Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.

abstract：:Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mechanisms have been described, no information is available to date conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Dupont M,James CE,Chevalier J,Pagès JM

更新日期：2007-09-01 00:00:00

abstract：:Drug repurposing affords the implementation of new treatments at a moderate cost and under a faster time-scale. Most of the clinical drugs against Leishmania share this origin. The antidepressant sertraline has been successfully assayed in a murine model of visceral leishmaniasis. Nevertheless, sertraline targets in L...

journal_title：Antimicrobial agents and chemotherapy

authors： Lima ML,Abengózar MA,Nácher-Vázquez M,Martínez-Alcázar MP,Barbas C,Tempone AG,López-Gonzálvez Á,Rivas L

更新日期：2018-11-26 00:00:00

abstract：:Amoxicillin and ampicillin were compared at a dose of 250 mg twice daily for 4 weeks to treat Salmonella typhi or Salmonella paratyphi A chronic bacteriuria with intermittent bacteremia. Eleven patients received amoxicillin, and 15 received ampicillin. Concentrations of the two drugs were measured in the urine and ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Bassily SB,Kilpatrick ME,Farid Z,Mikhail IA,El-Masry NA

更新日期：1981-11-01 00:00:00

abstract：:The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bauernfeind A,Stemplinger I,Jungwirth R,Giamarellou H

更新日期：1996-01-01 00:00:00

abstract：:Burkholderia cepacia complex (Bcc) pulmonary infections in people living with cystic fibrosis (CF) are difficult to treat because of the extreme intrinsic resistance of most isolates to a broad range of antimicrobials. Fosmidomycin is an antibacterial and antiparasitic agent that disrupts the isoprenoid biosynthesis p...

journal_title：Antimicrobial agents and chemotherapy

authors： Malott RJ,Wu CH,Lee TD,Hird TJ,Dalleska NF,Zlosnik JE,Newman DK,Speert DP

更新日期：2014-09-01 00:00:00

abstract：:Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. A lack of immunosuppressive effects compared to that of cyclosporine was demonstrated both in vitro and in vivo. For three cyclosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Ptak RG,Gallay PA,Jochmans D,Halestrap AP,Ruegg UT,Pallansch LA,Bobardt MD,de Béthune MP,Neyts J,De Clercq E,Dumont JM,Scalfaro P,Besseghir K,Wenger RM,Rosenwirth B

更新日期：2008-04-01 00:00:00

abstract：:The spread of antibiotic resistance among Gram-negative bacteria is a serious clinical threat, and infections with these organisms are a leading cause of mortality worldwide. Traditional novel drug development inevitably leads to the emergence of new resistant strains, rendering the new drugs ineffective. Therefore, r...

journal_title：Antimicrobial agents and chemotherapy

authors： Soren O,Brinch KS,Patel D,Liu Y,Liu A,Coates A,Hu Y

更新日期：2015-10-01 00:00:00

abstract：:Cats were experimentally inoculated parenterally with the ME49 strain of Toxoplasma gondii to characterize the efficacies of two different dosages of orally administered clindamycin hydrochloride in the treatment of ocular toxoplasmosis. Concentrations of clindamycin hydrochloride at levels previously suggested to be ...

journal_title：Antimicrobial agents and chemotherapy

authors： Davidson MG,Lappin MR,Rottman JR,Tompkins MB,English RV,Bruce AT,Jayawickrama J

更新日期：1996-06-01 00:00:00

abstract：:1-Oxa-beta-lactam (LY127935) (Shionogi 6059-S) is a new type beta-lactam antibiotic having a broad spectrum of antibacterial activity. It is highly active against ampicillin-resistant strains of Haemophilus influenzae exhibiting minimal inhibitory concentrations as low as 0.06 microgram/ml. This compound also has the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cordera CS,Pekarek RS

更新日期：1980-02-01 00:00:00

abstract：:MICs of a newly developed benzoxazinorifamycin derivative, KRM-1648, for Mycobacterium avium complex (MAC) were determined by the BACTEC 460 TB system and compared with those of other known antimicrobial agents. The radiometric method gave a fast, accurate, and reproducible MIC for each antimicrobial agent. MICs of KR...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomioka H,Saito H,Fujii K,Sato K,Hidaka T

更新日期：1993-01-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:Rates of metallo-beta-lactamase and 16S rRNA methylase production were investigated in 51 imipenem-resistant Pseudomonas aeruginosa clinical isolates collected from hospitals in São Paulo, Brazil. Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their copr...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Ghilardi AC,Adams J,de Oliveira Garcia D,Paterson DL

更新日期：2007-09-01 00:00:00

abstract：:Resistance of Mycobacterium tuberculosis to fluoroquinolones (FQ) results mostly from mutations in the gyrA gene. We developed a reverse hybridization-based line probe assay in which oligonucleotide probes carrying the wild-type gyrA sequence, a serine-to-threonine (S95T) polymorphism, and gyrA mutations (A90V, A90V-S...

journal_title：Antimicrobial agents and chemotherapy

authors： Giannoni F,Iona E,Sementilli F,Brunori L,Pardini M,Migliori GB,Orefici G,Fattorini L

更新日期：2005-07-01 00:00:00

abstract：:The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP50...

journal_title：Antimicrobial agents and chemotherapy

authors： Grgurina I,Bensaci M,Pocsfalvi G,Mannina L,Cruciani O,Fiore A,Fogliano V,Sorensen KN,Takemoto JY

更新日期：2005-12-01 00:00:00

abstract：:β-Lactams are often used to treat Helicobacter cinaedi infections; however, the mechanism underlying β-lactam resistance is unknown. In this study, we investigated β-lactam resistance in an H. cinaedi strain, MRY12-0051 (MICs of amoxicillin [AMX] and ceftriaxone [CRO], 32 and 128 μg/ml; obtained from human feces). Bas...

journal_title：Antimicrobial agents and chemotherapy

authors： Rimbara E,Mori S,Kim H,Suzuki M,Shibayama K

更新日期：2018-01-25 00:00:00

abstract：:Antimicrobial resistance (AMR) is an ever-growing public health problem worldwide. The low rate of antibiotic discovery coupled with the rapid spread of drug-resistant bacterial pathogens is causing a global health crisis. To facilitate the drug discovery processes, we present a large-scale study of reference antibiot...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Rourke A,Beyhan S,Choi Y,Morales P,Chan AP,Espinoza JL,Dupont CL,Meyer KJ,Spoering A,Lewis K,Nierman WC,Nelson KE

更新日期：2020-02-21 00:00:00

abstract：:Ertapenem at 1 g once daily has been suggested to be underdosed in intensive care unit (ICU) patients to attain optimal concentrations in target tissues. Therefore, our study aimed to assess the kinetics of ertapenem in plasma and skeletal muscle in ICU patients using microdialysis. Average muscle free-ertapenem conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyadjiev I,Boulamery A,Simon N,Martin C,Bruguerolle B,Leone M

更新日期：2011-07-01 00:00:00

abstract：:The occurrence of resistance to last-resort antibiotics was evaluated among Enterobacteriaceae isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan-amin...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Aires-de-Sousa M,Kudyba P,Kieffer N,Nordmann P

更新日期：2018-08-27 00:00:00

abstract：:In this study, we investigated the in vitro activity of SCH-56592 (SCH), a new triazole antifungal agent. We compared the activity of SCH with those of itraconazole (ITZ) and amphotericin B (AB) against 60 clinical isolates of Aspergillus spp. by using a microtiter format. Incubation was done at 37 degrees C for 48 h,...

journal_title：Antimicrobial agents and chemotherapy

authors： Oakley KL,Moore CB,Denning DW

更新日期：1997-05-01 00:00:00

abstract：:The judicious use of perioperative antibiotic prophylaxis reduces the infectious complications of surgery. However, increased bacterial resistance within hospitals may make antibiotic prophylaxis less effective in the future and alternative strategies are needed. New immunomodulatory agents might prevent wound infecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kernodle DS,Gates H,Kaiser AB

更新日期：1998-03-01 00:00:00

abstract：:Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagenic agent, often a nucleotide analogue. One of its advantages is its broad spectrum nature that renders the strategy potentially effective against emergent...

journal_title：Antimicrobial agents and chemotherapy

authors： Gallego I,Soria ME,Gregori J,de Ávila AI,García-Crespo C,Moreno E,Gadea I,Esteban J,Fernández-Roblas R,Esteban JI,Gómez J,Quer J,Domingo E,Perales C

更新日期：2019-09-30 00:00:00

abstract：:EDP-239, a novel hepatitis C virus (HCV) inhibitor targeting nonstructural protein 5A (NS5A), has been investigated in vitro and in vivo EDP-239 is a potent, selective inhibitor with potency at picomolar to nanomolar concentrations against HCV genotypes 1 through 6. In the presence of human serum, the potency of EDP-2...

journal_title：Antimicrobial agents and chemotherapy

authors： Owens CM,Brasher BB,Polemeropoulos A,Rhodin MH,McAllister N,Peng X,Wang C,Ying L,Cao H,Lawitz E,Poordad F,Rondon J,Box TD,Zeuzem S,Buggisch P,Lin K,Qiu YL,Jiang L,Colvin R,Or YS

更新日期：2016-09-23 00:00:00

abstract：:The susceptibility of 49 strains of Clostridium ramosum to 10 antibiotics was determined by agar dilution and disk diffusion tests. Results showed that, among the anaerobes, C. ramosum is second only to Bacteroides fragilis in its resistance to antimicrobial agents. All strains were susceptible to penicillin, carbenic...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Armfield AY,Dowell VR Jr,Kwok YY,Sutter VL,Finegold SM

更新日期：1974-06-01 00:00:00

abstract：:Metronidazole (MDZ) and related 5-nitroimidazoles are the recommended drugs for treatment of trichomoniasis, a sexually transmitted disease caused by the protozoan parasite Trichomonas vaginalis. However, novel treatment options are needed, as recent reports have claimed resistance to these drugs in T. vaginalis isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Mallo N,Lamas J,Leiro JM

更新日期：2013-06-01 00:00:00

abstract：:Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniaecarbapenemases (KPC). It has been developed in combination with meropenem. The objective of these studies was to identify the concentrations of both ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Rubio-Aparicio D,Nelson K,Dudley MN,Lomovskaya O

更新日期：2017-11-22 00:00:00

abstract：:We previously showed that simian immunodeficiency virus-infected macaque macrophages contacting uninfected CD4+ lymphocytes caused extensive cell fusion and synthesis of phlogistic cytokines. In this study, macaque macrophage cultures inoculated with SIVmac251 and treated simultaneously with 10 microM 3'-azidothymidin...

journal_title：Antimicrobial agents and chemotherapy

authors： McEntee MF,Flexner C,Farzadegan H,Pitha P,Narayan O

更新日期：1993-02-01 00:00:00

abstract：:Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S beta-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (Ki, 730+/-80 nM), while the D104K G238S variant was th...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson JM,Prati F,Bethel CR,Bonomo RA

更新日期：2007-04-01 00:00:00

abstract：:The quinolones inhibit the A subunit of DNA gyrase in the presence of Mg2+ by interrupting the DNA breakage and resealing steps, and the latter step is also retarded without quinolones if Mg2+ is replaced by Ca2+. Pyrimido[1,6-a]benzimidazoles have been found to represent a new class of potent DNA gyrase inhibitors wh...

journal_title：Antimicrobial agents and chemotherapy

authors： Gmünder H,Kuratli K,Keck W

更新日期：1995-01-01 00:00:00

abstract：:Platelet microbicidal proteins (PMPs) are believed to be integral to host defense against endovascular infection. We previously demonstrated that susceptibility to thrombin-induced PMP 1 (tPMP-1) in vitro negatively influences Candida albicans virulence in the rabbit model of infective endocarditis (IE). This study ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeaman MR,Cheng D,Desai B,Kupferwasser LI,Xiong YQ,Gank KD,Edwards JE Jr,Bayer AS

更新日期：2004-08-01 00:00:00

abstract：:Echinocandins are recommended as the first-line drugs for the treatment of systemic candidiasis. Cas5 is a key transcription factor involved in the response to cell wall damage induced by echinocandins. In this study, through a genetic screen, we identified a second transcription factor, Efg1, that is also crucial for...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong K,Su C,Sun Q,Lu Y

更新日期：2021-01-20 00:00:00