Fitness cost of VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus.

abstract：:Wild-type Proteus strains are usually resistant to colistin. We have observed an increase in the level of colistin resistance in four clinical isolates of P. vulgaris, P. morganii, and P. rettgeri by prior treatment with subinhibitory concentrations of the drug. The enhanced resistance in these strains was lost after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu S,Iyobe S,Mitsuhashi S

更新日期：1977-07-01 00:00:00

abstract：:The antiviral activity of a new series of thymidine analogs was determined against vaccinia virus (VV), cowpox virus (CV), herpes simplex virus, and varicella-zoster virus. Several compounds were identified that had good activity against each of the viruses, including a set of novel 5-substituted deoxyuridine analogs....

journal_title：Antimicrobial agents and chemotherapy

authors： Prichard MN,Keith KA,Johnson MP,Harden EA,McBrayer A,Luo M,Qiu S,Chattopadhyay D,Fan X,Torrence PF,Kern ER

更新日期：2007-05-01 00:00:00

abstract：:The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent body clearance was found to be significantly lower (1.99 +/- 1.49 ml/min per kg) in patients with total serum bilirubin concentrations of >1.5 mg/100 ml than in patients with serum bilirubin conc...

journal_title：Antimicrobial agents and chemotherapy

authors： Koup JR,Lau AH,Brodsky B,Slaughter RL

更新日期：1979-05-01 00:00:00

abstract：:We studied the activity of voriconazole against 400 clinical strains of Aspergillus from the pre-voriconazole (1999 to 2002) and post-voriconazole (2003 to 2007) periods. Although the mean MICs of strains from the post-voriconazole period were slightly higher (0.39 versus 0.57 microg/ml; P < 0.001), all strains were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Guinea J,Recio S,Peláez T,Torres-Narbona M,Bouza E

更新日期：2008-09-01 00:00:00

abstract：:We investigated the impact of low-level resistance to fluoroquinolones on the bactericidal activity of ciprofloxacin in a murine model of urinary tract infection. The susceptible Escherichia coli strain CFT073 (ciprofloxacin MIC [CIP MIC] of 0.008 microg/ml) was compared to its transconjugants harboring qnrA1 or qnrS1...

journal_title：Antimicrobial agents and chemotherapy

authors： Allou N,Cambau E,Massias L,Chau F,Fantin B

更新日期：2009-10-01 00:00:00

abstract：:The susceptibilities of 216 strains of Neisseria gonorrhoeae to a new fluoroquinolone, CP-99,219 were determined. For strains for which the MICs of ciprofloxacin were < or = 0.06 microgram/ml, the MICs at which 90% of the isolates are inhibited (MIC90s) of CP-99,219, ciprofloxacin, and ofloxacin were 0.008, 0.015, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Neal SW,Parekh MC,Rice RJ

更新日期：1995-04-01 00:00:00

abstract：:Two new fluorinated oxazolidinones, U-100592 and U-100766, were evaluated against more than 659 gram-positive and -negative organisms and compared with glycopeptides, erythromycin, clindamycin, clinafloxacin, and chloramphenicol. U-100592 and U-100766 were usually equally potent, but the MICs at which 90% of the isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Johnson DM,Erwin ME

更新日期：1996-03-01 00:00:00

abstract：:The two groups of chromosomal beta-lactamases from Klebsiella oxytoca (OXY-1 and OXY-2) can be overproduced 73- to 223-fold, due to point mutations in the consensus sequences of their promoters. The different versions of promoters from blaOXY-1 and blaOXY-2 were cloned upstream of the chloramphenicol acetyltransferase...

journal_title：Antimicrobial agents and chemotherapy

authors： Fournier B,Gravel A,Hooper DC,Roy PH

更新日期：1999-04-01 00:00:00

abstract：:Antiviral drugs do not currently exist for the treatment of enterovirus infections, which are often severe and potentially life-threatening. We conducted high-throughput molecular screening and identified a structurally diverse set of compounds that inhibit the replication of coxsackievirus B3, a commonly encountered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zuo J,Kye S,Quinn KK,Cooper P,Damoiseaux R,Krogstad P

更新日期：2015-12-28 00:00:00

abstract：:The rate of occurrence of the extended-spectrum beta-lactamase (ESBL)-producing phenotype among Escherichia coli isolates in Tel Aviv is 12% (22). The aim of this study was to understand the molecular epidemiology of E. coli ESBL producers and to identify the ESBL genes carried by them. We studied 20 single-patient ES...

journal_title：Antimicrobial agents and chemotherapy

authors： Chmelnitsky I,Carmeli Y,Leavitt A,Schwaber MJ,Navon-Venezia S

更新日期：2005-11-01 00:00:00

abstract：:Establishing an effective empirical antifungal therapy requires that national surveillance studies be conducted. Herein, we report the clinical outcome of infections with and the microbiological features of Iranian isolates of Candidaglabrata derived from patients suffering from candidemia. C. glabrata isolates were r...

journal_title：Antimicrobial agents and chemotherapy

authors： Arastehfar A,Daneshnia F,Zomorodian K,Najafzadeh MJ,Khodavaisy S,Zarrinfar H,Hagen F,Zare Shahrabadi Z,Lackner M,Mirhendi H,Salehi M,Roudbary M,Pan W,Kostrzewa M,Boekhout T

更新日期：2019-06-24 00:00:00

abstract：:The influence of a mission hospital on the evolution of antibiotic resistance in coliform bacteria from a remote antibiotic-free Xhosa community and environment is described. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Burt SJ,Woods DR

更新日期：1976-09-01 00:00:00

abstract：:Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention tri...

journal_title：Antimicrobial agents and chemotherapy

authors： Polhemus ME,Remich S,Ogutu B,Waitumbi J,Lievens M,Ballou WR,Heppner DG Jr

更新日期：2008-04-01 00:00:00

abstract：:Clostridioides difficile causes severe antibiotic-associated diarrhea and colitis. C. difficile is an anaerobic, Gram-positive sporeformer that is highly resistant to β-lactams, the most commonly prescribed antibiotics. The resistance of C. difficile to β-lactam antibiotics allows the pathogen to replicate and cause d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandhu BK,Edwards AN,Anderson SE,Woods EC,McBride SM

更新日期：2019-12-20 00:00:00

abstract：:A new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999. Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K, M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Segatore B,de Massis MR,Riccio ML,Bianchi C,Zollo A,Rossolini GM,Amicosante G

更新日期：2000-09-01 00:00:00

abstract：:Cefmenoxime, an investigational semisynthetic cephalosporin, was evaluated in 18 pediatric patients with a variety of infections. There were seven patients with urinary tract infections, two with wound infections, two with osteomyelitis, two with abscess infections, one with cervical adenitis, one with hidradenitis, o...

journal_title：Antimicrobial agents and chemotherapy

authors： Tansino GF,Hammerschlag MR,Congeni BL,Cox PA,Doraiswamy B,duBouchet L

更新日期：1985-10-01 00:00:00

abstract：:Candida lusitaniae is usually susceptible to echinocandins. Beta-1,3-glucan synthase encoded by FKS genes is the target of echinocandins. A few missense mutations in the C. lusitaniae FKS1 hot spot 1 (HS1) have been reported. We report here the rapid emergence of antifungal resistance in C. lusitaniae isolated during ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asner SA,Giulieri S,Diezi M,Marchetti O,Sanglard D

更新日期：2015-12-01 00:00:00

abstract：:Eleven patients about to undergo pulmonary surgery received a bolus injection of 1 g of cefoxitin. The concentrations of cefoxitin in the serum 1 and 2 h after dosage were 38.5 +/- 1.89 and 23.7 +/- 2.56 mug/ml; the lung concentrations at the respective times were 12.6 +/- 0.7 and 10.06 +/- 0.43 mug/ml. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Perea EJ,Garcia-Iglesias MC,Ayarra J,Loscertales J

更新日期：1983-02-01 00:00:00

abstract：:Weak T-cell reactivity to hepatitis B virus (HBV) is thought to be the dominant cause for chronic HBV infection. Treatment with adefovir dipivoxil (ADV) increases the rate of HBV e antigen (HBeAg) loss; however, the immune mechanisms associated with this treatment response are not understood. Serial analysis of HBV-sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Cooksley H,Chokshi S,Maayan Y,Wedemeyer H,Andreone P,Gilson R,Warnes T,Paganin S,Zoulim F,Frederick D,Neumann AU,Brosgart CL,Naoumov NV

更新日期：2008-01-01 00:00:00

abstract：:Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hatfaludi T,Al-Hasani K,Dunstone M,Boyce J,Adler B

更新日期：2008-11-01 00:00:00

abstract：:During its intraerythrocytic phase, the most lethal human malarial parasite, Plasmodium falciparum, digests host cell hemoglobin as a source of some of the amino acids required for its own protein synthesis. A number of parasite endopeptidases (including plasmepsins and falcipains) process the globin into small peptid...

journal_title：Antimicrobial agents and chemotherapy

authors： Cunningham E,Drag M,Kafarski P,Bell A

更新日期：2008-09-01 00:00:00

abstract：:Leishmania mexicana is a protozoan parasite that causes a disease in humans with frequent relapses after treatment. It is also highly resistant to the currently available drugs. For this reason, there is an urgent need for more effective antileishmanial drugs. Hydroxyurea, an anticancer drug, is toxic to replicating e...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez-Rojano H,Mancilla-Ramirez J,Quiñonez-Diaz L,Galindo-Sevilla N

更新日期：2008-10-01 00:00:00

abstract：:VT-1129 is a novel fungal enzyme-specific Cyp51 inhibitor with potent cryptococcal activity. Because of its long half-life (>6 days in mice) and our desire to quickly reach potent efficacy, we evaluated a VT-1129 loading dose-maintenance dose strategy against cryptococcal meningitis. VT-1129 plasma and brain pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Xu X,Wang A,Najvar LK,Garvey EP,Ottinger EA,Alimardanov A,Cradock J,Behnke M,Hoekstra WJ,Brand SR,Schotzinger RJ,Jaramillo R,Olivo M,Kirkpatrick WR,Patterson TF

更新日期：2018-10-24 00:00:00

abstract：:The cell wall composition and autolytic properties of passage-selected glycopeptide-intermediate Staphylococcus aureus (GISA) isolates and their parent strains were studied in order to investigate the mechanism of decreased vancomycin susceptibility. GISA had relatively modest changes in peptidoglycan composition invo...

journal_title：Antimicrobial agents and chemotherapy

authors： Koehl JL,Muthaiyan A,Jayaswal RK,Ehlert K,Labischinski H,Wilkinson BJ

更新日期：2004-10-01 00:00:00

abstract：:Here, we report twoEnterobacter cloacaesequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. TheblaNDM-1-harboring plasmids carry IncA/C2and IncR replicons, showing a mosaic plasmid structure, and theblaNDM-1is harbored on a novel class I integron-li...

journal_title：Antimicrobial agents and chemotherapy

authors： Du H,Chen L,Chavda KD,Pandey R,Zhang H,Xie X,Tang YW,Kreiswirth BN

更新日期：2016-03-25 00:00:00

abstract：:We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses fou...

journal_title：Antimicrobial agents and chemotherapy

authors： Borkow G,Sidwell RW,Smee DF,Barnard DL,Morrey JD,Lara-Villegas HH,Shemer-Avni Y,Gabbay J

更新日期：2007-07-01 00:00:00

abstract：:Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 microg/ml; MIC at which 50% of isolates are inhibited [MIC50], 0.25 microg/ml). The MIC50 of rifabutin was 0.008 microg/ml (n = 16). All resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exc...

journal_title：Antimicrobial agents and chemotherapy

authors： Heep M,Beck D,Bayerdörffer E,Lehn N

更新日期：1999-06-01 00:00:00

abstract：:3-Deazauridine, a synthetic analogue of uridine and a potential antitumor agent, was found to possess antiviral activity against a number of ribonucleic acid-containing animal viruses in mammalian cell culture. Inhibition of virus-induced cytopathogenic effects by 3-deazauridine was observed in cells infected with rhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Shannon WM,Arnett G,Schabel FM Jr

更新日期：1972-09-01 00:00:00

abstract：:The majority of clinical isolates of Moraxella catarrhalis produce beta-lactamase. The role of this enzyme in the phenomenon of indirect pathogenicity, in which a true pathogen such as Streptococcus pneumoniae is protected from the action of certain beta-lactam antibiotics, is well recognized. By using a simple contin...

journal_title：Antimicrobial agents and chemotherapy

authors： Budhani RK,Struthers JK

更新日期：1998-10-01 00:00:00

abstract：:Cryptosporidium parvum arginine aminopeptidase (RAP) was studied during in vitro excystation. Specific RAP inhibitors were identified by using C. parvum extracts. Amastatin, a series of alpha-aminoboronic acids, and the chelating agents EDTA and 1,10-phenanthrolene, but not endoproteinase inhibitors, blocked enzymatic...

journal_title：Antimicrobial agents and chemotherapy

authors： Okhuysen PC,Chappell CL,Kettner C,Sterling CR

更新日期：1996-12-01 00:00:00