Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.

abstract：:Prior investigators have reported a broad gram-negative spectrum and a marked anti-Pseudomonas activity in vitro with BL-P1654, 6-[R-alpha-(guanylureido)phenylacetamido]-penicillanic acid. An in vitro comparison of BL-P1654 to carbenicillin was performed against 84 strains of Pseudomonas and 39 strains of Enterobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Ressler R,Wilkins J

更新日期：1974-11-01 00:00:00

abstract：:The dependence of microbial killing on chloride ions present in solutions undergoing iontophoresis is addressed. A 400-microA current was applied to vials containing synthetic urine or saline, and the production of chlorine-based substances (CBSs) was detected by the N,N-diethyl-p-phenylene diamine colorimetric method...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis CP,Shirtliff ME,Trieff NM,Hoskins SL,Warren MM

更新日期：1994-12-01 00:00:00

abstract：:We assessed the in vitro toxicity of tenofovir (TFV) and compared it with those of zidovudine (AZT), didanosine (ddI), ritonavir (RTV), and lopinavir (LPV) alone and in combination in human renal proximal tubule epithelial cells (RPTECs). The cells were treated with various concentrations and combinations of the teste...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidal F,Domingo JC,Guallar J,Saumoy M,Cordobilla B,Sánchez de la Rosa R,Giralt M,Alvarez ML,López-Dupla M,Torres F,Villarroya F,Cihlar T,Domingo P

更新日期：2006-11-01 00:00:00

abstract：:The host immune response to human cytomegalovirus (HCMV) is effective against HCMV reactivation from latency, though not sufficient to clear the virus. T cells are primarily responsible for the control of viral reactivation. When the host immune system is compromised, as in transplant recipients with immunosuppression...

journal_title：Antimicrobial agents and chemotherapy

authors： Meng W,Tang A,Ye X,Gui X,Li L,Fan X,Schultz RD,Freed DC,Ha S,Wang D,Zhang N,Fu TM,An Z

更新日期：2017-12-21 00:00:00

abstract：:Amphotericin B derivatives, such as MS-8209, have been evaluated as a therapeutic approach to human immunodeficiency virus (HIV) infection. We show that MS-8209, like amphotericin B, increases tumor necrosis factor alpha (TNF-alpha) mRNA expression and TNF-alpha production and consequently HIV replication in human mac...

journal_title：Antimicrobial agents and chemotherapy

authors： Clayette P,Martin M,Beringue V,Dereuddre-Bosquet N,Adjou KT,Seman M,Dormont D

更新日期：2000-02-01 00:00:00

abstract：:We tested 32 Candida isolates recovered in the early 1990s from the bloodstreams of patients with candidemia for in vitro susceptibility to fluconazole and determined if MIC and/or the daily dose of fluconazole/MIC ratio correlated with the response to therapy. This is a unique data set since 87.5% (28/32) of patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Clancy CJ,Yu VL,Morris AJ,Snydman DR,Nguyen MH

更新日期：2005-08-01 00:00:00

abstract：:The multiple antibiotic resistance (mar) locus in Escherichia coli consists of two divergently expressed operons (marC and marRAB), both of which contribute to the Mar phenotype. Overexpression of the marRAB operon protected E. coli against rapid cell killing by fluoroquinolones. Inactivation of the operon in mar muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldman JD,White DG,Levy SB

更新日期：1996-05-01 00:00:00

abstract：:Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarnet therapy of AIDS patients with cytomegalovirus disease. We therefore...

journal_title：Antimicrobial agents and chemotherapy

authors： Mellors JW,Bazmi HZ,Schinazi RF,Roy BM,Hsiou Y,Arnold E,Weir J,Mayers DL

更新日期：1995-05-01 00:00:00

abstract：:Rezafungin is a new long-acting echinocandin currently in phase 3 development. Epidemiological cutoff values are necessary for breakpoint setting but have not been established due to unexplained interlaboratory MIC variations observed in a prior multicenter study. Here we investigated if the choice of microtiter plate...

journal_title：Antimicrobial agents and chemotherapy

authors： Arendrup MC,Jørgensen KM,Hare RK,Cuenca-Estrella M,Zaragoza O

更新日期：2019-08-23 00:00:00

abstract：:Salmonella spp. are important food-borne pathogens that are demonstrating increasing antimicrobial resistance rates in isolates obtained from food animals and humans. In this study, 10 multidrug-resistant, cephalosporin-resistant Salmonella isolates from bovine, porcine, and human sources from a single geographic regi...

journal_title：Antimicrobial agents and chemotherapy

authors： Winokur PL,Brueggemann A,DeSalvo DL,Hoffmann L,Apley MD,Uhlenhopp EK,Pfaller MA,Doern GV

更新日期：2000-10-01 00:00:00

abstract：:Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage end...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaspar U,de Haro Sautto JA,Molinaro S,Peters G,Idelevich EA,Becker K

更新日期：2018-06-26 00:00:00

abstract：:Automated DNA sequencing was used to analyze the oxyR-ahpC region in 229 Mycobacterium tuberculosis complex isolates recently recovered from diseased humans and animals. The entire 1,221-bp region was studied in 118 isolates, and 111 other isolates were sequenced for oxyR, ahpC, or the 105-bp oxyR-ahpC intergenic regi...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Zhang Y,Deretic V,Musser JM

更新日期：1997-03-01 00:00:00

abstract：:We have developed a chromatographic assay with high sensitivity and specificity to quantify G418 sulfate (Geneticin), an antibiotic used routinely in molecular genetics experiments for selecting eukaryotic transformants. With this method, G418 in tissues and plasma samples can be quantitated without the confounding fa...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethune C,Bui T,Liu ML,Kay MA,Ho RJ

更新日期：1997-03-01 00:00:00

abstract：:The in vivo efficacy of ciprofloxacin or pefloxacin alone or in combination with fosfomycin was evaluated in experimental aortic valve endocarditis induced in 133 rabbits by a multidrug-susceptible or multidrug-resistant strain of Pseudomonas aeruginosa. Therapy was initiated early (12 h after infection), when bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong YQ,Potel G,Caillon J,Stephant G,Jehl F,Bugnon D,Le Conte P,Baron D,Drugeon H

更新日期：1995-02-01 00:00:00

abstract：:Ethambutol at 3.0 micrograms/ml inhibited the transfer of label from D-[14C]glucose into the D-arabinose residue of arabinogalactan in whole cells of a drug-susceptible strain of Mycobacterium smegmatis. This inhibition began almost immediately after exposure of the cells to the drug. When drug-resistant M. smegmatis ...

journal_title：Antimicrobial agents and chemotherapy

authors： Takayama K,Kilburn JO

更新日期：1989-09-01 00:00:00

abstract：:The killing of Candida albicans by a series of amphiphilic quaternary ammonium compounds (QACs) with different hydrocarbon chain lengths was closely related to the binding of the compounds to the cells and damage of the cell membranes. The membrane damage was measured as the level of release of the UV-absorbing materi...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlström B,Chelminska-Bertilsson M,Thompson RA,Edebo L

更新日期：1997-03-01 00:00:00

abstract：:Bay 12-8039, a new 8-methoxy quinolone, was compared with other agents for activity against clinically relevant anaerobes. Bay 12-8039 inhibited 91 and 96% of the 410 test isolates at 2 and 4 micrograms/ml, respectively. Bay 12-8039 had activity comparable to that metronidazole and overall was at least 16-fold more ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Ashcraft DS

更新日期：1997-03-01 00:00:00

abstract：:Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both...

journal_title：Antimicrobial agents and chemotherapy

authors： Arrighi RB,Ebikeme C,Jiang Y,Ranford-Cartwright L,Barrett MP,Langel U,Faye I

更新日期：2008-09-01 00:00:00

abstract：:Mycobacterium abscessus is increasingly recognized as an emerging opportunistic pathogen causing severe lung diseases. As it is intrinsically resistant to most conventional antibiotics, there is an unmet medical need for effective treatments. Repurposing of clinically validated pharmaceuticals represents an attractive...

journal_title：Antimicrobial agents and chemotherapy

authors： Johansen MD,Daher W,Roquet-Banères F,Raynaud C,Alcaraz M,Maurer FP,Kremer L

更新日期：2020-10-20 00:00:00

abstract：:The objective of this study was to develop a population pharmacokinetic model and to determine a dosing regimen for caspofungin in critically ill patients. Nine blood samples were drawn per dosing occasion. Fifteen patients with (suspected) invasive candidiasis had one dosing occasion and five had two dosing occasions...

journal_title：Antimicrobial agents and chemotherapy

authors： Märtson AG,van der Elst KCM,Veringa A,Zijlstra JG,Beishuizen A,van der Werf TS,Kosterink JGW,Neely M,Alffenaar JW

更新日期：2020-08-20 00:00:00

abstract：:WCK 5222 consists of cefepime combined with zidebactam, a bicyclo-acyl hydrazide β-lactam enhancer antibiotic with a dual action involving binding to Gram-negative bacterial PBP2 and β-lactamase inhibition. We evaluated the in vitro activity of cefepime-zidebactam against 7,876 contemporary (2015) clinical isolates of...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Castanheira M,Huband M,Jones RN,Flamm RK

更新日期：2017-04-24 00:00:00

abstract：:The emergence of clinical enterococcal isolates resistant to both ampicillin and vancomycin is a cause of great concern, as there are few therapeutic alternatives for treatment of infections caused by such organisms. We evaluated the effects of the combination of ampicillin with vancomycin against vancomycin-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Cercenado E,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1992-10-01 00:00:00

abstract：:This study determined the phylogenetic groups and virulence factors of 37 Escherichia coli isolates producing types of CTX-M compared with those of 19 isolates producing different types of extended-spectrum beta-lactamases (ESBLs) in a well-defined North American population. Most CTX-M-14 producers (97%) were from phy...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitout JD,Laupland KB,Church DL,Menard ML,Johnson JR

更新日期：2005-11-01 00:00:00

abstract：:Artemisinin and its derivatives are important new antimalarials which are now used widely in Southeast Asia. Clinically relevant artemisinin resistance has not yet been reported but is likely to occur. In order to understand how the malaria parasite might become resistant to this drug, we studied artemisinin resistanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Walker DJ,Pitsch JL,Peng MM,Robinson BL,Peters W,Bhisutthibhan J,Meshnick SR

更新日期：2000-02-01 00:00:00

abstract：:We assessed cutaneous ethanol (ETOH) and isopropanol (ISOP) absorption after intensive (30 times per h) use of alcohol-based hand-rub solutions by healthcare workers (HCWs). ETOH was detectable in the breath of 6/20 HCWs (0.001 to 0.0025%) at 1 to 2 min postexposure and in the serum of 2/20 HCWs at 5 to 7 min postexpo...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown TL,Gamon S,Tester P,Martin R,Hosking K,Bowkett GC,Gerostamoulos D,Grayson ML

更新日期：2007-03-01 00:00:00

abstract：:This work investigated the molecular events driving the evolution of the CTX-M-type β-lactamases by the use of DNA shuffling of fragments of the blaCTX-M-14 and blaCTX-M-15 genes. Analysis of a total of 51 hybrid enzymes showed that enzymatic activity could be maintained in most cases, yet hybrids that were active pos...

journal_title：Antimicrobial agents and chemotherapy

authors： Po KHL,Chan EWC,Chen S

更新日期：2017-11-22 00:00:00

abstract：:ST-246, a novel compound that inhibits egress of orthopoxvirus from infected cells, is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, placebo-controlled, escalating multiple-dose study was conducted to determine the safety, tolerability, and ph...

journal_title：Antimicrobial agents and chemotherapy

authors： Jordan R,Chinsangaram J,Bolken TC,Tyavanagimatt SR,Tien D,Jones KF,Frimm A,Corrado ML,Pickens M,Landis P,Clarke J,Marbury TC,Hruby DE

更新日期：2010-06-01 00:00:00

abstract：:A total of 113 patients were randomly allocated to receive either ticarcillin plus clavulanic acid (total dose, 20.8 g) or clindamycin (total dose, 2.4 g) plus amikacin (total dose, 1 g) as perioperative antimicrobial prophylaxis for major head and neck surgery. The two groups were similar in age, prior antineoplastic...

journal_title：Antimicrobial agents and chemotherapy

authors： Gerard M,Meunier F,Dor P,Andry G,Chantrain G,Van der Auwera P,Daneau D,Klastersky J

更新日期：1988-10-01 00:00:00

abstract：:A Klebsiella pneumoniae strain resistant to third-generation cephalosporins was isolated in the eastern Netherlands. The strain was found to carry a novel extended-spectrum beta-lactamase, namely, SHV-31. The combination of the two mutations by which SHV-31 differs from SHV-1, namely, L35Q and E240K, had previously on...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazzariol A,Roelofsen E,Koncan R,Voss A,Cornaglia G

更新日期：2007-03-01 00:00:00

abstract：:In both primary rabbit kidney cells and human skin fibroblasts, 5-propyl-2'-deoxyuridine proved inhibitory to herpes simplex virus at a concentration as low as 1 micrograms/ml, whereas concentrations higher than 200 micrograms/ml were required to inhibit vaccinia virus replication or normal cell metabolism. ...

journal_title：Antimicrobial agents and chemotherapy

authors： De Clercq E,Descamps J,Shugar D

更新日期：1978-03-01 00:00:00