Pharmacokinetics of Clindamycin in Obese and Nonobese Children.


:Although obesity is prevalent among children in the United States, pharmacokinetic (PK) data for obese children are limited. Clindamycin is a commonly used antibiotic that may require dose adjustment in obese children due to its lipophilic properties. We performed a clindamycin population PK analysis using data from three separate trials. A total of 420 samples from 220 children, 76 of whom had a body mass index greater than or equal to the 95th percentile for age, were included in the analysis. Compared to other metrics, total body weight (TBW) was the most robust measure of body size. The final model included TBW and a sigmoidal maturation relationship between postmenstrual age (PMA) and clearance (CL): CL (liters/hour) = 13.8 × (TBW/70)0.75 × [PMA2.83/(39.52.83+PMA2.83)]; volume of distribution (V) was associated with TBW, albumin (ALB), and alpha-1 acid glycoprotein (AAG): V (liters) = 63.6 × (TBW/70) × (ALB/3.3)-0.83 × (AAG/2.4)-0.25 After accounting for differences in TBW, obesity status did not explain additional interindividual variability in model parameters. Our findings support TBW-based dosing for obese and nonobese children.


Smith MJ,Gonzalez D,Goldman JL,Yogev R,Sullivan JE,Reed MD,Anand R,Martz K,Berezny K,Benjamin DK Jr,Smith PB,Cohen-Wolkowiez M,Watt K,Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee.




Has Abstract


2017-03-24 00:00:00












  • Antibiotic Resistance and Epigenetics: More to It than Meets the Eye.

    abstract::The discovery of antibiotics in the last century is considered one of the most important achievements in the history of medicine. Antibiotic usage has significantly reduced morbidity and mortality associated with bacterial infections. However, inappropriate use of antibiotics has led to emergence of antibiotic resista...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,评审


    authors: Ghosh D,Veeraraghavan B,Elangovan R,Vivekanandan P

    更新日期:2020-01-27 00:00:00

  • Incorporating Stage-Specific Drug Action into Pharmacological Modeling of Antimalarial Drug Treatment.

    abstract::Pharmacological modeling of antiparasitic treatment based on a drug's pharmacokinetic and pharmacodynamic properties plays an increasingly important role in identifying optimal drug dosing regimens and predicting their potential impact on control and elimination programs. Conventional modeling of treatment relies on m...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hodel EM,Kay K,Hastings IM

    更新日期:2016-04-22 00:00:00

  • Six groups of the OXY beta-Lactamase evolved over millions of years in Klebsiella oxytoca.

    abstract::The diversity and evolution of the class A OXY beta-lactamase from Klebsiella oxytoca were investigated and compared to housekeeping gene diversity. The entire bla(OXY) coding region was sequenced in 18 clinical isolates representative of the four K. oxytoca beta-lactamase gene groups bla(OXY-1) to bla(OXY-4) and of t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fevre C,Jbel M,Passet V,Weill FX,Grimont PA,Brisse S

    更新日期:2005-08-01 00:00:00

  • Structural origins of oxacillinase specificity in class D β-lactamases.

    abstract::Since the discovery and use of penicillin, the increase of antibiotic resistance among bacterial pathogens has become a major health concern. The most prevalent resistance mechanism in Gram-negative bacteria is due to β-lactamase expression. Class D β-lactamases are of particular importance due to their presence in mu...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: June CM,Vallier BC,Bonomo RA,Leonard DA,Powers RA

    更新日期:2014-01-01 00:00:00

  • Efficacy of ticarcillin-clavulanic acid for treatment of experimental Staphylococcus aureus endocarditis in rats.

    abstract::The efficacy of ticarcillin-clavulanic acid was compared with the efficacies of standard antistaphylococcal agents (flucloxacillin, oxacillin, nafcillin, and vancomycin) and ticarcillin in an experimental model of Staphylococcus aureus endocarditis. Therapy was either initiated soon (8 h) after infection, when numbers...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Catherall EJ,Gillon V,Hurn S,Irwin R,Mizen L

    更新日期:1992-02-01 00:00:00

  • Do formulation differences between the reference listed drug and generic piperacillin-tazobactam impact reconstitution?

    abstract::Pharmaceutical differences between the reference listed drug (RLD) and generic formulations of piperacillin-tazobactam may impact the reconstitution process for intravenous administration. This study evaluated the RLD against three generic formulations and measured their reconstitution times using a standardized proce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Zheng H,Truong J,Carroll F,Pai MP

    更新日期:2015-03-01 00:00:00

  • Imipenem Population Pharmacokinetics: Therapeutic Drug Monitoring Data Collected in Critically Ill Patients with or without Extracorporeal Membrane Oxygenation.

    abstract::Carbapenem pharmacokinetic (PK) profiles are significantly different in critically ill patients because of the drastic variability of the patients' physiological parameters. Published population PK studies have mainly focused on specific diseases, and the majority of these studies had small sample sizes. The aim of th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chen W,Zhang D,Lian W,Wang X,Du W,Zhang Z,Guo D,Zhang X,Zhan Q,Li P

    更新日期:2020-05-21 00:00:00

  • Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis.

    abstract::Current treatment options for bacterial vaginosis (BV) have been shown to be inadequate at preventing recurrence and do not provide protection against associated infections, such as that with HIV. This study examines the feasibility of incorporating the antimicrobial peptide subtilosin within covalently cross-linked p...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sundara Rajan S,Cavera VL,Zhang X,Singh Y,Chikindas ML,Sinko PJ

    更新日期:2014-05-01 00:00:00

  • Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: antimicrobial susceptibility patterns from the SENTRY antimicrobial Surveillance Program (United States and Canada, 1997).

    abstract::Between February and June of 1997, a large number of community-acquired respiratory tract isolates of Haemophilus influenzae (n = 1,077) and Moraxella catarrhalis (n = 503) from 27 U.S. and 7 Canadian medical centers were characterized as part of the SENTRY Antimicrobial Surveillance Program. Overall prevalences of be...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Doern GV,Jones RN,Pfaller MA,Kugler K

    更新日期:1999-02-01 00:00:00

  • In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM.

    abstract::During a 6-month period, 21 pairs of Pseudomonas aeruginosa isolates susceptible (pretherapy) and resistant (posttherapy) to antipseudomonal beta-lactam antibiotics were isolated from hospitalized patients. In vivo emergence of beta-lactam resistance was associated with the overexpression of AmpC beta-lactamase in 10 ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ziha-Zarifi I,Llanes C,Köhler T,Pechere JC,Plesiat P

    更新日期:1999-02-01 00:00:00

  • Drug susceptibility testing of anaerobic protozoa.

    abstract::A simple technique for routine, reproducible global surveillance of the drug susceptibility status of the anaerobic protozoa Trichomonas, Entamoeba, and Giardia is described. Data collected using this technique can be readily compared among different laboratories and with previously reported data. The technique employ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Upcroft JA,Upcroft P

    更新日期:2001-06-01 00:00:00

  • Comparative antimicrobial activity of O-demethylfortimicin A, a derivative of fortimicin A.

    abstract::The in vitro antimicrobial activity of O-demethylfortimicin A (ODMF), a derivative of fortimicin A, was compared with those of fortimicin A and gentamicin against a spectrum of 256 organisms. All three antibiotics were active in low concentrations against all strains of Enterobacteriaceae, Acinetobacter sp., and Staph...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Girolami RL,Stamm JM

    更新日期:1980-11-01 00:00:00

  • Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hirakata Y,Ohmori K,Mikuriya M,Saika T,Matsuzaki K,Hasegawa M,Hatta M,Yamamoto N,Kunishima H,Yano H,Kitagawa M,Arai K,Kawakami K,Kobayashi I,Jones RN,Kohno S,Yamaguchi K,Kaku M

    更新日期:2009-10-01 00:00:00

  • Susceptibility of Haemophilus influenzae type b to ampicillin-sulbactam.

    abstract::Seventy-five strains of Haemophilus influenzae type b, including 45 beta-lactamase-positive strains, were tested by MIC and time kill studies for susceptibility to ampicillin-sulbactam at various ratios. beta-Lactamase-negative strains were inhibited by lower concentrations of ampicillin-sulbactam than beta-lactamase-...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Azimi PH,Dunphy MG

    更新日期:1989-09-01 00:00:00

  • Antimicrobial activities of BMY-28142, cefbuperazone, and cefpiramide compared with those of other cephalosporins.

    abstract::The antimicrobial activities of BMY-28142, cefbuperazone (BMY-25182; formerly T-1982), and cefpiramide (WY-44635; formerly SM-1652) were compared with those of cefmenoxime, cefoperazone, cefotaxime, ceftizoxime, and moxalactam. BMY-28142 was the most active cephalosporin against the majority of aerobic and facultative...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Khan NJ,Bihl JA,Schell RF,LeFrock JL,Weber SJ

    更新日期:1984-10-01 00:00:00

  • An Exposure-Response Perspective on the Clinical Dose of Pretomanid.

    abstract::Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nedelman JR,Salinger DH,Subramoney V,Woolson R,Wade K,Li M,Everitt D,Mendel CM,Spigelman M

    更新日期:2020-12-16 00:00:00

  • Double-blind comparison of teicoplanin versus vancomycin in febrile neutropenic patients receiving concomitant tobramycin and piperacillin: effect on cyclosporin A-associated nephrotoxicity.

    abstract::A prospective, randomized, and double-blind study comparing teicoplanin with vancomycin in the initial management of febrile neutropenic patients was conducted. Teicoplanin was administered at 6 mg per kg of body weight every 24 h (q24h) intravenously (i.v.) after initial loading at 6 mg/kg q12h for three doses. Vanco...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kureishi A,Jewesson PJ,Rubinger M,Cole CD,Reece DE,Phillips GL,Smith JA,Chow AW

    更新日期:1991-11-01 00:00:00

  • Antimicrobial therapy of experimental group B streptococcal infection in mice.

    abstract::Group B beta-hemolytic streptococci (GB-BHS) frequently cause severe infection in newborns. Previous in vitro studies showed accelerated killing of GB-BHS by ampicillin plus gentamicin as compared with ampicillin alone. To extend the in vitro observations, mice were infected experimentally with GB-BHS and treated with...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Deveikis A,Schauf V,Mizen M,Riff L

    更新日期:1977-05-01 00:00:00

  • NVC-422 inactivates Staphylococcus aureus toxins.

    abstract::Bacterial pathogens have specific virulence factors (e.g., toxins) that contribute significantly to the virulence and infectivity of microorganisms within the human hosts. Virulence factors are molecules expressed by pathogens that enable colonization, immunoevasion, and immunosuppression, obtaining nutrients from the...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jekle A,Yoon J,Zuck M,Najafi R,Wang L,Shiau T,Francavilla C,Rani SA,Eitzinger C,Nagl M,Anderson M,Debabov D

    更新日期:2013-02-01 00:00:00

  • Immunomodulation of pneumococcal pulmonary infection with N(G)-monomethyl-L-arginine.

    abstract::It has recently become apparent that inflammatory reactions including nitric oxide (NO) release contribute to the outcome of pulmonary infections. To investigate the effect of N(G)-monomethyl-L-arginine (L-NMMA), a NO synthase inhibitor, on the pathogenesis of pneumococcal pneumonia, we inoculated CD(1) Swiss mice wit...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bergeron Y,Ouellet N,Simard M,Olivier M,Bergeron MG

    更新日期:1999-09-01 00:00:00

  • In vitro activities of aztreonam, imipenem, and amoxycillin-clavulanate against ampicillin-resistant Haemophilus influenzae.

    abstract::Two hundred and fifty-seven ampicillin-resistant clinical isolates of Haemophilus influenzae were tested by disk diffusion and MIC determination for susceptibility to aztreonam, imipenem, and amoxycillin combined with clavulanate. The modal MICs and MICs for 50 and 90% of isolates of all three antimicrobial agents for...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Powell M,Williams JD

    更新日期:1987-12-01 00:00:00

  • Mechanism of fluconazole resistance in Candida krusei.

    abstract::The mechanisms of fluconazole resistance in three clinical isolates of Candida krusei were investigated. Analysis of sterols of organisms grown in the absence and presence of fluconazole demonstrated that the predominant sterol of C. krusei is ergosterol and that fluconazole inhibits 14alpha-demethylase in this organi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Orozco AS,Higginbotham LM,Hitchcock CA,Parkinson T,Falconer D,Ibrahim AS,Ghannoum MA,Filler SG

    更新日期:1998-10-01 00:00:00

  • Inhibitory effects of quinolones on pro- and eucaryotic DNA topoisomerases I and II.

    abstract::As a means of gaining information on the selectivity of quinolone antibacterial agents, we examined their effect on four topoisomerases, topoisomerases I and II purified from Escherichia coli and calf thymus. The inhibition of supercoiling and relaxation activities was monitored by using the classical gel electrophore...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Moreau NJ,Robaux H,Baron L,Tabary X

    更新日期:1990-10-01 00:00:00

  • Effect of carbon dioxide on erythromycin.

    abstract::Exposure of erythromycin solutions to CO(2) or air for 18 h resulted in minimal deterioration under both conditions. Saturated disks exposed to the two atmospheres resulted in greater erythromycin deterioration, with slightly more deterioration occurring in the presence of CO(2). Reduction of activity was greatest whe...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Goldstein EJ,Sutter VL

    更新日期:1983-02-01 00:00:00

  • Comparison of the inoculum effect of cefoxitin and other cephalosporins and of beta-lactamase inhibitors and their penicillin-derived components on the Bacteroides fragilis group.

    abstract::We compared the inoculum effects for 109 recent clinical isolates of the Bacteroides fragilis group of cefoxitin, cefotetan, ceftizoxime, ceftriaxone, and three beta-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) and their penicillin-derived components. Bactericidal activity was assayed and morpholo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Goldstein EJ,Citron DM,Cherubin CE

    更新日期:1991-09-01 00:00:00

  • Influence of plasma exchange pheresis on plasma elimination of ceftriaxone.

    abstract::The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bakken JS,Cavalieri SJ,Gangeness D

    更新日期:1990-06-01 00:00:00

  • Influence of urinary pH on the pharmacokinetics of cinoxacin in humans and on antibacterial activity in vitro.

    abstract::The impact of acidification and alkalinization of the urine on the pharmacokinetics of cinoxacin was examined after single 500-mg oral doses were administered to nine healthy male volunteers. Acidic and alkaline conditions were achieved by repeated oral doses of ammonium chloride or sodium bicarbonate, respectively. P...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Barbhaiya RH,Gerber AU,Craig WA,Welling PG

    更新日期:1982-03-01 00:00:00

  • beta-lactamase production and antimicrobial susceptibility of oral heterogeneous Fusobacterium nucleatum populations in young children.

    abstract::Oral Fusobacterium nucleatum populations from 20 young, healthy children were examined for beta-lactamase production. Ten children (50%) harbored, altogether, 25 beta-lactamase-positive F. nucleatum isolates that were identified as F. nucleatum subsp. polymorphum, F. nucleatum subsp. nucleatum, and F. nucleatum subsp....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Könönen E,Kanervo A,Salminen K,Jousimies-Somer H

    更新日期:1999-05-01 00:00:00

  • Interference with effects of amphotericin B on Candida albicans cells by 2-chloroethyl-1-nitrosoureas.

    abstract::Two nitrosoureas, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), with strong carbamoylating and weak alkylating activities, interfered with the induction of potassium leakage and lethal action of amphotericin B (AmB) on Candida albicans. 2-Cyclohexyl isocyanate, t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Brajtburg J,Elberg S,Kobayashi GS,Medoff G

    更新日期:1988-03-01 00:00:00

  • Screening and isolation of penicillinase inhibitor, KA-107.

    abstract::It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptom...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Iwai Y,Ono H,Takeshima H,Yamaguchi N,Omura S

    更新日期:1973-09-01 00:00:00