Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2.

abstract：:Plaque formation and dye uptake assays were used to measure the MICs of PD 127,391 and PD 131,628 against Rickettsia species. The MICs of PD 127,391 were 0.25 microgram/ml for Rickettsia rickettsii and 0.125 to 0.25 microgram/ml for Rickettsia conorii. The MICs of PD 131,628 were 0.25 to 0.5 microgram/ml for R. ricket...

journal_title：Antimicrobial agents and chemotherapy

authors： Jabarit-Aldighieri N,Torres H,Raoult D

更新日期：1992-11-01 00:00:00

abstract：:Pyrosequencing was used to detect rapidly and estimate the number of 23S rRNA genes with a G2576T mutation in 43 linezolid-resistant and -susceptible clinical isolates of enterococci. The method showed 100% concordance with PCR-restriction fragment length polymorphism for detecting isolates homozygous for either G2576...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinclair A,Arnold C,Woodford N

更新日期：2003-11-01 00:00:00

abstract：:CTX-M-1-producing Escherichia coli were isolated from 56 pigs, three farm personnel, two manure samples, and two air samples from two Danish pig farms where an association between prophylactic ceftiofur use and the occurrence of cephalosporin resistance was previously demonstrated. Human, animal, and environmental str...

journal_title：Antimicrobial agents and chemotherapy

authors： Moodley A,Guardabassi L

更新日期：2009-04-01 00:00:00

abstract：:To determine whether rifampin reduces concentrations of trimethoprim (TMP) and sulfamethoxazole (SMX) in serum of human immunodeficiency virus (HIV)-infected persons, levels of these agents were determined by high-performance liquid chromatography before and after more than 12 days of standard antituberculosis treatme...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Pou L,Fernandez-Sola A,Campos F,Lopez RM,Ocaña I,Ruiz I,Pahissa A

更新日期：2001-11-01 00:00:00

abstract：:The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bioconversion of rosamicin biosynthetic intermediates with Esc...

journal_title：Antimicrobial agents and chemotherapy

authors： Iizaka Y,Higashi N,Ishida M,Oiwa R,Ichikawa Y,Takeda M,Anzai Y,Kato F

更新日期：2013-03-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Srinivasan VB,Rajamohan G,Gebreyes WA

更新日期：2009-12-01 00:00:00

abstract：:In an effort to discover novel, noncarbohydrate inhibitors of influenza virus neuraminidase we hypothesized that compounds which contain positively charged amino groups in an appropriate position to interact with the Asp 152 or Tyr 406 side chains might be bound tightly by the enzyme. Testing of 300 alpha- and beta-am...

journal_title：Antimicrobial agents and chemotherapy

authors： Kati WM,Montgomery D,Maring C,Stoll VS,Giranda V,Chen X,Laver WG,Kohlbrenner W,Norbeck DW

更新日期：2001-09-01 00:00:00

abstract：:In a 1964 study of the pharmacokinetic determinants of penicillin cure of gonococcal urethritis, 45 male prisoner volunteers were experimentally infected with strains of Neisseria gonorrhoeae having known in vitro penicillin susceptibility. After developing urethritis, subjects received intramuscular penicillin G and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaffe HW,Schroeter AL,Reynolds GH,Zaidi AA,Martin JE Jr,Thayer JD

更新日期：1979-04-01 00:00:00

abstract：:Visceral leishmaniasis is a neglected tropical disease that causes significant morbidity and mortality worldwide. Characterization of the pharmacokinetics and pharmacodynamics of antileishmanial drugs in preclinical models is important for drug development and use. Here we investigated the pharmacodynamics and drug di...

journal_title：Antimicrobial agents and chemotherapy

authors： Voak AA,Harris A,Qaiser Z,Croft SL,Seifert K

更新日期：2017-08-24 00:00:00

abstract：:Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 microgram/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (vanA, vanB, vanC, vanD, and vanE). We have isolated a...

journal_title：Antimicrobial agents and chemotherapy

authors： McKessar SJ,Berry AM,Bell JM,Turnidge JD,Paton JC

更新日期：2000-11-01 00:00:00

abstract：:The role of linezolid in empirical therapy of suspected bacteremia remains unclear. The aim of this study was to evaluate the influence of empirical use of linezolid or glycopeptides in addition to other antibiotics on the 30-day mortality rates in patients with Gram-negative bacteremia. For this purpose, 1,126 patien...

journal_title：Antimicrobial agents and chemotherapy

authors： Ternavasio-de la Vega HG,Mateos-Díaz AM,Martinez JA,Almela M,Cobos-Trigueros N,Morata L,De-la-Calle C,Sala M,Mensa J,Marcos M,Soriano A

更新日期：2014-12-01 00:00:00

abstract：:A fluorometric assay, based on the natural fluorescence of the quinolone nucleus, was used to determine the uptake of ofloxacin by human polymorphonuclear leukocytes. The ratio of cellular concentration to extracellular concentration (C/E) at 20 min and 37 degrees C was 7.2, using an extracellular concentration of 5 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Pascual A,Garcia I,Perea EJ

更新日期：1989-05-01 00:00:00

abstract：:6-Nonadecynoic acid (6-NDA), a plant-derived acetylenic acid, exhibits strong inhibitory activity against the human fungal pathogens Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. In the present study, transcriptional profiling coupled with mutant and biochemical analyses were conducted usin...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu T,Tripathi SK,Feng Q,Lorenz MC,Wright MA,Jacob MR,Mask MM,Baerson SR,Li XC,Clark AM,Agarwal AK

更新日期：2012-06-01 00:00:00

abstract：:The opportunistic Gram-negative pathogen Pseudomonas aeruginosa, known for its intrinsic and acquired antibiotic resistance, has a notorious ability to form biofilms, which often facilitate chronic infections. The evolutionary paths to antibiotic resistance have mainly been investigated in planktonic cultures and are ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahmed MN,Porse A,Sommer MOA,Høiby N,Ciofu O

更新日期：2018-07-27 00:00:00

abstract：:Eravacycline (TP-434 or 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline) is a novel fluorocycline that was evaluated for antimicrobial activity against panels of recently isolated aerobic and anaerobic Gram-negative and Gram-positive bacteria. Eravacycline showed potent broad-spectrum activity against 9...

journal_title：Antimicrobial agents and chemotherapy

authors： Sutcliffe JA,O'Brien W,Fyfe C,Grossman TH

更新日期：2013-11-01 00:00:00

abstract：:Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics techniques also co...

journal_title：Antimicrobial agents and chemotherapy

authors： Vincent IM,Ehmann DE,Mills SD,Perros M,Barrett MP

更新日期：2016-03-25 00:00:00

abstract：:The in vitro interaction between triclosan and fluconazole against 24 azole-resistant clinical isolates of Candida albicans was evaluated by the microdilution checkerboard technique. The synergisms were verified by time-killing curves and agar diffusion tests in selected strains. Antagonistic activity was not detected...

journal_title：Antimicrobial agents and chemotherapy

authors： Yu L,Ling G,Deng X,Jin J,Jin Q,Guo N

更新日期：2011-07-01 00:00:00

abstract：:Thirty-five strains of Pasteurella multocida from humans and animals were tested for susceptibility to five cephalosporins by a broth dilution method. Cefcanel showed high activity against all isolates (MIC and MBC, less than or equal to 0.64 micrograms/ml). The corresponding figure for cefaclor and cefuroxime was 2.5...

journal_title：Antimicrobial agents and chemotherapy

authors： Holst E,Rollof J,Miörner H

更新日期：1989-12-01 00:00:00

abstract：:Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Parikh S,Fehintola F,Huang L,Olson A,Adedeji WA,Darin KM,Morse GD,Murphy RL,Taiwo BO,Akinyinka OO,Adewole IF,Aweeka FT,Scarsi KK

更新日期：2015-12-01 00:00:00

abstract：:Amoxicillin was studied in normal subjects after intravenous, oral, and intramuscular administration of 250-, 500-, and 1,000-mg doses. Serum drug levels were analyzed using a two-compartment open model, as well as area under the curve (AUC) and urinary recovery. The variations of these pharmacokinetic parameters were...

journal_title：Antimicrobial agents and chemotherapy

authors： Spyker DA,Rugloski RJ,Vann RL,O'Brien WM

更新日期：1977-01-01 00:00:00

abstract：:The effectiveness of spiramycin for the treatment of rhesus monkey fetuses congenitally infected with Toxoplasma gondii was studied. Eight monkeys were infected at day 90 of pregnancy. This is comparable to the second trimester of organogenetic development in humans. Transmission of infection was found prenatally in f...

journal_title：Antimicrobial agents and chemotherapy

authors： Schoondermark-Van de Ven E,Melchers W,Camps W,Eskes T,Meuwissen J,Galama J

更新日期：1994-09-01 00:00:00

abstract：:The spread of antibiotic-resistant bacteria presents a global health challenge. Efficient surveillance of bacteria harboring antibiotic resistance genes (ARGs) is a critical aspect to controlling the spread. Increased access to microbial genomic data from many diverse populations informs this surveillance but only whe...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim HL,Rodriguez RD,Morris SK,Zhao S,Donato JJ

更新日期：2020-10-20 00:00:00

abstract：:The global spread of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has been largely associated with sequence type 258 (ST258) and its related variants (clonal group 258 [CG258]). Here we describe the molecular epidemiology of CR-Kp from five tertiary care hospitals in Medellín, the second largest city in Colombia...

journal_title：Antimicrobial agents and chemotherapy

authors： Ocampo AM,Chen L,Cienfuegos AV,Roncancio G,Chavda KD,Kreiswirth BN,Jiménez JN

更新日期：2015-10-26 00:00:00

abstract：:TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied. In both strains the blaTEM gene was encoded as a single copy on a large conjugatively transferable plasmid. A single G-->T transversion at position 1 of the -10 consensus sequence was identified to be the mechanism of TE...

journal_title：Antimicrobial agents and chemotherapy

authors： Siu LK,Ho PL,Yuen KY,Wong SS,Chau PY

更新日期：1997-02-01 00:00:00

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:As a consequence of blood-borne bacterial sepsis, endotoxin or lipopolysaccharide (LPS) from the cell walls of gram-negative bacteria can trigger an acute inflammatory response, leading to a series of pathological events and often resulting in death. To block this inflammatory response to endotoxin, a novel lipid A an...

journal_title：Antimicrobial agents and chemotherapy

authors： Kobayashi S,Kawata T,Kimura A,Miyamoto K,Katayama K,Yamatsu I,Rossignol DP,Christ WJ,Kishi Y

更新日期：1998-11-01 00:00:00

abstract：:The activity of DX-619 was evaluated against 376 anaerobic isolates using the reference CLSI agar dilution method. Overall, 90% of the strains were susceptible to DX-619 at < or =1 microg/ml. It was more active than the other four compounds tested except for meropenem, which showed virtually identical overall activity...

journal_title：Antimicrobial agents and chemotherapy

authors： Molitoris D,Väisänen ML,Bolaños M,Finegold SM

更新日期：2006-05-01 00:00:00

abstract：:Because of the rising incidence of failures in the treatment of oropharyngeal candidosis in the case of severely immunosuppressed patients (mostly human immunodeficiency virus [HIV]-infected patients), there is need for the development of new, more effective agents and/or compounds that support the activity of the com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuipers ME,de Vries HG,Eikelboom MC,Meijer DK,Swart PJ

更新日期：1999-11-01 00:00:00

abstract：:Amphotericin B lipid complex for injection (ABLC) is a suspension of amphotericin B complexed with the lipids L-alpha-dimyristoylphosphatidylcholine (DMPC) and L-alpha-dimyristoylphosphatidylglycerol. ABLC is less toxic than amphotericin B deoxycholate (AmB-d), while it maintains the antifungal activity of AmB-d. Acti...

journal_title：Antimicrobial agents and chemotherapy

authors： Swenson CE,Perkins WR,Roberts P,Ahmad I,Stevens R,Stevens DA,Janoff AS

更新日期：1998-04-01 00:00:00