Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens.

abstract：:Although human immunodeficiency virus (HIV) coinfection is the most important risk factor for a poor antituberculosis (anti-TB) treatment response, its effect on the pharmacokinetics of the first-line drugs in children is understudied. This study examined the pharmacokinetics of the four first-line anti-TB drugs in ch...

journal_title：Antimicrobial agents and chemotherapy

authors： Antwi S,Yang H,Enimil A,Sarfo AM,Gillani FS,Ansong D,Dompreh A,Orstin A,Opoku T,Bosomtwe D,Wiesner L,Norman J,Peloquin CA,Kwara A

更新日期：2017-01-24 00:00:00

abstract：:A broad-spectrum vaginal microbicide must be effective against a variety of sexually transmitted disease pathogens and be minimally toxic to the cell types found within the vaginal epithelium, including vaginal keratinocytes. We assessed the sensitivity of primary human vaginal keratinocytes to potential topical vagin...

journal_title：Antimicrobial agents and chemotherapy

authors： Krebs FC,Miller SR,Catalone BJ,Welsh PA,Malamud D,Howett MK,Wigdahl B

更新日期：2000-07-01 00:00:00

abstract：:The frequencies of tetracycline resistance determinants of the classes A, B, C, and D were determined in 53 non-lactose-fermenting clinical isolates. The most frequent class of determinant in Salmonella typhimurium and Shigella flexneri strains was class B; however, the predominant determinant in Shigella sonnei strai...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Salazar JM,Alvarez G,Gómez-Eichelmann MC

更新日期：1986-10-01 00:00:00

abstract：:Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, 54 available Neisseria gonorrhoeae isolates collected in San Francisco, CA, from January to October 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pandori M,Barry PM,Wu A,Ren A,Whittington WL,Liska S,Klausner JD

更新日期：2009-09-01 00:00:00

abstract：:The in vitro activities of vancomycin and teicoplanin alone and in combination with gentamicin or tobramycin were studied by time-kill techniques with 11 strains of pathogenic diphtheroids (Corynebacterium group JK). The activities of vancomycin and teicoplanin were similar (MIC for 90% of strains tested [MIC90], 1 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Spitzer PG,Eliopoulos GM,Karchmer AW,Moellering RC Jr

更新日期：1988-04-01 00:00:00

abstract：:Pseudomonas aeruginosa infections result in high morbidity and mortality rates for individuals with cystic fibrosis (CF), with premature death often occurring. These infections are complicated by the formation of biofilms in the sputum. Antibiotic therapy is stymied by antibiotic resistance of the biofilm matrix, maki...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare W,Das T,Ibugo A,Buckle E,Manefield M,Manos J

更新日期：2016-07-22 00:00:00

abstract：:Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in prima...

journal_title：Antimicrobial agents and chemotherapy

authors： Clercq ED,Janik B,Sommer RG

更新日期：1977-04-01 00:00:00

abstract：:Viral regulatory complexes perform critical functions during virus replication and are important targets for therapeutic intervention. In HIV, the Tat and Rev proteins form complexes with multiple viral and cellular factors to direct transcription and export of the viral RNA. These complexes are composed of many prote...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura RL,Burlingame MA,Yang S,Crosby DC,Talbot DJ,Chui K,Frankel AD,Renslo AR

更新日期：2017-06-27 00:00:00

abstract：:In vitro susceptibility tests were performed on 84 strains of Clostridium difficile to 11 antimicrobial agents. All isolates were from the stools of patients with antibiotic-associated diarrhea or colitis in which there was a cytopathic toxin that was neutralized by Clostridium sordellii antitoxin. Over 95% of the str...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzink J,Bartlett JG

更新日期：1980-04-01 00:00:00

abstract：:Eravacycline is a fluorocycline antibiotic in phase 3 clinical development for complicated intra-abdominal and urinary tract infections. To support its clinical development, a study was conducted to evaluate the effects of various susceptibility test parameters on the MIC values for aerobic bacteria. The results showe...

journal_title：Antimicrobial agents and chemotherapy

authors： Grossman TH,Pillar CM,Sahm DF,Sutcliffe JA

更新日期：2015-04-01 00:00:00

abstract：:Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitory activity on the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Korduláková J,Janin YL,Liav A,Barilone N,Dos Vultos T,Rauzier J,Brennan PJ,Gicquel B,Jackson M

更新日期：2007-11-01 00:00:00

abstract：:The behavioral and convulsant effects of cefazolin, a beta-lactam derivative, were studied after intraperitoneal administration to DBA/2 mice, a strain genetically susceptible to sound-induced seizures, and Swiss mice. DBA/2 mice were more susceptible to seizures induced by cefazolin than were Swiss mice. The proconvu...

journal_title：Antimicrobial agents and chemotherapy

authors： De Sarro A,Zappalá M,Chimirri A,Grasso S,De Sarro GB

更新日期：1993-07-01 00:00:00

abstract：:Whole and fractionated latex of Asclepias syriaca was tested for antimicrobial or growth-promoting activity with 16 genera and species of bacteria. Latex and extracted fractions (distilled water, acetic acid, sodium bicarbonate, sulfuric acid, and ethyl ether) possessed no detectable antimicrobial activity. Comparison...

journal_title：Antimicrobial agents and chemotherapy

authors： McCay S,Mahlberg P

更新日期：1973-02-01 00:00:00

abstract：:Leishmania mexicana is a protozoan parasite that causes a disease in humans with frequent relapses after treatment. It is also highly resistant to the currently available drugs. For this reason, there is an urgent need for more effective antileishmanial drugs. Hydroxyurea, an anticancer drug, is toxic to replicating e...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez-Rojano H,Mancilla-Ramirez J,Quiñonez-Diaz L,Galindo-Sevilla N

更新日期：2008-10-01 00:00:00

abstract：:Ninety-two strains of Yersinia pestis recovered over a 21-year period were evaluated for susceptibility to traditional and newer antimicrobial agents. In vitro resistance was noted only against rifampin and imipenem (approximately 20% of strains). The most active compounds (MIC at which 90% of the isolates tested are ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wong JD,Barash JR,Sandfort RF,Janda JM

更新日期：2000-07-01 00:00:00

abstract：:We investigated both the structural and functional consequences of modifying the hydrophobic, lipopeptide-mimetic oligo-acyl-lysine (OAK) N(alpha)-hexadecanoyl-l-lysyl-l-lysyl-aminododecanoyl-l-lysyl-amide (c(16)KKc(12)K) to its unsaturated analog hexadecenoyl-KKc(12)K [c(16(omega7))KKc(12)K]. Despite similar tendenci...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarig H,Rotem S,Ziserman L,Danino D,Mor A

更新日期：2008-12-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children and other high-risk populations. RSV nucleoprotein (N) is essential for virus assembly and replication as part of the viral ribonucleoprotein (RNP) complex. RSV604 was a putative N inhibitor in phase 2 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Challa S,Scott AD,Yuzhakov O,Zhou Y,Tiong-Yip CL,Gao N,Thresher J,Yu Q

更新日期：2015-02-01 00:00:00

abstract：:Teicoplanin is an investigational glycopeptide antibiotic that is structurally and microbiologically similar to vancomycin. Since teicoplanin possesses a very long elimination half-life, the manufacturer suggests that the drug be administered every 12 h for the first day of therapy and once daily thereafter. We studie...

journal_title：Antimicrobial agents and chemotherapy

authors： Outman WR,Nightingale CH,Sweeney KR,Quintiliani R

更新日期：1990-11-01 00:00:00

abstract：:(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized dioxolanylpurine nucleoside derivatives being developed as potential prodrugs for the antiviral nucleoside analog (-)-beta-D-dioxolane guanine (DXG). In vitro, APD and ACPD are converted to DXG by x...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen H,Boudinot FD,Chu CK,Mcclure HM,Schinazi RF

更新日期：1996-10-01 00:00:00

abstract：:The in vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 μM. The growth of an amikacin-resistant Klebsiella pneumoniae strain isolated from a neonate with meningitis was inhibited when amikacin was supplemented by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiem K,Fuentes BA,Lin DL,Tran T,Jackson A,Ramirez MS,Tolmasky ME

更新日期：2015-09-01 00:00:00

abstract：:The increasing use of azole antifungals for the treatment of mucosal and systemic Candida glabrata infections has resulted in the selection and/or emergence of resistant strains. The main mechanisms of azole resistance include alterations in the C. glabrata ERG11 gene (CgERG11), which encodes the azole target enzyme, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanguinetti M,Posteraro B,Fiori B,Ranno S,Torelli R,Fadda G

更新日期：2005-02-01 00:00:00

abstract：:The dependence of microbial killing on chloride ions present in solutions undergoing iontophoresis is addressed. A 400-microA current was applied to vials containing synthetic urine or saline, and the production of chlorine-based substances (CBSs) was detected by the N,N-diethyl-p-phenylene diamine colorimetric method...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis CP,Shirtliff ME,Trieff NM,Hoskins SL,Warren MM

更新日期：1994-12-01 00:00:00

abstract：:We report on the cloning of the gene smeT, which encodes the transcriptional regulator of the Stenotrophomonas maltophilia efflux pump SmeDEF. SmeT belongs to the TetR and AcrR family of transcriptional regulators. The smeT gene is located upstream from the structural operon of the pump genes smeDEF and is divergently...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez P,Alonso A,Martinez JL

更新日期：2002-11-01 00:00:00

abstract：:The hyl(Efm) gene (encoding a putative hyaluronidase) has been found almost exclusively in Enterococcus faecium clinical isolates, and recently, it was shown to be on a plasmid which increased the ability of E. faecium strains to colonize the gastrointestinal tract. In this work, the results of mating experiments betw...

journal_title：Antimicrobial agents and chemotherapy

authors： Arias CA,Panesso D,Singh KV,Rice LB,Murray BE

更新日期：2009-10-01 00:00:00

abstract：:In the course of surveying for the carbapenem-hydrolyzing metallo-beta-lactamase gene bla(IMP) in pathogenic bacteria by the PCR method, we detected a gene encoding a variant metallo-beta-lactamase, designated IMP-3, which differed from IMP-1 by having low hydrolyzing activity for penicillins and carbapenems. PCR prod...

journal_title：Antimicrobial agents and chemotherapy

authors： Iyobe S,Kusadokoro H,Ozaki J,Matsumura N,Minami S,Haruta S,Sawai T,O'Hara K

更新日期：2000-08-01 00:00:00

abstract：:Minimum inhibitory concentrations (MICs) of six penicillins against 95 strains of Neisseria gonorrhoeae from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. Against all 117 strain...

journal_title：Antimicrobial agents and chemotherapy

authors： Sackel SG,Alpert S,Rosner B,McCormack WM,Finland M

更新日期：1977-07-01 00:00:00

abstract：:Concomitant treatment of tuberculosis (TB) and HIV is recommended and improves outcomes. Bedaquiline is a novel drug for the treatment of multidrug-resistant (MDR) TB; combined use with antiretroviral drugs, nevirapine, or ritonavir-boosted lopinavir (LPV/r) is anticipated, but no clinical data from coinfected patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Svensson EM,Dooley KE,Karlsson MO

更新日期：2014-11-01 00:00:00

abstract：:Fifty-seven Salmonella enterica serotype Typhimurium (S. typhimurium) isolates were collected from human patients in two French hospitals, Hôpital Antoine Béclère (Clamart, France) and Hôpital Bicêtre (Le Kremlin-Bicêtre, France), between 1996 and 1997. Thirty of them (52 percent) were resistant to amino-, carbeni-, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Guibert M,Bellais S,Naas T,Nordmann P

更新日期：1999-05-01 00:00:00

abstract：:Enterococci are intrinsically resistant to numerous antimicrobial agents. We examined the energy-dependent efflux of radiolabeled drugs from four reference strains of Enterococcus faecalis and a strain of Enterococcus faecium and found that most strains pumped out norfloxacin and chloramphenicol. Efflux of tetracyclin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lynch C,Courvalin P,Nikaido H

更新日期：1997-04-01 00:00:00

abstract：:A clinical isolate of Bacteroides vulgatus was resistant to tetracycline, clindamycin, ampicillin, cephaloridine, cefoxitin, and other beta-lactam antibiotics except imipenem. beta-Lactam resistance was mediated by a membrane-associated, clavulanate-sensitive cephalosporinase capable of degrading cephalosporins and pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Parker AC,Smith CJ

更新日期：1993-05-01 00:00:00