Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis.

abstract：:Since November 1982 at the Sainte-Justine Hospital in Montreal, ampicillin and cefotaxime were used in association as initial treatment (greater than or equal to 48 h) for childhood bacterial meningitis. In this report is described the in vitro interaction of the new regimen in comparison with that of the previous amp...

journal_title：Antimicrobial agents and chemotherapy

authors： Lapointe JR,Lavallée C,Michaud A,Chicoine L,Joncas JH

更新日期：1986-04-01 00:00:00

abstract：:Increasingly frequent reports have described the in vivo loss of daptomycin susceptibility in association with clinical treatment failures. The mechanism(s) of daptomycin resistance is not well understood. We studied an isogenic set of Staphylococcus aureus isolates from the bloodstream of a daptomycin-treated patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones T,Yeaman MR,Sakoulas G,Yang SJ,Proctor RA,Sahl HG,Schrenzel J,Xiong YQ,Bayer AS

更新日期：2008-01-01 00:00:00

abstract：:Drug repurposing affords the implementation of new treatments at a moderate cost and under a faster time-scale. Most of the clinical drugs against Leishmania share this origin. The antidepressant sertraline has been successfully assayed in a murine model of visceral leishmaniasis. Nevertheless, sertraline targets in L...

journal_title：Antimicrobial agents and chemotherapy

authors： Lima ML,Abengózar MA,Nácher-Vázquez M,Martínez-Alcázar MP,Barbas C,Tempone AG,López-Gonzálvez Á,Rivas L

更新日期：2018-11-26 00:00:00

abstract：:Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolf DG,Yaniv I,Ashkenazi S,Honigman A

更新日期：2001-02-01 00:00:00

abstract：:Serial passage of Pseudomonas aeruginosa ATCC 27853 or Escherichia coli ATCC 25922 on agar with subinhibitory concentrations of norfloxacin rapidly produced isolates with minimal inhibitory concentrations (MICs) of norfloxacin up to 512-fold higher than that for the original strain. Although MICs of seven unrelated an...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenney JH,Maack RW,Chippendale GR

更新日期：1983-01-01 00:00:00

abstract：:An efficient and reproducible procedure was developed for extracting aminoglycosides from renal cortical tissue. It involves a double homogenization and two rinsings with trichloroacetic acid. A higher recovery is obtained compared with that of other previously reported methods. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giuliano RA,Verpooten GA,Pollet DE,Verbist L,Scharpé SL,De Broe ME

更新日期：1984-06-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) type 1 (HIV-1) variants were selected for resistance to the (+) and (-) enantiomers of a novel nucleoside analogue, 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine (dOTFC), by use of the infectious molecular clone HIV HXB2D and the human T-cell line MT-4. The dOTFC-resistant variants that w...

journal_title：Antimicrobial agents and chemotherapy

authors： Richard N,Salomon H,Rando R,Mansour T,Bowlin TL,Wainberg MA

更新日期：2000-05-01 00:00:00

abstract：:The activity of cinoxacin, a synthetic organic acid antimicrobial agent, was studied and found to have in vitro activity similar to that previously reported for nalidixic acid. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kurtz S,Turck M

更新日期：1975-03-01 00:00:00

abstract：:A group H1 R factor encoding resistance to chloramphenicol, streptomycin, sulfonamide, and tetracycline was transferred into Salmonella typhimurium LT-2. The virulence of LT-2 for mice, as assessed by intraperitoneal 50% lethal dose and the number of organisms in the spleen, was not affected by the R factor. On the ot...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler T,Shuster CW,Franco A

更新日期：1979-03-01 00:00:00

abstract：:Fragments (414 bp) of the gene-encoding ribosomal protein L16 from Enterococcus faecium and Enterococcus faecalis that were resistant and susceptible to the oligosaccharide antibiotics avilamycin and evernimicin (SCH 27899) were sequenced and compared. The susceptible E. faecalis and E. faecium isolates had sequences ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aarestrup FM,Jensen LB

更新日期：2000-12-01 00:00:00

abstract：:Arguably, one of the most common and consequential laboratory tests performed in the world is Mycobacterium tuberculosis susceptibility testing. M. tuberculosis resistance is defined by growth of > or =1% of a bacillary inoculum on the critical concentration of an antibiotic. The critical concentration was chosen base...

journal_title：Antimicrobial agents and chemotherapy

authors： Gumbo T

更新日期：2010-04-01 00:00:00

abstract：:Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluc...

journal_title：Antimicrobial agents and chemotherapy

authors： Chau AS,Chen G,McNicholas PM,Mann PA

更新日期：2006-11-01 00:00:00

abstract：:There has been a marked increase in the resistance of Neisseria gonorrhoeae isolated in Korea to penicillin, ampicillin, and tetracycline. In contrast, there has been no increased resistance to spectinomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson C,Rose DL,Tramont EC

更新日期：1976-04-01 00:00:00

abstract：:Therapy with nucleoside reverse transcriptase inhibitors (NRTIs) can be associated with mitochondrial toxicity. In vitro studies have been used to predict the predisposition for and characterize the mechanisms causing mitochondrial toxicity. Entecavir (ETV) is an approved deoxyguanosine nucleoside for the treatment of...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazzucco CE,Hamatake RK,Colonno RJ,Tenney DJ

更新日期：2008-02-01 00:00:00

abstract：:7-[alpha-(1-Methyl-4-pyridiniothio)-acetamido] cephalosporanic acid, referred to herein as BL-S 217, is a new broad-spectrum semisynthetic cephalosporin that offers several advantages over cephalothin. A comparison of the activity in vitro of these antibiotics indicates that BL-S 217 is about eightfold more effective ...

journal_title：Antimicrobial agents and chemotherapy

authors： Buck RE,Leitner F,Price KE

更新日期：1972-01-01 00:00:00

abstract：:Previous studies showed an increased prevalence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) thumb subdomain polymorphisms Pro272, Arg277, and Thr286 in patients failing therapy with nucleoside analogue combinations. Interestingly, wild-type HIV-1(BH10) RT contains Pro272, Arg277, and Thr2...

journal_title：Antimicrobial agents and chemotherapy

authors： Betancor G,Puertas MC,Nevot M,Garriga C,Martínez MA,Martinez-Picado J,Menéndez-Arias L

更新日期：2010-11-01 00:00:00

abstract：:We used the Tn10-encoded Tet repressor, which has a highly specific binding capacity for tetracycline, to probe contacts between the drug and protein by chemical interference studies of the antibiotic. For that purpose, the equilibrium association constants of modified tetracyclines with the Tet repressor and Mg2+ cat...

journal_title：Antimicrobial agents and chemotherapy

authors： Degenkolb J,Takahashi M,Ellestad GA,Hillen W

更新日期：1991-08-01 00:00:00

abstract：:Bradyzoite-to-tachyzoite conversion plays a role in the pathogenesis of recrudescence of ocular toxoplasmosis and disease in immunocompromised persons. The currently available medicines are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. A previous study showed that the histone deacetyla...

journal_title：Antimicrobial agents and chemotherapy

authors： Maubon D,Bougdour A,Wong YS,Brenier-Pinchart MP,Curt A,Hakimi MA,Pelloux H

更新日期：2010-11-01 00:00:00

abstract：:The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin, and sitamaquine was assessed in vitro and additionally for the first three combinations in vivo. In vitro interactions were indifferent for miltefosine combined with amphotericin B (mean sums of fractional inhibitory concentrations...

journal_title：Antimicrobial agents and chemotherapy

authors： Seifert K,Croft SL

更新日期：2006-01-01 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:To determine if saquinavir mesylate (saquinavir) is a substrate of human multidrug resistance-associated protein 1 (hMRP1 [ABCC1]) or hMRP2 (cMOAT, or ABCC2), MDCKII cells that overexpress either hMRP1 (MDCKII-MRP1) or hMRP2 (MDCKII-MRP2) were used to investigate saquinavir's cytotoxicity and transport in comparison w...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams GC,Liu A,Knipp G,Sinko PJ

更新日期：2002-11-01 00:00:00

abstract：:In this study, our objective was to determine whether a synergistic antimicrobial combination in vitro would be beneficial in the downregulation of pneumococcal virulence genes and whether the associated inflammation of the lung tissue induced by multidrug-resistant Streptococcus pneumoniae infection in vivo needs to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Majhi A,Adhikary R,Bhattacharyya A,Mahanti S,Bishayi B

更新日期：2014-09-01 00:00:00

abstract：:Antisera produced against envelope fractions of tetracycline-resistant Escherichia coli and supernatant fluid of disrupted cells of tetracycline-resistant Salmonella typhi were adsorbed with the corresponding fractions of susceptible cultures. With these sera, cross-reacting antigens were demonstrated in the following...

journal_title：Antimicrobial agents and chemotherapy

authors： Boldur I,Sompolinsky D

更新日期：1974-08-01 00:00:00

abstract：:The in vitro pharmacodynamic properties of colistin and colistin methanesulfonate were investigated by studying the MICs, time-kill kinetics, and postantibiotic effect (PAE) against mucoid and nonmucoid strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis. Twenty-three clinical strains, includ...

journal_title：Antimicrobial agents and chemotherapy

authors： Li J,Turnidge J,Milne R,Nation RL,Coulthard K

更新日期：2001-03-01 00:00:00

abstract：:Topical administration of live commensal bacteria to the vaginal tract holds significant potential as a cost-effective strategy for the treatment of sexually transmitted infections and the delivery of mucosal vaccines. Probiotic-releasing intravaginal rings (IVRs) embody significant theoretical advantages over traditi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunawardana M,Mullen M,Yoo J,Webster P,Moss JA,Baum MM

更新日期：2014-01-01 00:00:00

abstract：:A multicenter collection of bacteremic isolates of Escherichia coli (n = 423), Klebsiella pneumoniae (n = 372), Pseudomonas aeruginosa (n = 300), and Acinetobacter baumannii complex (n = 199) was analyzed for susceptibility. Xpert Carba-R assay and sequencing for mcr genes were performed for carbapenem- or colistin-re...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu PY,Lee YL,Lu MC,Shao PL,Lu PL,Chen YH,Cheng SH,Ko WC,Lin CY,Wu TS,Yen MY,Wang LS,Liu CP,Lee WS,Chen YS,Wang FD,Tseng SH,Lin CN,Tang HJ,Chen YH,Sheng WH,Lee CM,Liao MH,Hsueh PR

更新日期：2020-09-21 00:00:00

abstract：:Lividomycin specifically inhibited bacterial protein synthesis and had codon misreading activity. Lividomycin, moreover, stimulated the binding of aminoacyl-transfer ribonucleic acid to ribosomes, but did not show any significant effects on the formation of aminoacyl-transfer ribonucleic acid and the puromycin reactio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamaguchi M,Eda J,Kobayashi F,Mitsuhashi S

更新日期：1973-09-01 00:00:00

abstract：:We have evaluated the susceptibility of the murine gamma herpesvirus 68 (MHV-68) to a variety of antiviral agents. The acyclic nucleoside phosphonate analogs cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine], (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA), and adefovir [9-(2-phosphonylmethox...

journal_title：Antimicrobial agents and chemotherapy

authors： Neyts J,De Clercq E

更新日期：1998-01-01 00:00:00

abstract：:Vancomycin-resistant enterococci (VRE) are endemic in health care settings. These organisms colonize the gastrointestinal tract and can lead to infection which is associated with increased mortality. There is no treatment for VRE colonization. We conducted a randomized, double-blind, placebo-controlled clinical trial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Doron S,Hibberd PL,Goldin B,Thorpe C,McDermott L,Snydman DR

更新日期：2015-08-01 00:00:00

abstract：:Catheters and other indwelling devices placed inside human body are prone to bacterial infection, causing serious risk to patients. Infections associated with implants are difficult to resolve, and hence the prevention of bacterial colonization of such surfaces is quite appropriate. In this context, the development of...

journal_title：Antimicrobial agents and chemotherapy

authors： Dave RN,Joshi HM,Venugopalan VP

更新日期：2011-02-01 00:00:00