Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin.

abstract：:As a relationship between nelfinavir antiretroviral efficacy and plasma concentrations has been previously established, nelfinavir pharmacokinetics was investigated in order to optimize the individual treatment schedule in a pediatric population. A population pharmacokinetic model was developed to describe the concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirt D,Urien S,Jullien V,Firtion G,Rey E,Pons G,Blanche S,Treluyer JM

更新日期：2006-03-01 00:00:00

abstract：:Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS]) infection. Novel di...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang S,Wenzler T,Miller PN,Wu H,Boykin DW,Brun R,Wang MZ

更新日期：2014-07-01 00:00:00

abstract：:Resistance of Plasmodium falciparum to drugs such as chloroquine and sulfadoxine-pyrimethamine is a major problem in malaria control. Artemisinin (ART) derivatives, particularly in combination with other drugs, are thus increasingly used to treat malaria, reducing the probability that parasites resistant to the compon...

journal_title：Antimicrobial agents and chemotherapy

authors： Afonso A,Hunt P,Cheesman S,Alves AC,Cunha CV,do Rosário V,Cravo P

更新日期：2006-02-01 00:00:00

abstract：:The Capnocytophaga sputigena isolate NOR, responsible for septicemia, was resistant to amoxicillin and narrow-spectrum cephalosporins. In a cloning experiment, a new gene, bla(CSP-1), was identified; this gene encodes a novel extended-spectrum beta-lactamase (ESBL) that shares only 52% and 49% identities with the CME-...

journal_title：Antimicrobial agents and chemotherapy

authors： Guillon H,Eb F,Mammeri H

更新日期：2010-05-01 00:00:00

abstract：:Acanthamoeba spp. are the causative agents of Acanthamoeba keratitis (AK), which mainly occurs in contact lens wearers, and of skin lesions, granulomatous amoebic encephalitis (GAE), and disseminating diseases in the immunocompromised host. AK therapy is complex and irritating for the eye, skin lesions are difficult t...

journal_title：Antimicrobial agents and chemotherapy

authors： Fürnkranz U,Nagl M,Gottardi W,Köhsler M,Aspöck H,Walochnik J

更新日期：2008-02-01 00:00:00

abstract：:We have reported previously that methylenecyclopropane analogs of nucleosides have excellent activity against certain members of the herpesvirus family. A second generation, the 2,2-bis-hydroxymethyl derivatives, were synthesized, and 18 compounds were tested for activity in vitro against herpes simplex virus types 1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Kushner NL,Hartline CB,Williams-Aziz SL,Harden EA,Zhou S,Zemlicka J,Prichard MN

更新日期：2005-03-01 00:00:00

abstract：:Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercia...

journal_title：Antimicrobial agents and chemotherapy

authors： Bennett JE,Jennings AE

更新日期：1978-04-01 00:00:00

abstract：:Resistance to daptomycin in enterococcal clinical isolates remains rare but is being increasingly reported in the United States and worldwide. There are limited data on the genetic relatedness and microbiological and clinical characteristics of daptomycin-nonsusceptible enterococcal clinical isolates. In this study, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang G,Kamalakaran S,Dhand A,Huang W,Ojaimi C,Zhuge J,Yee LL,Mayigowda P,Surendraiah PK,Dimitrova N,Fallon JT

更新日期：2014-08-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, septicemia, and middle ear infections. The incidence of S. pneumoniae isolates that are not susceptible to penicillin has risen worldwide and may be above 20% in some countries. Beta-lactam antibiotic resistance in pneumococci is associated with sig...

journal_title：Antimicrobial agents and chemotherapy

authors： Jensen A,Valdórsson O,Frimodt-Møller N,Hollingshead S,Kilian M

更新日期：2015-01-01 00:00:00

abstract：:A remarkably high rate of adverse events is associated with the use of trimethoprim-sulfamethoxazole in patients with human immunodeficiency virus type 1 infection. We examined the efficacies of sulfonamides alone in the prevention of Pneumocystis carinii pneumonitis, with the assumption that at least some of the adve...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes WT,Killmar J

更新日期：1996-04-01 00:00:00

abstract：:Chlorhexidine (Hibiscrub; ICI) is generally accepted to be effective as an antiseptic hand wash for methicillin-susceptible Staphylococcus aureus (MSSA), but there is dispute whether the chlorhexidine MIC for methicillin-resistant S. aureus (MRSA) strains is higher than that for MSSA strains and, indeed, whether it is...

journal_title：Antimicrobial agents and chemotherapy

authors： Cookson BD,Bolton MC,Platt JH

更新日期：1991-10-01 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic activity against Pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ittarat I,Asawamahasakda W,Bartlett MS,Smith JW,Meshnick SR

更新日期：1995-02-01 00:00:00

abstract：:We previously demonstrated that ginsenosides Rg1 and Re enhanced the immune response in C3H/HeB mice but not in C3H/HeJ mice carrying a mutation in the Tlr4 gene. The results of the present study showed that both Rg1 and Re inhibited mRNA expression and production of proinflammatory mediators that included tumor necro...

journal_title：Antimicrobial agents and chemotherapy

authors： Su F,Xue Y,Wang Y,Zhang L,Chen W,Hu S

更新日期：2015-09-01 00:00:00

abstract：:We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolain JM,Diene SM,Kempf M,Gimenez G,Robert C,Raoult D

更新日期：2013-01-01 00:00:00

abstract：:The human fungal pathogen Candida albicans releases a large glycofragment of the Msb2 surface protein (Msb2*) into the growth environment, which protects against the action of human antimicrobial peptides (AMPs) LL-37 and histatin-5. Quantitation of Msb2*/LL-37 interactions by microscale thermophoresis revealed high-a...

journal_title：Antimicrobial agents and chemotherapy

authors： Swidergall M,Ernst AM,Ernst JF

更新日期：2013-08-01 00:00:00

abstract：:The in vitro activities of magainin analogs against Blastocystis hominis, Entamoeba histolytica, and Trypanosoma cruzi were assessed by protozoan morphological integrity and motility. The antiprotozoan activities in descending order were magainin B greater than G greater than H, the same order as the alpha-helix conte...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang CM,Chen HC,Zierdt CH

更新日期：1990-09-01 00:00:00

abstract：:Carbovir is a novel carbocyclic nucleoside which has been shown to have potent in vitro activity against human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome. Sprague-Dawley male rats were used to investigate the pharmacokinetics and bioavailability of carbovir. Six rats received car...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeom YH,Remmel RP,Huang SH,Hua M,Vince R,Zimmerman CL

更新日期：1989-02-01 00:00:00

abstract：:Genes belonging to different erm DNA hybridization classes were selectively amplified by polymerase chain reaction with a pair of oligonucleotides that corresponded to conserved amino acid motifs in known ERM methylases. Identification of the resistance mechanism was possible despite substantial nucleotide sequence di...

journal_title：Antimicrobial agents and chemotherapy

authors： Arthur M,Molinas C,Mabilat C,Courvalin P

更新日期：1990-10-01 00:00:00

abstract：:Antibiotic dynamics in the fluid obtained from subcutaneously implanted chambers in rats were similar to those observed in serum following single intramuscular injections of carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gardner WG,Prior RB,Perkins RL

更新日期：1973-08-01 00:00:00

abstract：:A comparative evaluation of daptomycin and eight other antimicrobial agents was performed by the agar dilution technique with 56 strains of vancomycin-resistant gram-positive bacteria, including Leuconostoc, Lactobacillus, and Pediococcus spp. Erythromycin, deptomycin, clindamycin, and gentamicin exhibited the greates...

journal_title：Antimicrobial agents and chemotherapy

authors： de la Maza L,Ruoff KL,Ferraro MJ

更新日期：1989-08-01 00:00:00

abstract：:The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial n...

journal_title：Antimicrobial agents and chemotherapy

authors： Giacometti A,Cirioni O,Ghiselli R,Orlando F,D'Amato G,Kamysz W,Mocchegiani F,Sisti V,Silvestri C,Łukasiak J,Rocchi M,Saba V,Scalise G

更新日期：2004-08-01 00:00:00

abstract：:The therapeutic effect of intranasally administered enviroxime was tested against naturally occurring common colds. The double-blind evaluation was carried out in Tecumseh, Mich., during a period when rhinoviruses are usually the principal pathogen. Rhinovirus transmission followed the typical pattern during this peri...

journal_title：Antimicrobial agents and chemotherapy

authors： Miller FD,Monto AS,DeLong DC,Exelby A,Bryan ER,Srivastava S

更新日期：1985-01-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites lack the enzymes to salvage preformed pyrimidines. For this reason, a combination of a thymidylate synthase inhibitor and the nucleoside thymidine should provide selective antimalarial activity even in the absence of any known active site differences between malarial and mamm...

journal_title：Antimicrobial agents and chemotherapy

authors： Rathod PK,Reshmi S

更新日期：1994-03-01 00:00:00

abstract：:Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic fungi such as Candida albicans, its effect on Aspergillus fumigatus is less well understood. We used the fluorescent ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bowman JC,Hicks PS,Kurtz MB,Rosen H,Schmatz DM,Liberator PA,Douglas CM

更新日期：2002-09-01 00:00:00

abstract：:The JAK-STAT pathway is activated in both macrophages and lymphocytes upon human immunodeficiency virus type 1 (HIV-1) infection and thus represents an attractive cellular target to achieve HIV suppression and reduced inflammation, which may impact virus sanctuaries. Ruxolitinib and tofacitinib are JAK1/2 inhibitors t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavegnano C,Detorio M,Montero C,Bosque A,Planelles V,Schinazi RF

更新日期：2014-01-01 00:00:00

abstract：:Standard therapy of human visceral leishmaniasis with parenteral pentavalent antimonial agents is generally curative but has the disadvantages of a 28-day treatment course, occasional treatment failures, and toxicity. The antifungal and antileishmanial agent amphotericin B has been complexed with lipids to develop a l...

journal_title：Antimicrobial agents and chemotherapy

authors： Berman JD,Ksionski G,Chapman WL,Waits VB,Hanson WL

更新日期：1992-09-01 00:00:00

abstract：:Cefoxitin resistance, but not resistance to clindamycin, erythromycin, lincomycin, or tetracycline, was transferred by a conjugation-like process from Bacteroides thetaiotaomicron UN101, a clinical isolate haboring four kinds of plasmids, to other Bacteroides species. Of a sample of 20 cefoxitin-resistant transconjuga...

journal_title：Antimicrobial agents and chemotherapy

authors： Rashtchian A,Dubes GR,Booth SJ

更新日期：1982-10-01 00:00:00

abstract：:Vancomycin-resistant enterococci (VRE) are endemic in health care settings. These organisms colonize the gastrointestinal tract and can lead to infection which is associated with increased mortality. There is no treatment for VRE colonization. We conducted a randomized, double-blind, placebo-controlled clinical trial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Doron S,Hibberd PL,Goldin B,Thorpe C,McDermott L,Snydman DR

更新日期：2015-08-01 00:00:00

abstract：:The present study confirms that CBA/J mice are susceptible to several clinical isolates of Streptococcus pneumoniae, including four of five penicillin-susceptible and all five penicillin-resistant strains tested, thus providing the first noncompromised animal model for penicillin-resistant S. pneumoniae pneumonia. In ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tateda K,Takashima K,Miyazaki H,Matsumoto T,Hatori T,Yamaguchi K

更新日期：1996-06-01 00:00:00

abstract：:Sixteen healthy male volunteers participated in a randomized, balanced, three-way crossover study comparing the pharmacokinetics of cefmetazole, cefoxitin, and cefmetazole with probenecid pretreatment. Single 2-g doses of cefmetazole sodium and cefoxitin sodium were given intravenously as a 5-min infusion. Concentrati...

journal_title：Antimicrobial agents and chemotherapy

authors： Ko H,Cathcart KS,Griffith DL,Peters GR,Adams WJ

更新日期：1989-03-01 00:00:00