In vitro activities of daptomycin and other antimicrobial agents against vancomycin-resistant gram-positive bacteria.

abstract：:Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Muilwijk EW,Dekkers BGJ,Henriet SSV,Verweij PE,Witjes B,Lashof AMLO,Groeneveld GH,van der Hoeven J,Alffenaar JWC,Russel FGM,van de Veerdonk F,Brüggemann RJM

更新日期：2017-08-24 00:00:00

abstract：:The following compounds, which possess anti-R-plasmid activity (Hahn and Ciak, 1976) in decreasing order, were shown by viscometric titration to change systematically the superhelical density of closed circular PM2 deoxyribonucleic acid in the manner of intercalators: ethidium bromide, quinacrine, acridine orange, qui...

journal_title：Antimicrobial agents and chemotherapy

authors： Allison RG,Hahn FE

更新日期：1977-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) is the major cause of non-A, non-B hepatitis worldwide. Current treatments are not curative for most infected individuals, and there is an urgent need for both novel therapeutic agents and small-animal models which can be used to evaluate candidate drugs. A small-animal model of HCV gene expres...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang H,Hanecak R,Brown-Driver V,Azad R,Conklin B,Fox MC,Anderson KP

更新日期：1999-02-01 00:00:00

abstract：:The oxazolidinones are a novel class of antibiotics that inhibit initiation of protein synthesis in bacteria. In order to investigate their novel mechanism of action, the interactions of several oxazolidinones with bacterial 70S ribosomes, 50S subunits, and 30S subunits have been characterized by (1)H nuclear magnetic...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou CC,Swaney SM,Shinabarger DL,Stockman BJ

更新日期：2002-03-01 00:00:00

abstract：:Two large studies compared posaconazole and fluconazole or itraconazole for prophylaxis in subjects undergoing allogeneic hematopoietic stem cell transplantation or subjects with acute myelogenous leukemia. To assess the impact of prophylaxis on colonization and the development of resistance in Saccharomyces yeasts, i...

journal_title：Antimicrobial agents and chemotherapy

authors： Mann PA,McNicholas PM,Chau AS,Patel R,Mendrick C,Ullmann AJ,Cornely OA,Patino H,Black TA

更新日期：2009-12-01 00:00:00

abstract：:Arylimidamides (AIAs) have been shown to have considerable biological activity against intracellular pathogens, includingTrypanosoma cruzi, which causes Chagas disease. In the present study, the activities of 12 novel bis-AIAs and 2 mono-AIAs against different strains ofT. cruziin vitroandin vivowere analyzed. The mos...

journal_title：Antimicrobial agents and chemotherapy

authors： Guedes-da-Silva FH,Batista DG,Meuser MB,Demarque KC,Fulco TO,Araújo JS,Da Silva PB,Da Silva CF,Patrick DA,Bakunova SM,Bakunov SA,Tidwell RR,Oliveira GM,Britto C,Moreira OC,Soeiro MN

更新日期：2016-03-25 00:00:00

abstract：:A sensitive and specific high-pressure liquid chromatographic method is described for the determination of the antibacterial drug flumequine and a major metabolite, 7-hydroxyflumequine, in human plasma and urine. The assay was linear over a concentration range of 1 to 120 micrograms/ml for both compounds. This method ...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison LI,Schuppan D,Rohlfing SR,Hansen AR,Hansen CS,Funk ML,Collins SH,Ober RE

更新日期：1984-03-01 00:00:00

abstract：:Itraconazole is used for the prevention and treatment of infections caused by Aspergillus fumigatus. An understanding of the pharmacodynamics of itraconazole against wild-type and triazole-resistant strains provides a basis for innovative therapeutic strategies for treatment of infections. An in vitro model of the hum...

journal_title：Antimicrobial agents and chemotherapy

authors： Al-Nakeeb Z,Sudan A,Jeans AR,Gregson L,Goodwin J,Warn PA,Felton TW,Howard SJ,Hope WW

更新日期：2012-08-01 00:00:00

abstract：:The in vitro activity of GR-20263, a new aminothiazolyl cephalosporin, was compared with the activities of other beta-lactam antibiotics by using 800 clinical bacterial isolates. GR-20263 was highly active (inhibition of 90% of the isolates between 0.03 and 1 microgram/ml) against the common Enterobacteriaceae and 5 t...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L,Verhaegen J

更新日期：1980-05-01 00:00:00

abstract：:The stage-dependent susceptibility of Plasmodium falciparum to a short exposure to docetaxel (Taxotere) was evaluated by subjecting ring-infected, trophozoite-infected, and schizont-infected erythrocytes to a 5-h exposure to various concentrations of the drug. The schizont stage was shown to be the most sensitive stag...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinou V,Grellier P,Schrevel J

更新日期：1996-02-01 00:00:00

abstract：:Activity against the coccidial pathogen Eimeria tenella in chickens has been discovered among alpha 2 adrenergic agonists. The clonidine analog 7-bromo-N-(2-imidazolidinylidene)-1H-indazol-6-amine was active in feed at 7.5 ppm, a concentration similar to the use levels of potent commercial agents, e.g., maduramicin. A...

journal_title：Antimicrobial agents and chemotherapy

authors： McFarland JW,Ricketts AP,Newcomb DM,Shively JE,Glazer EA

更新日期：1992-02-01 00:00:00

abstract：:The unbound drug hypothesis states that only unbound drug concentrations are active and available for clearance, and highly variable results regarding unbound vancomycin fractions have been reported in the literature. We have determined the unbound vancomycin fractions in four different patient groups by a liquid chro...

journal_title：Antimicrobial agents and chemotherapy

authors： Oyaert M,Spriet I,Allegaert K,Smits A,Vanstraelen K,Peersman N,Wauters J,Verhaegen J,Vermeersch P,Pauwels S

更新日期：2015-11-01 00:00:00

abstract：:Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 microg/ml; MIC at which 50% of isolates are inhibited [MIC50], 0.25 microg/ml). The MIC50 of rifabutin was 0.008 microg/ml (n = 16). All resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exc...

journal_title：Antimicrobial agents and chemotherapy

authors： Heep M,Beck D,Bayerdörffer E,Lehn N

更新日期：1999-06-01 00:00:00

abstract：:We determined the nucleotide sequence of the blaOXA-3(pMG25) gene from Pseudomonas aeruginosa. The bla structural gene encoded a protein of 275 amino acids representing one monomer of 31,879 Da for the OXA-3 enzyme. Comparisons between the OXA-3 nucleotide and amino acid sequences and those of class A, B, C, and D bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanschagrin F,Couture F,Levesque RC

更新日期：1995-04-01 00:00:00

abstract：:Foscarnet is widely used for the treatment of acyclovir-resistant herpesvirus infections, and foscarnet-resistant herpesvirus infections are a serious concern in immunocompromised patients. Twenty-seven single-plaque isolates of herpes simplex virus type 1 (HSV-1) resistant to foscarnet were selected from foscarnet- a...

journal_title：Antimicrobial agents and chemotherapy

authors： Saijo M,Suzutani T,Morikawa S,Kurane I

更新日期：2005-02-01 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae carrying New Delhi metallo-β-lactamase 1 (NDM-1) have rarely been reported in Latin America. We report of an outbreak caused by a blaNDM-1-harboring plasmid spread through different bacterial species, including Escherichia coli (ST617) and Enterobacter cloacae (ST182) isolates f...

journal_title：Antimicrobial agents and chemotherapy

authors： Torres-González P,Bobadilla-Del Valle M,Tovar-Calderón E,Leal-Vega F,Hernández-Cruz A,Martínez-Gamboa A,Niembro-Ortega MD,Sifuentes-Osornio J,Ponce-de-León A

更新日期：2015-11-01 00:00:00

abstract：:Efavirenz-based antiretroviral regimen is preferred during rifampin-containing tuberculosis therapy. However, current pharmacokinetic data are insufficient to guide optimized concurrent dosing. This study aimed to better characterize the effects of rifampin on efavirenz pharmacokinetics. Subjects were randomized to re...

journal_title：Antimicrobial agents and chemotherapy

authors： Kwara A,Tashima KT,Dumond JB,Poethke P,Kurpewski J,Kashuba AD,Court MH,Greenblatt DJ

更新日期：2011-07-01 00:00:00

abstract：:To evaluate maternal-fetal pharmacology of cefatrizine (BL-S 640), a new oral cephalosporin, a single oral 1,000-mg dose was administered to 33 gravidas (8 to 20 weeks' gestation) at varying intervals within 46 h of an elective therapeutic abortion by hysterectomy or intra-amniotic prostaglandin F(2a) induction. Mean ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bernard B,Thielen P,Garcia-Cázares J,Ballard CA

更新日期：1977-08-01 00:00:00

abstract：:We previously demonstrated the potent in vitro activity of erythromycin against Mycobacterium leprae as determined by its effect on ATP pools and rates of palmitate oxidation and phenolic glycolipid I synthesis. In the present study, the relative in vitro activities of a number of new macrolides with superior pharmaco...

journal_title：Antimicrobial agents and chemotherapy

authors： Franzblau SG,Hastings RC

更新日期：1988-12-01 00:00:00

abstract：:HMR 3647 (telithromycin), a new ketolide, is active on intracellular pathogens. It was previously demonstrated that it inhibits superoxide anion production in a time- and concentration-dependent manner, at concentrations which inhibit 50% of the control response of about 55 microg/ml (5 min) to 30 microg/ml (30 min); ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vazifeh D,Abdelghaffar H,Labro MT

更新日期：2002-05-01 00:00:00

abstract：:Carbapenem-resistant Acinetobacter baumannii is a major source of nosocomial infections worldwide and is mainly associated with the acquisition of OXA-type carbapenemases and, to a lesser extent, metallo-β-lactamases (MBLs). In this study, 82 nonepidemiologically related Acinetobacter strains carrying different types ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Zboromyrska Y,Mosqueda N,Morosini MI,García-Fernández S,Roca I,Cantón R,Marco F,Vila J

更新日期：2014-12-01 00:00:00

abstract：:The effects of binding and the bactericidal action of vancomycin on the arrangement and mobilities of cell wall polymers in Bacillus licheniformis were investigated by (15)N nuclear magnetic resonance spectroscopy. The bactericidal action of vancomycin led to reduced mobilities of cell wall teichoic acid and teichuron...

journal_title：Antimicrobial agents and chemotherapy

authors： Irving CS,Lapidot A

更新日期：1978-11-01 00:00:00

abstract：:The racemic nucleoside analogue 2'-deoxy-3'-oxa-4'-thiocytidine (dOTC) is in clinical development for the treatment of human immunodeficiency virus (HIV) type 1 (HIV-1) infection. dOTC is structurally related to lamivudine (3TC), but the oxygen and sulfur in the furanosyl ring are transposed. Intracellular metabolism ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Muys JM,Gourdeau H,Nguyen-Ba N,Taylor DL,Ahmed PS,Mansour T,Locas C,Richard N,Wainberg MA,Rando RF

更新日期：1999-08-01 00:00:00

abstract：:The in vitro susceptibilities of 12 strains of Chlamydia pneumoniae to a new quinolone, trovafloxacin, and ofloxacin, doxycycline, erythromycin, and azithromycin were determined. The activity of trovafloxacin was similar to that of ofloxacin, with a MIC at which 90% of the isolates are inhibited and a minimal concentr...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Kutlin A,Hammerschlag MR

更新日期：1997-09-01 00:00:00

abstract：:Halocidin is an antimicrobial peptide found in the tunicate. A series of experiments were previously conducted in an attempt to develop a novel antibiotic derived from halocidin, as the peptide was determined to evidence profound antimicrobial activity against a variety of antibiotic-resistant microbes, with significa...

journal_title：Antimicrobial agents and chemotherapy

authors： Jang WS,Lee SC,Lee YS,Shin YP,Shin KH,Sung BH,Kim BS,Lee SH,Lee IH

更新日期：2007-11-01 00:00:00

abstract：:Alpha interferon and ribavirin are required in combination to achieve a sustained virological response in the treatment of hepatitis C virus (HCV) infection. Alpha interferon has direct antiviral activity and also enhances HCV-specific T-cell responses. Ribavirin has little direct activity against HCV but reduces hepa...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes E,Salio M,Cerundolo V,Medlin J,Murphy S,Dusheiko G,Klenerman P

更新日期：2004-09-01 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:An unusual In0-like class 1 integron containing a common region that includes the putative recombinase gene named orf513 (CR1) and bla(CTX-M-2) was characterized from Escherichia coli. The integron contained an unusual gene cassette array, estX-aadA1, embedded between the 5'-conserved segment (5'-CS) and 3'-CS1 region...

journal_title：Antimicrobial agents and chemotherapy

authors： Valverde A,Cantón R,Galán JC,Nordmann P,Baquero F,Coque TM

更新日期：2006-02-01 00:00:00

abstract：:A strain of Escherichia coli containing TEM-1 and CTX-M-1 was tested in an in vitro pharmacokinetic model against ceftazidime with and without AM-112, a serine beta-lactamase inhibitor. Ceftazidime alone was less effective than ceftazidime plus AM-112, and a single dose was more effective than three fractionated doses...

journal_title：Antimicrobial agents and chemotherapy

authors： Bowker KE,Noel AR,Walsh TR,Rogers CA,MacGowan AP

更新日期：2004-11-01 00:00:00

abstract：:Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for...

journal_title：Antimicrobial agents and chemotherapy

authors： Veiga MI,Osório NS,Ferreira PE,Franzén O,Dahlstrom S,Lum JK,Nosten F,Gil JP

更新日期：2014-12-01 00:00:00