Prevalence of Trichomonas vaginalis isolates with resistance to metronidazole and tinidazole.

abstract：:Microdialysis was applied to sample the unbound drug concentration in the extracellular fluid in brain and muscle of rats given zalcitabine (2',3'-dideoxycytidine; n = 4) or BEA005 (2', 3'-dideoxy-3'-hydroxymethylcytidine; n = 4) (50 mg/kg of body weight given subcutaneously). Zalcitabine and BEA005 were analyzed by h...

journal_title：Antimicrobial agents and chemotherapy

authors： Borg N,Ståhle L

更新日期：1998-09-01 00:00:00

abstract：:Accumulating data have brought the nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) into the forefront of antiretroviral therapy. Among the emerging compounds in this class, a particularly attractive one is efavirenz (Sustiva), recently approved for clinical use by the U.S. Food and Drug Administration. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Maga G,Ubiali D,Salvetti R,Pregnolato M,Spadari S

更新日期：2000-05-01 00:00:00

abstract：:We report on the cloning of the gene smeT, which encodes the transcriptional regulator of the Stenotrophomonas maltophilia efflux pump SmeDEF. SmeT belongs to the TetR and AcrR family of transcriptional regulators. The smeT gene is located upstream from the structural operon of the pump genes smeDEF and is divergently...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez P,Alonso A,Martinez JL

更新日期：2002-11-01 00:00:00

abstract：:Structure-function relationships in antimicrobial peptides have been extensively investigated in order to obtain improved analogs. Most of these studies have targeted either alpha-helical peptides or beta-sheet peptides with multiple disulfide bridges. Tigerinins are short, nonhelical antimicrobial peptides with a sin...

journal_title：Antimicrobial agents and chemotherapy

authors： Sitaram N,Sai KP,Singh S,Sankaran K,Nagaraj R

更新日期：2002-07-01 00:00:00

abstract：:Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, and expressed the wild-type B. gibsoni dhfr-ts gene in Escherichia coli and evaluated the inhib...

journal_title：Antimicrobial agents and chemotherapy

authors： Aboge GO,Jia H,Terkawi MA,Goo YK,Nishikawa Y,Sunaga F,Namikawa K,Tsuji N,Igarashi I,Suzuki H,Fujisaki K,Xuan X

更新日期：2008-11-01 00:00:00

abstract：:Within wounds, microorganisms predominantly exist as biofilms. Biofilms are associated with chronic infections and represent a tremendous clinical challenge. As antibiotics are often ineffective against biofilms, use of dispersal agents as adjunctive, topical therapies for the treatment of wound infections involving b...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanchez CJ Jr,Akers KS,Romano DR,Woodbury RL,Hardy SK,Murray CK,Wenke JC

更新日期：2014-08-01 00:00:00

abstract：:Fungal infections are a leading cause of morbidity and death for hospitalized patients, mainly because they remain difficult to diagnose and to treat. Diseases range from widespread superficial infections such as vulvovaginal infections to life-threatening systemic candidiasis. For systemic mycoses, only a restricted ...

journal_title：Antimicrobial agents and chemotherapy

authors： Keller P,Müller C,Engelhardt I,Hiller E,Lemuth K,Eickhoff H,Wiesmüller KH,Burger-Kentischer A,Bracher F,Rupp S

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to investigate the influence of hypovolemia on the distribution of imipenem in muscle extracellular fluid determined by microdialysis in awake rats. Microdialysis probes were inserted into the jugular vein and hind leg muscle. Imipenem recoveries in muscle and blood were determined in each ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchand S,Dahyot C,Lamarche I,Plan E,Mimoz O,Couet W

更新日期：2005-12-01 00:00:00

abstract：:Mammalian cathelicidins are a class of innate antimicrobial peptides isolated from leukocytes and epithelial cells that aid host defense against bacterial infections. Synthetic analogs of cathelicidins offer the promise of potent broad-spectrum antimicrobial efficacy. We developed a combined lung infection and ex vivo...

journal_title：Antimicrobial agents and chemotherapy

authors： Bartlett KH,McCray PB Jr,Thorne PS

更新日期：2003-12-01 00:00:00

abstract：:Norfloxacin is a quinolone (pyridonecarboxylic acid derivative) effective against Pseudomonas aeruginosa infections. We studied the effects of this drug on DNA metabolism in P. aeruginosa. Norfloxacin inhibits DNA replication immediately on its addition to a logarithmically growing culture of P. aeruginosa. It inhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Benbrook DM,Miller RV

更新日期：1986-01-01 00:00:00

abstract：:A rapid (6-7 hr), modified Kirby-Bauer disk-susceptibility method, by which derivatives of tetrazolium dyes are used to enhance delineation between areas of growth and zones of inhibition, has been developed. Inoculated petri plates, prepared by the Kirby-Bauer method, were sprayed, after 6 to 7 hr of incubation (37 C...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyle VJ,Fancher ME,Ross RW Jr

更新日期：1973-03-01 00:00:00

abstract：:Intravenous ampicillin-sulbactam is effective in the treatment of various infections in adults, but little is known about the pharmacokinetics (PK) of ampicillin-sulbactam in children. The objective of this study was to determine the PK of ampicillin and sulbactam in pediatric patients with intra-abdominal infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nahata MC,Vashi VI,Swanson RN,Messig MA,Chung M

更新日期：1999-05-01 00:00:00

abstract：:Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-...

journal_title：Antimicrobial agents and chemotherapy

authors： Weinberg A,Bate BJ,Masters HB,Schneider SA,Clark JC,Wren CG,Allaman JA,Levin MJ

更新日期：1992-09-01 00:00:00

abstract：:Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mechanisms have been described, no information is available to date conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Dupont M,James CE,Chevalier J,Pagès JM

更新日期：2007-09-01 00:00:00

abstract：:No studies have investigated whether discontinuation of ethambutol (EMB) based on the susceptibility to isoniazid and rifampin as determined by the GenoType MTBDRplus assay would be appropriate. We aimed to determine the feasibility of discontinuing EMB before the end of intensive phase treatment based on the result o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jo KW,Kim M,Kim YJ,Lee HK,Kim HK,Jeon D,Lyu J,Park HK,Mok J,Kim JS,Heo EY,Choi SB,Yim JJ,Shim TS

更新日期：2019-09-16 00:00:00

abstract：:The aim of this analysis was to identify therapeutic micafungin regimens for children that produce the same micafungin exposures known to be effective for the prevention and treatment of Candida infections in adults. Pediatric pharmacokinetic data from 229 patients between the ages of 4 months and <17 years were obtai...

journal_title：Antimicrobial agents and chemotherapy

authors： Hope WW,Kaibara A,Roy M,Arrieta A,Azie N,Kovanda LL,Benjamin DK Jr

更新日期：2015-02-01 00:00:00

abstract：:Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

更新日期：2020-12-16 00:00:00

abstract：:Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in prima...

journal_title：Antimicrobial agents and chemotherapy

authors： Clercq ED,Janik B,Sommer RG

更新日期：1977-04-01 00:00:00

abstract：:A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience. Infection was induced by inhalation of aerosolized Yersinia pestis organisms. Antibiotics were administered by intraperitoneal...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrne WR,Welkos SL,Pitt ML,Davis KJ,Brueckner RP,Ezzell JW,Nelson GO,Vaccaro JR,Battersby LC,Friedlander AM

更新日期：1998-03-01 00:00:00

abstract：:The direct or indirect interactions that antifungals have with the host immune response may play a significant role in defining their activity in vivo. However, the impact that acquired antifungal resistance has on the immunopharmacologic activity of antifungals is not well described. We assessed the immunopharmacolog...

journal_title：Antimicrobial agents and chemotherapy

authors： Beyda ND,Liao G,Endres BT,Lewis RE,Garey KW

更新日期：2015-09-01 00:00:00

abstract：:In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported. The pharmacokinetic properties of artesunate-azithromycin given in combination are comparable to those of the drugs given alone. Artesunate an...

journal_title：Antimicrobial agents and chemotherapy

authors： Chinh NT,Quang NN,Anh CX,Thanh NX,Dai B,Birrell GW,Chavchich M,Edstein MD

更新日期：2011-09-01 00:00:00

abstract：:Attenuated activity of echinocandin antifungals at high concentrations, known as the "paradoxical effect," is a well-established phenomenon in Candida albicans and Aspergillus fumigatus. In the yeast C. albicans, upregulation of chitin biosynthesis via the protein kinase C (PKC), high-osmolarity glycerol response (HOG...

journal_title：Antimicrobial agents and chemotherapy

authors： Fortwendel JR,Juvvadi PR,Perfect BZ,Rogg LE,Perfect JR,Steinbach WJ

更新日期：2010-04-01 00:00:00

abstract：:A number of compounds, as exemplified by verapamil and desipramine, have been shown to enhance the susceptibility of resistant malaria parasites to chloroquine. The mechanism by which these agents reverse resistance is still controversial but is though to involve alterations in drug transport causing an increase in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Ndifor AM,Howells RE,Bray PG,Ngu JL,Ward SA

更新日期：1993-06-01 00:00:00

abstract：:Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intra...

journal_title：Antimicrobial agents and chemotherapy

authors： van Wijk F,Waterval J,van Aerde K,Henriet SSV,Meijer FJA,Borra LC,Aarnoutse RE,van Ingen J

更新日期：2019-12-20 00:00:00

abstract：:Candida albicans remains the leading causative agent of invasive fungal infection. Although the importance of filamentation in C. albicans pathogenesis has been extensively investigated, in vivo studies to date have been unable to dissect the role of this developmental process in the establishment of infection versus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saville SP,Lazzell AL,Bryant AP,Fretzen A,Monreal A,Solberg EO,Monteagudo C,Lopez-Ribot JL,Milne GT

更新日期：2006-10-01 00:00:00

abstract：:Mining existing agents that enhance the therapeutic potential of ergosterol biosynthesis inhibitors (EBI) is a promising approach to improve Chagas disease chemotherapy. In this study, we evaluated the effect of ravuconazole, an EBI, combined with amlodipine, a calcium channel blocker, upon Trypanosoma cruzi experimen...

journal_title：Antimicrobial agents and chemotherapy

authors： Machado YA,Bahia MT,Caldas IS,Mazzeti AL,Novaes RD,Vilas Boas BR,Santos LJS,Martins-Filho OA,Marques MJ,Diniz LF

更新日期：2020-07-22 00:00:00

abstract：:We studied the incidence and type of side effects of minocycline in a double-blind study. A total of 45 volunteers (18 men and 27 women) were given minocycline, and 44 volunteers (23 men and 21 women) were given placebo. The men in both the minocycline and placebo groups were significantly (P < 0.0001) larger than the...

journal_title：Antimicrobial agents and chemotherapy

authors： Fanning WL,Gump DW,Sofferman RA

更新日期：1977-04-01 00:00:00

abstract：:Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I...

journal_title：Antimicrobial agents and chemotherapy

authors： Osburne MS,Maiese WM,Greenstein M

更新日期：1990-07-01 00:00:00

abstract：:Biofilm formation mediated by polysaccharide intercellular adhesin (PIA) is the major virulence factor of Staphylococcus epidermidis and is often associated with methicillin resistance. Transposon Tn917 insertions leading to a biofilm-negative phenotype in the biofilm-producing S. epidermidis strain 1457 (mecA-negativ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mack D,Sabottke A,Dobinsky S,Rohde H,Horstkotte MA,Knobloch JK

更新日期：2002-01-01 00:00:00

abstract：:Resistance to metronidazole, clarithromycin, and amoxicillin (amoxicilline) was found in 82, 3.8, and 1.9% of 106 Helicobacter pylori isolates, respectively. No tetracycline-resistant isolates were found. In all of the clarithromycin-resistant isolates, only one point mutation was present, either A2143G or A2142G. Our...

journal_title：Antimicrobial agents and chemotherapy

authors： Alvarez A,Moncayo JI,Santacruz JJ,Santacoloma M,Corredor LF,Reinosa E

更新日期：2009-09-01 00:00:00