Enhanced in vitro activity of WR99210 in combination with dapsone against Mycobacterium avium complex.

abstract：:Limited antiretrovirals are currently available for the management of multidrug-resistant (MDR) HIV-1 infection. Ibalizumab, a recombinant humanized monoclonal antibody, represents the first novel agent for HIV-1 management in over a decade and is the first monoclonal antibody for the treatment of MDR HIV-1 infection ...

journal_title：Antimicrobial agents and chemotherapy

authors： Beccari MV,Mogle BT,Sidman EF,Mastro KA,Asiago-Reddy E,Kufel WD

更新日期：2019-05-24 00:00:00

abstract：:Exposure to isoniazid induced the expression of several secreted proteins in Mycobacterium tuberculosis H37Rv. Two-dimensional gel electrophoresis and immunoblot analyses indicated that two of the prominent isonicotinic acid hydrazide-inducible polypeptides were members of the antigen 85 complex, recently demonstrated...

journal_title：Antimicrobial agents and chemotherapy

authors： Garbe TR,Hibler NS,Deretic V

更新日期：1996-07-01 00:00:00

abstract：:Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis. MRSA was inoculated into the proximal tibia, and a titanium wire was implanted. Four weeks after infection...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergidis P,Rouse MS,Euba G,Karau MJ,Schmidt SM,Mandrekar JN,Steckelberg JM,Patel R

更新日期：2011-03-01 00:00:00

abstract：:Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitchel B,Sundin DR,Patel JB

更新日期：2009-10-01 00:00:00

abstract：:Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ma G,Khan SI,Jacob MR,Tekwani BL,Li Z,Pasco DS,Walker LA,Khan IA

更新日期：2004-11-01 00:00:00

abstract：:Ampicillin resistance in Enterococcus faecium is a serious concern worldwide, complicating the treatment of E. faecium infections. Penicillin-binding protein 5 (PBP5) is considered the main ampicillin resistance determinant in E. faecium The three known E. faecium clades showed sequence variations in the pbp5 gene tha...

journal_title：Antimicrobial agents and chemotherapy

authors： Montealegre MC,Roh JH,Rae M,Davlieva MG,Singh KV,Shamoo Y,Murray BE

更新日期：2016-12-27 00:00:00

abstract：:The ST5 lineage of methicillin-resistant Staphylococcus aureus (MRSA) is one of the most globally disseminated hospital-associated MRSA (HA-MRSA) lineages. We isolated a new local variant (designated ST764) over at least 5 years that causes invasive infections, including necrotizing fasciitis, and is carried by medica...

journal_title：Antimicrobial agents and chemotherapy

authors： Takano T,Hung WC,Shibuya M,Higuchi W,Iwao Y,Nishiyama A,Reva I,Khokhlova OE,Yabe S,Ozaki K,Takano M,Yamamoto T

更新日期：2013-04-01 00:00:00

abstract：:During the second quarter each of 1988, 1989, and 1990, a French collaborative study group, including 12 university hospital laboratories, surveyed the resistance to beta-lactams of clinical isolates from hospitalized patients: consecutively, 10,641, 10,692, and 9,382 isolates were tested. The distribution of bacteria...

journal_title：Antimicrobial agents and chemotherapy

authors： Sirot DL,Goldstein FW,Soussy CJ,Courtieu AL,Husson MO,Lemozy J,Meyran M,Morel C,Perez R,Quentin-Noury C

更新日期：1992-08-01 00:00:00

abstract：:RBX11160 (OZ277) is a fully synthetic peroxidic antimalarial in clinical development. To study the possible mechanisms of action of RBX11160, we have examined its ability to inhibit PfATP6, a sarcoplasmic reticulum calcium ATPase and proposed target for semisynthetic peroxidic artemisinin derivatives. RBX11160 inhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Uhlemann AC,Wittlin S,Matile H,Bustamante LY,Krishna S

更新日期：2007-02-01 00:00:00

abstract：:Posaconazole (POS) is a new antifungal agent for prevention and therapy of mycoses in immunocompromised patients. Variable POS pharmacokinetics after oral dosing may influence efficacy: a trough threshold of 0.5 μg/ml has been recently proposed. Measurement of POS plasma concentrations by complex chromatographic techn...

journal_title：Antimicrobial agents and chemotherapy

authors： Rochat B,Pascual A,Pesse B,Lamoth F,Sanglard D,Decosterd LA,Bille J,Marchetti O

更新日期：2010-12-01 00:00:00

abstract：:Candida albicans remains the leading causative agent of invasive fungal infection. Although the importance of filamentation in C. albicans pathogenesis has been extensively investigated, in vivo studies to date have been unable to dissect the role of this developmental process in the establishment of infection versus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saville SP,Lazzell AL,Bryant AP,Fretzen A,Monreal A,Solberg EO,Monteagudo C,Lopez-Ribot JL,Milne GT

更新日期：2006-10-01 00:00:00

abstract：:Due to the rise of antibiotic resistance and the small number of effective antiviral drugs, new approaches for treating infectious diseases are urgently needed. Identifying targets for host-based therapies represents an emerging strategy for drug discovery. The ubiquitin-proteasome system is a central mode of signalin...

journal_title：Antimicrobial agents and chemotherapy

authors： Passalacqua KD,Charbonneau ME,Donato NJ,Showalter HD,Sun D,Wen B,He M,Sun H,O'Riordan MX,Wobus CE

更新日期：2016-06-20 00:00:00

abstract：:Two group F vibrio organisms have been identified among a collection of vibrio strains isolated from the aquatic environment in Bangladesh. Neither group F strain produced a cholera-like enterotoxin. One of the isolates, BV12, contained an R plasmid conferring resistance to streptomycin and chloramphenicol. ...

journal_title：Antimicrobial agents and chemotherapy

authors： McNicol LA,Kaper JB,Lockman HA,Remmers EF,Spira WM,Colwell RR

更新日期：1980-03-01 00:00:00

abstract：:We studied the susceptibilities of 77 strains of Neisseria gonorrhoeae to four antibiotics: cefpodoxime, ceftriaxone, penicillin, and tetracycline. All strains were susceptible to ceftriaxone. Cefpodoxime MICs (range, 0.001 to 0.125 micrograms/ml) were parallel to and approximately four times those of ceftriaxone, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Fekete T,Woodwell J,Cundy KR

更新日期：1991-03-01 00:00:00

abstract：:Bacterial sepsis is a major cause of morbidity and mortality in neonates, especially those involving methicillin-resistant Staphylococcus aureus (MRSA). Guidelines by the Infectious Diseases Society of America recommend the vancomycin 24-h area under the concentration-time curve to MIC ratio (AUC24/MIC) of >400 as the...

journal_title：Antimicrobial agents and chemotherapy

authors： Tseng SH,Lim CP,Chen Q,Tang CC,Kong ST,Ho PC

更新日期：2018-03-27 00:00:00

abstract：:A series of quaternary ammonium compounds that are esters of betaine and fatty alcohols with hydrocarbon chain lengths of 10 to 18 carbon atoms were tested with respect to antimicrobial activities and rates of hydrolysis. When the tetradecyl derivative was tested against some selected microorganisms, the killing effec...

journal_title：Antimicrobial agents and chemotherapy

authors： Lindstedt M,Allenmark S,Thompson RA,Edebo L

更新日期：1990-10-01 00:00:00

abstract：:In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28°C and 35°C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demonstrated susceptibil...

journal_title：Antimicrobial agents and chemotherapy

authors： Heine HS,Hershfield J,Marchand C,Miller L,Halasohoris S,Purcell BK,Worsham PL

更新日期：2015-04-01 00:00:00

abstract：:We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at positi...

journal_title：Antimicrobial agents and chemotherapy

authors： Welsh KJ,Barlow M,Tenover FC,Biddle JW,Rasheed JK,Clark LA,McGowan JE Jr

更新日期：2005-03-01 00:00:00

abstract：:We determined the pharmacodynamic parameter and the magnitude of that parameter that was predictive of the efficacy of fluconazole in the treatment of disseminated candidiasis. We used a neutropenic murine model of disseminated Candida albicans infection to characterize the time course of activity of fluconazole. Quan...

journal_title：Antimicrobial agents and chemotherapy

authors： Andes D,van Ogtrop M

更新日期：1999-09-01 00:00:00

abstract：:A major concern of immunocompromised patients, in particular those with AIDS, is susceptibility to infection caused by opportunistic pathogens such as Pneumocystis jirovecii, which is a leading cause of pneumonia in immunocompromised patients. We report the first kinetic and structural data for 2,4-diamino-6-[(2',5'-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Cody V,Pace J,Queener SF,Adair OO,Gangjee A

更新日期：2013-06-01 00:00:00

abstract：:The in vitro activity of a new oral antimicrobial agent, norfloxacin (MK-0366), was compared with those of nalidixic acid, nitrofurantoin, co-trimoxazole, trimethoprim, sulfamethoxazole, cinoxacin, tetracycline, ampicillin, carbenicillin, and cephalexin against 628 urinary bacterial isolates. Norfloxacin was the most ...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan MY,Gruninger RP,Nelson SM,Klicker RE

更新日期：1982-05-01 00:00:00

abstract：:Teicoplanin was evaluated in 47 patients with severe infections, including 14 patients with bone infections, 11 patients with soft-tissue infections, 7 patients with endocarditis, 5 patients with pneumonia, 3 patients with septic thrombophlebitis, 3 patients with septicemia of unknown origin, and 4 patients with misce...

journal_title：Antimicrobial agents and chemotherapy

authors： Glupczynski Y,Lagast H,Van der Auwera P,Thys JP,Crokaert F,Yourassowsky E,Meunier-Carpentier F,Klastersky J,Kains JP,Serruys-Schoutens E

更新日期：1986-01-01 00:00:00

abstract：:The multiple antibiotic resistance (mar) locus in Escherichia coli consists of two divergently expressed operons (marC and marRAB), both of which contribute to the Mar phenotype. Overexpression of the marRAB operon protected E. coli against rapid cell killing by fluoroquinolones. Inactivation of the operon in mar muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldman JD,White DG,Levy SB

更新日期：1996-05-01 00:00:00

abstract：:The dose dependence of mezlocillin pharmacokinetics was examined in relation to renal function after intravenous doses of 1 and 5 g in 16 subjects with various degrees of renal impairment. Dose and time-average model-independent physiological parameters were calculated from plasma concentration and urinary excretion d...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangione A,Boudinot FD,Schultz RM,Jusko WJ

更新日期：1982-03-01 00:00:00

abstract：:Mutants with multiple low-level antibiotic resistance were isolated from virulent wild-type Aeromonas salmonicida strains exposed to a low concentration of any one of several low-molecular-mass (approximately 635 daltons or less) antibiotics. Multiple resistance was toward beta-lactam compounds (penicillin G, ampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Wood SC,McCashion RN,Lynch WH

更新日期：1986-06-01 00:00:00

abstract：:The macrolide-aminoglycoside-streptothricin (MAS) element, an ∼4.2-kb insertion containing erm(B) and aphA3 resistance determinants, distinguishes Streptococcus pneumoniae transposon Tn1545/Tn6003 from Tn6002. Here, it is shown to be an unstable genetic element that, although it lacks recombinase genes, can exploit lo...

journal_title：Antimicrobial agents and chemotherapy

authors： Palmieri C,Mingoia M,Massidda O,Giovanetti E,Varaldo PE

更新日期：2012-11-01 00:00:00

abstract：:The host immune response to human cytomegalovirus (HCMV) is effective against HCMV reactivation from latency, though not sufficient to clear the virus. T cells are primarily responsible for the control of viral reactivation. When the host immune system is compromised, as in transplant recipients with immunosuppression...

journal_title：Antimicrobial agents and chemotherapy

authors： Meng W,Tang A,Ye X,Gui X,Li L,Fan X,Schultz RD,Freed DC,Ha S,Wang D,Zhang N,Fu TM,An Z

更新日期：2017-12-21 00:00:00

abstract：:The diversity of tet(S) genetic contexts of 13 enterococci from human, animal, and environmental samples from different geographical areas is reported. The tet(S) gene was linked to either CTn6000 variants of chromosomal location or composite platforms flanked by IS1216 located on plasmids (∼40 to 115 kb). The compara...

journal_title：Antimicrobial agents and chemotherapy

authors： Novais C,Freitas AR,Silveira E,Baquero F,Peixe L,Roberts AP,Coque TM

更新日期：2012-11-01 00:00:00

abstract：:Here, we report that the genetic structure of Tn1331 remained conserved in Argentina from 1989 to 2013 (72 of 73 isolates), with the exception being the plasmid-borne Tn1331-like transposon Tn6238 containing a new aac(6')-Ib-cr allele recovered from a colistin-resistant Klebsiella pneumoniae clinical isolate. A bioinf...

journal_title：Antimicrobial agents and chemotherapy

authors： Quiroga MP,Orman B,Errecalde L,Kaufman S,Centrón D

更新日期：2015-05-01 00:00:00

abstract：:Caseinomacropeptide (CMP) is a heterogeneous C-terminal fragment (residues 106 to 169) of bovine milk kappa-casein composed of glycosylated and phosphorylated forms of different genetic variants. We have demonstrated that CMP has growth-inhibitory activity against the oral opportunistic pathogens Streptococcus mutans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkoski M,Dashper SG,O'Brien-Simpson NM,Talbo GH,Macris M,Cross KJ,Reynolds EC

更新日期：2001-08-01 00:00:00