R-factor carriage in a group F vibrio isolated from Bangladesh.

abstract：:The in vitro activity of rosamicin and erythromycin was compared at various pH values against 311 strains of bacteria representing common urinary tract pathogens. Alkalinization of the media consistently and significantly increased the antibacterial activity of rosamicin against all of the organisms tested. This was a...

journal_title：Antimicrobial agents and chemotherapy

authors： Eickhoff TC,Ehret JM

更新日期：1979-07-01 00:00:00

abstract：:We studied the susceptibilities of 77 strains of Neisseria gonorrhoeae to four antibiotics: cefpodoxime, ceftriaxone, penicillin, and tetracycline. All strains were susceptible to ceftriaxone. Cefpodoxime MICs (range, 0.001 to 0.125 micrograms/ml) were parallel to and approximately four times those of ceftriaxone, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Fekete T,Woodwell J,Cundy KR

更新日期：1991-03-01 00:00:00

abstract：:The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma fermentans, Mycoplasma genitalium, and Ureaplasma species to DC-159a, an investigational fluoroquinolone, in comparison with those to other agents were determined. Macrolides were the most active agen...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB

更新日期：2008-10-01 00:00:00

abstract：:MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by beta-lactam-sensitive DD-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd DB,Ott JL

更新日期：1986-05-01 00:00:00

abstract：:While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy in non-HIV-infected patients with PcP. Patients undergoing fiber-optic bronchoscopy wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Moon SM,Kim T,Sung H,Kim MN,Kim SH,Choi SH,Jeong JY,Woo JH,Kim YS,Lee SO

更新日期：2011-10-01 00:00:00

abstract：:Cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. Cefamandole had activity equivalent to cefazolin against Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. Cefamandole was more active than cephalothin or cefazo...

journal_title：Antimicrobial agents and chemotherapy

authors： Shemonsky NK,Carrizosa J,Levison ME

更新日期：1975-12-01 00:00:00

abstract：:The increasing use of azole antifungals for the treatment of mucosal and systemic Candida glabrata infections has resulted in the selection and/or emergence of resistant strains. The main mechanisms of azole resistance include alterations in the C. glabrata ERG11 gene (CgERG11), which encodes the azole target enzyme, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanguinetti M,Posteraro B,Fiori B,Ranno S,Torelli R,Fadda G

更新日期：2005-02-01 00:00:00

abstract：:Using an isogenic system, we have determined the impact that the four promoters known to control bla(TEM) gene expression have on beta-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter...

journal_title：Antimicrobial agents and chemotherapy

authors： Lartigue MF,Leflon-Guibout V,Poirel L,Nordmann P,Nicolas-Chanoine MH

更新日期：2002-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) genotype (GT) 2 represents approximately 9% of all viral infections globally. While treatment outcomes for GT2-infected patients have improved substantially with direct-acting antiviral agents (DAAs) compared to interferon-α, the presence of polymorphisms in NS5A can impact efficacy of NS5A inh...

journal_title：Antimicrobial agents and chemotherapy

authors： Asante-Appiah E,Ingravallo P,McMonagle P,Bystol K,Xia E,Curry S,Qiu P,Black S,Chase R,Liu R,Lahser F

更新日期：2019-09-16 00:00:00

abstract：:We reviewed data for almost 300,000 clinical Escherichia coli urinary isolates (collected in 2009 through 2013) from 127 inpatient and outpatient facilities, to assess antibiotic resistance among Veterans Affairs health care system patients using Clinical and Laboratory Standards Institute and Centers for Disease Cont...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrill HJ,Morton JB,Caffrey AR,Jiang L,Dosa D,Mermel LA,LaPlante KL

更新日期：2017-04-24 00:00:00

abstract：:The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. s...

journal_title：Antimicrobial agents and chemotherapy

authors： Neyfakh AA,Borsch CM,Kaatz GW

更新日期：1993-01-01 00:00:00

abstract：:Biapenem is a parenteral carbapenem antibiotic that exhibits wide-ranging antibacterial activity, remarkable chemical stability, and extensive stability against human renal dehydropeptidase-I. Tebipenem is the active form of tebipenem pivoxil, a novel oral carbapenem antibiotic that has a high level of bioavailability...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamada M,Watanabe T,Baba N,Takeuchi Y,Ohsawa F,Gomi S

更新日期：2008-06-01 00:00:00

abstract：:Genotypes of samples from protease inhibitor-naïve patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes. The proportion of non-B subtypes increased with increasing scores, except in weighted algorithms. Virtual and i...

journal_title：Antimicrobial agents and chemotherapy

authors： Stürmer M,Stephan C,Gute P,Knecht G,Bickel M,Brodt HR,Doerr HW,Gürtler L,Lecocq P,van Houtte M

更新日期：2011-11-01 00:00:00

abstract：:On the basis of the antiviral action of sulfated polyanions in human immunodeficiency virus and other viral infections, we studied the effect of dextran sulfate and heparin on duck hepatitis B virus infection. These agents do not affect viral uptake and replication in liver cells in vitro or in vivo. Sulfated polyanio...

journal_title：Antimicrobial agents and chemotherapy

authors： Offensperger WB,Offensperger S,Walter E,Blum HE,Gerok W

更新日期：1991-11-01 00:00:00

abstract：:Avibactam is a new non-β-lactam β-lactamase inhibitor that shows promising restoration of ceftazidime activity against microorganisms producing Ambler class A extended-spectrum β-lactamases (ESBLs) and carbapenemases such as KPCs, class C β-lactamases (AmpC), and some class D enzymes. To determine optimal dosing combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berkhout J,Melchers MJ,van Mil AC,Seyedmousavi S,Lagarde CM,Schuck VJ,Nichols WW,Mouton JW

更新日期：2015-11-02 00:00:00

abstract：:beta-Lactamase production was investigated in cultures of 25 Klebsiella pneumoniae isolates isolated at a hospital in Durban, South Africa, in 1994 and 1996. Twenty of these isolates gave ceftazidime MIC/ceftazidime plus clavulanate MIC ratios of >/=8, implying production of extended-spectrum beta-lactamases (ESBLs), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Essack SY,Hall LM,Pillay DG,McFadyen ML,Livermore DM

更新日期：2001-01-01 00:00:00

abstract：:The linkage between the macrolide efflux gene mef(I) and the chloramphenicol inactivation gene catQ was first described in Streptococcus pneumoniae (strain Spn529), where the two genes are located in a module designated IQ element. Subsequently, two different defective IQ elements were detected in Streptococcus pyogen...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Morroni G,Giovanetti E,Del Grosso M,Pantosti A,Varaldo PE

更新日期：2014-10-01 00:00:00

abstract：:Meropenem-vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae The objective of these studies was to evaluate the efficacy of meropenem alone and in combination with vaborbactam in mouse thigh an...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabet M,Tarazi Z,Nolan T,Parkinson J,Rubio-Aparicio D,Lomovskaya O,Dudley MN,Griffith DC

更新日期：2017-12-21 00:00:00

abstract：:The objective of this study was to develop a population pharmacokinetic model and to determine a dosing regimen for caspofungin in critically ill patients. Nine blood samples were drawn per dosing occasion. Fifteen patients with (suspected) invasive candidiasis had one dosing occasion and five had two dosing occasions...

journal_title：Antimicrobial agents and chemotherapy

authors： Märtson AG,van der Elst KCM,Veringa A,Zijlstra JG,Beishuizen A,van der Werf TS,Kosterink JGW,Neely M,Alffenaar JW

更新日期：2020-08-20 00:00:00

abstract：:Mycobacterium simiae is a rare species of slow-growing nontuberculous mycobacteria (NTM). From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prev...

journal_title：Antimicrobial agents and chemotherapy

authors： Coolen-Allou N,Touron T,Belmonte O,Gazaille V,Andre M,Allyn J,Picot S,Payet A,Veziris N

更新日期：2018-06-26 00:00:00

abstract：:The judicious use of perioperative antibiotic prophylaxis reduces the infectious complications of surgery. However, increased bacterial resistance within hospitals may make antibiotic prophylaxis less effective in the future and alternative strategies are needed. New immunomodulatory agents might prevent wound infecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kernodle DS,Gates H,Kaiser AB

更新日期：1998-03-01 00:00:00

abstract：:Ciprofloxacin, clinafloxacin, PD 131628, sparfloxacin, and trovafloxacin were tested against 236 strains of Streptococcus pneumoniae, most of which were resistant to other agents. Resistance to multiple antibiotics did not affect the organism's susceptibility to the fluoroquinolones. The fluoroquinolones with in vitro...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Fuchs PC,Brown SD

更新日期：1996-10-01 00:00:00

abstract：:GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. We have characterized the in vivo pharmacodynamics (PD) of GSK1322322 in immunocompetent animal models of infection with Streptococcus pneumoniae a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoover J,Lewandowski T,Straub RJ,Novick SJ,DeMarsh P,Aubart K,Rittenhouse S,Zalacain M

更新日期：2015-10-19 00:00:00

abstract：:Potential alternatives, including linezolid, adjunctive rifampin, and moxifloxacin, were evaluated against vancomycin-tolerant (P9802-020) and vancomycin-susceptible clinical isolates of Streptococcus pneumoniae in an in vitro pharmacodynamic model. Vancomycin exhibited maximal killing of 2-log(10) CFU/ml against P980...

journal_title：Antimicrobial agents and chemotherapy

authors： Cha R,Rybak MJ

更新日期：2003-06-01 00:00:00

abstract：:The in vitro activity of trimethoprim plus dapsone against oxacillin-resistant Staphylococcus aureus was comparable to that of trimethoprim plus sulfamethoxazole. Because of its different pharmacologic properties, dapsone may be a useful agent in combination with trimethoprim for the treatment of patients colonized wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Lambertus MW,Kwok RY,Mulligan ME

更新日期：1990-07-01 00:00:00

abstract：:6-Nonadecynoic acid (6-NDA), a plant-derived acetylenic acid, exhibits strong inhibitory activity against the human fungal pathogens Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. In the present study, transcriptional profiling coupled with mutant and biochemical analyses were conducted usin...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu T,Tripathi SK,Feng Q,Lorenz MC,Wright MA,Jacob MR,Mask MM,Baerson SR,Li XC,Clark AM,Agarwal AK

更新日期：2012-06-01 00:00:00

abstract：:An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungals with a novel mechanism of action. Here we report the identification and characterization of two novel zinc-attenuating compounds, Z...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohrt KAO,Marín L,Kjellerup L,Clausen JD,Dalby-Brown W,Calera JA,Winther AL

更新日期：2018-04-26 00:00:00

abstract：:Antibiotic therapy with penicillin, doxycycline, and ceftriaxone has proven to be effective for the treatment of Lyme borreliosis. In some patients, however, it was noticed that borreliae can survival in the tissues in spite of seemingly adequate therapy. For a better understanding of this phenomenon, we investigated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kersten A,Poitschek C,Rauch S,Aberer E

更新日期：1995-05-01 00:00:00

abstract：:We have developed a chromatographic assay with high sensitivity and specificity to quantify G418 sulfate (Geneticin), an antibiotic used routinely in molecular genetics experiments for selecting eukaryotic transformants. With this method, G418 in tissues and plasma samples can be quantitated without the confounding fa...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethune C,Bui T,Liu ML,Kay MA,Ho RJ

更新日期：1997-03-01 00:00:00

abstract：:Hemolytic-uremic syndrome (HUS) is a serious complication of infection by Shiga toxin-producing Escherichia coli. Shiga toxin type 2 (Stx2) is responsible for the renal toxicity that can follow intestinal infection and hemorrhagic colitis due to E. coli. A chimeric mouse-human antibody, designated c alpha Stx2, that h...

journal_title：Antimicrobial agents and chemotherapy

authors： Dowling TC,Chavaillaz PA,Young DG,Melton-Celsa A,O'Brien A,Thuning-Roberson C,Edelman R,Tacket CO

更新日期：2005-05-01 00:00:00