Mezlocillin disposition in chronic hemodialysis patients.

abstract：:Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutt M,Khuller GK

更新日期：2001-01-01 00:00:00

abstract：:We describe the clinical outcome of 17 patients with secondary Acinetobacter bacteremia whose isolates had a tigecycline MIC of ≤2 mg/liter and who received tigecycline within 2 days of bacteremia onset. The 14-day mortality rate of the tigecycline cohort was 41.2% (7/17), which was significantly higher than that of t...

journal_title：Antimicrobial agents and chemotherapy

authors： Liou BH,Lee YT,Kuo SC,Liu PY,Fung CP

更新日期：2015-01-01 00:00:00

abstract：:Enfuvirtide is the first fusion and entry inhibitor approved for use for the treatment of human immunodeficiency virus (HIV) type 1 infection and as such represents a novel class of agents. For the population of patients experienced with three antiretroviral classes, enfuvirtide provides an additional option for treat...

journal_title：Antimicrobial agents and chemotherapy

authors： DeJesus E,Gottlieb MS,Gathe JC Jr,Greenberg ML,Guittari CJ,Zolopa AR

更新日期：2008-12-01 00:00:00

abstract：:The effects of amphotericin B and fluconazole on the extracellular and intracellular growth of Candida albicans were studied. With respect to the extracellular growth of C. albicans, antifungal activity was measured in terms of MICs and minimal fungicidal concentrations as well as by determination of the concentration...

journal_title：Antimicrobial agents and chemotherapy

authors： van Etten EW,van de Rhee NE,van Kampen KM,Bakker-Woudenberg IA

更新日期：1991-11-01 00:00:00

abstract：:Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis that is characterized by hyphal bronchopneumonia, aerosol amphotericin B (aero-AmB; 1.6 mg/kg given 2 days before infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmitt HJ,Bernard EM,Häuser M,Armstrong D

更新日期：1988-11-01 00:00:00

abstract：:NK-2, a membrane-acting antimicrobial peptide, was derived from the cationic core region of porcine NK-lysin and consists of 27 amino acid residues. It adopts an amphipathic, alpha-helical secondary structure and has been shown to interact specifically with membranes of negatively charged lipids. We therefore investig...

journal_title：Antimicrobial agents and chemotherapy

authors： Andrä J,Koch MH,Bartels R,Brandenburg K

更新日期：2004-05-01 00:00:00

abstract：:When growing bacteria are exposed to bactericidal concentrations of antibiotics, the sensitivity of the bacteria to the antibiotic commonly decreases with time, and substantial fractions of the bacteria survive. Using Escherichia coli CAB1 and antibiotics of five different classes (ampicillin, ciprofloxacin, rifampin,...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiuff C,Zappala RM,Regoes RR,Garner KN,Baquero F,Levin BR

更新日期：2005-04-01 00:00:00

abstract：:Approximately 150,000 small-molecule compounds were tested by a robotic screening assay for their ability to inhibit nucleoside triphosphate hydrolase (NTPase), a novel enzyme of the tachyzoite form of Toxoplasma gondii. Five unrelated species of compounds were found to inhibit the activities of both NTPase isoforms (...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai T,Takeuchi T,Diffenderfer J,Sibley LD

更新日期：2002-08-01 00:00:00

abstract：:N-Formimidoyl thienamycin (MK0787) was active against beta-lactamase-producing strains and was an effective inhibitor of beta-lactamases extracted and purified from these strains except for plasmid-mediated penicillinase type IV. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Toda M,Sato K,Nakazawa H,Inoue M,Mitsuhashi S

更新日期：1980-11-01 00:00:00

abstract：:A pyridodiazepine amine inhibitor of Helicobacter pylori glutamate racemase (MurI) was characterized. The compound was selectively active against H. pylori, and growth suppression was shown to be mediated through the inhibition of MurI by several methods. In killing kinetics experiments, the compound showed concentrat...

journal_title：Antimicrobial agents and chemotherapy

authors： de Jonge BL,Kutschke A,Newman JV,Rooney MT,Yang W,Cederberg C

更新日期：2015-04-01 00:00:00

abstract：:The in vitro activities of tedizolid and 10 antistaphylococcal agents were compared against 111 methicillin-resistant Staphylococcus aureus (MRSA) strains from 14 epidemiologically characterized groups. Tedizolid, tigecycline, and daptomycin were the most potent agents, with tedizolid 4-fold more potent than linezolid...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson KS,Goering RV

更新日期：2013-06-01 00:00:00

abstract：:Ciprofloxacin, a fluorinated 4-quinolone, is useful for the clinical treatment of infections due to its antibacterial properties and also modulates the immune response of monocytes isolated from human peripheral blood mononuclear cells. In the present study, we found that ciprofloxacin induced the production of prosta...

journal_title：Antimicrobial agents and chemotherapy

authors： Takahashi HK,Iwagaki H,Xue D,Katsuno G,Sugita S,Mizuno K,Mori S,Saito S,Yoshino T,Tanaka N,Nishibori M

更新日期：2005-08-01 00:00:00

abstract：:The class C beta-lactamase of Citrobacter freundii GN346 is a typical cephalosporinase comprising 361 amino acids, and substitution of the glutamic acid at position 219 in the enzyme by lysine was previously shown to broaden its substrate spectrum to oxyimino beta-lactams (K. Tsukamoto, R. Ohno, and T. Sawai, J. Bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Nukaga M,Tsukamoto K,Yamaguchi H,Sawai T

更新日期：1994-06-01 00:00:00

abstract：:Protozoan parasites of the Leishmania donovani complex are the causative agents of visceral leishmaniasis (VL), the most severe form of leishmaniasis, with high rates of mortality if left untreated. Leishmania parasites are transmitted to humans through the bite of infected female sandflies (Diptera: Phlebotominae), a...

journal_title：Antimicrobial agents and chemotherapy

authors： Vacchina P,Norris-Mullins B,Abengózar MA,Viamontes CG,Sarro J,Stephens MT,Pfrender ME,Rivas L,Morales MA

更新日期：2016-06-20 00:00:00

abstract：:Pseudomonas asiatica is a recently proposed species of the genus Pseudomonas This study describes eight isolates of carbapenem-resistant P. asiatica harboring blaNDM-1 and blaVIM-2, genes encoding metallo-β-lactamase (MBL). These isolates were obtained from urine samples of patients hospitalized in Myanmar. These isol...

journal_title：Antimicrobial agents and chemotherapy

authors： Tohya M,Tada T,Watanabe S,Kuwahara-Arai K,Zin KN,Zaw NN,Aung MY,Mya S,Zan KN,Kirikae T,Tin HH

更新日期：2019-07-25 00:00:00

abstract：:Penicillin-binding protein 5 (PBP5) is one of the most abundant PBPs in Pseudomonas aeruginosa. Although its main function is that of a cell wall dd-carboxypeptidase, it possesses sufficient β-lactamase activity to contribute to the ability of P. aeruginosa to resist the antibiotic activity of the β-lactams. The study...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith JD,Kumarasiri M,Zhang W,Hesek D,Lee M,Toth M,Vakulenko S,Fisher JF,Mobashery S,Chen Y

更新日期：2013-07-01 00:00:00

abstract：:The activity of four antifungal agents against 15 systemic (blood and vascular catheter) and 10 superficial (skin) Malassezia furfur isolates was evaluated. MIC ranges were similar for the two groups of organisms: amphotericin B, 0.3 to 2.5 micrograms/ml; flucytosine, greater than 100 micrograms/ml; miconazole, 0.4 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Marcon MJ,Durrell DE,Powell DA,Buesching WJ

更新日期：1987-06-01 00:00:00

abstract：:We previously showed that the mouse inorganic phosphate transporter Npt1 operates in the hepatic sinusoidal membrane transport of anionic drugs such as benzylpenicillin and mevalonic acid. In the present study, the mechanism of renal secretion of penem antibiotics was examined by using a Xenopus oocyte expression syst...

journal_title：Antimicrobial agents and chemotherapy

authors： Uchino H,Tamai I,Yabuuchi H,China K,Miyamoto K,Takeda E,Tsuji A

更新日期：2000-03-01 00:00:00

abstract：:A spontaneous Escherichia coli mutant, named Q3, resistant to nalidixic acid was obtained from a previously described clinical isolate of E. coli, Q2, resistant to fluoroquinolones but susceptible to nalidixic acid (E. Cambau, F. Bordon, E. Collatz, and L. Gutmann, Antimicrob. Agents Chemother. 37:1247-1252, 1993). Q3...

journal_title：Antimicrobial agents and chemotherapy

authors： Truong QC,Nguyen Van JC,Shlaes D,Gutmann L,Moreau NJ

更新日期：1997-01-01 00:00:00

abstract：:We determined whether gyrA mutations were present in fluoroquinolone-resistant laboratory mutants derived from the Bacteroides fragilis reference strain ATCC 25285 and in clinical isolates of B. fragilis. The two first-step mutants selected on ciprofloxacin (CIP) were devoid of gyrA mutations, whereas two of the three...

journal_title：Antimicrobial agents and chemotherapy

authors： Bachoual R,Dubreuil L,Soussy CJ,Tankovic J

更新日期：2000-07-01 00:00:00

abstract：:The Burkholderia cepacia complex (BCC) is a group of bacterial pathogens that are highly antibiotic resistant and associated with debilitating respiratory infections. Although bacteriophages of the BCC have been isolated and characterized, no studies have yet examined phage therapy against the BCC in vivo. In a caterp...

journal_title：Antimicrobial agents and chemotherapy

authors： Seed KD,Dennis JJ

更新日期：2009-05-01 00:00:00

abstract：:Antibiotic tolerance is an underappreciated antibiotic escape strategy that is associated with recurrent and relapsing infections, as well as acting as a precursor to resistance. Tolerance describes the ability of a bacterial population to survive transient exposure to an otherwise lethal concentration of antibiotic w...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryson D,Hettle AG,Boraston AB,Hobbs JK

更新日期：2020-02-21 00:00:00

abstract：:Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus...

journal_title：Antimicrobial agents and chemotherapy

authors： Reig M,Galan J,Baquero F,Perez-Diaz JC

更新日期：2001-02-01 00:00:00

abstract：:The purpose of this study was to assess the effect of voriconazole on the blood tacrolimus concentration in a liver transplant recipient and to examine the interaction between voriconazole and tacrolimus by using human liver microsomes. Two subjects were enrolled in the clinical study: one received voriconazole, and t...

journal_title：Antimicrobial agents and chemotherapy

authors： Venkataramanan R,Zang S,Gayowski T,Singh N

更新日期：2002-09-01 00:00:00

abstract：:More than 10(6) compounds were evaluated in a human immunodeficiency virus type 1 (HIV-1) high-throughput antiviral screen, resulting in the identification of a novel HIV-1 inhibitor (UK-201844). UK-201844 exhibited antiviral activity against HIV-1 NL4-3 in MT-2 and PM1 cells, with 50% effective concentrations of 1.3 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Blair WS,Cao J,Jackson L,Jimenez J,Peng Q,Wu H,Isaacson J,Butler SL,Chu A,Graham J,Malfait AM,Tortorella M,Patick AK

更新日期：2007-10-01 00:00:00

abstract：:The 747-bp cfiA gene, which encodes a metallo-beta-lactamase, and the regions flanking cfiA in six imipenem-resistant and four imipenem-susceptible Bacteroides fragilis strains isolated in Japan were analyzed by PCR and DNA sequencing. The nucleotide sequences of the cfiA genes (designated cfiA(1) to cfiA(10)) of all ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kato N,Yamazoe K,Han CG,Ohtsubo E

更新日期：2003-03-01 00:00:00

abstract：:Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 mug/ml. Rifampin alone was without effect. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rifkind D,Crowder ED,Hyland RN

更新日期：1974-12-01 00:00:00

abstract：:We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of m...

journal_title：Antimicrobial agents and chemotherapy

authors： Spreghini E,Orlando F,Santinelli A,Pisa E,Loretelli C,Manso E,Milici ME,Scalise G,Barchiesi F

更新日期：2009-09-01 00:00:00

abstract：:The antiviral activity of zinc salts against rhinovirus types 1A and 39 was assayed by yield reduction and inhibition of cytopathic effect in cell culture. The findings indicate that the zinc salts tested have low in vitro therapeutic indices and suggest that the possible beneficial effects of zinc lozenges in reducin...

journal_title：Antimicrobial agents and chemotherapy

authors： Geist FC,Bateman JA,Hayden FG

更新日期：1987-04-01 00:00:00

abstract：:Treatment of mucocutaneous and cutaneous Candida albicans infections with photosensitizing agents and light, termed photodynamic therapy (PDT), offers an alternative to conventional treatments. Initial studies using the clinically approved photosensitizer Photofrin demonstrated the susceptibility of C. albicans to its...

journal_title：Antimicrobial agents and chemotherapy

authors： Chabrier-Roselló Y,Foster TH,Pérez-Nazario N,Mitra S,Haidaris CG

更新日期：2005-10-01 00:00:00