Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.

abstract：:The activities of ampicillin, meropenem, azithromycin, gentamicin, ciprofloxacin, and moxifloxacin against intracellular hemolysin-positive Listeria monocytogenes were measured in human THP-1 macrophages and were compared with the extracellular activities observed in broth. All extracellular concentrations were adjust...

journal_title：Antimicrobial agents and chemotherapy

authors： Carryn S,Van Bambeke F,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-07-01 00:00:00

abstract：:Drug repurposing affords the implementation of new treatments at a moderate cost and under a faster time-scale. Most of the clinical drugs against Leishmania share this origin. The antidepressant sertraline has been successfully assayed in a murine model of visceral leishmaniasis. Nevertheless, sertraline targets in L...

journal_title：Antimicrobial agents and chemotherapy

authors： Lima ML,Abengózar MA,Nácher-Vázquez M,Martínez-Alcázar MP,Barbas C,Tempone AG,López-Gonzálvez Á,Rivas L

更新日期：2018-11-26 00:00:00

abstract：:Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro;...

journal_title：Antimicrobial agents and chemotherapy

authors： Lopes SC,Blanco YC,Justo GZ,Nogueira PA,Rodrigues FL,Goelnitz U,Wunderlich G,Facchini G,Brocchi M,Duran N,Costa FT

更新日期：2009-05-01 00:00:00

abstract：:Serratia marcescens S-95, which displayed an unusually high degree of resistance to aminoglycosides, including kanamycins and gentamicins, was isolated in 2002 from a patient in Japan. The resistance was mediated by a large plasmid which was nonconjugative but transferable to an Escherichia coli recipient by transform...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Yokoyama K,Yamane K,Wachino J,Shibata N,Yagi T,Shibayama K,Kato H,Arakawa Y

更新日期：2004-02-01 00:00:00

abstract：:Infection is one of the most important causes of titanium implant failure in vivo A developing prophylactic method involves the immobilization of antibiotics, especially vancomycin, onto the surface of the titanium implant. However, these methods have a limited effect in curbing multiple bacterial infections due to an...

journal_title：Antimicrobial agents and chemotherapy

authors： Nie B,Long T,Ao H,Zhou J,Tang T,Yue B

更新日期：2016-12-27 00:00:00

abstract：:The activity of nalidixic acid combined with each of 10 other antimicrobial agents on 95 strains of Enterobacteriaceae was studied. Synergism was found less often than antagonism, and the commonest outcome was indifference. Combinations of nalidixic acid with kanamycin, gentamicin, or colistin were more often synergis...

journal_title：Antimicrobial agents and chemotherapy

authors： Michel J,Luboshitzky R,Sacks T

更新日期：1973-09-01 00:00:00

abstract：:Cell-free amino acid incorporation using ribosomes from strains of either Clostridium perfringens or Bacteroides fragilis was shown to be susceptible to inhibition by streptomycin and gentamicin. Ribosomes bound dihydrostreptomycin as effectively as ribosomes from Escherichia coli. No inactivation of streptomycin or g...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryan LE,Kowand SK,Van Den Elzen HM

更新日期：1979-01-01 00:00:00

abstract：:Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substituti...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Castanheira M,Carrër A,Rodriguez CP,Jones RN,Smayevsky J,Nordmann P

更新日期：2011-06-01 00:00:00

abstract：:The novel triazole D0870 was tested for in vitro activity, as well as in vivo in a murine model of pulmonary blastomycosis. In vitro, D0870 had inhibitory and fungicidal activity against Blastomyces dermatitidis (MIC = 0.048 microgram/ml; minimal fungicidal concentration = 0.097 microgram/ml). In vivo, D0870 was appro...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Hanson LH,Stevens DA

更新日期：1993-05-01 00:00:00

abstract：:The susceptibilities to 20 antimicrobial agents of Bordetella bronchiseptica variants in C mode and degraded phases were compared with those of their parents in X mode. Increases in MICs of 4- to 32-fold were observed for ampicillin, carbenicillin, erythromycin, novobiocin, rifampin, chloramphenicol, nalidixic acid, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishikawa H,Isayama Y,Ohmae K

更新日期：1988-12-01 00:00:00

abstract：:The effect of liposomal encapsulation of ampicillin on the antibacterial activity against intracellular Listeria monocytogenes was studied by comparing survival of L. monocytogenes within peritoneal mouse macrophages in the presence of free ampicillin alone or in combination with liposome-entrapped ampicillin. In the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakker-Woudenberg IA,Lokerse AF,Vink-van den Berg JC,Roerdink FH,Michel MF

更新日期：1986-08-01 00:00:00

abstract：:The susceptibilities of 87 periodontitis-associated strains of Actinobacillus actinomycetemcomitans to clarithromycin and erythromycin were determined by standard methodology recommended for Haemophilus influenzae. For clarithromycin the MIC at which 90% of the isolates were inhibited was

journal_title：Antimicrobial agents and chemotherapy

authors： Piccolomini R,Catamo G,Di Bonaventura G

更新日期：1998-11-01 00:00:00

abstract：:We adopted an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VAN), arbekacin (ABK), and gentamicin (GEN) alone or in combination. Using two strains of clinically isolated methicillin-resistant Staphylococcus aureus, one GEN susceptible (GS171) and one GEN resistant (GR153), fibrin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee DG,Chun HS,Yim DS,Choi SM,Choi JH,Yoo JH,Shin WS,Kang MW

更新日期：2003-12-01 00:00:00

abstract：:Expression of eight transporter genes of Escherichia coli K-12 and its DeltaacrAB mutant prior to and after induction of both strains to tetracycline resistance and after reversal of induced resistance were analyzed by quantitative reverse transcriptase PCR. All transporter genes were overexpressed after induced resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Viveiros M,Jesus A,Brito M,Leandro C,Martins M,Ordway D,Molnar AM,Molnar J,Amaral L

更新日期：2005-08-01 00:00:00

abstract：:The effect of protein binding on the activity of teicoplanin against Staphylococcus aureus was evaluated. Bactericidal rates of teicoplanin in cation-supplemented Mueller-Hinton broth (SMHB) and in a 1:1 mixture of pooled human serum and cation-supplemented Mueller-Hinton broth (PHS-SMHB) were compared with those of v...

journal_title：Antimicrobial agents and chemotherapy

authors： Bailey EM,Rybak MJ,Kaatz GW

更新日期：1991-06-01 00:00:00

abstract：:Lipopolysaccharide (LPS) samples isolated from a parent and two antibiotic-hypersusceptible mutant strains of Escherichia coli were analyzed for polycation affinity and level of binding. Purified salts of the LPSs from the parent strain, UB1005, and from one of the mutant strains, DC1, bound similar amounts of sodium ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rocque WJ,Fesik SW,Haug A,McGroarty EJ

更新日期：1988-03-01 00:00:00

abstract：:As drug resistance continues to grow, treatment strategies that turn resistance into a disadvantage for the organism will be increasingly relied upon to treat infections and to lower the rate of multidrug resistance. The majority of work in this area has investigated how resistance evolution toward a single antibiotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez de Evgrafov MC,Faza M,Asimakopoulos K,Sommer MOA

更新日期：2020-12-16 00:00:00

abstract：:Multidrug-resistant Enterobacteriaceae (MRE) colonize the intestine asymptomatically from where they can breach into the bloodstream and cause life-threatening infections, especially in heavily colonized patients. Despite the clinical relevance of MRE colonization levels, we know little about how they vary in hospital...

journal_title：Antimicrobial agents and chemotherapy

authors： Djukovic A,González-Barberá EM,Sanz J,Artacho A,Peñaranda I,Herrera B,Garzón MJ,Salavert M,López-Hontangas JL,Xavier KB,Kuster B,Debrauwer L,Rolain JM,Sanz MA,Xavier JB,Ubeda C

更新日期：2020-01-27 00:00:00

abstract：:The effects of trifluorothymidine (5-trifluoromethyl-2'-deoxyuridine, F3dThd) on the replication of three mouse cell lines, LM929, Ltk- (and LM929 derivative devoid of cytosolic deoxythymidine [dThd] kinase activity), and Ltk- c139 (a Ltk- derivative which expresses herpes simplex virus type 1-specified dThd kinase su...

journal_title：Antimicrobial agents and chemotherapy

authors： Wigdahl BL,Parkhurst JR

更新日期：1981-05-01 00:00:00

abstract：:Tn5801, originally detected in Staphylococcus aureus Mu50, is a Tn916 family element in which a unique int gene (int5801) replaces the int and xis genes in Tn916 (int916 and xis916). Among 62 tet(M)-positive tetracycline-resistant Streptococcus agalactiae isolates, 43 harbored Tn916, whereas 19 harbored a Tn5801-like ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Tili E,Giovanetti E,Montanari MP,Varaldo PE

更新日期：2013-09-01 00:00:00

abstract：:Management of treatment-experienced human immunodeficiency virus patients has become complex, and therapy may need to include two protease inhibitors at therapeutic doses. The objective of this study was to characterize the pharmacokinetics in serum of saquinavir (1,000 mg twice daily [b.i.d.]), lopinavir (400 mg b.i....

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Lopez RM,Diaz M,Pou L,Ruiz L,Falcó V,Crespo M,Azuaje C,Ruiz I,Ocaña I,Clotet B,Pahissa A

更新日期：2004-11-01 00:00:00

abstract：:Ethambutol (EMB) is a major component of the first-line therapy of tuberculosis. Mutations in codon 306 of embB (embB306) were suggested as a major resistance mechanism in clinical isolates. To directly analyze the impact of individual embB306 mutations on EMB resistance, we used allelic exchange experiments to genera...

journal_title：Antimicrobial agents and chemotherapy

authors： Plinke C,Walter K,Aly S,Ehlers S,Niemann S

更新日期：2011-06-01 00:00:00

abstract：:The activity of methacycline against microbial L-forms and their parent bacteria was compared with that of oxytetracycline, chlortetracycline, tetracycline, and demethylchlortetracycline, as well as with that of 22 other antibiotics which included examples of major groups of antibiotics. The L-forms and bacteria used ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hubert EG,Kalmanson GM,Montgomerie JZ,Guze LB

更新日期：1972-10-01 00:00:00

abstract：:Antibiotic-impregnated beads are used in the dead bone space following debridement surgery to deliver local, high concentrations of antibiotics. Polymethylmethacrylate (PMMA), 2,000-molecular-weight (MW) polylactic acid (PLA), Poly(DL-lactide)-coglycolide (PL:CG; 90:10, 80:20, and 70:30), and the combination 2,000-MW ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mader JT,Calhoun J,Cobos J

更新日期：1997-02-01 00:00:00

abstract：:A vancomycin-resistant, anaerobic, gram-positive coccus containing the vanD and vanG-like genes (strain CCRI-16110) was isolated from a human fecal specimen during a hospital surveillance program to detect carriers of vancomycin-resistant enterococci. Comparison of the 16S rRNA gene sequence of strain CCRI-16110 with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Domingo MC,Huletsky A,Giroux R,Picard FJ,Bergeron MG

更新日期：2007-11-01 00:00:00

abstract：:Seventy-one strains of 15 species of rapidly growing mycobacteria were studied for their susceptibilities to fatty acids with 2 to 20 carbons by the agar dilution method at pH 7.0. Most mycobacteria other than potential pathogens (Mycobacterium fortuitum and Mycobacterium chelonei) were resistant to saturated fatty ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Saito H,Tomioka H,Yoneyama T

更新日期：1984-08-01 00:00:00

abstract：:Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of approximately 60 h. Rifalazil has potent bactericidal activity against Mycobacterium tuberculosis in vitro and in animal models of tuberculosis (TB). Prior studies in healthy volunteers showed that once...

journal_title：Antimicrobial agents and chemotherapy

authors： Dietze R,Teixeira L,Rocha LM,Palaci M,Johnson JL,Wells C,Rose L,Eisenach K,Ellner JJ

更新日期：2001-07-01 00:00:00

abstract：:The mechanisms of herpes simplex virus (HSV) inactivation by sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), two anionic surfactants with protein denaturant potency, have been evaluated in cultured cells. Results showed that pretreatment of HSV type 1 (HSV-1) strain F and HSV-2 strain 333 with either surfacta...

journal_title：Antimicrobial agents and chemotherapy

authors： Piret J,Roy S,Gagnon M,Landry S,Désormeaux A,Omar RF,Bergeron MG

更新日期：2002-09-01 00:00:00

abstract：:While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry DR,Holmes DJ

更新日期：2008-03-01 00:00:00

abstract：:In published studies, cohorts of patients with bacteremia due to vancomycin-resistant Enterococcus (VRE) have predominantly been infected with Enterococcus faecium. Little is known about the epidemiology and outcomes associated with bacteremia due to VR Enterococcus faecalis. A retrospective study of isolates obtained...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayakawa K,Marchaim D,Martin ET,Tiwari N,Yousuf A,Sunkara B,Pulluru H,Kotra H,Hasan A,Bheemreddy S,Sheth P,Lee DW,Kamatam S,Bathina P,Nanjireddy P,Chalana IK,Patel S,Kumar S,Vahia A,Ku K,Yee V,Swan J,Pogue JM

更新日期：2012-05-01 00:00:00