose-limiting renal toxicity make it less effective in the respiratory setting. As inhaled administrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Waterer G,Lord J,Hofmann T,Jouhikainen T

更新日期：2020-02-21 00:00:00

abstract：:Pharmacological modeling of antiparasitic treatment based on a drug's pharmacokinetic and pharmacodynamic properties plays an increasingly important role in identifying optimal drug dosing regimens and predicting their potential impact on control and elimination programs. Conventional modeling of treatment relies on m...

journal_title：Antimicrobial agents and chemotherapy

authors： Hodel EM,Kay K,Hastings IM

更新日期：2016-04-22 00:00:00

abstract：:We developed a multiplex real-time SYBR green-based PCR assay for rapid detection of tet(X) and its variants, including tet(X1) and tet(X2) and high-level tigecycline resistance genes tet(X3), tet(X4), and tet(X5). We showed that the real-time PCR assay developed had high linearity (R2 ≥ 0.996), sensitivity (low detec...

journal_title：Antimicrobial agents and chemotherapy

authors： Fu Y,Liu D,Song H,Liu Z,Jiang H,Wang Y

更新日期：2020-03-24 00:00:00

abstract：:Mycobacterium chimaera is a slow-growing nontuberculous Mycobacterium species belonging to the Mycobacterium avium complex (MAC). It has been identified globally as the cause of a large outbreak of cardiovascular infections following open heart surgery, but it can also cause respiratory infections in individuals with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mok S,Hannan MM,Nölke L,Stapleton P,O'Sullivan N,Murphy P,McLaughlin AM,McNamara E,Fitzgibbon MM,Rogers TR

更新日期：2019-08-23 00:00:00

abstract：:All known DNA ligases catalyze the formation of a phosphodiester linkage between adjacent termini in double-stranded DNA via very similar mechanisms. The ligase family can, however, be divided into two classes: eubacterial ligases, which require NAD(+) as a cofactor, and other ligases, from viruses, archaea, and eukar...

journal_title：Antimicrobial agents and chemotherapy

authors： Ciarrocchi G,MacPhee DG,Deady LW,Tilley L

更新日期：1999-11-01 00:00:00

abstract：:Management of treatment-experienced human immunodeficiency virus patients has become complex, and therapy may need to include two protease inhibitors at therapeutic doses. The objective of this study was to characterize the pharmacokinetics in serum of saquinavir (1,000 mg twice daily [b.i.d.]), lopinavir (400 mg b.i....

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Lopez RM,Diaz M,Pou L,Ruiz L,Falcó V,Crespo M,Azuaje C,Ruiz I,Ocaña I,Clotet B,Pahissa A

更新日期：2004-11-01 00:00:00

abstract：:The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreas...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Mellado E,Díaz-Guerra TM,Monzón A,Rodríguez-Tudela JL

更新日期：2001-06-01 00:00:00

abstract：:Twelve straight-chain esters, C(5) to C(14), C(16), and C(18), of p-hydroxybenzoic acid were prepared, and their melting points, solubilities in water at 25 degrees C, infrared spectra, dissociation constants (pK(a)), and activities against Clostridium botulinum were determined. These studies also included four commer...

journal_title：Antimicrobial agents and chemotherapy

authors： Dymicky M,Huhtanen CN

更新日期：1979-06-01 00:00:00

abstract：:The long-term cumulative cytotoxicity of antiretrovirals (ARVs) is among the major causes of treatment failure in patients infected with human immunodeficiency virus (HIV) and patients with AIDS. This calls for the development of novel ARVs with less or no cytotoxicity. In the present study, we compared the cytotoxic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lopes de Campos WR,Coopusamy D,Morris L,Mayosi BM,Khati M

更新日期：2009-07-01 00:00:00

abstract：:Fosfomycin tromethamine (previously fosfomycin trometamol) is an orally administered fosfomycin which may be used for single-dose therapy of uncomplicated urinary tract infections. Fosfomycin tromethamine, norfloxacin, and trimethoprim-sulfamethoxazole inhibited greater than 90% of 352 bacterial isolates representing ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Fuchs PC

更新日期：1991-06-01 00:00:00

abstract：:Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis. MRSA was inoculated into the proximal tibia, and a titanium wire was implanted. Four weeks after infection...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergidis P,Rouse MS,Euba G,Karau MJ,Schmidt SM,Mandrekar JN,Steckelberg JM,Patel R

更新日期：2011-03-01 00:00:00

abstract：:We present a 31-year-old female who had undergone an allogeneic bone marrow transplantation and who was started on intravenous posaconazole for pulmonary mycosis while undergoing continuous venovenous hemofiltration (CVVH). We performed steady-state pharmacokinetic evaluations for both posaconazole and sulfobutylether...

journal_title：Antimicrobial agents and chemotherapy

authors： Morris AA,Mueller SW,Rower JE,Washburn T,Kiser TH

更新日期：2015-10-01 00:00:00

abstract：:Microdialysis was applied to sample the unbound drug concentration in the extracellular fluid in brain and muscle of rats given zalcitabine (2',3'-dideoxycytidine; n = 4) or BEA005 (2', 3'-dideoxy-3'-hydroxymethylcytidine; n = 4) (50 mg/kg of body weight given subcutaneously). Zalcitabine and BEA005 were analyzed by h...

journal_title：Antimicrobial agents and chemotherapy

authors： Borg N,Ståhle L

更新日期：1998-09-01 00:00:00