Comparative efficacy of trovafloxacin in experimental endocarditis caused by ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus.

abstract：:Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Munita JM,Panesso D,Diaz L,Tran TT,Reyes J,Wanger A,Murray BE,Arias CA

更新日期：2012-08-01 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:A novel streptogramin A, pleuromutilin, and lincosamide resistance determinant, Vga(E), was identified in porcine methicillin-resistant Staphylococcus aureus (MRSA) ST398. The vga(E) gene encoded a 524-amino-acid protein belonging to the ABC transporter family. It was found on a multidrug resistance-conferring transpo...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwendener S,Perreten V

更新日期：2011-10-01 00:00:00

abstract：:While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infection, excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP) who were treated with macrolides and aspirin would receive benefit beyond that of c...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcone M,Russo A,Shindo Y,Farcomeni A,Pieralli F,Cangemi R,Liu J,Xia J,Okumura J,Sano M,Jones C,Vannucchi V,Mancone M,Micek S,Xu F,Violi F,Kollef M

更新日期：2019-01-29 00:00:00

abstract：:Mycoplasma hominis was highly susceptible to two new quinolones, with MICs for 90% of isolates tested of 0.004 micrograms/ml for WIN 57273 and 0.063 micrograms/ml for sparfloxacin, which were activities much greater than the 1 microgram/ml found for ofloxacin and tetracycline. Although Ureaplasma urealyticum was less ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kenny GE,Cartwright FD

更新日期：1991-07-01 00:00:00

abstract：:The biochemical properties of tetrahydrofuranyl (THF) carbapenems, carbapenems with THF substituents, were evaluated with respect to enzyme stability, binding to penicillin-binding proteins (PBPs), and penetration into gram-negative organisms. THF carbapenems showed increased stability to hog renal dehydropeptidases (...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang Y,Testa RT,Bhachech N,Rasmussen BA,Bush K

更新日期：1999-12-01 00:00:00

abstract：:An a priori pharmacokinetic/pharmacodynamic (PK/PD) target of 40% daily time above the MIC (T >MIC; based on the MIC(90) of 0.06 microg/ml for Streptococcus pyogenes reported in the literature) was shown to be achievable in a phase 1 study of 23 children with a once-daily (QD) modified-release, multiparticulate formul...

journal_title：Antimicrobial agents and chemotherapy

authors： Pichichero ME,Casey JR,Block SL,Guttendorf R,Flanner H,Markowitz D,Clausen S

更新日期：2008-07-01 00:00:00

abstract：:Minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of penicillin, ampicillin, cefoxitin, and cefuroxime were determined for 103 beta-lactamase-negative Neisseria gonorrhoeae clinical isolates belonging to five different auxotypes. MBC determinations were base on killing 99.9% of th...

journal_title：Antimicrobial agents and chemotherapy

authors： de Repentigny L,Turgeon PL

更新日期：1981-04-01 00:00:00

abstract：:Fluoroquinolone antibiotics are prescribed for the treatment of Salmonella enterica infections, but resistance to this family of antibiotics is growing. Here we report that loss of the global regulatory protein cyclic AMP (cAMP) receptor protein (CRP) or its allosteric effector, cAMP, reduces susceptibility to fluoroq...

journal_title：Antimicrobial agents and chemotherapy

authors： Kary SC,Yoneda JRK,Olshefsky SC,Stewart LA,West SB,Cameron ADS

更新日期：2017-10-24 00:00:00

abstract：:Because rifampin-resistant strains of Staphylococcus aureus emerge during monotherapy with this drug, a search was made for potentially useful companion drugs. Bactericidal titers of spiked serum were determined, and time kill studies were performed for 10 strains of methicillin-susceptible S. aureus. We tested rifamp...

journal_title：Antimicrobial agents and chemotherapy

authors： Hackbarth CJ,Chambers HF,Sande MA

更新日期：1986-04-01 00:00:00

abstract：:Thirty-nine fosfomycin-resistant Escherichia coli isolates carrying fosA3 were obtained from pigs, chickens, dairy cows, and staff in four northeastern provinces of China between June 2015 and April 2016. The fosA3 gene was colocated with blaCTX-M genes on conjugative plasmids of the incompatibility groups IncN (n = 1...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang XM,Dong Z,Schwarz S,Zhu Y,Hua X,Zhang Y,Liu S,Zhang WJ

更新日期：2017-08-24 00:00:00

abstract：:Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 mug/ml. Rifampin alone was without effect. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rifkind D,Crowder ED,Hyland RN

更新日期：1974-12-01 00:00:00

abstract：:The mode of action of a new type of UDP-glucose analog against herpes simplex virus type 1 (HSV-1) replication was examined. The analog showed good selectivity and potent activity. At 10 micrograms/ml, P-536 inhibited the formation of infectious HSV-1 by more than 90%, whereas at 100 micrograms/ml it had no cytotoxic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Alarcón B,González ME,Carrasco L,Méndez-Castrillón PP,García-López MT,de las Heras FG

更新日期：1988-08-01 00:00:00

abstract：:The time-kill effect of moxifloxacin on 20 genetically distinct isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole was studied. The majority (80%) were killed by a concentration equivalent to four times the MIC; the MIC induced a transient decrease in bacterial counts at 4 h, followed ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellos-Bourboulis EJ,Karnesis L,Galani I,Giamarellou H

更新日期：2002-12-01 00:00:00

abstract：:Azole antifungal agents such as fluconazole exhibit fungistatic activity against Candida albicans. Strategies to enhance azole antifungal activity would be therapeutically appealing. In an effort to identify transcriptional pathways that influence the killing activity of fluconazole, we sought to identify transcriptio...

journal_title：Antimicrobial agents and chemotherapy

authors： Vasicek EM,Berkow EL,Bruno VM,Mitchell AP,Wiederhold NP,Barker KS,Rogers PD

更新日期：2014-11-01 00:00:00

abstract：:We compared the in vitro activities of isavuconazole, posaconazole, voriconazole, and fluconazole against Dipodascus capitatus (n = 21), Saccharomyces cerevisiae (n = 20), Rhodotorula mucilaginosa (n = 18), and Trichosporon spp. (n = 15). The MIC(50)s, MIC(90)s, and MIC ranges (in microg/ml) obtained using the CLSI M2...

journal_title：Antimicrobial agents and chemotherapy

authors： Guinea J,Recio S,Escribano P,Peláez T,Gama B,Bouza E

更新日期：2010-09-01 00:00:00

abstract：:Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious top...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti S,Cevini C,Bruno A,Penso G,Rama P,Scaglia M

更新日期：1998-09-01 00:00:00

abstract：:Clostridium difficile is the most frequently identified enteric pathogen in patients with nosocomially acquired, antibiotic-associated diarrhea. The drugs most commonly used to treat diseases associated with C. difficile are metronidazole and vancomycin. Most clinical laboratories assume that all C. difficile isolates...

journal_title：Antimicrobial agents and chemotherapy

authors： Peláez T,Alcalá L,Alonso R,Rodríguez-Créixems M,García-Lechuz JM,Bouza E

更新日期：2002-06-01 00:00:00

abstract：:A Cedecea davisae isolate, which was intermediate or resistant to third-generation cephalosporins and carbapenems, was recovered from a urine sample. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC β-lactamase expression combined with porin deficiency accounted fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ammenouche N,Dupont H,Mammeri H

更新日期：2014-11-01 00:00:00

abstract：:We assessed the activity and safety of liposomal nystatin, a broad-spectrum antifungal agent, for invasive aspergillosis in patients refractory to or intolerant of amphotericin B. Thirty-three patients were enrolled, received at least one dose of the study drug, and were evaluable for safety. Twenty-six patients had c...

journal_title：Antimicrobial agents and chemotherapy

authors： Offner F,Krcmery V,Boogaerts M,Doyen C,Engelhard D,Ribaud P,Cordonnier C,de Pauw B,Durrant S,Marie JP,Moreau P,Guiot H,Samonis G,Sylvester R,Herbrecht R,EORTC Invasive Fungal Infections Group.

更新日期：2004-12-01 00:00:00

abstract：:Moxifloxacin has enhanced potency against Staphylococcus aureus, lower propensity to select for resistant mutants, and higher bactericidal activity against highly resistant strains than ciprofloxacin. Despite similar activity against purified S. aureus topoisomerase IV and DNA gyrase, it selects for topoisomerase IV m...

journal_title：Antimicrobial agents and chemotherapy

authors： Ince D,Zhang X,Hooper DC

更新日期：2003-04-01 00:00:00

abstract：:We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses fou...

journal_title：Antimicrobial agents and chemotherapy

authors： Borkow G,Sidwell RW,Smee DF,Barnard DL,Morrey JD,Lara-Villegas HH,Shemer-Avni Y,Gabbay J

更新日期：2007-07-01 00:00:00

abstract：:The activity of NXL103 against 108 strains of Haemophilus influenzae was tested using Haemophilus test media (HTM) obtained from various sources. With the exception of those obtained with stored HTM, MICs did not differ significantly, with MIC(50) and MIC(90) values of 0.5 and 0.5 to 1 microg/ml, respectively, in each...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman D,Bryskier A,Lowther J,Appelbaum PC

更新日期：2006-11-01 00:00:00

abstract：:"Shock and kill" therapeutic strategies toward HIV eradication are based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) and the consequent killing of the reactivated cell by either the cytopathic effect of HIV or an arm of the immune system. We have recently found several benzotri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sorensen ES,Macedo AB,Resop RS,Howard JN,Nell R,Sarabia I,Newman D,Ren Y,Jones RB,Planelles V,Spivak AM,Bosque A

更新日期：2020-07-22 00:00:00

abstract：:Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison EM,Paterson GK,Holden MT,Morgan FJ,Larsen AR,Petersen A,Leroy S,De Vliegher S,Perreten V,Fox LK,Lam TJ,Sampimon OC,Zadoks RN,Peacock SJ,Parkhill J,Holmes MA

更新日期：2013-03-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is an essential chaperone involved in the fungal stress response that can be harnessed as a novel antifungal target for the treatment of invasive aspergillosis. We previously showed that genetic repression of Hsp90 reduced Aspergillus fumigatus virulence and potentiated the effect of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Asfaw YG,Steinbach WJ

更新日期：2014-01-01 00:00:00

abstract：:Genome editing using zinc finger nucleases (ZFNs) has been successfully applied to disrupt CCR5 or CXCR4 host factors and inhibit viral entry and infection. Gene therapy using ZFNs to modify the PSIP1 gene, which encodes the lens epithelium-derived growth factor (LEDGF) protein, might restrain an early step of the vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Badia R,Pauls E,Riveira-Munoz E,Clotet B,Esté JA,Ballana E

更新日期：2014-08-01 00:00:00

abstract：:The class C beta-lactamase of Citrobacter freundii GN346 is a typical cephalosporinase comprising 361 amino acids, and substitution of the glutamic acid at position 219 in the enzyme by lysine was previously shown to broaden its substrate spectrum to oxyimino beta-lactams (K. Tsukamoto, R. Ohno, and T. Sawai, J. Bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Nukaga M,Tsukamoto K,Yamaguchi H,Sawai T

更新日期：1994-06-01 00:00:00

abstract：:One hundred clinical isolates of methicillin-resistant (Metr) Staphylococcus aureus from five different geographical origins were tested for their susceptibility to 12 non-beta-lactam antibiotics by the broth microdilution technique recommended by the National Committee for Clinical Laboratory Standards. Coumermycin a...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Janney A,Sanders CV

更新日期：1985-11-01 00:00:00

abstract：:We have quantified the biological cost of VanA-type glycopeptide resistance due to the acquisition of the resistance operon by methicillin-resistant Staphylococcus aureus (MRSA) from Enterococcus sp. Exponential growths of recipient strain HIP11713, its transconjugant VRSA-1, VRSA-5, and VRSA-6 were compared in the ab...

journal_title：Antimicrobial agents and chemotherapy

authors： Foucault ML,Courvalin P,Grillot-Courvalin C

更新日期：2009-06-01 00:00:00