Streptomycin resistance in mycobacteria.

abstract：:Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for...

journal_title：Antimicrobial agents and chemotherapy

authors： Veiga MI,Osório NS,Ferreira PE,Franzén O,Dahlstrom S,Lum JK,Nosten F,Gil JP

更新日期：2014-12-01 00:00:00

abstract：:The promotion of colonization with vancomycin-resistant enterococci (VRE) is one potential side effect during treatment of Clostridium difficile-associated diarrhea (CDAD), resulting from disturbances in gut microbiota. Cadazolid (CDZ) is an investigational antibiotic with potent in vitro activity against C. difficile...

journal_title：Antimicrobial agents and chemotherapy

authors： Seiler P,Enderlin-Paput M,Pfaff P,Weiss M,Ritz D,Clozel M,Locher HH

更新日期：2015-10-26 00:00:00

abstract：:Presently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, the in vitro susceptibilities of 34 Madurella mycetomatis strains ...

journal_title：Antimicrobial agents and chemotherapy

authors： van Belkum A,Fahal AH,van de Sande WW

更新日期：2011-04-01 00:00:00

abstract：:Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane permeability. However, the genetic and molecular mechanisms of transformation of a penicillin-susceptible strain of N. gonorrhoeae to high-leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Ropp PA,Hu M,Olesky M,Nicholas RA

更新日期：2002-03-01 00:00:00

abstract：:Wild-type Proteus strains are usually resistant to colistin. We have observed an increase in the level of colistin resistance in four clinical isolates of P. vulgaris, P. morganii, and P. rettgeri by prior treatment with subinhibitory concentrations of the drug. The enhanced resistance in these strains was lost after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu S,Iyobe S,Mitsuhashi S

更新日期：1977-07-01 00:00:00

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more act...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Hashizume T,Matsuda K,Sanada M,Okamoto O,Fukatsu H,Tanaka N

更新日期：1993-12-01 00:00:00

abstract：:The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except against Corynebacterium jeikeium and C. urealyticum, HMR 3647 showed high activity against Corynebacterium spp., being more active than 14- and 16-membered macrolides, azithromycin, or clindamyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Martínez L,Pascual A,Suárez AI,Perea EJ

更新日期：1998-12-01 00:00:00

abstract：:A Klebsiella pneumoniae strain resistant to third-generation cephalosporins was isolated in the eastern Netherlands. The strain was found to carry a novel extended-spectrum beta-lactamase, namely, SHV-31. The combination of the two mutations by which SHV-31 differs from SHV-1, namely, L35Q and E240K, had previously on...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazzariol A,Roelofsen E,Koncan R,Voss A,Cornaglia G

更新日期：2007-03-01 00:00:00

abstract：:The goal of the present study was to examine the ability of cytochrome P450-2C9 (CYP2C9) to activate cyclophosphamide (CPA) and elicit tumor cell death. A CYP2C9-deficient human lymphoblastoid cell line (AHH-1 cells) and a derivative cell line (H2C9 cells) stably transfected with a cDNA encoding CYP2C9 were used. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou D,Lu Y,Steiner MS,Dalton JT

更新日期：2000-10-01 00:00:00

abstract：:Potential alternatives, including linezolid, adjunctive rifampin, and moxifloxacin, were evaluated against vancomycin-tolerant (P9802-020) and vancomycin-susceptible clinical isolates of Streptococcus pneumoniae in an in vitro pharmacodynamic model. Vancomycin exhibited maximal killing of 2-log(10) CFU/ml against P980...

journal_title：Antimicrobial agents and chemotherapy

authors： Cha R,Rybak MJ

更新日期：2003-06-01 00:00:00

abstract：:The increasing prevalence of drug-resistant pathogens highlights the need to identify novel antibiotics. Here we investigated the efficacies of four new antimicrobial peptides (AMPs) for potential drug development. The antibacterial activities, synergistic effects, and antibiofilm properties of the four chimeric AMPs ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gopal R,Kim YG,Lee JH,Lee SK,Chae JD,Son BK,Seo CH,Park Y

更新日期：2014-01-01 00:00:00

abstract：:The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L

更新日期：1974-11-01 00:00:00

abstract：:Because of the potential for an interaction between cephalosporins and aminoglycosides leading to renal injury, an evaluation of the effect of a new cephalosporin, cefamandole nafate, on the toxicity of the aminoglycoside tobramycin was performed in laboratory animals. High doses of cefamandole nafate did not increase...

journal_title：Antimicrobial agents and chemotherapy

authors： Wold JS,Turnipseed SA,Broddle WD,Owen NV

更新日期：1977-10-01 00:00:00

abstract：:9-R-[2-(Phosphonomethoxy)propyl]-adenine (tenofovir) is an acyclic nucleoside phosphonate with antiviral activity against human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV). Tenofovir is not orally bioavailable but becomes orally active against HIV-1 infection as the disoproxil ester (tenofovir di...

journal_title：Antimicrobial agents and chemotherapy

authors： Painter GR,Almond MR,Trost LC,Lampert BM,Neyts J,De Clercq E,Korba BE,Aldern KA,Beadle JR,Hostetler KY

更新日期：2007-10-01 00:00:00

abstract：:Hypermutable Pseudomonas aeruginosa strains are found with high frequency in the lungs of patients with chronic infections and are associated with high antibiotic resistance rates. The in vivo consequences of hypermutation for treatment in a mouse model of lung infection using strain PAO1 and its hypermutable derivati...

journal_title：Antimicrobial agents and chemotherapy

authors： Maciá MD,Borrell N,Segura M,Gómez C,Pérez JL,Oliver A

更新日期：2006-03-01 00:00:00

abstract：:The production of Klebsiella pneumoniae carbapenemases (KPCs) by Enterobacteriaceae has become a significant problem in recent years. To identify factors that could predict isolation of KPC-producing K. pneumoniae (KPCKP) in clinical samples from hospitalized patients, we conducted a retrospective, matched (1:2) case-...

journal_title：Antimicrobial agents and chemotherapy

authors： Tumbarello M,Trecarichi EM,Tumietto F,Del Bono V,De Rosa FG,Bassetti M,Losito AR,Tedeschi S,Saffioti C,Corcione S,Giannella M,Raffaelli F,Pagani N,Bartoletti M,Spanu T,Marchese A,Cauda R,Viscoli C,Viale P

更新日期：2014-06-01 00:00:00

abstract：:Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-...

journal_title：Antimicrobial agents and chemotherapy

authors： Weinberg A,Bate BJ,Masters HB,Schneider SA,Clark JC,Wren CG,Allaman JA,Levin MJ

更新日期：1992-09-01 00:00:00

abstract：:Shigella flexneri continues to be a major cause of diarrhea-associated illness, and increasing resistance to first-line antimicrobials complicates the treatment of infections caused by this pathogen. We investigated the pharmacodynamics of current antimicrobial treatments for shigellosis to determine the likelihood of...

journal_title：Antimicrobial agents and chemotherapy

authors： Allen GP,Harris KA

更新日期：2017-06-27 00:00:00

abstract：:aac(6')-Ib-cr is a plasmid-mediated quinolone resistance gene embedded within a gene cassette, most often within an integron. It confers resistance to quinolones and aminoglycosides. We investigated the role of a 101-bp fragment frequently present upstream of the aac(6')-Ib-cr gene cassette and found that it contribut...

journal_title：Antimicrobial agents and chemotherapy

authors： Raherison S,Jove T,Gaschet M,Pinault E,Tabesse A,Torres C,Ploy MC

更新日期：2017-04-24 00:00:00

abstract：:Acute pulmonary exacerbations (APE) involving Pseudomonas aeruginosa are associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Drug resistance is a significant challenge to treatment. Ceftazidime-avibactam (CZA) demonstrates excellent in vitro activity against isolates recovered from CF p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Wang J,Jayne J,Fukushima L,Rao AP,D'Argenio DZ,Beringer PM

更新日期：2017-09-22 00:00:00

abstract：:Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which Acinetobacter-derived cephalosporinase-7 (ADC-7), a chromosomal AmpC enzyme, hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Curtis BN,Smolen KA,Barlow SJ,Caselli E,Prati F,Taracila MA,Bonomo RA,Wallar BJ,Powers RA

更新日期：2020-11-17 00:00:00

abstract：:We determined the complete nucleotide sequence of a self-transmissible IncL/M plasmid, pKOI-34, from a Klebsiella oxytoca isolate. pKOI-34 possessed the core structure of an IncL/M plasmid found in Erwinia amylovora, pEL60, with two mobile elements inserted, a transposon carrying the arsenic resistance operon and a Tn...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimada N,Kayama S,Shigemoto N,Hisatsune J,Kuwahara R,Nishio H,Yamasaki K,Wada Y,Sueda T,Ohge H,Sugai M

更新日期：2016-04-22 00:00:00

abstract：:An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungals with a novel mechanism of action. Here we report the identification and characterization of two novel zinc-attenuating compounds, Z...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohrt KAO,Marín L,Kjellerup L,Clausen JD,Dalby-Brown W,Calera JA,Winther AL

更新日期：2018-04-26 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) involved in the development of resistance represent powerful markers for the rapid detection of first- and second-line resistance in clinical Mycobacterium tuberculosis complex (MTBC) isolates. However, the association between particular mutations and phenotypic resistance is not...

journal_title：Antimicrobial agents and chemotherapy

authors： Feuerriegel S,Köser C,Trübe L,Archer J,Rüsch Gerdes S,Richter E,Niemann S

更新日期：2010-11-01 00:00:00

abstract：:The global dissemination and increasing incidence of carbapenem-resistant, Gram-negative organisms have resulted in acute public health concerns. Here, we present a retrospective multicenter study on molecular characterization of metallo-β-lactamase (MBL)-producing clinical Escherichia coli isolates recovered from ext...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranjan A,Shaik S,Mondal A,Nandanwar N,Hussain A,Semmler T,Kumar N,Tiwari SK,Jadhav S,Wieler LH,Ahmed N

更新日期：2016-10-21 00:00:00

abstract：:Artemisinins are peroxidic antimalarial drugs known to be very potent but highly chemically unstable; they degrade in the presence of ferrous iron, Fe(II)-heme, or biological reductants. Less documented is how this translates into chemical stability and antimalarial activity across a range of conditions applying to in...

journal_title：Antimicrobial agents and chemotherapy

authors： Parapini S,Olliaro P,Navaratnam V,Taramelli D,Basilico N

更新日期：2015-07-01 00:00:00

abstract：:Three sizes of inserted regions of DNA (800, 1,000, and 1,500 bp) were shown to be common among class I integrons in unrelated clinical isolates of Enterobacteriaceae from different European hospitals. Sequencing showed that 800-bp inserted regions comprised identical sequences including aacA4, that 1,000-bp inserted ...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez-Freijo P,Fluit AC,Schmitz FJ,Verhoef J,Jones ME

更新日期：1999-03-01 00:00:00

abstract：:A clinical isolate of Enterobacter cloacae, strain NOR-1, exhibited resistance to imipenem and remained susceptible to extended-spectrum cephalosporins. Clavulanic acid partially restored the susceptibility of the strain to imipenem. Two beta-lactamases with isoelectric points (pI) of 6.9 and > 9.2 were detected in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Nordmann P,Mariotte S,Naas T,Labia R,Nicolas MH

更新日期：1993-05-01 00:00:00

abstract：:Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes. This assay provides a us...

journal_title：Antimicrobial agents and chemotherapy

authors： Page S,Vernel-Pauillac F,O'Connor O,Bremont S,Charavay F,Courvalin P,Goarant C,Le Hello S

更新日期：2008-11-01 00:00:00