100 Years of Suramin.

Abstract:

:Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma bruceirhodesiense Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism. Suramin is also an enigmatic molecule: What are its targets? How does it get into cells in the first place? Here, we provide an overview of the many different candidate targets of suramin and discuss its modes of action and routes of cellular uptake. We reason that, once the polypharmacology of suramin is understood at the molecular level, new, more specific, and less toxic molecules can be identified for the numerous potential applications of suramin.

authors

Wiedemar N,Hauser DA,Mäser P

doi

10.1128/AAC.01168-19

subject

Has Abstract

pub_date

2020-02-21 00:00:00

issue

3

eissn

0066-4804

issn

1098-6596

pii

AAC.01168-19

journal_volume

64

pub_type

杂志文章,评审
  • Dose-ranging study of CP-99,219 (trovafloxacin) for treatment of uncomplicated gonorrhea.

    abstract::Thirty-nine patients with uncomplicated gonorrhea were randomized to receive single, oral 50-, 100-, or 200-mg doses of trovafloxacin (CP-99,219), a new quinolone antibiotic. All 31 evaluable patients were cured of infection. Trovafloxacin was well tolerated. The trovafloxacin MICs at which 50 and 90% of 36 Neisseria ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1128/AAC.40.7.1720

    authors: Hook EW 3rd,Pinson GB,Blalock CJ,Johnson RB

    更新日期:1996-07-01 00:00:00

  • Effect of ginkgo biloba on the pharmacokinetics of raltegravir in healthy volunteers.

    abstract::Medicinal herbs may cause clinically relevant drug interactions with antiretroviral agents. Ginkgo biloba extract is a popular herbal product among HIV-infected patients because of its positive effects on cognitive function. Raltegravir, an HIV integrase inhibitor, is increasingly being used as part of combined antire...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1128/AAC.00672-12

    authors: Blonk M,Colbers A,Poirters A,Schouwenberg B,Burger D

    更新日期:2012-10-01 00:00:00

  • Efficacy of high doses of levofloxacin in experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus.

    abstract::Antimicrobial efficacy in orthopedic device infections is diminished because of bacterial biofilms which express tolerance to antibiotics. Recently, the use of high doses of levofloxacin with rifampin has been recommended for staphylococcal infections. In the present study, we evaluated the efficacy of levofloxacin at...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00523-06

    authors: Murillo O,Doménech A,Garcia A,Tubau F,Cabellos C,Gudiol F,Ariza J

    更新日期:2006-12-01 00:00:00

  • In Vitro and Intracellular Activities of Omadacycline against Legionella pneumophila.

    abstract::Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory i...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01972-19

    authors: Dubois J,Dubois M,Martel JF

    更新日期:2020-04-21 00:00:00

  • Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA.

    abstract::The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.41.5.1162

    authors: Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

    更新日期:1997-05-01 00:00:00

  • Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species.

    abstract::Two large studies compared posaconazole and fluconazole or itraconazole for prophylaxis in subjects undergoing allogeneic hematopoietic stem cell transplantation or subjects with acute myelogenous leukemia. To assess the impact of prophylaxis on colonization and the development of resistance in Saccharomyces yeasts, i...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1128/AAC.01031-09

    authors: Mann PA,McNicholas PM,Chau AS,Patel R,Mendrick C,Ullmann AJ,Cornely OA,Patino H,Black TA

    更新日期:2009-12-01 00:00:00

  • Pharmacokinetics of ketoconazole in patients with neoplastic diseases.

    abstract::Twenty-seven patients with advanced malignancies were given 200 mg of ketoconazole orally every 6 or 12 h. Blood samples were collected during these intervals and after the last dose to determine plasma concentrations and half-lives. The mean plasma concentrations measured after the initial dose were 1.7 +/- 1.1 micro...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.22.1.43

    authors: Maksymiuk AW,Levine HB,Bodey GP

    更新日期:1982-07-01 00:00:00

  • Effectiveness of combination antimicrobial therapy for Pseudomonas aeruginosa bacteremia.

    abstract::It remains controversial whether combination therapy, given empirically or as definitive treatment, for Pseudomonas aeruginosa bacteremia is associated with a better outcome than monotherapy. The aim of the present study was to compare the rates of survival among patients who received either combination therapy or mon...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.47.9.2756-2764.2003

    authors: Chamot E,Boffi El Amari E,Rohner P,Van Delden C

    更新日期:2003-09-01 00:00:00

  • Trailing or paradoxical growth of Candida albicans when exposed to caspofungin is not associated with microsatellite genotypes.

    abstract::Multilocus microsatellite polymorphisms in 27 clinical Candida albicans isolates were found to be clearly unrelated to in vitro paradoxical growth or trailing effect with caspofungin. These findings suggest that such in vitro phenotypes are either gained or lost too rapidly to be predicted by more stable genomic marke...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00530-09

    authors: Khlif M,Bogreau H,Michel-Nguyen A,Ayadi A,Ranque S

    更新日期:2010-03-01 00:00:00

  • Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.

    abstract::Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin great...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.17.4.750

    authors: Jones RN,Fuchs PC,Sommers HM,Gavan TL,Barry AL,Gerlach EH

    更新日期:1980-04-01 00:00:00

  • Influence of indomethacin on the intrarenal uptake of gentamicin in endotoxemic rats.

    abstract::Gentamicin is a commonly used antibiotic for the treatment of gram-negative-bacterial infections. Bacterial endotoxin is liberated during antibiotic therapy, and we have shown that endotoxemic animals accumulate more aminoglycosides in their renal parenchyma than normal animals. Vasoactive mediators, such as prostagla...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.33.8.1342

    authors: Bergeron MG,Bergeron Y,Tardif M,Marchand S,Beauchamp D

    更新日期:1989-08-01 00:00:00

  • Use of adjuvants for enhancement of rectal absorption of cefoxitin in humans.

    abstract::The biological availability of cefoxitin administered rectally in the form of suppositories was examined in six human subjects by a cross-over design. Four different suppository systems containing adjuvants expected to enhance the absorption of the drug were studied. The presence of sodium salicylate and a nonionic su...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1128/aac.28.2.211

    authors: Davis SS,Burnham WR,Wilson P,O'Brien J

    更新日期:1985-08-01 00:00:00

  • Evaluation of reduced susceptibility to quaternary ammonium compounds and bisbiguanides in clinical isolates and laboratory-generated mutants of Staphylococcus aureus.

    abstract::The MICs and minimum bactericidal concentrations (MBCs) for the biocides benzalkonium chloride and chlorhexidine were determined against 1,602 clinical isolates of Staphylococcus aureus. Both compounds showed unimodal MIC and MBC distributions (2 and 4 or 8 mg/liter, respectively) with no apparent subpopulation with r...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00498-13

    authors: Furi L,Ciusa ML,Knight D,Di Lorenzo V,Tocci N,Cirasola D,Aragones L,Coelho JR,Freitas AT,Marchi E,Moce L,Visa P,Northwood JB,Viti C,Borghi E,Orefici G,BIOHYPO Consortium.,Morrissey I,Oggioni MR

    更新日期:2013-08-01 00:00:00

  • Bac 32, a novel bacteriocin widely disseminated among clinical isolates of Enterococcus faecium.

    abstract::A total of 636 vancomycin-resistant Enterococcus faecium (VRE) isolates that had been obtained between 1994 and 1999 from the Medical School Hospital of the University of Michigan, Ann Arbor, were tested for bacteriocin production. Two hundred seventy-seven (44%) of the strains were bacteriocinogenic; and 193 of these...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.50.4.1202-1212.2006

    authors: Inoue T,Tomita H,Ike Y

    更新日期:2006-04-01 00:00:00

  • Lipid segregation explains selective toxicity of a series of fragments derived from the human cathelicidin LL-37.

    abstract::The only human cathelicidin, the 37-residue peptide LL-37, exhibits antimicrobial activity against both gram-positive and gram-negative bacteria. We studied the ability of several fragments of LL-37, exhibiting different antimicrobial activities, to interact with membranes whose compositions mimic the cytoplasmic memb...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00321-09

    authors: Epand RF,Wang G,Berno B,Epand RM

    更新日期:2009-09-01 00:00:00

  • Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci.

    abstract::Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章

    doi:10.1128/aac.47.12.3964-3966.2003

    authors: Kutscha-Lissberg F,Hebler U,Muhr G,Köller M

    更新日期:2003-12-01 00:00:00

  • Mycobacterium tuberculosis gyrase inhibitors as a new class of antitubercular drugs.

    abstract::One way to speed up the TB drug discovery process is to search for antitubercular activity among compound series that already possess some of the key properties needed in anti-infective drug discovery, such as whole-cell activity and oral absorption. Here, we present MGIs, a new series of Mycobacterium tuberculosis gy...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.03913-14

    authors: Blanco D,Perez-Herran E,Cacho M,Ballell L,Castro J,González Del Río R,Lavandera JL,Remuiñán MJ,Richards C,Rullas J,Vázquez-Muñiz MJ,Woldu E,Zapatero-González MC,Angulo-Barturen I,Mendoza A,Barros D

    更新日期:2015-04-01 00:00:00

  • Indirect mouse model for the evaluation of potential antiviral compounds: results with Venezuelan equine encephalomyelitis virus.

    abstract::An indirect mouse model was utilized to evaluate the antiviral activity of several compounds against Venezuelan equine encephalomyelitis (VEE) virus infection in mice. Mice were given various dosages of lysine-stabilized polyriboinosinic acid-polyribocytidylic acid, a tilorone analogue, kethoxal, or mepacrine before a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.11.4.683

    authors: Kuehne RW,Pannier WL,Stephen EL

    更新日期:1977-04-01 00:00:00

  • Distribution of [14C]aztreonam in rat tissue.

    abstract::[14C]aztreonam was administered intramuscularly (50 mg/kg) to male and female rats. Groups of 10 rats (five male and five female) were sacrificed at 0.25, 2, 6, and 24 h after dosing. Blood and various tissues were removed from six rats (three male and three female) in each group for determination of total radioactivi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.26.2.127

    authors: Singhvi SM,Ita CE,Shaw JM,Migdalof BH

    更新日期:1984-08-01 00:00:00

  • Evidence for Inhibition of Topoisomerase 1A by Gold(III) Macrocycles and Chelates Targeting Mycobacterium tuberculosis and Mycobacterium abscessus.

    abstract::Mycobacterium tuberculosis and the fast-growing species Mycobacterium abscessus are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug-resistant M. tuberculosis strains and the high level of intrinsic resistance of M....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01696-17

    authors: Gupta R,Rodrigues Felix C,Akerman MP,Akerman KJ,Slabber CA,Wang W,Adams J,Shaw LN,Tse-Dinh YC,Munro OQ,Rohde KH

    更新日期:2018-04-26 00:00:00

  • Amoxicillin pharmacokinetics in preterm infants with gestational ages of less than 32 weeks.

    abstract::The multiple-dose pharmacokinetics of amoxicillin (AM [administered twice daily in a 25-mg/kg of body weight intravenous dose]) in 17 preterm infants (11 males; gestational age, 29 +/- 1.9 weeks; birth weight, 1,175 +/- 278 g) were evaluated on day 3 of life. Blood samples were collected from an arterial catheter at 0...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.39.2.431

    authors: Huisman-de Boer JJ,van den Anker JN,Vogel M,Goessens WH,Schoemaker RC,de Groot R

    更新日期:1995-02-01 00:00:00

  • Use of novel boronic acid transition state inhibitors to probe substrate affinity in SHV-type extended-spectrum beta-lactamases.

    abstract::Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S beta-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (Ki, 730+/-80 nM), while the D104K G238S variant was th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01293-06

    authors: Thomson JM,Prati F,Bethel CR,Bonomo RA

    更新日期:2007-04-01 00:00:00

  • Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice.

    abstract::Oral administration of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652), a nucleoside analog structurally similar to lamivudine (3TC), caused dose-dependent inhibition of viral replication in SCID-hu Thy/Liv mice infected with human immunodeficiency virus type 1 NL4-3 and with an NL4-3 clone containing the M184V mutation i...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.44.3.783-786.2000

    authors: Stoddart CA,Moreno ME,Linquist-Stepps VD,Bare C,Bogan MR,Gobbi A,Buckheit RW Jr,Bedard J,Rando RF,McCune JM

    更新日期:2000-03-01 00:00:00

  • Effects of Antiviral Drugs on Organic Anion Transport in Human Placental BeWo Cells.

    abstract::Placental drug transfer is important for achieving better pharmacotherapy in pregnant women and in fetuses. In the present study, we examined the effects of anti-hepatitis C virus (HCV) and anti-HIV drugs on organic anion transport in human placental BeWo cells. The cellular uptake of two fluorescence organic anions, ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01634-15

    authors: Nabekura T,Kawasaki T,Kamiya Y,Uwai Y

    更新日期:2015-12-01 00:00:00

  • Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca.

    abstract::Klebsiella oxytoca 1731, which showed a wide spectrum of resistance to beta-lactams, including cefoxitin, was isolated in 1994 from a patient in Genoa, Italy. This strain contained a plasmid-mediated AmpC beta-lactamase with a pI of 7.25. Sequencing of the corresponding DNA of K. oxytoca 1731 revealed 96 and 97% ident...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:

    authors: Marchese A,Arlet G,Schito GC,Lagrange PH,Philippon A

    更新日期:1998-02-01 00:00:00

  • Acquisition of Rifampin Resistance in Pulmonary Tuberculosis.

    abstract::Mycobacterium tuberculosis strains with spontaneous mutations conferring resistance to rifampin (RIF) are exceedingly rare, and fixed drug combinations typically prevent augmentation of resistance to single drugs. Fourteen newly diagnosed tuberculosis patients were treated with RIF alone for 14 days, and bacterial loa...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章

    doi:10.1128/AAC.02220-16

    authors: Kayigire XA,Friedrich SO,van der Merwe L,Diacon AH

    更新日期:2017-03-24 00:00:00

  • Discovery of New Inhibitors of Toxoplasma gondii via the Pathogen Box.

    abstract::Toxoplasma gondii is a cosmopolitan protozoan parasite which affects approximately 30% of the population worldwide. The drugs currently used against toxoplasmosis are few in number and show several limitations, such as drug intolerance, poor bioavailability, or drug resistance mechanism developed by the parasite. Thus...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01640-17

    authors: Spalenka J,Escotte-Binet S,Bakiri A,Hubert J,Renault JH,Velard F,Duchateau S,Aubert D,Huguenin A,Villena I

    更新日期:2018-01-25 00:00:00

  • Assessment of serum bactericidal activity after administration of cefoperazone, cefotaxime, ceftizoxime, and moxalactam to healthy subjects.

    abstract::Bactericidal activity in serum produced after administration of 1-g intravenous doses of cefoperazone, cefotaxime, ceftizoxime, and moxalactam was ascertained in six healthy subjects. The assay organisms were a strain of Staphylococcus aureus which was moderately susceptible to the drugs (MBC, 2 to 8 micrograms/ml) an...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.28.1.55

    authors: Barriere SL,Ozasa DC,Mordenti J

    更新日期:1985-07-01 00:00:00

  • Use of real-time PCR and fluorimetry to detect lamivudine resistance-associated mutations in hepatitis B virus.

    abstract::Very rapid amplification of DNA by PCR in small volumes can be continuously monitored by the detection of the binding of probes with a rapid cycler with built-in fluorometric detection. Primers were designed to amplify approximately 100 bp of the polymerase gene of hepatitis B virus (HBV) spanning codon 550, where mut...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.43.7.1600

    authors: Cane PA,Cook P,Ratcliffe D,Mutimer D,Pillay D

    更新日期:1999-07-01 00:00:00

  • Efficacy of alcohol-based hand rinses under frequent-use conditions.

    abstract::Fifty volunteers randomly assigned to one of five hand washing agents (10 subjects per agent)--a nonantiseptic liquid soap (control), an antiseptic hand rinse containing 60% isopropyl alcohol (IPA) with emollients (Alc A), an antiseptic hand rinse containing 70% IPA and 0.5% chlorhexidine gluconate with emollients (Al...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1128/aac.30.4.542

    authors: Larson EL,Eke PI,Laughon BE

    更新日期:1986-10-01 00:00:00