In vitro activity of cinoxacin, an organic acid antibacterial.

abstract：:Isolates of Legionella pneumophila serogroup 1, obtained from guinea pigs with experimentally induced Legionnaires disease, were tested for rifampin resistance. Thirteen isolates were from animals treated with rifampin alone, four isolates were from animals treated with saline, and three isolates each were from animal...

journal_title：Antimicrobial agents and chemotherapy

authors： Edelstein PH

更新日期：1991-01-01 00:00:00

abstract：:Herpes simplex ocular infection is a major cause of corneal blindness. Local antiviral treatments exist but are associated with corneal toxicity, and resistance has become an issue. We evaluated the biodistribution and efficacy of a humanized anti-herpes simplex virus (anti-HSV) IgG FAb fragment (AC-8; 53 kDa) followi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berdugo M,Larsen IV,Abadie C,Deloche C,Kowalczuk L,Touchard E,Dubielzig R,Brandt CR,Behar-Cohen F,Combette JM

更新日期：2012-03-01 00:00:00

abstract：:An outbreak of meningococcal disease occurred among basic combat trainees at Fort Lewis, Wash., in the first 3 months of 1971. After five recruits developed meningitis within a 2-week period, 8,721 recruits were given 100 mg of minocycline every 12 hr for 5 days. No new cases of meningococcal disease occurred for almo...

journal_title：Antimicrobial agents and chemotherapy

authors： Guttler RB,Beaty HN

更新日期：1972-05-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans, a pathogen associated with aggressive periodontitis, resists phagocytic killing by polymorphonuclear leukocytes (PMNs). It is susceptible to ciprofloxacin, which PMNs actively accumulate. This study tested the hypothesis that ciprofloxacin-loaded PMNs are more effective at killing...

journal_title：Antimicrobial agents and chemotherapy

authors： Cacchillo DA,Walters JD

更新日期：2002-06-01 00:00:00

abstract：:Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant t...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang W,Sun Y,Phadke A,Deshpande M,Huang M

更新日期：2007-01-01 00:00:00

abstract：:The pharmacokinetics of a single 1-g intravenous dose of mezlocillin were examined in six functionally anephric patients undergoing hemodialysis. Hemodialysis clearance calculated by plasma extraction ratios across the dialyzer membrane and by dialysis fluid agree well, averaging 26 and 32 ml/min. Dialyzer extraction ...

journal_title：Antimicrobial agents and chemotherapy

authors： Janicke DM,Mangione A,Schultz RW,Jusko WJ

更新日期：1981-11-01 00:00:00

abstract：:Encephalomyocarditis virus (EMCV), like hepatitis C virus (HCV), requires phosphatidylinositol 4-kinase IIIα (PI4KA) for genome replication. Here, we demonstrate that tyrphostin AG1478, a known epidermal growth factor receptor (EGFR) inhibitor, also inhibits PI4KA activity, both in vitro and in cells. AG1478 impaired ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dorobantu CM,Harak C,Klein R,van der Linden L,Strating JR,van der Schaar HM,Lohmann V,van Kuppeveld FJ

更新日期：2016-09-23 00:00:00

abstract：:The purpose of this study was to compare the activity of HMR 1043 with those of daptomycin and teicoplanin against gram-positive isolates. Susceptibility tests were performed for 52 strains, 26 parental strains, including staphylococcal, streptococcal, enterococcal, and listerial strains, and 26 HMR 1043-resistant mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Bemer P,Juvin ME,Bryskier A,Drugeon H

更新日期：2003-09-01 00:00:00

abstract：:The antibiotic bleomycin stimulates deoxyribonucleic acid (DNA) synthesis in toluene-treated Escherichia coli cells. The increase in synthesis is linear with bleomycin concentration. Bleomycin-stimulated DNA synthesis is independent of replication and dependent on DNA polymerase I. Replication is spared as the DNA pol...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross SL,Moses RE

更新日期：1976-02-01 00:00:00

abstract：:Aspergillus fumigatus is the primary etiologic agent of invasive aspergillosis (IA), a major cause of death among immunosuppressed patients. Echinocandins (e.g., caspofungin) are increasingly used as second-line therapy for IA, but their activity is only fungistatic. Heat shock protein 90 (Hsp90) was previously shown ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Steinbach WJ

更新日期：2015-08-01 00:00:00

abstract：:Current treatments of disseminated infection caused by the Mycobacterium avium-M. intracellulare complex (MAC) are generally ineffective. Liposome-mediated delivery of antibiotics to MAC-infected tissues in vivo can enhance the efficacy of the drugs (N. Düzgüneş, V. K. Perumal, L. Kesavalu, J. A. Goldstein, R. J. Debs...

journal_title：Antimicrobial agents and chemotherapy

authors： Majumdar S,Flasher D,Friend DS,Nassos P,Yajko D,Hadley WK,Düzgüneş N

更新日期：1992-12-01 00:00:00

abstract：:In concert with the development of novel beta-lactams and broad-spectrum cephalosporins, bacterially encoded beta-lactamases have evolved to accommodate the new agents. This study was designed to identify, at the sequence level, the genes responsible for the extended-spectrum-beta-lactamase (ESBL) phenotypes of Escher...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones CH,Tuckman M,Keeney D,Ruzin A,Bradford PA

更新日期：2009-02-01 00:00:00

abstract：:We have determined the antifungal susceptibilities of 34 clinical isolates of the dimorphic fungus Sporothrix schenckii to 11 drugs using a microdilution method. In general, the type of growth phase (mycelial or yeast) and the temperature of incubation (30 or 35 degrees C) exerted a significant influence on the MICs. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Trilles L,Fernández-Torres B,Dos Santos Lazéra M,Wanke B,de Oliveira Schubach A,de Almeida Paes R,Inza I,Guarro J

更新日期：2005-09-01 00:00:00

abstract：:A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and characterize its disposit...

journal_title：Antimicrobial agents and chemotherapy

authors： Almond DS,Szwandt IS,Edwards G,Lee MG,Winstanley PA

更新日期：2000-06-01 00:00:00

abstract：:Data comparing the treatment outcomes of the two most frequently recommended empirical antibiotic regimens for community-acquired pneumonia (CAP)--combination therapy with an extended-spectrum beta-lactam and a macrolide (BL+M) or fluoroquinolone (F) monotherapy--for patients with severe CAP are sparse. The purpose of...

journal_title：Antimicrobial agents and chemotherapy

authors： Lodise TP,Kwa A,Cosler L,Gupta R,Smith RP

更新日期：2007-11-01 00:00:00

abstract：:The determination of antibiotic potency against bacterial strains by assessment of their minimum inhibitory concentration normally uses a standardized broth microdilution assay procedure developed more than 50 years ago. However, certain antibiotics require modified assay conditions in order to observe optimal activit...

journal_title：Antimicrobial agents and chemotherapy

authors： Kavanagh A,Ramu S,Gong Y,Cooper MA,Blaskovich MAT

更新日期：2018-12-21 00:00:00

abstract：:A total of 91 multiply resistant bacterial strains, including Klebsiella pneumoniae (32 strains), Pseudomonas aeruginosa (16 strains), and Serratia marcescens (43 strains), were collected during hospital epidemics of nosocomial infection from 1975 to 1979. These strains were resistant to gentamicin, tobramycin, cephal...

journal_title：Antimicrobial agents and chemotherapy

authors： Hall WH,Opfer BJ,Gerding DN

更新日期：1980-02-01 00:00:00

abstract：:Platelet microbicidal proteins (PMPs) are believed to be integral to host defense against endovascular infection. We previously demonstrated that susceptibility to thrombin-induced PMP 1 (tPMP-1) in vitro negatively influences Candida albicans virulence in the rabbit model of infective endocarditis (IE). This study ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeaman MR,Cheng D,Desai B,Kupferwasser LI,Xiong YQ,Gank KD,Edwards JE Jr,Bayer AS

更新日期：2004-08-01 00:00:00

abstract：:Despite the development of novel antibiotics active against Gram-positive bacteria, vancomycin generally remains the first treatment, although rapidly achieving concentrations associated with maximal efficacy provides an unresolved challenge. The objective of this study was to conduct a population pharmacokinetic anal...

journal_title：Antimicrobial agents and chemotherapy

authors： Roberts JA,Taccone FS,Udy AA,Vincent JL,Jacobs F,Lipman J

更新日期：2011-06-01 00:00:00

abstract：:Laboratory-based in vitro antimicrobial susceptibility testing is the foundation for guiding anti-infective therapy and monitoring antimicrobial resistance trends. We used whole-genome sequencing (WGS) technology to identify known antimicrobial resistance determinants among strains of nontyphoidal Salmonella and corre...

journal_title：Antimicrobial agents and chemotherapy

authors： McDermott PF,Tyson GH,Kabera C,Chen Y,Li C,Folster JP,Ayers SL,Lam C,Tate HP,Zhao S

更新日期：2016-08-22 00:00:00

abstract：:Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under the concentration cur...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Elsen SHJ,Sturkenboom MGG,Van't Boveneind-Vrubleuskaya N,Skrahina A,van der Werf TS,Heysell SK,Mpagama S,Migliori GB,Peloquin CA,Touw DJ,Alffenaar JC

更新日期：2018-11-26 00:00:00

abstract：:We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no di...

journal_title：Antimicrobial agents and chemotherapy

authors： Lionakis MS,Chamilos G,Lewis RE,Wiederhold NP,Raad II,Samonis G,Kontoyiannis DP

更新日期：2006-01-01 00:00:00

abstract：:A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience. Infection was induced by inhalation of aerosolized Yersinia pestis organisms. Antibiotics were administered by intraperitoneal...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrne WR,Welkos SL,Pitt ML,Davis KJ,Brueckner RP,Ezzell JW,Nelson GO,Vaccaro JR,Battersby LC,Friedlander AM

更新日期：1998-03-01 00:00:00

abstract：:Because of the widespread occurrence of resistance to sulfonamides among Enterobacteriaceae, some researchers have suggested using trimethoprim (TMP) alone instead of the combination sulfamethoxazole-trimethoprim (SMX-TMP) in treating infections with TMP-susceptible organisms. To answer whether SMX-TMP suppresses the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Guerrant RL,Wood SJ,Krongaard L,Reid RA,Hodge RH

更新日期：1981-01-01 00:00:00

abstract：:Minibacterium massiliensis strain CIP107820 is a recently discovered waterborne Gram-negative rod isolated from hospital water samples. It harbors a chromosomally located gene encoding an Ambler class A extended-spectrum β-lactamase termed MIN-1, sharing 56%, 54%, and 51% amino acid identities with β-lactamases LUT-1,...

journal_title：Antimicrobial agents and chemotherapy

authors： Bercot B,Nordmann P,Drancourt M,Poirel L

更新日期：2012-07-01 00:00:00

abstract：:A biodegradable system of poly-D,L-dilactide releasing ciprofloxacin was assessed in a Pseudomonas aeruginosa osteomyelitis model after inoculation of the test pathogen into the left tibia of 76 New Zealand White rabbits; 31 were controls (group A), and 45 were implanted with the polymer at the infection site (group B...

journal_title：Antimicrobial agents and chemotherapy

authors： Kanellakopoulou K,Thivaios GC,Kolia M,Dontas I,Nakopoulou L,Dounis E,Giamarellos-Bourboulis EJ,Andreopoulos A,Karagiannakos P,Giamarellou H

更新日期：2008-07-01 00:00:00

abstract：:We identified GRL-1388 and -1398, potent nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran (Tp-THF). GRL-1388 was as potent as darunavir (DRV) against various drug-resistant HIV-1 laboratory strains with 50% ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Ide K,Aoki M,Amano M,Koh Y,Yedidi RS,Das D,Leschenko S,Chapsal B,Ghosh AK,Mitsuya H

更新日期：2011-04-01 00:00:00

abstract：:Ceftizoxime was evaluated in the treatment of 18 patients (6 adults and 12 children) with bacterial meningitis. In seven patients Haemophilus influenzae was the causative agent, in three Neisseria meningitidis, in five Streptococcus pneumoniae, and in one each alpha-streptococcus and Escherichia coli; one case was cul...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Cable DC,Forthal DN,Shikuma C

更新日期：1984-02-01 00:00:00

abstract：:Ampicillin-resistant Enterococcus faecium (ARE) and vancomycin-resistant E. faecium (VRE) are important nosocomial pathogens. We quantified effects of probiotics and antibiotics on intestinal acquisition of ARE colonization in patients hospitalized in two non-intensive care unit (non-ICU) wards with high ARE prevalenc...

journal_title：Antimicrobial agents and chemotherapy

authors： de Regt MJ,Willems RJ,Hené RJ,Siersema PD,Verhaar HJ,Hopmans TE,Bonten MJ

更新日期：2010-07-01 00:00:00

abstract：:Saccharomicins A and B, two new heptadecaglycoside antibiotics, were isolated from the fermentation broth of the rare actinomycete Saccharothrix espanaensis. They represent a novel class of bactericidal antibiotics that are active both in vitro and in vivo against bacteria and yeast (MICs: Staphylococcus aureus, <0.12...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Kong F,Greenstein M

更新日期：2000-08-01 00:00:00