Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp.

abstract：:Nitazoxanide (NTZ), a drug currently being tested in human clinical trials for efficacy against chronic cryptosporidiosis, was assessed in cell culture and in two animal models. The inhibitory activity of NTZ was compared with that of paromomycin (PRM), a drug that is partially effective against Cryptosporidium parvum...

journal_title：Antimicrobial agents and chemotherapy

authors： Theodos CM,Griffiths JK,D'Onfro J,Fairfield A,Tzipori S

更新日期：1998-08-01 00:00:00

abstract：:Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkevich NV,Basu S,Rudge TL Jr,Clement KH,Chakrabarti AC,Aimes RT,Nabors GS,Skiadopoulos MH,Ionin B

更新日期：2013-11-01 00:00:00

abstract：:Polyhexylcyanoacrylate nanoparticles loaded with either the human immunodeficiency virus (HIV) protease inhibitor saquinavir (Ro 31-8959) or the nucleoside analog zalcitabine (2',3'-dideoxycytidine) were prepared by emulsion polymerization and tested for antiviral activity in primary human monocytes/macrophages in vit...

journal_title：Antimicrobial agents and chemotherapy

authors： Bender AR,von Briesen H,Kreuter J,Duncan IB,Rübsamen-Waigmann H

更新日期：1996-06-01 00:00:00

abstract：:We previously demonstrated the potent in vitro activity of erythromycin against Mycobacterium leprae as determined by its effect on ATP pools and rates of palmitate oxidation and phenolic glycolipid I synthesis. In the present study, the relative in vitro activities of a number of new macrolides with superior pharmaco...

journal_title：Antimicrobial agents and chemotherapy

authors： Franzblau SG,Hastings RC

更新日期：1988-12-01 00:00:00

abstract：:Multiresistant enterococci were tested for susceptibility to trimethoprim (TMP). Although most enterococci are inhibited by less than or equal to 1.0 microgram/ml, the MICs for 7 of 29 selected multiresistant isolates were greater than or equal to 8 micrograms/ml, including for two beta-lactamase positive (Bla+) strai...

journal_title：Antimicrobial agents and chemotherapy

authors： Frosolono M,Hodel-Christian SL,Murray BE

更新日期：1991-09-01 00:00:00

abstract：:Tetracycline-resistant isolates of Pasteurella multocida and Pasteurella haemolytica obtained from various locations in the United States and Canada were studied to determine the distribution of the tet(H) gene. Of the 31 isolates examined, 25 were found to contain the tet(H) gene. Chromosomal or plasmid DNA obtained ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hansen LM,Blanchard PC,Hirsh DC

更新日期：1996-06-01 00:00:00

abstract：:The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS were potent inhibitors of the infectivity of HSV-2 str...

journal_title：Antimicrobial agents and chemotherapy

authors： Roy S,Gourde P,Piret J,Désormeaux A,Lamontagne J,Haineault C,Omar RF,Bergeron MG

更新日期：2001-06-01 00:00:00

abstract：:Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both...

journal_title：Antimicrobial agents and chemotherapy

authors： Arrighi RB,Ebikeme C,Jiang Y,Ranford-Cartwright L,Barrett MP,Langel U,Faye I

更新日期：2008-09-01 00:00:00

abstract：:No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Downey AS,Chong CR,Graczyk TK,Sullivan DJ

更新日期：2008-09-01 00:00:00

abstract：:The mechanism of action of quinolones was investigated by use of various DNA gyrases reconstituted from wild-type and mutant GyrA and GyrB proteins of Escherichia coli. The quinolone sensitivities of the DNA supercoiling activity of the gyrases were generally parallel to the quinolone susceptibilities of strains havin...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoshida H,Nakamura M,Bogaki M,Ito H,Kojima T,Hattori H,Nakamura S

更新日期：1993-04-01 00:00:00

abstract：:The gyrA and gyrB genes of Chlamydia pneumoniae TW-183 were cloned, and their proteins were purified by use of a fusion system with a maltose-binding protein. The 50% inhibitory concentrations of garenoxacin, sparfloxacin, moxifloxacin, gatifloxacin, and levofloxacin were 10.1, 47.5, 39.6, 64.2, and 156.9 microg/ml, r...

journal_title：Antimicrobial agents and chemotherapy

authors： Ameyama S,Shinmura Y,Takahata M

更新日期：2003-07-01 00:00:00

abstract：:Clinical isolates of Trichomonas vaginalis were obtained from women consecutively enrolled in a study of partner notification. Testing of susceptibility to metronidazole and tinidazole was performed. Resistance to metronidazole and tinidazole was present in 17/178 (9.6%) and 1/178 (0.56%) strains, respectively. In vit...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwebke JR,Barrientes FJ

更新日期：2006-12-01 00:00:00

abstract：:The in vitro activity of rosamicin and erythromycin was compared at various pH values against 311 strains of bacteria representing common urinary tract pathogens. Alkalinization of the media consistently and significantly increased the antibacterial activity of rosamicin against all of the organisms tested. This was a...

journal_title：Antimicrobial agents and chemotherapy

authors： Eickhoff TC,Ehret JM

更新日期：1979-07-01 00:00:00

abstract：:Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Stockbauer KE,Williams DL,Kreiswirth BN,Musser JM

更新日期：1996-04-01 00:00:00

abstract：:Surveillance of the circulating Mycobacterium tuberculosis complex (MTC) strains in a given locality is important for understanding tuberculosis (TB) epidemiology. We performed molecular epidemiological studies on sputum smear-positive isolates that were collected for anti-TB drug resistance surveillance to establish ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lukoye D,Katabazi FA,Musisi K,Kateete DP,Asiimwe BB,Okee M,Joloba ML,Cobelens FG

更新日期：2014-07-01 00:00:00

abstract：:We have developed a new recombinant retroviral system in which a library of infectious molecular clones of human immunodeficiency virus type 1 (HIV-1) is constructed with reverse transcriptase (RT) genes derived from viral RNA sequences in plasma. HIV-1 RT is amplified from plasma HIV-1 RNA by nested RT-PCR and cloned...

journal_title：Antimicrobial agents and chemotherapy

authors： Shi C,Mellors JW

更新日期：1997-12-01 00:00:00

abstract：:We recently reported the chromosomal location of the staphylococcal beta-lactamase gene in four strains of Enterococcus faecalis. Transfer of this gene from strain CH19 to an enterococcal recipient was accompanied by transfer of numerous other antimicrobial resistance determinants in the absence of detectable plasmid ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rice LB,Marshall SH

更新日期：1992-09-01 00:00:00

abstract：:The present study investigated the effect of a model urease-binding polysaccharide in combination with a histamine H(2) receptor antagonist on Helicobacter pylori colonization in vivo. Euthymic hairless mice were treated daily with dextran sulfate via drinking water and/or famotidine via intragastric gavage starting a...

journal_title：Antimicrobial agents and chemotherapy

authors： Icatlo FC Jr,Kimura N,Goshima H,Kodama Y

更新日期：2000-09-01 00:00:00

abstract：:The pore-forming microcin E492 was purified by solid-phase extraction and reversed-phase high-pressure liquid chromatography. Its molecular mass was 7,886 Da. The entire 84-amino-acid sequence was determined. There is no postranslational modification in the secreted microcin, and the sequence has homologies with the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Pons AM,Zorn N,Vignon D,Delalande F,Van Dorsselaer A,Cottenceau G

更新日期：2002-01-01 00:00:00

abstract：:Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 mug/ml. Rifampin alone was without effect. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rifkind D,Crowder ED,Hyland RN

更新日期：1974-12-01 00:00:00

abstract：:Forty-one patients with erythema migrans were enrolled in an open-labelled pilot study of oral clarithromycin, 500 mg twice daily for 21 days, for the treatment of early Lyme disease. Immediately posttherapy, pretreatment signs and symptoms resolved among 91% of the 33 evaluable patients. At 6 months, all 28 of the ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Dattwyler RJ,Grunwaldt E,Luft BJ

更新日期：1996-02-01 00:00:00

abstract：:We have reported previously that methylenecyclopropane analogs of nucleosides have excellent activity against certain members of the herpesvirus family. A second generation, the 2,2-bis-hydroxymethyl derivatives, were synthesized, and 18 compounds were tested for activity in vitro against herpes simplex virus types 1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Kushner NL,Hartline CB,Williams-Aziz SL,Harden EA,Zhou S,Zemlicka J,Prichard MN

更新日期：2005-03-01 00:00:00

abstract：:Colistin is increasingly being utilized against Gram-negative pathogens, including Pseudomonas aeruginosa, resistant to all other antibiotics. Since limited data exist regarding killing by colistin at different initial inocula (CFUo), we evaluated killing of Pseudomonas aeruginosa by colistin at several CFUo and devel...

journal_title：Antimicrobial agents and chemotherapy

authors： Bulitta JB,Yang JC,Yohonn L,Ly NS,Brown SV,D'Hondt RE,Jusko WJ,Forrest A,Tsuji BT

更新日期：2010-05-01 00:00:00

abstract：:Alpha interferon and ribavirin are required in combination to achieve a sustained virological response in the treatment of hepatitis C virus (HCV) infection. Alpha interferon has direct antiviral activity and also enhances HCV-specific T-cell responses. Ribavirin has little direct activity against HCV but reduces hepa...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes E,Salio M,Cerundolo V,Medlin J,Murphy S,Dusheiko G,Klenerman P

更新日期：2004-09-01 00:00:00

abstract：:The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 microCi) of [(3)H]caspofungin to healthy men, plasma, urine, and feces were collected over 27 days in study A (n = 6) and plasma was collected over 26 weeks in study B (n = 7). Su...

journal_title：Antimicrobial agents and chemotherapy

authors： Stone JA,Xu X,Winchell GA,Deutsch PJ,Pearson PG,Migoya EM,Mistry GC,Xi L,Miller A,Sandhu P,Singh R,deLuna F,Dilzer SC,Lasseter KC

更新日期：2004-03-01 00:00:00

abstract：:Ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB], is a first-line drug used to treat tuberculosis. To gain insight into the molecular basis of EMB resistance, we characterized the 10-kb embCAB locus in 16 EMB-resistant and 3 EMB-susceptible genetically distinct Mycobacterium tuberculosis strains from divers...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Stockbauer KE,Pan X,Kreiswirth BN,Moghazeh SL,Jacobs WR Jr,Telenti A,Musser JM

更新日期：1997-08-01 00:00:00

abstract：:Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam hydrolysis and class B metalloenzymes which require divalent zinc ions for substrate hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Jacoby GA

更新日期：2010-03-01 00:00:00

abstract：:We report a microanalytical high-performance liquid chromatography method for quantitation of cefpirome (HR 810) from serum. The drug was extracted from 0.05 ml of serum with 0.2 ml of isopropanol containing beta-hydroxypropyltheophylline, the internal standard. Separations were performed on a C18 column at ambient te...

journal_title：Antimicrobial agents and chemotherapy

authors： Turley CP,Kearns GL,Jacobs RF

更新日期：1988-10-01 00:00:00

abstract：:Ninety-four patients with recurrences of genital herpes were randomized in a double-blind trial to receive topical therapy for 5 days with either alpha-2a interferon at 30 X 10(6) IU/ml or 10 X 10(6) IU/ml or placebo six times daily. No differences were noted between either interferon dose and placebo with respect to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eron LJ,Toy C,Salsitz B,Scheer RR,Wood DL,Nadler PI

更新日期：1987-07-01 00:00:00

abstract：:Ribonucleoside analog inhibitors (rNAI) target the hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B) and cause RNA chain termination. Here, we expand our studies on β-d-2'-C-methyl-2,6-diaminopurine-ribonucleotide (DAPN) phosphoramidate prodrug 1 (PD1) as a novel investigational inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Ehteshami M,Tao S,Ozturk T,Zhou L,Cho JH,Zhang H,Amiralaei S,Shelton JR,Lu X,Khalil A,Domaoal RA,Stanton RA,Suesserman JE,Lin B,Lee SS,Amblard F,Whitaker T,Coats SJ,Schinazi RF

更新日期：2016-07-22 00:00:00