Transferable resistance to cefoxitin in Bacteroides thetaiotaomicron.

abstract：:In separate previous studies, we have shown that lipid-complexed amphotericin B (Abelcet [ABLC]) and liposomal amphotericin B (AmBisome [AmBi]) are efficacious against coccidioidal meningitis in rabbits. Here, we compared ABLC and AmBi directly in a coccidioidal meningitis model. Male New Zealand White rabbits were in...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Capilla J,Sobel RA,Martinez M,Tong AJ,Stevens DA

更新日期：2009-05-01 00:00:00

abstract：:Bacterial resistance studies using in vitro dynamic models are highly dependent on the starting inoculum that might or might not contain spontaneously resistant mutants (RMs). To delineate concentration-resistance relationships with linezolid-exposed Staphylococcus aureus, a mixed inoculum containing both susceptible ...

journal_title：Antimicrobial agents and chemotherapy

authors： Firsov AA,Golikova MV,Strukova EN,Portnoy YA,Romanov AV,Edelstein MV,Zinner SH

更新日期：2015-02-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant pathogen that poses a significant risk to global health today. We have developed a promising new FtsZ-targeting agent (TXA707) with potent activity against MRSA isolates resistant to current standard-of-care antibiotics. We present here result...

journal_title：Antimicrobial agents and chemotherapy

authors： Ferrer-González E,Kaul M,Parhi AK,LaVoie EJ,Pilch DS

更新日期：2017-08-24 00:00:00

abstract：:Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nedelman JR,Salinger DH,Subramoney V,Woolson R,Wade K,Li M,Everitt D,Mendel CM,Spigelman M

更新日期：2020-12-16 00:00:00

abstract：:Changes in plasmid DNA supercoiling were measured following treatment of Escherichia coli cells, carrying topoisomerase mutations, with the quinolone ciprofloxacin. In quinolone-susceptible cells (top+ gyr+) as well as in topA mutants and in gyrB mutants, plasmid DNA was relaxed after the addition of ciprofloxacin. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleixandre V,Herrera G,Urios A,Blanco M

更新日期：1991-01-01 00:00:00

abstract：:Two new antifungal triazoles, BAY n7133 and ICI 153,066, were compared with ketoconazole in treatment of mice challenged intraperitoneally with Cryptococcus neoformans. At high challenge doses, thymus-containing normal mice had prolonged survival after treatment with BAY n7133. Athymic mice, which have severely defici...

journal_title：Antimicrobial agents and chemotherapy

authors： Graybill JR,Kaster SR,Drutz DJ

更新日期：1983-12-01 00:00:00

abstract：:Early studies of immobilized peptides mainly focused upon the relationship between structural properties and the activity of soluble and surface-tethered sequences. The intention of this study was to analyze the influence of immobilization parameters upon the activity profile of peptides. Resin beads (TentaGel S NH(2)...

journal_title：Antimicrobial agents and chemotherapy

authors： Bagheri M,Beyermann M,Dathe M

更新日期：2009-03-01 00:00:00

abstract：:SDZ MRL 953, a new synthetic monosaccharidic lipid A, was investigated in vitro and in vivo for immunopharmacological activities. In experimental models of microbial infections, the compound was highly protective when it was administered prophylactically either once or three times to myelosuppressed or immunocompetent...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam C,Schütze E,Hildebrandt J,Aschauer H,Liehl E,Macher I,Stütz P

更新日期：1991-03-01 00:00:00

abstract：:There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens. A combination formulation of amikacin-fosfomycin is currently undergoing clinical testing although the exposure-response relationships of these drugs have no...

journal_title：Antimicrobial agents and chemotherapy

authors： Sime FB,Johnson A,Whalley S,Santoyo-Castelazo A,Montgomery AB,Walters KA,Lipman J,Hope WW,Roberts JA

更新日期：2016-12-27 00:00:00

abstract：:Novel penem molecules with heterocycle substitutions at the 6 position via a methylidene linkage were investigated for their activities and efficacy as beta-lactamase inhibitors. The concentrations of these molecules that resulted in 50% inhibition of enzyme activity were 0.4 to 3.1 nM for the TEM-1 enzyme, 7.8 to 72 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Petersen PJ,Murphy TM,Tardio L,Yang Y,Bradford PA,Venkatesan AM,Abe T,Isoda T,Mihira A,Ushirogochi H,Takasake T,Projan S,O'Connell J,Mansour TS

更新日期：2004-12-01 00:00:00

abstract：:The pharmacokinetics and therapeutic efficacy of gentamicin were investigated in an experimental pleural empyema rabbit model. Pleural effusion was induced by the intrapleural administration of turpentine, and empyema was induced by direct inoculation of the effusion with Klebsiella pneumoniae. Pleural empyema compare...

journal_title：Antimicrobial agents and chemotherapy

authors： Shohet I,Yellin A,Meyerovitch J,Rubinstein E

更新日期：1987-07-01 00:00:00

abstract：:The mechanisms of herpes simplex virus (HSV) inactivation by sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), two anionic surfactants with protein denaturant potency, have been evaluated in cultured cells. Results showed that pretreatment of HSV type 1 (HSV-1) strain F and HSV-2 strain 333 with either surfacta...

journal_title：Antimicrobial agents and chemotherapy

authors： Piret J,Roy S,Gagnon M,Landry S,Désormeaux A,Omar RF,Bergeron MG

更新日期：2002-09-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is usually benign in healthy individuals but can cause life-threatening disease in those with compromised immune systems. Approved drugs available to treat HCMV disease, including ganciclovir, cidofovir, and foscarnet, have significant toxicities that limit their use in certain p...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel HD,Nikitin P,Gesner T,Lin JJ,Barkan DT,Ciferri C,Carfi A,Akbarnejad Yazdi T,Skewes-Cox P,Wiedmann B,Jarousse N,Zhong W,Feire A,Hebner CM

更新日期：2016-07-22 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:All cells need to protect themselves against the osmotic challenges of their environment by maintaining low permeability to ions across their cell membranes. This is a basic principle of cellular function, which is reflected in the interactions among ion transport and drug efflux genes that have arisen during cellular...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen BE

更新日期：2014-01-01 00:00:00

abstract：:Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hawser SP,Bouchillon SK,Hoban DJ,Badal RE,Hsueh PR,Paterson DL

更新日期：2009-08-01 00:00:00

abstract：:The two groups of chromosomal beta-lactamases from Klebsiella oxytoca (OXY-1 and OXY-2) can be overproduced 73- to 223-fold, due to point mutations in the consensus sequences of their promoters. The different versions of promoters from blaOXY-1 and blaOXY-2 were cloned upstream of the chloramphenicol acetyltransferase...

journal_title：Antimicrobial agents and chemotherapy

authors： Fournier B,Gravel A,Hooper DC,Roy PH

更新日期：1999-04-01 00:00:00

abstract：:GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. We have characterized the in vivo pharmacodynamics (PD) of GSK1322322 in immunocompetent animal models of infection with Streptococcus pneumoniae a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoover J,Lewandowski T,Straub RJ,Novick SJ,DeMarsh P,Aubart K,Rittenhouse S,Zalacain M

更新日期：2015-10-19 00:00:00

abstract：:The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 microCi) of [(3)H]caspofungin to healthy men, plasma, urine, and feces were collected over 27 days in study A (n = 6) and plasma was collected over 26 weeks in study B (n = 7). Su...

journal_title：Antimicrobial agents and chemotherapy

authors： Stone JA,Xu X,Winchell GA,Deutsch PJ,Pearson PG,Migoya EM,Mistry GC,Xi L,Miller A,Sandhu P,Singh R,deLuna F,Dilzer SC,Lasseter KC

更新日期：2004-03-01 00:00:00

abstract：:WR99210, a dihydrofolate reductase inhibitor, has promising in vitro activity against Mycobacterium avium complex (MAC). The in vitro activities of WR99210 alone and in combination with a fixed concentration of dapsone (0.5 microgram/ml) were evaluated against 35 clinical MAC isolates by a broth dilution method. The M...

journal_title：Antimicrobial agents and chemotherapy

authors： Shah LM,DeStefano MS,Cynamon MH

更新日期：1996-11-01 00:00:00

abstract：:As part of the CANCER Antimicrobial Surveillance Program in North America, a Pseudomonas aeruginosa isolate, strain 07-406, was shown to possess a metallo-beta-lactamase, designated VIM-7. bla(VIM-7) is located on a 24-kb plasmid which can be readily transferred into Enterobacteriaceae and other pseudomonads. This is ...

journal_title：Antimicrobial agents and chemotherapy

authors： Toleman MA,Rolston K,Jones RN,Walsh TR

更新日期：2004-01-01 00:00:00

abstract：:Echinocandins are recommended as the first-line drugs for the treatment of systemic candidiasis. Cas5 is a key transcription factor involved in the response to cell wall damage induced by echinocandins. In this study, through a genetic screen, we identified a second transcription factor, Efg1, that is also crucial for...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong K,Su C,Sun Q,Lu Y

更新日期：2021-01-20 00:00:00

abstract：:The 72 Escherichia coli strains of the ECOR collection were examined for resistance to 10 different antimicrobial agents including ampicillin, tetracycline, mercury, trimethoprim, and sulfonamides. Eighteen strains were resistant to at least one of the antibiotics tested, and nearly 20% (14 of 72) were resistant to tw...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazel D,Dychinco B,Webb VA,Davies J

更新日期：2000-06-01 00:00:00

abstract：:An increase in the number of tuberculosis cases caused by multiple-drug-resistant strains of Mycobacterium tuberculosis has stimulated search for new antituberculous agents. Beta-lactam antibiotics, traditionally regarded as ineffective against tuberculosis, merit consideration. Four major penicillin-binding proteins ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chambers HF,Moreau D,Yajko D,Miick C,Wagner C,Hackbarth C,Kocagöz S,Rosenberg E,Hadley WK,Nikaido H

更新日期：1995-12-01 00:00:00

abstract：:Although obesity is prevalent among children in the United States, pharmacokinetic (PK) data for obese children are limited. Clindamycin is a commonly used antibiotic that may require dose adjustment in obese children due to its lipophilic properties. We performed a clindamycin population PK analysis using data from t...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith MJ,Gonzalez D,Goldman JL,Yogev R,Sullivan JE,Reed MD,Anand R,Martz K,Berezny K,Benjamin DK Jr,Smith PB,Cohen-Wolkowiez M,Watt K,Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee.

更新日期：2017-03-24 00:00:00

abstract：:Rabbits with nutritionally variant viridans group streptococcal experimental endocarditis were treated three times daily for 3 days with procaine penicillin (1.2 X 10(6) U) alone or together with low-dose streptomycin (2 mg/kg), high-dose streptomycin (8 mg/kg), low-dose gentamicin (0.32 mg/kg), or high-dose gentamici...

journal_title：Antimicrobial agents and chemotherapy

authors： Henry NK,Wilson WR,Roberts RB,Acar JF,Geraci JE

更新日期：1986-09-01 00:00:00

abstract：:We compared the inoculum effects for 109 recent clinical isolates of the Bacteroides fragilis group of cefoxitin, cefotetan, ceftizoxime, ceftriaxone, and three beta-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) and their penicillin-derived components. Bactericidal activity was assayed and morpholo...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Cherubin CE

更新日期：1991-09-01 00:00:00

abstract：:A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luque S,Hope W,Campillo N,Muñoz-Bermúdez R,Sorli L,Barceló-Vidal J,González-Colominas E,Alvarez-Lerma F,Masclans JR,Montero M,Horcajada JP,Grau S

更新日期：2019-06-24 00:00:00

abstract：:The pharmacokinetic disposition of 2 g of cefoxitin administered intravenously over 30 min was determined in six patients undergoing continuous ambulatory peritoneal dialysis for chronic renal failure. During the 6-h dialysate dwell time after the drug infusion, the mean apparent volume of distribution for cefoxitin w...

journal_title：Antimicrobial agents and chemotherapy

authors： Greaves WL,Kreeft JH,Ogilvie RI,Richards GK

更新日期：1981-02-01 00:00:00

abstract：:The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore a...

journal_title：Antimicrobial agents and chemotherapy

authors： Arthur M,Molinas C,Bugg TD,Wright GD,Walsh CT,Courvalin P

更新日期：1992-04-01 00:00:00