Abstract:
:The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP508 differed from SP22 and other syringopeptins by having three instead of four alpha,beta-unsaturated amino acids and a longer beta-hydroxy acyl chain. Both SP508 and SP22 displayed growth-inhibitory activities against Mycobacterium smegmatis, other gram-positive bacteria, and yeasts but not against gram-negative bacteria. Structure-activity analyses of the SP508 and SP22 homologs indicated chemical structural features that lead to enhanced antimycobacterial activity by these pseudomonad cyclic lipodepsipeptides.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Grgurina I,Bensaci M,Pocsfalvi G,Mannina L,Cruciani O,Fiore A,Fogliano V,Sorensen KN,Takemoto JYdoi
10.1128/AAC.49.12.5037-5045.2005subject
Has Abstractpub_date
2005-12-01 00:00:00pages
5037-45issue
12eissn
0066-4804issn
1098-6596pii
49/12/5037journal_volume
49pub_type
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