当前位置： SCI文献检索 > ANTIMICROBIAL AGENTS AND CHEMOTHERAPY期刊下所有文献 > Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus-specific CD4+ T-cell reactivity.

Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus-specific CD4+ T-cell reactivity.

Abstract：

:Weak T-cell reactivity to hepatitis B virus (HBV) is thought to be the dominant cause for chronic HBV infection. Treatment with adefovir dipivoxil (ADV) increases the rate of HBV e antigen (HBeAg) loss; however, the immune mechanisms associated with this treatment response are not understood. Serial analysis of HBV-specific CD4+ T-cell reactivity was performed during 48 weeks of therapy with ADV and correlated with treatment outcome for 19 HBeAg-positive patients receiving ADV (n = 13) or the placebo (n = 6). We tested T-cell reactivity to HBV at seven protocol time points by proliferation, cytokine production, and enzyme-linked immunospot assays. A panel of serum cytokines was quantitated by cytokine bead array. ADV-treated patients showed increased CD4+ T-cell responses to HBV and lower serum levels of cytokines compared to those of placebo-treated patients. Enhanced CD4+ T-cell reactivity to HBV, which peaked at treatment week 16, was confined to a subgroup of ADV-treated patients who achieved greater viral suppression (5.3 +/- 0.3 log(10) copies/ml [mean +/- standard error of the mean {SEM}] serum HBV DNA reduction from baseline) and HBeAg loss, but not to ADV-treated patients with moderate (3.4 +/- 0.2 log(10) copies/ml [mean +/- SEM]) viremia reduction who remained HBeAg positive or to patients receiving the placebo. In conclusion, T-cell reactivity to HBV increases in a proportion of ADV-treated patients and is associated with greater suppression of HBV replication and HBeAg loss.

journal_name

Antimicrob Agents Chemother

journal_title

Antimicrobial agents and chemotherapy

authors

Cooksley H,Chokshi S,Maayan Y,Wedemeyer H,Andreone P,Gilson R,Warnes T,Paganin S,Zoulim F,Frederick D,Neumann AU,Brosgart CL,Naoumov NV

doi

10.1128/AAC.00467-07

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

312-20

issue

1

eissn

0066-4804

issn

1098-6596

pii

AAC.00467-07

journal_volume

52

pub_type

杂志文章

相关文献

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY文献大全
  • Nonradioactive DNA probe for detection of gene for methicillin resistance in Staphylococcus aureus.

    abstract：:A DNA probe was developed by inserting, in the SmaI site of pBluescript sK, a 528-bp fragment of the gene responsible for intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus (mec determinant). The mec probe provided a useful tool for the rapid identification of the intrinsic resistance trait and f...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.35.3.575

    authors： Ligozzi M,Rossolini GM,Tonin EA,Fontana R

    更新日期：1991-03-01 00:00:00

  • In vitro activities of methylenecyclopropane analogues of nucleosides and their phosphoralaninate prodrugs against cytomegalovirus and other herpesvirus infections.

    abstract：:Human cytomegalovirus (HCMV) infection does not generally cause problems in the immunocompetent adult but can result in severe clinical disease in the fetus, neonate, and immunocompromised host. Ganciclovir (GCV), the agent currently used to treat most HCMV infections, has resulted in much therapeutic success; however...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.44.6.1506-1511.2000

    authors： Rybak RJ,Hartline CB,Qiu YL,Zemlicka J,Harden E,Marshall G,Sommadossi JP,Kern ER

    更新日期：2000-06-01 00:00:00

  • Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736.

    abstract：:A fosmid library from genomic DNA of Streptomyces viridochromogenes DSM 40736 was constructed and screened for the presence of genes known to be involved in the biosynthesis of phosphinothricin tripeptide (PTT). Eight positives were identified, one of which was able to confer PTT biosynthetic capability upon Streptomy...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.49.1.230-240.2005

    authors： Blodgett JA,Zhang JK,Metcalf WW

    更新日期：2005-01-01 00:00:00

  • Effect of 2'-nor-cyclic GMP against guinea pig cytomegalovirus infection.

    abstract：:Cyclic phosphate derivative of DHPG, 2'-nor-cGMP [9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl]-guani ne phosphate-oxide] was evaluated for activity against guinea pig cytomegalovirus (GPCMV) infection in cultured guinea pig embryo cells and in guinea pigs. By virus yield reduction and plaque reduction assays,...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.33.9.1563

    authors： Yang ZH,Lucia HL,Tolman RL,Colonno RJ,Hsiung GD

    更新日期：1989-09-01 00:00:00

  • Characterization of high-level quinolone resistance in Campylobacter jejuni.

    abstract：:High-level resistance to quinolones has previously been shown to occur in Campylobacter spp. both in vitro and in patients treated with quinolones. We have selected isolates that are resistant to quinolones by plating cells from a susceptible C. jejuni strain, UA535, on medium containing nalidixic acid at 32 microgram...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.35.5.840

    authors： Gootz TD,Martin BA

    更新日期：1991-05-01 00:00:00

  • Evaluation of the Carba NP test for rapid detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa.

    abstract：:The Carba NP test was evaluated against a panel of 244 carbapenemase- and non-carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa isolates. We confirmed the 100% specificity and positive predictive value of the test, but the sensitivity and negative predictive value were 72.5% and 69.2%, respectively...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00878-13

    authors： Tijet N,Boyd D,Patel SN,Mulvey MR,Melano RG

    更新日期：2013-09-01 00:00:00

  • Classification of R plasmids by incompatibility in Pseudomonas aeruginosa.

    abstract：:R plasmids identified in Pseudomonas aeruginosa strains isolated in our laboratories were classified by their incompatibility characters by using intraspecies conjugation in P. aeruginosa. The fertility factor, FP2, was compatible with R plasmids belonging to all groups, and was classified in a new group. From these d...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.10.4.573

    authors： Sagai H,Hasuda K,Iyobe S,Bryan LE,Holloway BW,Mitsuhashi S

    更新日期：1976-10-01 00:00:00

  • Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection Model.

    abstract：:Persistent infections with Chlamydia pneumoniae have been implicated in the development of chronic diseases, such as atherosclerosis and asthma. Although azithromycin, clarithromycin, and levofloxacin are frequently used for the treatment of respiratory C. pneumoniae infections, little is known about the dose and dura...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.46.2.409-412.2002

    authors： Kutlin A,Roblin PM,Hammerschlag MR

    更新日期：2002-02-01 00:00:00

  • Combined effect of acyclovir and amphotericin B on the replication of pseudorabies virus in BHK-21 cells.

    abstract：:Acyclovir, known as an antiherpetic agent, showed an inhibitory effect on the propagation of pseudorabies virus in BHK-21 cells. The antiviral effect of acyclovir was observed by plaque reduction, as well as by the inhibition of the virus-stimulated uptake of thymidine by BHK-21 cells. Amphotericin B potentiated the a...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.23.1.119

    authors： Malewicz B,Momsen M,Jenkin HM

    更新日期：1983-01-01 00:00:00

  • Modulation of gyrase-mediated DNA cleavage and cell killing by ATP.

    abstract：:An uncoupler of oxidative phosphorylation, 2,4-dinitrophenol, and an aconitase inhibitor, fluoroacetic acid, both of which are known to lower the cellular ATP pool, protected Escherichia coli cells from the bactericidal actions of gyrase poisons including quinolone antibiotics, nalidixic acid and ciprofloxacin, and th...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.42.5.1022

    authors： Li TK,Liu LF

    更新日期：1998-05-01 00:00:00

  • Experimental central nervous system aspergillosis therapy: efficacy, drug levels and localization, immunohistopathology, and toxicity.

    abstract：:We have shown previously that high-dose lipid amphotericin preparations are not more efficacious than lower doses in aspergillosis. We studied toxicity, drug concentrations and localization, and quantitative infection concurrently, using a 4-day model of central nervous system (CNS) aspergillosis to assess early event...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.06015-11

    authors： Clemons KV,Schwartz JA,Stevens DA

    更新日期：2012-08-01 00:00:00

  • Antibiotic treatment of experimental pneumonic plague in mice.

    abstract：:A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience. Infection was induced by inhalation of aerosolized Yersinia pestis organisms. Antibiotics were administered by intraperitoneal...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.42.3.675

    authors： Byrne WR,Welkos SL,Pitt ML,Davis KJ,Brueckner RP,Ezzell JW,Nelson GO,Vaccaro JR,Battersby LC,Friedlander AM

    更新日期：1998-03-01 00:00:00

  • Comparative nephrotoxicity of gentamicin and tobramycin: pharmacokinetic and clinical studies in 201 patients.

    abstract：:A total of 201 critically ill patients were studied during 267 courses of gentamicin or tobramycin treatment (139 gentamicin courses and 128 tobramycin courses). Of these 267 courses, pharmacokinetic and clinical data were obtained for 240 (120 gentamicin and 120 tobramycin). The data collected for pharmacokinetic ana...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1128/aac.19.5.859

    authors： Schentag JJ,Plaut ME,Cerra FB

    更新日期：1981-05-01 00:00:00

  • Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.

    abstract：:Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserv...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01208-09

    authors： Hölzel CS,Harms KS,Schwaiger K,Bauer J

    更新日期：2010-03-01 00:00:00

  • Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids.

    abstract：:Previous studies have shown that various short- and medium-chain free fatty acids (FFAs) and their corresponding monoacylglycerol esters (MGs) have antibacterial activity in vitro against primarily gram-positive bacteria. More recent studies have also shown that the growth of Helicobacter spp. is inhibited by linoleic...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.40.2.302

    authors： Petschow BW,Batema RP,Ford LL

    更新日期：1996-02-01 00:00:00

  • Experimental therapy of cladosporiosis and sporotrichosis with 5-fluorocytosine.

    abstract：:Cladosporium trichoides and Sporothrix schenckii are fungi known to be pathogenic for man. No effective chemotherapy is available for cladosporiosis, and systemic sporotrichosis can be very resistant to antifungal chemotherapy. Experimental infections of mice with these fungi resembled their respective infections in m...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.3.1.95

    authors： Block ER,Jennings AE,Bennett JE

    更新日期：1973-01-01 00:00:00

  • In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

    abstract：:The in vitro pharmacodynamic properties of colistin and colistin methanesulfonate were investigated by studying the MICs, time-kill kinetics, and postantibiotic effect (PAE) against mucoid and nonmucoid strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis. Twenty-three clinical strains, includ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.45.3.781-785.2001

    authors： Li J,Turnidge J,Milne R,Nation RL,Coulthard K

    更新日期：2001-03-01 00:00:00

  • Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii.

    abstract：:Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (leading to delta5 stero...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.41.7.1428

    authors： Urbina JA,Visbal G,Contreras LM,McLaughlin G,Docampo R

    更新日期：1997-07-01 00:00:00

  • Viability Screen of LOPAC1280 Reveals Phosphorylation Inhibitor Auranofin as a Potent Inhibitor of Blastocystis Subtype 1, 4, and 7 Isolates.

    abstract：:Blastocystis is an enteric parasite with extensive global prevalence. Studies have linked infection with this protist with a variety of gastrointestinal disorders, including irritable bowel syndrome. Due to the polymorphic nature of Blastocystis, studies on the parasite could be complicated, as results can be easily m...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00208-18

    authors： Yason JA,Koh KARP,Tan KSW

    更新日期：2018-07-27 00:00:00

  • Real-time sequencing to decipher the molecular mechanism of resistance of a clinical pan-drug-resistant Acinetobacter baumannii isolate from Marseille, France.

    abstract：:We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01314-12

    authors： Rolain JM,Diene SM,Kempf M,Gimenez G,Robert C,Raoult D

    更新日期：2013-01-01 00:00:00

  • Disparate Candida albicans Biofilm Formation in Clinical Lipid Emulsions Due to Capric Acid-Mediated Inhibition.

    abstract：:Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungus Candida albicans, which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN s...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01394-19

    authors： Willems HME,Stultz JS,Coltrane ME,Fortwendel JP,Peters BM

    更新日期：2019-10-22 00:00:00

  • Multiple low-level antibiotic resistance in Aeromonas salmonicida.

    abstract：:Mutants with multiple low-level antibiotic resistance were isolated from virulent wild-type Aeromonas salmonicida strains exposed to a low concentration of any one of several low-molecular-mass (approximately 635 daltons or less) antibiotics. Multiple resistance was toward beta-lactam compounds (penicillin G, ampicill...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.29.6.992

    authors： Wood SC,McCashion RN,Lynch WH

    更新日期：1986-06-01 00:00:00

  • Chemical genomic screening of a Saccharomyces cerevisiae genomewide mutant collection reveals genes required for defense against four antimicrobial peptides derived from proteins found in human saliva.

    abstract：:To compare the effects of four antimicrobial peptides (MUC7 12-mer, histatin 12-mer, cathelicidin KR20, and a peptide containing lactoferricin amino acids 1 to 11) on the yeast Saccharomyces cerevisiae, we employed a genomewide fitness screen of combined collections of mutants with homozygous deletions of nonessential...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01439-12

    authors： Lis M,Bhatt S,Schoenly NE,Lee AY,Nislow C,Bobek LA

    更新日期：2013-02-01 00:00:00

  • Mechanism of action of quinolones against Escherichia coli DNA gyrase.

    abstract：:The mechanism of action of quinolones was investigated by use of various DNA gyrases reconstituted from wild-type and mutant GyrA and GyrB proteins of Escherichia coli. The quinolone sensitivities of the DNA supercoiling activity of the gyrases were generally parallel to the quinolone susceptibilities of strains havin...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.37.4.839

    authors： Yoshida H,Nakamura M,Bogaki M,Ito H,Kojima T,Hattori H,Nakamura S

    更新日期：1993-04-01 00:00:00

  • A double-blind placebo-controlled study of an infusion of lexipafant (Platelet-activating factor receptor antagonist) in patients with severe sepsis.

    abstract：:Platelet-activating factor (PAF) is a potent endogenous proinflammatory mediator implicated in the pathogenesis of septic shock. A double-blind randomized placebo-controlled trial of an intravenous PAF receptor antagonist (lexipafant) was conducted with 131 adult Thai patients with suspected severe sepsis (66 of whom ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1128/aac.44.3.693-696.2000

    authors： Suputtamongkol Y,Intaranongpai S,Smith MD,Angus B,Chaowagul W,Permpikul C,Simpson JA,Leelarasamee A,Curtis L,White NJ

    更新日期：2000-03-01 00:00:00

  • Successful Treatment of Saksenaea sp. Osteomyelitis by Conservative Surgery and Intradiaphyseal Incorporation of Amphotericin B Cement Beads.

    abstract：:Osteoarticular mucormycosis cases are quite rare and challenging infections that are mostly due to direct inoculation during traumatic injury among immunocompetent patients. Classic management includes a combination of aggressive surgical debridement, which may lead to amputation, and long-term systemic liposomal amph...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01006-18

    authors： Parize P,Mamez AC,Garcia-Hermoso D,Dumaine V,Poirée S,Kauffmann-Lacroix C,Jullien V,Lortholary O,Lanternier F

    更新日期：2018-12-21 00:00:00

  • In vitro synergistic activity between bismuth subcitrate and various antimicrobial agents against Campylobacter pyloridis (C. pylori).

    abstract：:The in vitro interactions between bismuth subcitrate and a variety of antimicrobial agents against 12 Campylobacter pyloridis (C. pylori) isolates were studied by the agar dilution checkerboard technique. The combination of bismuth subcitrate with the older quinolone, oxolinic acid, produced synergistic activity again...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.31.9.1429

    authors： Van Caekenberghe DL,Breyssens J

    更新日期：1987-09-01 00:00:00

  • Pharmacokinetics of the aminoglycoside antibiotic tobramycin in humans.

    abstract：:The pharmacokinetics, distribution, and plasma and renal clearance of a new aminoglycoside antibiotic, tobramycin, was studied in the treatment of 18 elderly male patients (average age, 69 years) with urinary tract infections. Ten of these patients had normal renal function and eight had impaired renal function of var...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.3.4.469

    authors： Naber KG,Westenfelder SR,Madsen PO

    更新日期：1973-04-01 00:00:00

  • Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.

    abstract：:Hepatitis C virus (HCV) NS3 protease inhibitors (PIs) are important components of novel HCV therapy regimens. Studies of PI resistance initially focused on genotype 1. Therefore, knowledge about the determinants of PI resistance for the highly prevalent genotypes 2 to 6 remains limited. Using Huh7.5 cell culture-infec...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.02929-15

    authors： Serre SB,Jensen SB,Ghanem L,Humes DG,Ramirez S,Li YP,Krarup H,Bukh J,Gottwein JM

    更新日期：2016-05-23 00:00:00

  • Evaluation of the Combination of Azithromycin and Naphthoquine in Animal Malaria Models.

    abstract：:Combination therapy using drugs with different mechanisms of action is the current state of the art in antimalarial treatment. However, except for artemisinin-based combination therapies, only a few other combinations are now available. Increasing concern regarding the emergence and spread of artemisinin resistance in...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.02307-19

    authors： Bei ZC,Li GF,Zhao JH,Zhang M,Ji XG,Wang JY

    更新日期：2020-10-20 00:00:00