Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations.

Abstract:

:Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.

authors

Muilwijk EW,Dekkers BGJ,Henriet SSV,Verweij PE,Witjes B,Lashof AMLO,Groeneveld GH,van der Hoeven J,Alffenaar JWC,Russel FGM,van de Veerdonk F,Brüggemann RJM

doi

10.1128/AAC.00915-17

subject

Has Abstract

pub_date

2017-08-24 00:00:00

issue

9

eissn

0066-4804

issn

1098-6596

pii

AAC.00915-17

journal_volume

61

pub_type

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