Experimental bacteriophage therapy increases survival of Galleria mellonella larvae infected with clinically relevant strains of the Burkholderia cepacia complex.

abstract：:Antibiotics are generally not effective against organisms in exopolysaccharide biofilms. A simple method of studying the effect of antibiotics on bacteria in established biofilms is reported. Escherichia coli ATCC 25922 cells grown overnight at 37 degrees C on Mueller-Hinton agar were suspended in buffer and dispensed...

journal_title：Antimicrobial agents and chemotherapy

authors： Prosser BL,Taylor D,Dix BA,Cleeland R

更新日期：1987-10-01 00:00:00

abstract：:Properties of a population of carbenicillin- and gentamicin-resistant, tobramycin-susceptible Pseudomonas aeruginosa at Veteran's Administration Hospital, Cincinnati, Ohio, have been followed during a 16-month period. As originally described, the strains were isolated from patients with urinary tract colonizations and...

journal_title：Antimicrobial agents and chemotherapy

authors： Korfhagen TR,Ferrel JA,Menefee CL,Loper JC

更新日期：1976-05-01 00:00:00

abstract：:Amphotericin B and N-D-ornithyl amphotericin B methyl ester were compared for therapeutic efficacies against experimentally induced cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis in rabbits. Antifungal activity of the two polyenes in vitro was similar for the yeasts used in these experim...

journal_title：Antimicrobial agents and chemotherapy

authors： Perfect JR,Durack DT

更新日期：1985-12-01 00:00:00

abstract：:Accurate assessment of the risk factors for colonization with vancomycin-resistant enterococci (VRE) among high-risk patients is often confounded by nosocomial VRE transmission. We undertook a 15-month prospective cohort study of adults admitted to high-risk units (hematology, renal, transplant, and intensive care) in...

journal_title：Antimicrobial agents and chemotherapy

authors： Padiglione AA,Wolfe R,Grabsch EA,Olden D,Pearson S,Franklin C,Spelman D,Mayall B,Johnson PD,Grayson ML

更新日期：2003-08-01 00:00:00

abstract：:Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmici...

journal_title：Antimicrobial agents and chemotherapy

authors： K N Lam P,Tian Q,Ip M,Gomersall CD

更新日期：2010-02-01 00:00:00

abstract：:Tn5801, originally detected in Staphylococcus aureus Mu50, is a Tn916 family element in which a unique int gene (int5801) replaces the int and xis genes in Tn916 (int916 and xis916). Among 62 tet(M)-positive tetracycline-resistant Streptococcus agalactiae isolates, 43 harbored Tn916, whereas 19 harbored a Tn5801-like ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Tili E,Giovanetti E,Montanari MP,Varaldo PE

更新日期：2013-09-01 00:00:00

abstract：:Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The objective of this study was to characterize the dose-response relationship of ceftaroline fosamil against S. aureus in an immunocompromised murine pneumonia model, as ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhalodi AA,Crandon JL,Biek D,Nicolau DP

更新日期：2012-12-01 00:00:00

abstract：:Bacteria require at least one pathway to rescue ribosomes stalled at the ends of mRNAs. The primary pathway for ribosome rescue is trans-translation, which is conserved in >99% of sequenced bacterial genomes. Some species also have backup systems, such as ArfA or ArfB, which can rescue ribosomes in the absence of suff...

journal_title：Antimicrobial agents and chemotherapy

authors： Goralski TD,Dewan KK,Alumasa JN,Avanzato V,Place DE,Markley RL,Katkere B,Rabadi SM,Bakshi CS,Keiler KC,Kirimanjeswara GS

更新日期：2016-05-23 00:00:00

abstract：:The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithr...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman DB,Lin G,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：1998-11-01 00:00:00

abstract：:The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals are thought to play a role in suppressing the HBV-specific immune response. Current therapeutics are not directed at reducing this viral antigenemia; thus, our group has focuse...

journal_title：Antimicrobial agents and chemotherapy

authors： Dougherty AM,Guo H,Westby G,Liu Y,Simsek E,Guo JT,Mehta A,Norton P,Gu B,Block T,Cuconati A

更新日期：2007-12-01 00:00:00

abstract：:An important determinant of nephrotoxicity, which is the major complication of long-term amphotericin B treatment, is dysfunction of distal tubular epithelial cells. The underlying cause for this rather selective damage to the cells is unknown. In the present investigation, it was shown that kidney epithelial cells we...

journal_title：Antimicrobial agents and chemotherapy

authors： Walev I,Bhakdi S

更新日期：1996-05-01 00:00:00

abstract：:Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma bruceirhodesiense Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism. Suramin is also an e...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiedemar N,Hauser DA,Mäser P

更新日期：2020-02-21 00:00:00

abstract：:We examined the influences of different pH levels and three different buffers on flucytosine activity against 12 isolates of Candida albicans in two synthetic media, yeast nitrogen base (YNB) and synthetic amino acid medium-fungal (SAAMF), using broth dilution techniques and measuring the endpoints of visual MICs and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Calhoun DL,Galgiani JN

更新日期：1984-09-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically...

journal_title：Antimicrobial agents and chemotherapy

authors： Forrest A,Garonzik SM,Thamlikitkul V,Giamarellos-Bourboulis EJ,Paterson DL,Li J,Silveira FP,Nation RL

更新日期：2017-10-24 00:00:00

abstract：:Pharmacokinetic modeling has often been applied to evaluate vancomycin pharmacokinetics in neonates. However, clinical application of the model-based personalized vancomycin therapy is still limited. The objective of the present study was to evaluate the clinical utility and safety of a model-based patient-tailored do...

journal_title：Antimicrobial agents and chemotherapy

authors： Leroux S,Jacqz-Aigrain E,Biran V,Lopez E,Madeleneau D,Wallon C,Zana-Taïeb E,Virlouvet AL,Rioualen S,Zhao W

更新日期：2016-03-25 00:00:00

abstract：:Resistance to metronidazole, clarithromycin, and amoxicillin (amoxicilline) was found in 82, 3.8, and 1.9% of 106 Helicobacter pylori isolates, respectively. No tetracycline-resistant isolates were found. In all of the clarithromycin-resistant isolates, only one point mutation was present, either A2143G or A2142G. Our...

journal_title：Antimicrobial agents and chemotherapy

authors： Alvarez A,Moncayo JI,Santacruz JJ,Santacoloma M,Corredor LF,Reinosa E

更新日期：2009-09-01 00:00:00

abstract：:Acinetobacter baumannii is responsible for severe nosocomial pneumonia. To evaluate new therapeutic regimens for infections due to multiresistant strains and to study the pharmacodynamic properties of various antibiotics, we developed an experimental mouse model of acute A. baumannii pneumonia. C3H/HeN mice rendered t...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly-Guillou ML,Wolff M,Pocidalo JJ,Walker F,Carbon C

更新日期：1997-02-01 00:00:00

abstract：:In this study, the plasmid content of clinical and commensal strains was analyzed and compared. The replicon profile was similar in both populations, except for L, M, A/C, and N (detected only in clinical strains) and HI1 (only in commensal strains). Although I1 and F were the most frequent replicons, only IncI1, sequ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Navarro J,Miró E,Brown-Jaque M,Hurtado JC,Moreno A,Muniesa M,González-López JJ,Vila J,Espinal P,Navarro F

更新日期：2020-04-21 00:00:00

abstract：:Disk susceptibility tests with two structurally related aminoglycosides (amikacin and Sch 21420) were evaluated. Tests with 10- and 30-micrograms amikacin disks confirmed previous recommendations for interpretive zone standards; 30-micrograms disks are preferred. Tests with 10-, 20-, and 30-micrograms Sch 21420 disks ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Thornsberry C,Jones RN,Gerlach EH

更新日期：1980-10-01 00:00:00

abstract：:Visceral leishmaniasis is a neglected tropical disease that causes significant morbidity and mortality worldwide. Characterization of the pharmacokinetics and pharmacodynamics of antileishmanial drugs in preclinical models is important for drug development and use. Here we investigated the pharmacodynamics and drug di...

journal_title：Antimicrobial agents and chemotherapy

authors： Voak AA,Harris A,Qaiser Z,Croft SL,Seifert K

更新日期：2017-08-24 00:00:00

abstract：:The in vitro activity of cefaclor against 556 clinical isolates of gram-positive and gram-negative bacteria was compared with that of other cephalosporins. Cefaclor had activity similar to that of cephalexin against gram-positive bacteria. It showed greater activity against Haemophilus strains than did cephalexin and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Neu HC,Fu KP

更新日期：1978-04-01 00:00:00

abstract：:A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eshaghi A,Zittermann S,Bharat A,Mulvey MR,Allen VG,Patel SN

更新日期：2020-04-21 00:00:00

abstract：:Hepatitis C virus (HCV) genotype (GT) 2 represents approximately 9% of all viral infections globally. While treatment outcomes for GT2-infected patients have improved substantially with direct-acting antiviral agents (DAAs) compared to interferon-α, the presence of polymorphisms in NS5A can impact efficacy of NS5A inh...

journal_title：Antimicrobial agents and chemotherapy

authors： Asante-Appiah E,Ingravallo P,McMonagle P,Bystol K,Xia E,Curry S,Qiu P,Black S,Chase R,Liu R,Lahser F

更新日期：2019-09-16 00:00:00

abstract：:In light of the need for new antifungal regimens, we report that at noncandidacidal concentrations, the lactoferrin-derived peptide hLF(1-11), which is highly active against fluconazole-resistant Candida albicans, acts synergistically with fluconazole against this yeast and a fluconazole-sensitive C. albicans strain a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lupetti A,Paulusma-Annema A,Welling MM,Dogterom-Ballering H,Brouwer CP,Senesi S,Van Dissel JT,Nibbering PH

更新日期：2003-01-01 00:00:00

abstract：:Treatment of mucocutaneous and cutaneous Candida albicans infections with photosensitizing agents and light, termed photodynamic therapy (PDT), offers an alternative to conventional treatments. Initial studies using the clinically approved photosensitizer Photofrin demonstrated the susceptibility of C. albicans to its...

journal_title：Antimicrobial agents and chemotherapy

authors： Chabrier-Roselló Y,Foster TH,Pérez-Nazario N,Mitra S,Haidaris CG

更新日期：2005-10-01 00:00:00

abstract：:Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory i...

journal_title：Antimicrobial agents and chemotherapy

authors： Dubois J,Dubois M,Martel JF

更新日期：2020-04-21 00:00:00

abstract：:Valproic acid (VPA) has the potential to benefit patients suffering from human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine if VPA affects the plasma concentration of efavirenz (EFV) or lopinavir. HIV type 1 (HIV-1)-infected patients receiving EFV or lopinavi...

journal_title：Antimicrobial agents and chemotherapy

authors： DiCenzo R,Peterson D,Cruttenden K,Morse G,Riggs G,Gelbard H,Schifitto G

更新日期：2004-11-01 00:00:00

abstract：:We investigated the efficacies of cefotaxime (CTX) and amoxicillin (AMX)-clavulanate (CLA) (AMC) against extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli in vitro and in a murine model of urinary tract infection (UTI). MICs, the checkerboard dilution method, and time-kill curves were used to explore the...

journal_title：Antimicrobial agents and chemotherapy

authors： Rossi B,Soubirou JF,Chau F,Massias L,Dion S,Lepeule R,Fantin B,Lefort A

更新日期：2015-11-02 00:00:00

abstract：:In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2.7.1.21) activity. Plaque-purified clones derived from the original clinical sample were heterogeneous with respect to plaque siz...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellis MN,Keller PM,Fyfe JA,Martin JL,Rooney JF,Straus SE,Lehrman SN,Barry DW

更新日期：1987-07-01 00:00:00

abstract：:Itraconazole is used for the prevention and treatment of infections caused by Aspergillus fumigatus. An understanding of the pharmacodynamics of itraconazole against wild-type and triazole-resistant strains provides a basis for innovative therapeutic strategies for treatment of infections. An in vitro model of the hum...

journal_title：Antimicrobial agents and chemotherapy

authors： Al-Nakeeb Z,Sudan A,Jeans AR,Gregson L,Goodwin J,Warn PA,Felton TW,Howard SJ,Hope WW

更新日期：2012-08-01 00:00:00