Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole.

abstract：:Lysobactor enzymogenes strain OH11 is an emerging biological control agent of fungal and bacterial diseases. We recently completed its genome sequence and found it contains a large number of gene clusters putatively responsible for the biosynthesis of nonribosomal peptides and polyketides, including the previously ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang W,Li Y,Qian G,Wang Y,Chen H,Li YZ,Liu F,Shen Y,Du L

更新日期：2011-12-01 00:00:00

abstract：:INX-08189 is an aryl-phosphoramidate of 6-O-methyl-2'-C-methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10±6 nM against hepatitis C genotype 1b at 72 h. The inhibitory effect on viral replication was rapid, with a 50% effective concentration (EC50) of 35±8 nM at ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vernachio JH,Bleiman B,Bryant KD,Chamberlain S,Hunley D,Hutchins J,Ames B,Gorovits E,Ganguly B,Hall A,Kolykhalov A,Liu Y,Muhammad J,Raja N,Walters CR,Wang J,Williams K,Patti JM,Henson G,Madela K,Aljarah M,Gilles

更新日期：2011-05-01 00:00:00

abstract：:ME1100 (arbekacin inhalation solution) is an inhaled aminoglycoside that is being developed to treat patients with hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP, respectively). Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses were undertaken to evaluate ME1100 regimen...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhavnani SM,Hammel JP,Lakota EA,Safir MC,VanScoy BD,Nagira Y,Rubino CM,Sato N,Koresawa T,Kondo K,Ambrose PG

更新日期：2020-09-21 00:00:00

abstract：:As opposed to Enterococcus faecalis, which is intrinsically resistant to lincosamides, streptogramins A, and pleuromutilins (LSAP phenotype) by production of the ABC protein Lsa(A), Enterococcus faecium is naturally susceptible. Since this phenotype may be selected for in vivo by quinupristin-dalfopristin (Q-D), the a...

journal_title：Antimicrobial agents and chemotherapy

authors： Isnard C,Malbruny B,Leclercq R,Cattoir V

更新日期：2013-09-01 00:00:00

abstract：:A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience. Infection was induced by inhalation of aerosolized Yersinia pestis organisms. Antibiotics were administered by intraperitoneal...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrne WR,Welkos SL,Pitt ML,Davis KJ,Brueckner RP,Ezzell JW,Nelson GO,Vaccaro JR,Battersby LC,Friedlander AM

更新日期：1998-03-01 00:00:00

abstract：:Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Covering only first-line antituberculosis drugs, this review addresses whether and how...

journal_title：Antimicrobial agents and chemotherapy

authors： Yew WW,Chang KC,Chan DP

更新日期：2018-07-27 00:00:00

abstract：:The effects of free amphotericin B (as Fungizone) and amphotericin B (AMB) incorporated into liposomes on the proliferation of lymphocytes were determined. Freshly obtained guinea pig and rat antigen-specific lymphocytes were compared with rat T-lymphocyte cell lines cultured for a long period of time. Incorporation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Boggs JM,Chang NH,Goundalkar A

更新日期：1991-05-01 00:00:00

abstract：:Surveillance of the circulating Mycobacterium tuberculosis complex (MTC) strains in a given locality is important for understanding tuberculosis (TB) epidemiology. We performed molecular epidemiological studies on sputum smear-positive isolates that were collected for anti-TB drug resistance surveillance to establish ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lukoye D,Katabazi FA,Musisi K,Kateete DP,Asiimwe BB,Okee M,Joloba ML,Cobelens FG

更新日期：2014-07-01 00:00:00

abstract：:The killing of Candida albicans by a series of amphiphilic quaternary ammonium compounds (QACs) with different hydrocarbon chain lengths was closely related to the binding of the compounds to the cells and damage of the cell membranes. The membrane damage was measured as the level of release of the UV-absorbing materi...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlström B,Chelminska-Bertilsson M,Thompson RA,Edebo L

更新日期：1997-03-01 00:00:00

abstract：:Hydrophilic albumin microspheres are proposed as a new delivery system for amphotericin B (AMB; AMB microspheres). The acute toxicity of AMB microspheres was lower than that of the AMB-deoxycholate (AMB-Doc) reference formulation in hamsters. Lethal doses in healthy and infected animals were improved at least eight ti...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez-Brunete JA,Dea MA,Rama S,Bolás F,Alunda JM,Raposo R,Méndez MT,Torrado-Santiago S,Torrado JJ

更新日期：2004-09-01 00:00:00

abstract：:The opportunistic apicomplexan parasite Toxoplasma gondii damages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which target the folate pathway, underscores the importance of examining alternative pharmacological strategies. Parasitic pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan WJ Jr,Dixon SE,Li C,Striepen B,Queener SF

更新日期：2005-06-01 00:00:00

abstract：:Antifungal azoles are widely used for controlling fungal infections. Fungi are able to change the expression of many genes when they adapt to azole stress, and increased expression of some of these genes can elevate resistance to azoles. However, the regulatory mechanisms behind transcriptional adaption to azoles in f...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun X,Wang K,Yu X,Liu J,Zhang H,Zhou F,Xie B,Li S

更新日期：2014-01-01 00:00:00

abstract：:Clindamycin was given intravenously to 15 patients undergoing colorectal surgery in an initial dose of 600 mg, given at induction of anesthesia followed by 6 doses of 600 mg at 8-h intervals. Series of serum samples and fecal specimens were taken for analysis of clindamycin concentrations. Tissue samples from the gut ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kager L,Liljeqvist L,Malmborg AS,Nord CE

更新日期：1981-12-01 00:00:00

abstract：:The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

journal_title：Antimicrobial agents and chemotherapy

authors： Queener SF,Bartlett MS,Nasr M,Smith JW

更新日期：1993-10-01 00:00:00

abstract：:Development of resistance to the antipseudomonal penicillins and cephalosporins mediated by hyperproduction of the chromosomal cephalosporinase AmpC is a major threat to the successful treatment of Pseudomonas aeruginosa infections. Although ampD inactivation has been previously found to lead to a partially derepresse...

journal_title：Antimicrobial agents and chemotherapy

authors： Juan C,Moyá B,Pérez JL,Oliver A

更新日期：2006-05-01 00:00:00

abstract：:PSI-352938 is a novel cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine 5'-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with other inhibitors of H...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam AM,Espiritu C,Murakami E,Zennou V,Bansal S,Micolochick Steuer HM,Niu C,Keilman M,Bao H,Bourne N,Veselenak RL,Reddy PG,Chang W,Du J,Nagarathnam D,Sofia MJ,Otto MJ,Furman PA

更新日期：2011-06-01 00:00:00

abstract：:Prosthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as a surgical antibiotic prophylaxis at the time of arthroplasty. This retrospective cohort study conducted across 10 hospitals over a 3-year period (January 2006 to December 2008...

journal_title：Antimicrobial agents and chemotherapy

authors： Peel TN,Cheng AC,Buising KL,Choong PF

更新日期：2012-05-01 00:00:00

abstract：:The antiviral effects of four compounds, phosphonoacetate, phosphonoformate, acycloguanosine, and purified human lymphoblastic interferon, were tested against two neurotropic herpesviruses, herpesvirus platyrrhine and herpes simplex virus, and two oncogenic herpesviruses, herpesvirus saimiri and herpesvirus ateles. Al...

journal_title：Antimicrobial agents and chemotherapy

authors： Daniel MD,Falk LA,King NW,Tamulevich R,Holland JS,Bekesi JG

更新日期：1980-10-01 00:00:00

abstract：:Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes ribosomal protein L16)...

journal_title：Antimicrobial agents and chemotherapy

authors： Adrian PV,Mendrick C,Loebenberg D,McNicholas P,Shaw KJ,Klugman KP,Hare RS,Black TA

更新日期：2000-11-01 00:00:00

abstract：:Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative p...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeifer Y,Schlatterer K,Engelmann E,Schiller RA,Frangenberg HR,Stiewe D,Holfelder M,Witte W,Nordmann P,Poirel L

更新日期：2012-04-01 00:00:00

abstract：:The in vitro activity of PD 127,391, a dihalogenated quinolone, was compared with those of ofloxacin, ciprofloxacin, nalidixic acid, gentamicin, and cefuroxime against 525 recent isolates and well-characterized antimicrobial agent-resistant strains. The MICs of PD 127,391 against 90% of members of the family Enterobac...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Ashby JP,Andrews JM

更新日期：1988-08-01 00:00:00

abstract：:Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these factors, quantify their effect, and determine the dose adjustments necessary for optimal drug concentrations....

journal_title：Antimicrobial agents and chemotherapy

authors： Sekaggya-Wiltshire C,Chirehwa M,Musaazi J,von Braun A,Buzibye A,Muller D,Gutteck U,Motta I,Calcagno A,Fehr JS,Kambugu A,Castelnuovo B,Lamorde M,Denti P

更新日期：2019-05-24 00:00:00

abstract：:The pace of resistance against antibiotics almost exceeds that of the development of new drugs. As many bacteria have become resistant to conventional antibiotics, new drugs or drug resources are badly needed to combat antibiotic-resistant pathogens, like methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobi...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao Z,Ma Y,Dai C,Zhao R,Li S,Wu Y,Cao Z,Li W

更新日期：2009-08-01 00:00:00

abstract：:The Infectious Diseases Society of America advocates trimethoprim-sulfamethoxazole (SXT) as initial therapy for females with acute uncomplicated bacterial cystitis in settings where the prevalence of SXT resistance does not exceed 10 to 20%. To determine trends in the activities of SXT, ampicillin, ciprofloxacin, and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Karlowsky JA,Kelly LJ,Thornsberry C,Jones ME,Sahm DF

更新日期：2002-08-01 00:00:00

abstract：:Piperacillin and vancomycin were used as initial empirical therapy for 211 febrile episodes in cancer patients. The response rate in 95 episodes of documented infection was 72%. The response of bacteremias, soft tissue infections, and pneumonias was 78, 71, and 38%, respectively. The response in infections caused by g...

journal_title：Antimicrobial agents and chemotherapy

authors： Jadeja L,Bolivar R,Fainstein V,Keating M,McCredie K,Hay M,Bodey GP

更新日期：1984-09-01 00:00:00

abstract：:Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). S...

journal_title：Antimicrobial agents and chemotherapy

authors： Morse GD,Rosenkranz S,Para MF,Segal Y,Difrancesco R,Adams E,Brizz B,Yarasheski KE,Reichman RC

更新日期：2005-08-01 00:00:00

abstract：:Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo for 6 weeks. Levels of serum glutamic oxalacetic transami...

journal_title：Antimicrobial agents and chemotherapy

authors： McCormack WM,George H,Donner A,Kodgis LF,Alpert S,Lowe EW,Kass EH

更新日期：1977-11-01 00:00:00

abstract：:Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to β-1,3 glucan. Here, we show this i...

journal_title：Antimicrobial agents and chemotherapy

authors： Mitchell KF,Taff HT,Cuevas MA,Reinicke EL,Sanchez H,Andes DR

更新日期：2013-04-01 00:00:00

abstract：:Endoplasmic reticulum (ER)-resident glucosidases I and II sequentially trim the three terminal glucose moieties on the N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Because m...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao X,Guo F,Comunale MA,Mehta A,Sehgal M,Jain P,Cuconati A,Lin H,Block TM,Chang J,Guo JT

更新日期：2015-01-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading pathogen for bacterial pneumonia, which can be treated with bacteriophage lysins harboring a conserved choline binding module (CBM). Such lysins regularly function as choline-recognizing dimers. Previously, we reported a pneumococcus-specific lysin ClyJ comprising the binding doma...

journal_title：Antimicrobial agents and chemotherapy

authors： Luo D,Huang L,Gondil VS,Zhou W,Yang W,Jia M,Hu S,He J,Yang H,Wei H

更新日期：2020-11-17 00:00:00