Structure-function relationship studies on the frog skin antimicrobial peptide tigerinin 1: design of analogs with improved activity and their action on clinical bacterial isolates.

abstract：:ST-246, a novel compound that inhibits egress of orthopoxvirus from infected cells, is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, placebo-controlled, escalating multiple-dose study was conducted to determine the safety, tolerability, and ph...

journal_title：Antimicrobial agents and chemotherapy

authors： Jordan R,Chinsangaram J,Bolken TC,Tyavanagimatt SR,Tien D,Jones KF,Frimm A,Corrado ML,Pickens M,Landis P,Clarke J,Marbury TC,Hruby DE

更新日期：2010-06-01 00:00:00

abstract：:Francisella tularensis, a bacterium which causes tularemia in humans, is classified as a CDC category A bioterrorism agent. In this study, we demonstrate that celecoxib, an anti-inflammatory cyclooxygenase-2 inhibitor in clinical use, exhibits activity against a type A strain of F. tularensis (Schu S4), the live vacci...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiu HC,Yang J,Soni S,Kulp SK,Gunn JS,Schlesinger LS,Chen CS

更新日期：2009-07-01 00:00:00

abstract：:The pharmacokinetics of the antifungal pradimicin derivative BMS 181184 in plasma of normal, catheterized rabbits were characterized after single and multiple daily intravenous administrations of dosages of 10, 25, 50, or 150 mg/kg of body weight, and drug levels in tissues were assessed after multiple dosing. Concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Sein T,Petraitis V,Petraitiene R,Callender D,Gonzalez CE,Giri N,Bacher J,Piscitelli S,Walsh TJ

更新日期：1998-10-01 00:00:00

abstract：:Miloxacin, a synthetic antibacterial agent structurally related to oxolinic acid, has a broad spectrum of activity in vitro against gram-negative bacteria and considerable activity in vivo against infections with these bacteria. These observations led to studies on the absorption and excretion of miloxacin in mice, ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Izawa A,Yoshitake A,Komatsu T

更新日期：1980-07-01 00:00:00

abstract：:Yersinia enterocolitica has emerged as an enteropathogen associated with several types of human infections that often require antimicrobial therapy, but little is known about the antimicrobial susceptibilities of pathogenic strains isolated from humans in Canada. To determine the present patterns of antimicrobial susc...

journal_title：Antimicrobial agents and chemotherapy

authors： Preston MA,Brown S,Borczyk AA,Riley G,Krishnan C

更新日期：1994-09-01 00:00:00

abstract：:The objective of this study is to evaluate the results of single-day doxycycline therapy for Mediterranean spotted fever (MSF). This is a prospective cohort study of cases with confirmed MSF treated with the single-day doxycycline regimen in a teaching hospital from 1990 to 2015. Patients received two oral doses of 20...

journal_title：Antimicrobial agents and chemotherapy

authors： Espejo E,Andrés M,Garcia MC,Fajardo A,Pérez J,Bella F

更新日期：2018-10-24 00:00:00

abstract：:Trypanosomiasis remains a significant disease across the sub-Saharan African continent, with 50,000 to 70,000 individuals infected. The utility of current therapies is limited by issues of toxicity and the need to administer compounds intravenously. We have begun a program to pursue lead optimization around MDL 73811,...

journal_title：Antimicrobial agents and chemotherapy

authors： Barker RH Jr,Liu H,Hirth B,Celatka CA,Fitzpatrick R,Xiang Y,Willert EK,Phillips MA,Kaiser M,Bacchi CJ,Rodriguez A,Yarlett N,Klinger JD,Sybertz E

更新日期：2009-05-01 00:00:00

abstract：:Resistance to β-lactam antibiotics is a frequent problem in Pseudomonas aeruginosa lung infection of cystic fibrosis (CF) patients. This resistance is mainly due to the hyperproduction of chromosomally encoded β-lactamase and biofilm formation. The purpose of this study was to investigate the role of β-lactamase in th...

journal_title：Antimicrobial agents and chemotherapy

authors： Hengzhuang W,Ciofu O,Yang L,Wu H,Song Z,Oliver A,Høiby N

更新日期：2013-01-01 00:00:00

abstract：:In vitro interactions of ciprofloxacin with imipenem and amikacin were evaluated by the killing-curve technique against 26 Pseudomonas aeruginosa strains resistant to amikacin and resistant or moderately susceptible to ciprofloxacin and imipenem. Imipenem enhanced killing by ciprofloxacin in tests with 11 strains, whe...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellou H,Petrikkos G

更新日期：1987-06-01 00:00:00

abstract：:The effects of free amphotericin B (as Fungizone) and amphotericin B (AMB) incorporated into liposomes on the proliferation of lymphocytes were determined. Freshly obtained guinea pig and rat antigen-specific lymphocytes were compared with rat T-lymphocyte cell lines cultured for a long period of time. Incorporation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Boggs JM,Chang NH,Goundalkar A

更新日期：1991-05-01 00:00:00

abstract：:The pharmacokinetics of gentamicin C(1), C(2), and C(1a) were studied in six beagles after administration of gentamicin at 4 mg/kg of body weight as a single intravenous bolus dose. Plasma concentrations of the gentamicin components were analyzed with a novel high-performance liquid chromatography method capable of id...

journal_title：Antimicrobial agents and chemotherapy

authors： Isoherranen N,Lavy E,Soback S

更新日期：2000-06-01 00:00:00

abstract：:Numerous bacterial pathogens, particularly those that colonize fast-flow areas in the bladder and gastrointestinal tract, require motility to establish infection and spread beyond the initially colonized tissue. Vibrio cholerae strains of serogroups O1 and O139, the causative agents of the diarrheal illness cholera, e...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen L,White EL,Pathak A,Ayala JC,Wang H,Wu JH,Benitez JA,Silva AJ

更新日期：2011-09-01 00:00:00

abstract：:Metronidazole is now being used with increasing frequency for various infectious conditions in patients with renal failure. It is commonly administered to septic patients who have developed acute renal failure requiring hemodialysis. The hemodialysis clearances of metronidazole and its metabolites were evaluated in ni...

journal_title：Antimicrobial agents and chemotherapy

authors： Lau AH,Chang CW,Sabatini S

更新日期：1986-02-01 00:00:00

abstract：:The in vitro activity of rosamicin and erythromycin was compared at various pH values against 311 strains of bacteria representing common urinary tract pathogens. Alkalinization of the media consistently and significantly increased the antibacterial activity of rosamicin against all of the organisms tested. This was a...

journal_title：Antimicrobial agents and chemotherapy

authors： Eickhoff TC,Ehret JM

更新日期：1979-07-01 00:00:00

abstract：:Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-...

journal_title：Antimicrobial agents and chemotherapy

authors： Weinberg A,Bate BJ,Masters HB,Schneider SA,Clark JC,Wren CG,Allaman JA,Levin MJ

更新日期：1992-09-01 00:00:00

abstract：:In separate previous studies, we have shown that lipid-complexed amphotericin B (Abelcet [ABLC]) and liposomal amphotericin B (AmBisome [AmBi]) are efficacious against coccidioidal meningitis in rabbits. Here, we compared ABLC and AmBi directly in a coccidioidal meningitis model. Male New Zealand White rabbits were in...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Capilla J,Sobel RA,Martinez M,Tong AJ,Stevens DA

更新日期：2009-05-01 00:00:00

abstract：:The gyrA and gyrB genes of Chlamydia pneumoniae TW-183 were cloned, and their proteins were purified by use of a fusion system with a maltose-binding protein. The 50% inhibitory concentrations of garenoxacin, sparfloxacin, moxifloxacin, gatifloxacin, and levofloxacin were 10.1, 47.5, 39.6, 64.2, and 156.9 microg/ml, r...

journal_title：Antimicrobial agents and chemotherapy

authors： Ameyama S,Shinmura Y,Takahata M

更新日期：2003-07-01 00:00:00

abstract：:The rate of occurrence of the extended-spectrum beta-lactamase (ESBL)-producing phenotype among Escherichia coli isolates in Tel Aviv is 12% (22). The aim of this study was to understand the molecular epidemiology of E. coli ESBL producers and to identify the ESBL genes carried by them. We studied 20 single-patient ES...

journal_title：Antimicrobial agents and chemotherapy

authors： Chmelnitsky I,Carmeli Y,Leavitt A,Schwaber MJ,Navon-Venezia S

更新日期：2005-11-01 00:00:00

abstract：:Despite the availability of >30 effective drugs for managing HIV-1 infection, no current therapy is curative, and long-term management is challenging owing to the emergence and spread of drug-resistant mutants. Identification of drugs against novel HIV-1 targets would expand the current treatment options and help to c...

journal_title：Antimicrobial agents and chemotherapy

authors： Halambage UD,Wong JP,Melancon BJ,Lindsley CW,Aiken C

更新日期：2015-09-01 00:00:00

abstract：:The in vitro activities of four fluoroquinolone compounds were tested against 92 Escherichia coli strains of ovine and caprine origin under aerobic and anaerobic incubation conditions. The four fluoroquinolones proved to be highly effective against the E. coli isolates tested. When bacteria were cultured anaerobically...

journal_title：Antimicrobial agents and chemotherapy

authors： Cid D,Piriz S,Ruiz-Santa-Quiteria JA,Valle J,Garcia S,Vadillo S,de la Fuente R

更新日期：1994-10-01 00:00:00

abstract：:Leptospirosis and scrub typhus are important causes of acute fever in Southeast Asia. Options for empirical therapy include doxycycline and azithromycin, but it is unclear whether their efficacies are equivalent. We conducted a multicenter, open, randomized controlled trial with adult patients presenting with acute fe...

journal_title：Antimicrobial agents and chemotherapy

authors： Phimda K,Hoontrakul S,Suttinont C,Chareonwat S,Losuwanaluk K,Chueasuwanchai S,Chierakul W,Suwancharoen D,Silpasakorn S,Saisongkorh W,Peacock SJ,Day NP,Suputtamongkol Y

更新日期：2007-09-01 00:00:00

abstract：:We studied the effects of two N,N'-bis(benzyl)-substituted polyamine analogs on the capacities of Trypanosoma cruzi to invade and multiply within a mammalian host cell. At concentrations as low as 1 microM, these compounds reduced significantly the infectivity of the parasite for rat heart myoblasts in a time-dependen...

journal_title：Antimicrobial agents and chemotherapy

authors： Majumder S,Kierszenbaum F

更新日期：1993-10-01 00:00:00

abstract：:Mycobactin biosynthesis in Mycobacterium tuberculosis facilitates iron acquisition, which is required for growth and virulence. The mycobactin biosynthesis inhibitor salicyl-AMS [5'-O-(N-salicylsulfamoyl)adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. Here, we conducted a single-dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Lun S,Guo H,Adamson J,Cisar JS,Davis TD,Chavadi SS,Warren JD,Quadri LE,Tan DS,Bishai WR

更新日期：2013-10-01 00:00:00

abstract：:At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephradine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadrox...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeffer M,Jackson A,Ximenes J,de Menezes JP

更新日期：1977-02-01 00:00:00

abstract：:The activity of cephradine and the influence of pH on its activity against 70 Gardnerella vaginalis strains were determined. Serial dilutions of cephradine (0.062 to 256 micrograms/ml) were incorporated into Dunkelberg agar, inoculated with a Steers replicator, incubated in 5% CO2 for 48 h, and examined. The minimal i...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Kwok YY,Sutter VL

更新日期：1983-09-01 00:00:00

abstract：:Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which Acinetobacter-derived cephalosporinase-7 (ADC-7), a chromosomal AmpC enzyme, hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Curtis BN,Smolen KA,Barlow SJ,Caselli E,Prati F,Taracila MA,Bonomo RA,Wallar BJ,Powers RA

更新日期：2020-11-17 00:00:00

abstract：:Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes ribosomal protein L16)...

journal_title：Antimicrobial agents and chemotherapy

authors： Adrian PV,Mendrick C,Loebenberg D,McNicholas P,Shaw KJ,Klugman KP,Hare RS,Black TA

更新日期：2000-11-01 00:00:00

abstract：:We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaco...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernández-Silva F,Capilla J,Mayayo E,Sutton DA,Hernández P,Guarro J

更新日期：2013-12-01 00:00:00

abstract：:Concentration-QTc modeling was applied to pretomanid, a new nitroimidazooxazine antituberculosis drug. Data came from eight phase 2 and phase 3 studies. Besides pretomanid alone, various combinations with bedaquiline, linezolid, moxifloxacin, and pyrazinamide were considered; special attention was given to the bedaqui...

journal_title：Antimicrobial agents and chemotherapy

authors： Li H,Salinger DH,Everitt D,Li M,Del Parigi A,Mendel C,Nedelman JR

更新日期：2019-09-23 00:00:00

abstract：:The pharmacokinetics of cefdinir were investigated in six hemodialysis patients. For the present study, two tests were carried out, one with 4 h of hemodialysis and the other without hemodialysis. Cefdinir was given orally to each patient in a dose of 100 mg, and blood was collected serially for 48 h after dosing in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hishida A,Ohishi K,Nagashima S,Kanamaru M,Obara M,Kitada A

更新日期：1998-07-01 00:00:00