Abstract:
:Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producing Klebsiella pneumoniae strain in two hospitals.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Pfeifer Y,Schlatterer K,Engelmann E,Schiller RA,Frangenberg HR,Stiewe D,Holfelder M,Witte W,Nordmann P,Poirel Ldoi
10.1128/AAC.05315-11subject
Has Abstractpub_date
2012-04-01 00:00:00pages
2125-8issue
4eissn
0066-4804issn
1098-6596pii
AAC.05315-11journal_volume
56pub_type
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