Quinolones potentiate cefazolin-induced seizures in DBA/2 mice.

abstract：:The pore-forming microcin E492 was purified by solid-phase extraction and reversed-phase high-pressure liquid chromatography. Its molecular mass was 7,886 Da. The entire 84-amino-acid sequence was determined. There is no postranslational modification in the secreted microcin, and the sequence has homologies with the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Pons AM,Zorn N,Vignon D,Delalande F,Van Dorsselaer A,Cottenceau G

更新日期：2002-01-01 00:00:00

abstract：:The emergence of human immunodeficiency virus type 1 (HIV-1) strains resistant to highly active antiretroviral therapy necessitates continued drug discovery for the treatment of HIV-1 infection. Most current drug discovery strategies focus upon a single aspect of HIV-1 replication. A virus-cell-based assay, which can ...

journal_title：Antimicrobial agents and chemotherapy

authors： Adelson ME,Pacchia AL,Kaul M,Rando RF,Ron Y,Peltz SW,Dougherty JP

更新日期：2003-02-01 00:00:00

abstract：:The aminoglycoside Geneticin (G418) is known to inhibit cell culture proliferation, via virus-specific mechanisms, of two different virus genera from the family Flaviviridae. Here, we tried to determine whether Geneticin can selectively alter the switching of the nucleotide 1 to 570 RNA region of hepatitis C virus (HC...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza-Mateos A,Díaz-Toledano R,Block TM,Prieto-Vega S,Birk A,Gómez J

更新日期：2015-11-30 00:00:00

abstract：:According to recommendations of the 6th WHO Advisory Committee on Buruli ulcer, directly observed treatment with the combination of rifampin and streptomycin, administered daily for 8 weeks, was recommended to 310 patients diagnosed with Buruli ulcer in Pobè, Bénin. Among the 224 (72%) eligible patients for whom treat...

journal_title：Antimicrobial agents and chemotherapy

authors： Chauty A,Ardant MF,Adeye A,Euverte H,Guédénon A,Johnson C,Aubry J,Nuermberger E,Grosset J

更新日期：2007-11-01 00:00:00

abstract：:The effects of probenecid on the pharmacokinetics and renal clearance of acyclovir were studied in humans. Acyclovir (5 mg/kg) was given as a 1-h infusion to three volunteers with normal renal function both before and after oral administration of probenecid (1 g). The kinetics were well described by a two-compartment ...

journal_title：Antimicrobial agents and chemotherapy

authors： Laskin OL,de Miranda P,King DH,Page DA,Longstreth JA,Rocco L,Lietman PS

更新日期：1982-05-01 00:00:00

abstract：:In vitro susceptibility tests were performed on 84 strains of Clostridium difficile to 11 antimicrobial agents. All isolates were from the stools of patients with antibiotic-associated diarrhea or colitis in which there was a cytopathic toxin that was neutralized by Clostridium sordellii antitoxin. Over 95% of the str...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzink J,Bartlett JG

更新日期：1980-04-01 00:00:00

abstract：:The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although several drugs are available for the treatment of giardiasis, drug resistance has been reported and is likely to increase, and recurrent infections are common. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CZ,Kulakova L,Southall N,Marugan JJ,Galkin A,Austin CP,Herzberg O,Zheng W

更新日期：2011-02-01 00:00:00

abstract：:Two aminocyclitol-negative Micromonospora mutants representing two different species, M. purpurea and M. inyoensis, and blocked at different steps in the biosynthetic pathway were paired and cofermented for the synthesis of antibiotics. The two blocked mutants were incapable of producing antibiotics alone except when ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee BK,Nagabhushan TL,Condon RG,Cooper AB,Waitz JA

更新日期：1978-07-01 00:00:00

abstract：:Mutants of feline immunodeficiency virus (FIV) were selected in cell culture in the continuous presence of 10 microM (each) 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). These mutants (AIR-1 and AIR-3) displayed a 13-fold resistance to AZT but had less than a 2-fold decrease in susceptibility to ddI...

journal_title：Antimicrobial agents and chemotherapy

authors： Gobert JM,Remington KM,Zhu YQ,North TW

更新日期：1994-04-01 00:00:00

abstract：:The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DN...

journal_title：Antimicrobial agents and chemotherapy

authors： Fourel I,Hantz O,Watanabe KA,Jacquet C,Chomel B,Fox JJ,Trepo C

更新日期：1990-03-01 00:00:00

abstract：:Miconazole, a broad-spectrum antimycotic agent with some antibacterial activity, has recently become available for experimental parenteral use in the United States. Its efficacy as an anticandidal drug was tested in adult Wistar rats. A previously established infectious dose of 5 x 10(6)Candida albicans was intravenou...

journal_title：Antimicrobial agents and chemotherapy

authors： Balk MW,Crumrine MH,Fischer GW

更新日期：1978-02-01 00:00:00

abstract：:Genome studies suggest that DNA gyrase is the sole type II topoisomerase and likely the unique target of quinolones in Mycobacterium tuberculosis. Despite the emerging importance of quinolones in the treatment of mycobacterial disease, the slow growth and high pathogenicity of M. tuberculosis have precluded direct pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Aubry A,Pan XS,Fisher LM,Jarlier V,Cambau E

更新日期：2004-04-01 00:00:00

abstract：:The free ligand, deferroviridomycin A, and its iron(II) complex, viridomycin A, were detected in culture supernatant fluids of Streptomyces viridans 1671 and were structurally characterized as 4-hydroxy-3-nitrosobenzaldehyde and tris(4-hydroxy-3-nitrosobenzaldehydato-N3,O4)ferrate(II), respectively. We investigated th...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang CC,Leong J

更新日期：1981-10-01 00:00:00

abstract：:Among 730 Escherichia coli, 438 Klebsiella pneumoniae, and 141 Proteus mirabilis isolates obtained between September 2000 and September 2001 in seven hospitals in Ho Chi Minh City, Vietnam, 26.6% were resistant to ceftazidime, 30% were resistant to cefotaxime, 31.5% were resistant to ceftriaxone, 15.9% were resistant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao V,Lambert T,Nhu DQ,Loan HK,Hoang NK,Arlet G,Courvalin P

更新日期：2002-12-01 00:00:00

abstract：:A Staphylococcus aureus surveillance program was initiated in the United States to examine the in vitro activity of ceftaroline and epidemiologic trends. Susceptibility testing by Clinical and Laboratory Standards Institute broth microdilution was performed on 4,210 clinically significant isolates collected in 2009 fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter SS,Heilmann KP,Dohrn CL,Riahi F,Costello AJ,Kroeger JS,Biek D,Critchley IA,Diekema DJ,Doern GV

更新日期：2011-09-01 00:00:00

abstract：:The pharmacokinetic disposition of 2 g of cefoxitin administered intravenously over 30 min was determined in six patients undergoing continuous ambulatory peritoneal dialysis for chronic renal failure. During the 6-h dialysate dwell time after the drug infusion, the mean apparent volume of distribution for cefoxitin w...

journal_title：Antimicrobial agents and chemotherapy

authors： Greaves WL,Kreeft JH,Ogilvie RI,Richards GK

更新日期：1981-02-01 00:00:00

abstract：:Whole and fractionated latex of Asclepias syriaca was tested for antimicrobial or growth-promoting activity with 16 genera and species of bacteria. Latex and extracted fractions (distilled water, acetic acid, sodium bicarbonate, sulfuric acid, and ethyl ether) possessed no detectable antimicrobial activity. Comparison...

journal_title：Antimicrobial agents and chemotherapy

authors： McCay S,Mahlberg P

更新日期：1973-02-01 00:00:00

abstract：:Ga(3+) is a semimetal element that competes for the iron-binding sites of transporters and enzymes. We investigated the activity of gallium maltolate (GaM), an organic gallium salt with high solubility, against laboratory and clinical strains of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Baldoni D,Steinhuber A,Zimmerli W,Trampuz A

更新日期：2010-01-01 00:00:00

abstract：:Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nedelman JR,Salinger DH,Subramoney V,Woolson R,Wade K,Li M,Everitt D,Mendel CM,Spigelman M

更新日期：2020-12-16 00:00:00

abstract：:Secondary resistance to azoles in Aspergillus fumigatus isolates from patients taking long-term itraconazole therapy has been described. We studied the acquisition of secondary azole resistance in 20 A. fumigatus isolates with no mutations at codon 54, 98, 138, 220, 432, or 448 in the cyp51A gene. Adjusted conidium in...

journal_title：Antimicrobial agents and chemotherapy

authors： Escribano P,Recio S,Peláez T,González-Rivera M,Bouza E,Guinea J

更新日期：2012-01-01 00:00:00

abstract：:Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye KS,Cosgrove S,Harris A,Eliopoulos GM,Carmeli Y

更新日期：2001-09-01 00:00:00

abstract：:Multivariate techniques such as principal component analysis or similar factor analysis help in analyses of the simultaneous interrelationships among several variables. A comparative multivariate analysis on the in vitro activities of eight antimicrobial agents, including the novel molecule daptomycin, is presented. M...

journal_title：Antimicrobial agents and chemotherapy

authors： Hernández JM,Conforti P

更新日期：1994-02-01 00:00:00

abstract：:Mutants of attenuated Bacillus anthracis with high-level ciprofloxacin resistance were isolated using a three-step in vitro selection. Ciprofloxacin MICs were 0.5 micro g/ml for first-step mutants, which had one of two gyrA quinolone resistance-determining region (QRDR) mutations. Ciprofloxacin MICs were 8 and 16 micr...

journal_title：Antimicrobial agents and chemotherapy

authors： Price LB,Vogler A,Pearson T,Busch JD,Schupp JM,Keim P

更新日期：2003-07-01 00:00:00

abstract：:Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing Alcaligenes faecalis isolates associated with a small outb...

journal_title：Antimicrobial agents and chemotherapy

authors： Al Laham N,Chavda KD,Cienfuegos-Gallet AV,Kreiswirth BN,Chen L

更新日期：2017-10-24 00:00:00

abstract：:Artermisinin and its derivatives are now the mainstays of antimalarial treatment; however, their mechanism of action is only poorly understood. We report on the synthesis of a novel series of epoxy-endoperoxides that can be prepared in high yields from simple starting materials. Endoperoxides that are disubstituted wi...

journal_title：Antimicrobial agents and chemotherapy

authors： del Pilar Crespo M,Avery TD,Hanssen E,Fox E,Robinson TV,Valente P,Taylor DK,Tilley L

更新日期：2008-01-01 00:00:00

abstract：:In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported. The pharmacokinetic properties of artesunate-azithromycin given in combination are comparable to those of the drugs given alone. Artesunate an...

journal_title：Antimicrobial agents and chemotherapy

authors： Chinh NT,Quang NN,Anh CX,Thanh NX,Dai B,Birrell GW,Chavchich M,Edstein MD

更新日期：2011-09-01 00:00:00

abstract：:The K70E mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has become more prevalent in clinical samples, particularly in isolates derived from patients for whom triple-nucleoside regimens that include tenofovir (TNV), abacavir, and lamivudine (3TC) failed. To elucidate the molecular m...

journal_title：Antimicrobial agents and chemotherapy

authors： Sluis-Cremer N,Sheen CW,Zelina S,Torres PS,Parikh UM,Mellors JW

更新日期：2007-01-01 00:00:00

abstract：:The beta-lactamases in 154 clinical Mycobacterium tuberculosis strains were studied. Susceptibilities to beta-lactam antibiotics, their combination with clavulanate (2:1), and two fluoroquinolones were determined in 24 M. tuberculosis strains susceptible to antimycobacterial drugs and in nine multiresistant strains. A...

journal_title：Antimicrobial agents and chemotherapy

authors： Segura C,Salvadó M,Collado I,Chaves J,Coira A

更新日期：1998-06-01 00:00:00

abstract：:The objectives of this study were to (i) construct a population pharmacokinetic (PK) model able to describe vancomycin (VAN) concentrations in serum in pediatric patients, (ii) determine VAN PK parameters in this population, and (iii) validate the predictive ability of this model in a naive pediatric population. Data ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamarre P,Lebel D,Ducharme MP

更新日期：2000-02-01 00:00:00

abstract：:Liposomal formulations of rifabutin were developed, and the effects of some parameters on the incorporation efficiency were studied. The antimycobacterial activity of rifabutin incorporated into liposomes prepared with phosphatidylcholine and phosphatidylserine (molar ratio, 7:3) was evaluated in a murine model of inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaspar MM,Neves S,Portaels F,Pedrosa J,Silva MT,Cruz ME

更新日期：2000-09-01 00:00:00