Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.

abstract：:Both ampicillin and cefuroxime therapy of neonates selected drug- and species-dependent beta-lactam resistance patterns in fecal strains of Escherichia coli and Klebsiella spp. This was in contrast to our previous findings that ampicillin, but not cefuroxime, contributed to the emergence of beta-lactam resistance also...

journal_title：Antimicrobial agents and chemotherapy

authors： Tullus K,Berglund B,Burman LG

更新日期：1990-02-01 00:00:00

abstract：:We studied the incidence and type of side effects of minocycline in a double-blind study. A total of 45 volunteers (18 men and 27 women) were given minocycline, and 44 volunteers (23 men and 21 women) were given placebo. The men in both the minocycline and placebo groups were significantly (P < 0.0001) larger than the...

journal_title：Antimicrobial agents and chemotherapy

authors： Fanning WL,Gump DW,Sofferman RA

更新日期：1977-04-01 00:00:00

abstract：:Many gram-negative bacteria are known to be remarkably resistant to hydrophobic noxious agents by virtue of their outer membranes (OM). We investigated, by using four different assay methods, the ability of sodium hexametaphosphate (HMP) to disrupt this OM barrier. (i) In the growth inhibition assay, HMP was found to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Jaakkola J

更新日期：1989-10-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitors (NRTIs) used against the human immunodeficiency virus (HIV) need to be activated intracellularly to their triphosphate moiety to inhibit HIV replication. Intracellular concentrations of these NRTI triphosphates, especially zidovudine triphosphate (ZDV-TP), are relatively low...

journal_title：Antimicrobial agents and chemotherapy

authors： Font E,Rosario O,Santana J,García H,Sommadossi JP,Rodriguez JF

更新日期：1999-12-01 00:00:00

abstract：:Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carraguard. Although the trial did not show that Carraguard is effective in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernández-Romero JA,Abraham CJ,Rodriguez A,Kizima L,Jean-Pierre N,Menon R,Begay O,Seidor S,Ford BE,Gil PI,Peters J,Katz D,Robbiani M,Zydowsky TM

更新日期：2012-01-01 00:00:00

abstract：:Various parameters were examined for their effects on interferon production with human fibroblast cells (FS-4) grown on microcarriers, using a superinduction procedure. Optimal concentrations of cycloheximide and actinomycin D during induction were 10 micrograms/ml, respectively. Cells required 5 to 6 h of exposure to...

journal_title：Antimicrobial agents and chemotherapy

authors： Giard DJ,Fleischaker RJ

更新日期：1980-07-01 00:00:00

abstract：:The antiviral effects of four compounds, phosphonoacetate, phosphonoformate, acycloguanosine, and purified human lymphoblastic interferon, were tested against two neurotropic herpesviruses, herpesvirus platyrrhine and herpes simplex virus, and two oncogenic herpesviruses, herpesvirus saimiri and herpesvirus ateles. Al...

journal_title：Antimicrobial agents and chemotherapy

authors： Daniel MD,Falk LA,King NW,Tamulevich R,Holland JS,Bekesi JG

更新日期：1980-10-01 00:00:00

abstract：:Clinical isolates of the Bacteroides melaninogenicus and Bacteroides fragilis groups were tested for in vitro and in vivo susceptibility to penicillin, clindamycin, and metronidazole, used singly or in combination with gentamicin. The in vitro tests consisted of determinations of minimal inhibitory concentrations (MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Brook I,Coolbaugh JC,Walker RI,Weiss E

更新日期：1984-01-01 00:00:00

abstract：:Vancomycin resistance in Enterococcus faecium 180, a clinical isolate from England, was studied. Resistance to vancomycin was transferable by conjugation to other enterococci. Expression of resistance was inducible and coincided with the appearance of a new membrane protein. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nicas TI,Wu CY,Hobbs JN Jr,Preston DA,Allen NE

更新日期：1989-07-01 00:00:00

abstract：:Letermovir, GW275175X (a benzimidazole), and tomeglovir (Bay38-4766) are chemically unrelated human cytomegalovirus (CMV) terminase complex inhibitors that have been tested in human subjects. UL56 gene mutations are the dominant pathway of letermovir resistance, while UL89 and UL56 mutations are known to confer benzim...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S

更新日期：2017-10-24 00:00:00

abstract：:Two group F vibrio organisms have been identified among a collection of vibrio strains isolated from the aquatic environment in Bangladesh. Neither group F strain produced a cholera-like enterotoxin. One of the isolates, BV12, contained an R plasmid conferring resistance to streptomycin and chloramphenicol. ...

journal_title：Antimicrobial agents and chemotherapy

authors： McNicol LA,Kaper JB,Lockman HA,Remmers EF,Spira WM,Colwell RR

更新日期：1980-03-01 00:00:00

abstract：:Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezo...

journal_title：Antimicrobial agents and chemotherapy

authors： Battaglini D,Motos A,Li Bassi G,Yang H,Pagliara F,Yang M,Aguilera Xiol E,Meli A,Bobi J,Frigola G,Senussi T,Idone F,Travierso C,Chiurazzi C,Fernandez-Barat L,Rigol M,Ramirez J,Pelosi P,Chiumello D,Antonelli M,Nicol

更新日期：2020-12-16 00:00:00

abstract：:The in vitro activity of ceftriaxone was compared with those of other recently introduced beta-lactam antimicrobial agents (cefoperazone, cefotaxime, and moxalactam) and with those of cefoxitin, clindamycin, and metronidazole against 227 strains of anaerobic bacteria. The data obtained in this investigation suggest th...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolfe RD,Finegold SM

更新日期：1982-08-01 00:00:00

abstract：:Plasmodium falciparum, the deadliest species of malaria parasites, is dependent on glycolysis for the generation of ATP during the pathogenic red blood cell stage. Hexokinase (HK) catalyzes the first step in glycolysis, transferring the γ-phosphoryl group of ATP to glucose to yield glucose-6-phosphate. Here, we descri...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis MI,Patrick SL,Blanding WM,Dwivedi V,Suryadi J,Golden JE,Coussens NP,Lee OW,Shen M,Boxer MB,Hall MD,Sharlow ER,Drew ME,Morris JC

更新日期：2016-09-23 00:00:00

abstract：:The effects of cefodizime and cefuroxime on neutrophil phagocytosis and reactive oxygen production in 54 patients undergoing elective coronary artery bypass grafting were studied. Both drugs were administered twice at a dosage of 40 mg/kg of body weight (pre- and intraoperative). Phagocytic capacity was assessed by me...

journal_title：Antimicrobial agents and chemotherapy

authors： Wenisch C,Bartunek A,Zedtwitz-Liebenstein K,Hiesmayr M,Parschalk B,Pernerstorfer T,Graninger W

更新日期：1997-07-01 00:00:00

abstract：:Fusidic acid (FA), which was approved in the 1960s in many European and Asian countries, has gained renewed interest due to its continued effectiveness against methicillin-resistant Staphylococcus aureus As rhabdomyolysis has been reported upon coadministration of FA with statins, we aimed to elucidate the underlying ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta A,Harris JJ,Lin J,Bulgarelli JP,Birmingham BK,Grimm SW

更新日期：2016-09-23 00:00:00

abstract：:Cryptococcus gattii isolates from the Pacific Northwest have exhibited higher fluconazole MICs than isolates from other sites. The mechanism of fluconazole resistance in C. gattii is unknown. We sought to determine the role of the efflux pumps Mdr1 and Pdr11 in fluconazole susceptibility. Using biolistic transformatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang ML,Uhrig J,Vu K,Singapuri A,Dennis M,Gelli A,Thompson GR 3rd

更新日期：2015-12-07 00:00:00

abstract：:Ceftizoxime was evaluated in the treatment of 18 patients (6 adults and 12 children) with bacterial meningitis. In seven patients Haemophilus influenzae was the causative agent, in three Neisseria meningitidis, in five Streptococcus pneumoniae, and in one each alpha-streptococcus and Escherichia coli; one case was cul...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Cable DC,Forthal DN,Shikuma C

更新日期：1984-02-01 00:00:00

abstract：:Itraconazole is used for the prevention and treatment of infections caused by Aspergillus fumigatus. An understanding of the pharmacodynamics of itraconazole against wild-type and triazole-resistant strains provides a basis for innovative therapeutic strategies for treatment of infections. An in vitro model of the hum...

journal_title：Antimicrobial agents and chemotherapy

authors： Al-Nakeeb Z,Sudan A,Jeans AR,Gregson L,Goodwin J,Warn PA,Felton TW,Howard SJ,Hope WW

更新日期：2012-08-01 00:00:00

abstract：:Selection of resistance to cefamandole has been observed, and the drug has failed to protect animals lethally infected with certain Enterobacteriaceae that appeared to be highly susceptible in vitro. Using spectrophotometric assays, some of these organisms were found to produce beta-lactamases highly active against ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr

更新日期：1979-06-01 00:00:00

abstract：:Two new fluorinated oxazolidinones, U-100592 and U-100766, were evaluated against more than 659 gram-positive and -negative organisms and compared with glycopeptides, erythromycin, clindamycin, clinafloxacin, and chloramphenicol. U-100592 and U-100766 were usually equally potent, but the MICs at which 90% of the isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Johnson DM,Erwin ME

更新日期：1996-03-01 00:00:00

abstract：:We describe the pharmacokinetics of raltegravir of a preterm newborn after short-course treatment of the mother tested HIV + the day of delivery. At age 1 month, the circulating concentration of raltegravir in the newborn was 29 ng/ml (the IC95 of RAL against HIV-1 is 15 ng/ml). Raltegravir should therefore be conside...

journal_title：Antimicrobial agents and chemotherapy

authors： Clavel-Osorio C,Cazassus F,Stegmann S,Huc-Anaïs P,Lecam D,Peytavin G

更新日期：2013-12-01 00:00:00

abstract：:Many pathogenic and commensal organisms are multidrug resistant due to exposure to various antibiotics. Often, this antimicrobial resistance is encoded by integrons that occur on plasmids or that are integrated into the bacterial chromosome. Integrons are commonly associated with bacterial genera in the family Enterob...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein C,Lee MD,Sanchez S,Hudson C,Phillips B,Register B,Grady M,Liebert C,Summers AO,White DG,Maurer JJ

更新日期：2001-03-01 00:00:00

abstract：:Azoles are widely used antifungals; however, their efficacy is compromised by fungistatic activity and selection of resistant strains during treatment. Recent studies demonstrated roles for the protein kinase C and calcium signaling pathways in modulating azole activity. Here we explored a role for the signaling pathw...

journal_title：Antimicrobial agents and chemotherapy

authors： Jain P,Akula I,Edlind T

更新日期：2003-10-01 00:00:00

abstract：:Aminoglycoside acetyltransferase was detected in Mycobacterium kansasii and M. fortuitum but not in M. avium-M. intracellulare when they were screened by a radioassay. Aminoglycoside phosphotransferase and nucleotidyltransferase activities were absent from all three species tested. Acetyltransferases from both M. kans...

journal_title：Antimicrobial agents and chemotherapy

authors： Ho II,Chan CY,Cheng AF

更新日期：2000-01-01 00:00:00

abstract：:The NS3/4A protease from hepatitis C virus (HCV) plays a key role in viral replication. We report a system for monitoring the activity of this enzyme in single living mammalian cells. We constructed a fluorescence resonance energy transfer (FRET) probe that consists of an enhanced cyan fluorescent protein-citrine fusi...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabariegos R,Picazo F,Domingo B,Franco S,Martinez MA,Llopis J

更新日期：2009-02-01 00:00:00

abstract：:Ten (0.05%) of 18,628 strains of Streptococcus pyogenes isolated from clinical specimens in the 3 years 1968 to 1970 were resistant to lincomycin and erythromycin. All 10 strains were highly resistant to lincomycin, having minimal inhibitory concentration (MIC) values of 200 mug/ml. There were two degrees of resistanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon JM,Lipinski AE

更新日期：1972-04-01 00:00:00

abstract：:The influence of reduced susceptibilities to glycopeptides on the activities of vancomycin and teicoplanin against an isogenic pair of clinical Staphylococcus aureus strains in experimental endocarditis was investigated. While vancomycin was similarly active against both strains, teicoplanin was approximately 100-fold...

journal_title：Antimicrobial agents and chemotherapy

authors： Pavie J,Lefort A,Ploy MC,Massias L,Chau F,Garry L,Denis F,Fantin B

更新日期：2003-06-01 00:00:00

abstract：:The new fluoroquinolone trovafloxacin was tested against a ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus strain in the rabbit model of endocarditis. Trovafloxacin was more effective than vancomycin (CFU/g of vegetation, 2.65 +/- 1.87 versus 4.54 +/- 2.80 [mean +/- standard deviation]; P < 0.05) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim YS,Liu Q,Chow LL,Chambers HF,Täuber MG

更新日期：1998-12-01 00:00:00

abstract：:Arylimidamides (AIAs) are inspired by diamidine antimicrobials but show superior activity against intracellular parasites. The AIA DB766 {2,5-bis[2-(2-i-propoxy)-4-(2-pyridylimino)aminophenyl]furan hydrochloride} displays outstanding potency against intracellular Leishmania parasites and is effective in murine and ham...

journal_title：Antimicrobial agents and chemotherapy

authors： Pandharkar T,Zhu X,Mathur R,Jiang J,Schmittgen TD,Shaha C,Werbovetz KA

更新日期：2014-08-01 00:00:00